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The map label for this gene is dfp

Identifier: 41407223

GI number: 41407223

Start: 1177704

End: 1178966

Strand: Direct

Name: dfp

Synonym: MAP1125

Alternate gene names: 41407223

Gene position: 1177704-1178966 (Clockwise)

Preceding gene: 41407222

Following gene: 41407224

Centisome position: 24.38

GC content: 72.92

Gene sequence:

>1263_bases
GTGTACGACCGCAATCGGGCTTCCACACGGGCCGCGAGGATCGTCGTCGGCGTCTCCGGCGGCATCGCCGCCTACAAGGC
GTGCACCGTCGTCCGCCAGCTGTCTGAGGCCGGTCATTCGGTCCGGGTCATCCCCACCGAGTCCGCGCTGCGCTTCGTCG
GCGCCGCCACCTTCGAGGCGCTGTCCGGCCAGCCGGTGCACACCGGCGTCTTCGACGACGTGCCCGAGGTGCCGCACGTG
CAGCTGGGCAAGCAGGCCGACCTGGTGGTGGTGGCACCGGCCACCGCCGACCTGCTGGCCCGTGCGGTGCACGGCCGGGC
CGACGACCTGCTGACCGCCACCCTGCTCACCGCCCGATGTCCGGTGCTGTTCGCGCCGGCGATGCACACCGAGATGTGGT
TGCACCCGGCCACCGTCGACAACGTGGCCACGCTGCGCCGCCGCGGGGCGGTGGTGCTCGAGCCCGCCGCCGGGCGGCTC
ACCGGCACCGACAGCGGGTCGGGCCGGCTGCCCGAGGCCGAGGAGATCACCACCCTGGCCCAGCTGCTGCTGGAACGCCA
CGACGCGCTGCCCTACGACCTGGCCGGCTGCAAGATGGTGGTCACCGCCGGCGGCACCCGCGAACCCGTCGACCCGGTGC
GCTTCATCGGCAACCGCAGCTCCGGCAAGCAGGGCTACGCGGTGGCCCGGGTGGCCGCCCAGCGCGGCGCCGAGGTCACG
CTGATCGCCGGGCACACCGCCGGACTGATCGACCCCGCCGGGGTCGAGGTGGTGCACGTCAGCTCGGCGGAGCAGCTGGG
CAACGCGGTGTCCAAGCACGCGGCCGAGGCCGACGTGCTGGTGATGGCCGCCGCCGTCGCCGACTTCCGGCCCGCCCGGG
TTGCCGCCGCCAAGATCAAAAAGGGTGTCGAGGCACCGACGATCGAGTTGGTCCGCAACGACGACGTGCTGGCCGGCGCG
GTGCGGGCGCGCGCCCACGGCGAGCTGCCCAACCTGCGGGCCATCGTGGGATTCGCCGCCGAGACCGGAGACGCCAACGG
GGACGTGCTGTTTCACGCCCGCGCCAAGCTGCGCAACAAGGGCTGTGACCTGTTGGTGGTCAACGCGGTGGGCGAGGGCC
GGGCCTTCGAGGTGGACAGCAACGACGGCTGGCTGCTGGCGGCCGACGGGACCGAGTCGGCGCTGCAGCACGGCTCCAAG
ACGCTGATGGCCAGTCGTATCGTGGATGCGATCGCCGCCTTCCTGCGCGGGGACGGCGGATAA

Upstream 100 bases:

>100_bases
GGGGCTGCAGGAGAAACCGCTTTCGATCGCGCTGCGCGAGATCCACGGCGACCTGCTCGAGCACACCGAGGGCGAGTAAC
GGGGCCGGGCCGGGCGCGCT

Downstream 100 bases:

>100_bases
CACGGTCGAGTGCTTCTCGGCGCCGGGACCGCTGTGGGCCGGGCCGACGCCAGCCGATATAATTCGGCTACCTAACTATT
TGGAAGGATTGGGATTGTGA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MYDRNRASTRAARIVVGVSGGIAAYKACTVVRQLSEAGHSVRVIPTESALRFVGAATFEALSGQPVHTGVFDDVPEVPHV
QLGKQADLVVVAPATADLLARAVHGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPAAGRL
TGTDSGSGRLPEAEEITTLAQLLLERHDALPYDLAGCKMVVTAGGTREPVDPVRFIGNRSSGKQGYAVARVAAQRGAEVT
LIAGHTAGLIDPAGVEVVHVSSAEQLGNAVSKHAAEADVLVMAAAVADFRPARVAAAKIKKGVEAPTIELVRNDDVLAGA
VRARAHGELPNLRAIVGFAAETGDANGDVLFHARAKLRNKGCDLLVVNAVGEGRAFEVDSNDGWLLAADGTESALQHGSK
TLMASRIVDAIAAFLRGDGG

Sequences:

>Translated_420_residues
MYDRNRASTRAARIVVGVSGGIAAYKACTVVRQLSEAGHSVRVIPTESALRFVGAATFEALSGQPVHTGVFDDVPEVPHV
QLGKQADLVVVAPATADLLARAVHGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPAAGRL
TGTDSGSGRLPEAEEITTLAQLLLERHDALPYDLAGCKMVVTAGGTREPVDPVRFIGNRSSGKQGYAVARVAAQRGAEVT
LIAGHTAGLIDPAGVEVVHVSSAEQLGNAVSKHAAEADVLVMAAAVADFRPARVAAAKIKKGVEAPTIELVRNDDVLAGA
VRARAHGELPNLRAIVGFAAETGDANGDVLFHARAKLRNKGCDLLVVNAVGEGRAFEVDSNDGWLLAADGTESALQHGSK
TLMASRIVDAIAAFLRGDGG
>Mature_420_residues
MYDRNRASTRAARIVVGVSGGIAAYKACTVVRQLSEAGHSVRVIPTESALRFVGAATFEALSGQPVHTGVFDDVPEVPHV
QLGKQADLVVVAPATADLLARAVHGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPAAGRL
TGTDSGSGRLPEAEEITTLAQLLLERHDALPYDLAGCKMVVTAGGTREPVDPVRFIGNRSSGKQGYAVARVAAQRGAEVT
LIAGHTAGLIDPAGVEVVHVSSAEQLGNAVSKHAAEADVLVMAAAVADFRPARVAAAKIKKGVEAPTIELVRNDDVLAGA
VRARAHGELPNLRAIVGFAAETGDANGDVLFHARAKLRNKGCDLLVVNAVGEGRAFEVDSNDGWLLAADGTESALQHGSK
TLMASRIVDAIAAFLRGDGG

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=191, Percent_Identity=32.4607329842932, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI87082301, Length=405, Percent_Identity=39.5061728395062, Blast_Score=224, Evalue=6e-60,
Organism=Drosophila melanogaster, GI24657262, Length=179, Percent_Identity=28.4916201117318, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43688; Mature: 43688

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDRNRASTRAARIVVGVSGGIAAYKACTVVRQLSEAGHSVRVIPTESALRFVGAATFEA
CCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHH
LSGQPVHTGVFDDVPEVPHVQLGKQADLVVVAPATADLLARAVHGRADDLLTATLLTARC
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHCC
PVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPAAGRLTGTDSGSGRLPEAEEITTLA
CEEECCCHHHHHEECCCCHHHHHHHHHCCCEEEECCCCCEECCCCCCCCCCCHHHHHHHH
QLLLERHDALPYDLAGCKMVVTAGGTREPVDPVRFIGNRSSGKQGYAVARVAAQRGAEVT
HHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCEEE
LIAGHTAGLIDPAGVEVVHVSSAEQLGNAVSKHAAEADVLVMAAAVADFRPARVAAAKIK
EEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHH
KGVEAPTIELVRNDDVLAGAVRARAHGELPNLRAIVGFAAETGDANGDVLFHARAKLRNK
CCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCEEEEEHHHHCCC
GCDLLVVNAVGEGRAFEVDSNDGWLLAADGTESALQHGSKTLMASRIVDAIAAFLRGDGG
CCCEEEEEECCCCEEEEECCCCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYDRNRASTRAARIVVGVSGGIAAYKACTVVRQLSEAGHSVRVIPTESALRFVGAATFEA
CCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHH
LSGQPVHTGVFDDVPEVPHVQLGKQADLVVVAPATADLLARAVHGRADDLLTATLLTARC
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHCC
PVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPAAGRLTGTDSGSGRLPEAEEITTLA
CEEECCCHHHHHEECCCCHHHHHHHHHCCCEEEECCCCCEECCCCCCCCCCCHHHHHHHH
QLLLERHDALPYDLAGCKMVVTAGGTREPVDPVRFIGNRSSGKQGYAVARVAAQRGAEVT
HHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCEEE
LIAGHTAGLIDPAGVEVVHVSSAEQLGNAVSKHAAEADVLVMAAAVADFRPARVAAAKIK
EEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHH
KGVEAPTIELVRNDDVLAGAVRARAHGELPNLRAIVGFAAETGDANGDVLFHARAKLRNK
CCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCEEEEEHHHHCCC
GCDLLVVNAVGEGRAFEVDSNDGWLLAADGTESALQHGSKTLMASRIVDAIAAFLRGDGG
CCCEEEEEECCCCEEEEECCCCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]