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The map label for this gene is fmu

Identifier: 41407232

GI number: 41407232

Start: 1188309

End: 1189703

Strand: Direct

Name: fmu

Synonym: MAP1134

Alternate gene names: 41407232

Gene position: 1188309-1189703 (Clockwise)

Preceding gene: 41407231

Following gene: 41407233

Centisome position: 24.6

GC content: 75.99

Gene sequence:

>1395_bases
ATGAGCCGGCCACAGCAGCGGGGGCGCGCCAACAGGCGCCGGCCGCTGGACCCGGCCCGGGCCGCCGCGTTCGAGGTGCT
GCGGGCGGTCAGCGAGCGCGACGCGTATGCGAACCTGGCGCTGCCCGCACTGCTGCGCGAGCGCGGGATCATCGGCCGTG
ACGCCGCATTCGCCACCGAGCTGACCTACGGCACCTGCCGCACCCGGGGCCTGCTGGACGCGGTCATCGGCGCGGCGGCC
GGGCGCCCGCCGGAAGCCATCGACCCGGTGCTGCTCGACCTGCTGCGCCTGGGCACCTACCAGTTGCTGCGCACCAGGGT
GGACGCCCACGCGGCGGTGTCCACCACCGTGGAGCAGGCGGCTATCGAATTCGACTCGGCGCGAGCGGGTTTCGTCAACG
GGGTGCTGCGCAGGATCGCCGGCCGCGACGAGCGGTCCTGGGTGCAGGAGCTGGCCCCGGACCCGGCCCGCGATCCGATC
GGACACGCCGCGTTCGTGCACGCCCATCCCCGGTGGATCGCCCAGGCCTTCGCCGACGCGCTGGGCGCCGCCGCGGCCGA
ACTCGACGCGGTGCTGGCAAGCGACGACGAACGACCGCAGGTGCATCTGGCGGCGCGACCGGGCGTGCTGACCGCCGCCG
AGCTGGCCGACGCGGTGGGCGGCACGGTCGGCCGCCACTCGCCCTTCGCGGTGTATCTGGCCGGCGGCGACCCCGGCCGG
CTGGCGCCGGTGCGCGACGGGCTGGCCCTGGTCCAGGACGAGGGCAGCCAATTGGTGGCCCGGGCGCTGACGCTGGCCCC
GGTGGACGGCGACTGCGGACGGTGGCTGGACTTGTGCGCCGGGCCGGGCGGCAAGACGGCTCTGCTGGCTTCCCTTGGCG
CCCAACGGTTTTCGGAGTCACAGTTCCGGGTCACCGCGGTCGAGCCGGCGCCGCGTCGCGCGGACCTGGTGGTCGAGAAC
ACCCGCGGATTGCCGGTCGAGGTGCTGCGGGTGGACGGGCGGCACACCGGCCTGCAGCCGGCGTTCGACCGGGTGCTCGT
CGACGCGCCGTGCACCGGGCTGGGGGCGCTGCGCCGCCGGCCGGAGGCGCGGTGGCGGCGGCAGCCCGGCGACGTGCCGG
CGCTGACCAAGCTGCAGCGCGAGTTGCTGGGCGCCGCGATTGCGCTGACCCGGCCGGGCGGGGTGGTGCTCTACGCGACC
TGCTCGCCGCACCTGGCCGAGACGGTCGGCGTGGTCGCCGACGCGTTGCGCCGCCACCCGGTCAGCGCGCTGGACGCCCG
GCCGCTGTTCGAGCCGGTCGCCGACCTGGGCGACGGGCCGCATGTTCAGCTCTGGCCGCACCGGCACGGCACCGACGCCA
TGTTCGCGTCGGCGCTACGCCGCGAAGCGGGGTAG

Upstream 100 bases:

>100_bases
ATCCGGTGCGGTTGGGTCAGATCCAGCCGCCCGGAAAGAAATTCATGAACGCCGTGGACTGGGCGCGCGGCGCCCGGCTC
GATCCCGCGGCGCGGGCCAC

Downstream 100 bases:

>100_bases
GGCGGACGCGACACAAATGGACCTGGCCGCGTCGGCCCTGCGCCGCGAAGCGGGGTAGGGCGGCGGTCTCCGGATGTGAA
CAGAGCGGCGGCGCTTCAGT

Product: Fmu

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSRPQQRGRANRRRPLDPARAAAFEVLRAVSERDAYANLALPALLRERGIIGRDAAFATELTYGTCRTRGLLDAVIGAAA
GRPPEAIDPVLLDLLRLGTYQLLRTRVDAHAAVSTTVEQAAIEFDSARAGFVNGVLRRIAGRDERSWVQELAPDPARDPI
GHAAFVHAHPRWIAQAFADALGAAAAELDAVLASDDERPQVHLAARPGVLTAAELADAVGGTVGRHSPFAVYLAGGDPGR
LAPVRDGLALVQDEGSQLVARALTLAPVDGDCGRWLDLCAGPGGKTALLASLGAQRFSESQFRVTAVEPAPRRADLVVEN
TRGLPVEVLRVDGRHTGLQPAFDRVLVDAPCTGLGALRRRPEARWRRQPGDVPALTKLQRELLGAAIALTRPGGVVLYAT
CSPHLAETVGVVADALRRHPVSALDARPLFEPVADLGDGPHVQLWPHRHGTDAMFASALRREAG

Sequences:

>Translated_464_residues
MSRPQQRGRANRRRPLDPARAAAFEVLRAVSERDAYANLALPALLRERGIIGRDAAFATELTYGTCRTRGLLDAVIGAAA
GRPPEAIDPVLLDLLRLGTYQLLRTRVDAHAAVSTTVEQAAIEFDSARAGFVNGVLRRIAGRDERSWVQELAPDPARDPI
GHAAFVHAHPRWIAQAFADALGAAAAELDAVLASDDERPQVHLAARPGVLTAAELADAVGGTVGRHSPFAVYLAGGDPGR
LAPVRDGLALVQDEGSQLVARALTLAPVDGDCGRWLDLCAGPGGKTALLASLGAQRFSESQFRVTAVEPAPRRADLVVEN
TRGLPVEVLRVDGRHTGLQPAFDRVLVDAPCTGLGALRRRPEARWRRQPGDVPALTKLQRELLGAAIALTRPGGVVLYAT
CSPHLAETVGVVADALRRHPVSALDARPLFEPVADLGDGPHVQLWPHRHGTDAMFASALRREAG
>Mature_463_residues
SRPQQRGRANRRRPLDPARAAAFEVLRAVSERDAYANLALPALLRERGIIGRDAAFATELTYGTCRTRGLLDAVIGAAAG
RPPEAIDPVLLDLLRLGTYQLLRTRVDAHAAVSTTVEQAAIEFDSARAGFVNGVLRRIAGRDERSWVQELAPDPARDPIG
HAAFVHAHPRWIAQAFADALGAAAAELDAVLASDDERPQVHLAARPGVLTAAELADAVGGTVGRHSPFAVYLAGGDPGRL
APVRDGLALVQDEGSQLVARALTLAPVDGDCGRWLDLCAGPGGKTALLASLGAQRFSESQFRVTAVEPAPRRADLVVENT
RGLPVEVLRVDGRHTGLQPAFDRVLVDAPCTGLGALRRRPEARWRRQPGDVPALTKLQRELLGAAIALTRPGGVVLYATC
SPHLAETVGVVADALRRHPVSALDARPLFEPVADLGDGPHVQLWPHRHGTDAMFASALRREAG

Specific function: May act as RNA methyltransferase [H]

COG id: COG0144

COG function: function code J; tRNA and rRNA cytosine-C5-methylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmB/NOP family [H]

Homologues:

Organism=Homo sapiens, GI32698918, Length=209, Percent_Identity=31.1004784688995, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI76150625, Length=225, Percent_Identity=29.7777777777778, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI76150623, Length=225, Percent_Identity=29.7777777777778, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI40316918, Length=201, Percent_Identity=35.3233830845771, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI2367212, Length=397, Percent_Identity=30.9823677581864, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI87081985, Length=241, Percent_Identity=28.2157676348548, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17536757, Length=220, Percent_Identity=29.0909090909091, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324268, Length=206, Percent_Identity=28.1553398058252, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319447, Length=160, Percent_Identity=30.625, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI22024126, Length=223, Percent_Identity=29.5964125560538, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21356513, Length=184, Percent_Identity=32.6086956521739, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24668781, Length=185, Percent_Identity=32.4324324324324, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001678
- InterPro:   IPR018314
- InterPro:   IPR006027 [H]

Pfam domain/function: PF01189 Nol1_Nop2_Fmu; PF01029 NusB [H]

EC number: NA

Molecular weight: Translated: 49399; Mature: 49268

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: PS01153 NOL1_NOP2_SUN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPQQRGRANRRRPLDPARAAAFEVLRAVSERDAYANLALPALLRERGIIGRDAAFATE
CCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LTYGTCRTRGLLDAVIGAAAGRPPEAIDPVLLDLLRLGTYQLLRTRVDAHAAVSTTVEQA
HCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIEFDSARAGFVNGVLRRIAGRDERSWVQELAPDPARDPIGHAAFVHAHPRWIAQAFADA
HHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHH
LGAAAAELDAVLASDDERPQVHLAARPGVLTAAELADAVGGTVGRHSPFAVYLAGGDPGR
HHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCC
LAPVRDGLALVQDEGSQLVARALTLAPVDGDCGRWLDLCAGPGGKTALLASLGAQRFSES
CCHHHCCHHEECCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
QFRVTAVEPAPRRADLVVENTRGLPVEVLRVDGRHTGLQPAFDRVLVDAPCTGLGALRRR
CEEEEEECCCCCCCCEEEECCCCCCEEEEEECCCCCCCCHHHHHEEECCCCCCHHHHHCC
PEARWRRQPGDVPALTKLQRELLGAAIALTRPGGVVLYATCSPHLAETVGVVADALRRHP
CHHHHCCCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEEECCCHHHHHHHHHHHHHHHCC
VSALDARPLFEPVADLGDGPHVQLWPHRHGTDAMFASALRREAG
CHHHCCCHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SRPQQRGRANRRRPLDPARAAAFEVLRAVSERDAYANLALPALLRERGIIGRDAAFATE
CCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LTYGTCRTRGLLDAVIGAAAGRPPEAIDPVLLDLLRLGTYQLLRTRVDAHAAVSTTVEQA
HCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIEFDSARAGFVNGVLRRIAGRDERSWVQELAPDPARDPIGHAAFVHAHPRWIAQAFADA
HHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHH
LGAAAAELDAVLASDDERPQVHLAARPGVLTAAELADAVGGTVGRHSPFAVYLAGGDPGR
HHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCC
LAPVRDGLALVQDEGSQLVARALTLAPVDGDCGRWLDLCAGPGGKTALLASLGAQRFSES
CCHHHCCHHEECCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
QFRVTAVEPAPRRADLVVENTRGLPVEVLRVDGRHTGLQPAFDRVLVDAPCTGLGALRRR
CEEEEEECCCCCCCCEEEECCCCCCEEEEEECCCCCCCCHHHHHEEECCCCCCHHHHHCC
PEARWRRQPGDVPALTKLQRELLGAAIALTRPGGVVLYATCSPHLAETVGVVADALRRHP
CHHHHCCCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEEECCCHHHHHHHHHHHHHHHCC
VSALDARPLFEPVADLGDGPHVQLWPHRHGTDAMFASALRREAG
CHHHCCCHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]