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The map label for this gene is fmt

Identifier: 41407231

GI number: 41407231

Start: 1187365

End: 1188312

Strand: Direct

Name: fmt

Synonym: MAP1133

Alternate gene names: 41407231

Gene position: 1187365-1188312 (Clockwise)

Preceding gene: 41407229

Following gene: 41407232

Centisome position: 24.58

GC content: 74.16

Gene sequence:

>948_bases
GTGCGCCTCGTCTTCGCCGGTACGCCCGAACCCGCGCTGCCGGCGCTGCGTCGCCTCCTCGACTCGCCGCGCCACGAGAT
GATCGCCGTGCTGACCCGGCCCGACGCCGCTTCCGGTCGGCGCGGCAAGCCCGAGCCGTCGCCGGTGGCCCGCGAGGCGC
TCGACCGCGGGATCCCGGTGCTGCGGCCGGCGCGGCCGAACTCGCCCGAATTCGTCGCCGAACTGGCGCAGTTGGCGCCG
GACTGCTGCGCGGTGGTGGCCTACGGCGCGCTGCTGCGCGACGAGCTGCTGGCGGTTCCCCCGCACGGGTGGATCAACCT
GCACTTCTCGCTGCTGCCGGCCTGGCGCGGCGCGGCGCCGGTGCAGGCGGCCATCGCGGCGGGGGACATCATCACCGGGG
CGTCGACGTTCCGGATCGAGCCGGCCCTGGACTCGGGCCCGATCTACGGGGTCGTGACCGAGGCGATCCGCCCCACCGAC
ACCGCCGGGGAACTGCTTGCGCGACTGGCGGTTTCGGGTGCGGAGCTGCTGTCCGCCACCCTGGACGGCATCGCCGACTC
GACGCTGACGCCGCGACCGCAACCCGCCGAGGGCGTCAGCATCGCGCCCAAGATCACCGTCGAGCAGGCCCGGGTGCGCT
GGGACCTGCCGGCCCCGGTGGTGGAGCGCCGCATCCGCGCCGTCACGCCCAACCCGGGCGCATGGACGGTGATCAGCGAC
CTGCGCATCAAACTCGGACCCGTGCGGCTCGGCGCGGCCTCCGACCTGCCCGCTCCGCCGGAACCGTTGCCGCCCGGCGC
AATTCACGTCGACCGCAAGAGCGTCTGGGTGGGCACCGGATCCGATCCGGTGCGGTTGGGTCAGATCCAGCCGCCCGGAA
AGAAATTCATGAACGCCGTGGACTGGGCGCGCGGCGCCCGGCTCGATCCCGCGGCGCGGGCCACATGA

Upstream 100 bases:

>100_bases
CAATTGCTCTGAGCAATAGTAGCCACAAGCAATAGTGTACGCACGCAATTTCTGGGCGGCGCCGCGGCCGTGCTTCGCCG
GGGCTTTCTAGACTGTGCCG

Downstream 100 bases:

>100_bases
GCCGGCCACAGCAGCGGGGGCGCGCCAACAGGCGCCGGCCGCTGGACCCGGCCCGGGCCGCCGCGTTCGAGGTGCTGCGG
GCGGTCAGCGAGCGCGACGC

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MRLVFAGTPEPALPALRRLLDSPRHEMIAVLTRPDAASGRRGKPEPSPVAREALDRGIPVLRPARPNSPEFVAELAQLAP
DCCAVVAYGALLRDELLAVPPHGWINLHFSLLPAWRGAAPVQAAIAAGDIITGASTFRIEPALDSGPIYGVVTEAIRPTD
TAGELLARLAVSGAELLSATLDGIADSTLTPRPQPAEGVSIAPKITVEQARVRWDLPAPVVERRIRAVTPNPGAWTVISD
LRIKLGPVRLGAASDLPAPPEPLPPGAIHVDRKSVWVGTGSDPVRLGQIQPPGKKFMNAVDWARGARLDPAARAT

Sequences:

>Translated_315_residues
MRLVFAGTPEPALPALRRLLDSPRHEMIAVLTRPDAASGRRGKPEPSPVAREALDRGIPVLRPARPNSPEFVAELAQLAP
DCCAVVAYGALLRDELLAVPPHGWINLHFSLLPAWRGAAPVQAAIAAGDIITGASTFRIEPALDSGPIYGVVTEAIRPTD
TAGELLARLAVSGAELLSATLDGIADSTLTPRPQPAEGVSIAPKITVEQARVRWDLPAPVVERRIRAVTPNPGAWTVISD
LRIKLGPVRLGAASDLPAPPEPLPPGAIHVDRKSVWVGTGSDPVRLGQIQPPGKKFMNAVDWARGARLDPAARAT
>Mature_315_residues
MRLVFAGTPEPALPALRRLLDSPRHEMIAVLTRPDAASGRRGKPEPSPVAREALDRGIPVLRPARPNSPEFVAELAQLAP
DCCAVVAYGALLRDELLAVPPHGWINLHFSLLPAWRGAAPVQAAIAAGDIITGASTFRIEPALDSGPIYGVVTEAIRPTD
TAGELLARLAVSGAELLSATLDGIADSTLTPRPQPAEGVSIAPKITVEQARVRWDLPAPVVERRIRAVTPNPGAWTVISD
LRIKLGPVRLGAASDLPAPPEPLPPGAIHVDRKSVWVGTGSDPVRLGQIQPPGKKFMNAVDWARGARLDPAARAT

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI164663775, Length=313, Percent_Identity=28.7539936102236, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI21614513, Length=293, Percent_Identity=28.6689419795222, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI238814322, Length=251, Percent_Identity=29.4820717131474, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1789683, Length=301, Percent_Identity=38.2059800664452, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI1788589, Length=290, Percent_Identity=30, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI133930964, Length=349, Percent_Identity=25.5014326647564, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45550868, Length=314, Percent_Identity=30.5732484076433, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28571984, Length=233, Percent_Identity=35.1931330472103, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 33291; Mature: 33291

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVFAGTPEPALPALRRLLDSPRHEMIAVLTRPDAASGRRGKPEPSPVAREALDRGIPV
CEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCE
LRPARPNSPEFVAELAQLAPDCCAVVAYGALLRDELLAVPPHGWINLHFSLLPAWRGAAP
ECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCCCCCC
VQAAIAAGDIITGASTFRIEPALDSGPIYGVVTEAIRPTDTAGELLARLAVSGAELLSAT
HHHHHHHCCEEECCCEEEEECCCCCCCCCEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LDGIADSTLTPRPQPAEGVSIAPKITVEQARVRWDLPAPVVERRIRAVTPNPGAWTVISD
HHHHCCCCCCCCCCCCCCCCCCCEEEEEHHHEEECCCCHHHHHHHEECCCCCCCEEEEEC
LRIKLGPVRLGAASDLPAPPEPLPPGAIHVDRKSVWVGTGSDPVRLGQIQPPGKKFMNAV
CEEEECCEEECCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCEEECCCCCCHHHHHHHH
DWARGARLDPAARAT
HHHCCCCCCCHHCCC
>Mature Secondary Structure
MRLVFAGTPEPALPALRRLLDSPRHEMIAVLTRPDAASGRRGKPEPSPVAREALDRGIPV
CEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCE
LRPARPNSPEFVAELAQLAPDCCAVVAYGALLRDELLAVPPHGWINLHFSLLPAWRGAAP
ECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCCCCCC
VQAAIAAGDIITGASTFRIEPALDSGPIYGVVTEAIRPTDTAGELLARLAVSGAELLSAT
HHHHHHHCCEEECCCEEEEECCCCCCCCCEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LDGIADSTLTPRPQPAEGVSIAPKITVEQARVRWDLPAPVVERRIRAVTPNPGAWTVISD
HHHHCCCCCCCCCCCCCCCCCCCEEEEEHHHEEECCCCHHHHHHHEECCCCCCCEEEEEC
LRIKLGPVRLGAASDLPAPPEPLPPGAIHVDRKSVWVGTGSDPVRLGQIQPPGKKFMNAV
CEEEECCEEECCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCEEECCCCCCHHHHHHHH
DWARGARLDPAARAT
HHHCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA