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The map label for this gene is cysS

Identifier: 41406576

GI number: 41406576

Start: 504306

End: 505712

Strand: Direct

Name: cysS

Synonym: MAP0478

Alternate gene names: 41406576

Gene position: 504306-505712 (Clockwise)

Preceding gene: 41406575

Following gene: 41406577

Centisome position: 10.44

GC content: 70.43

Gene sequence:

>1407_bases
GTGACCGATCGCCCCCGCTTGCGGCTACACGACACGGCAGCCGGTGCTGTGCGTGATTTCGTACCGCTGCGCGACGGCCA
CGTCTCCATCTACCTCTGCGGCGCCACCGTGCAGGGCCTGCCGCACATCGGCCACGTCCGCAGCGGGGTGGCCTTCGACA
TCCTGCGCCGCTGGCTGATCGCCCTCGGCTACGACGTCGCCTTCATCCGCAACGTCACCGACATCGACGACAAGATCCTC
AACAAGGCCGCCGCGGCGGGCCGGCCGTGGTGGGAGTGGGCGGCCACCTACGAACGCGCGTTCAGCGCCGCCTACGACGC
CCTGGACGTGTTGCCGCCGTCGGCCGAGCCGCGCGCCACCGGGCACATCACCCAGATGGTCGAATTGATCGAGCGGCTGA
TCGAAAAGGGCCACGCCTACACCGGCGACGGCGACGTCTACTTCGACGTGCTCAGCTACCCCGAGTACGGGCAGCTGTCC
GGGCACAGGATCGACGACGTCCACCAGGGCGAGGGCGTGGCCAGCGGCAAGCGTGACCAACGCGACTTCACGCTGTGGAA
GGGCGCCAAGCCCGGCGAGCCGTCCTGGCCCACGCCGTGGGGCCGCGGGCGCCCGGGCTGGCACACCGAATGCGTGGCCA
TGGCCCACGAGTACCTCGGCCCCGAATTCGACATCCATTGCGGCGGAATGGATTTGGTGTTCCCCCACCACGAGAACGAG
ATCGCCCAGAGCCGCGCGGCCGGGGACGGGTTCGCCCGCTACTGGCTGCACAACGGCTGGGTGACCATGGGCGGGGAGAA
GATGAGCAAGTCGCTGGGCAACGTGCTGGCCATCCCGGCGATGCTGCAGCGGGTGCGGCCCGCCGAGCTGCGCTACTACC
TGGGCAGCGCGCACTACCGGTCGATGCTGGAGTTCTCCGACACCGCGCTGCAGGACGCCGTGAAAGCCTATGTGGGAGTT
GAGGAATTCCTGCACCGGGTGCGGGTGCGAGTCGGCGCGGTGGAGCCGGGCGAGCCCAACCCGCGGTTCGCCGACGCGCT
CAACGACGACCTGGCGGTGCCGGCCGCGCTGGCCGAGGTGCACCAGGCCCGCGCCGAAGGCAACCGCGCCCTGGACAGCG
GCGATCACGAGGGCGCGCTGCGGCAGGCCCGCTCCATCCGCGCGATGATGGGCATCCTGGGCTGCGACCCGCTGCACGAA
CGCTGGGAGACCCGCGACGAGACATCGGCGGCCCTGGCCGCCGTCGACGTGCTGGTGCGCGCGGAGCTGCAGAATCGGGA
GAAGGCGCGCGAGCAGCGCAACTGGGCGCTCGCCGACGAGATCCGAAACCGGCTCAAGCAGGCCGGCATCGAGGTCACCG
ACACCGCCGACGGGCCGCAGTGGACGTTGGGCGGAGACGGCAAGTAG

Upstream 100 bases:

>100_bases
CGGTGAGGGCCTGGCCGCCATCGCCACCGCGCTGGTGGTCCCCACCGGCTGAGCCCGCGCGGCGCGGACGCCGCGGAACC
ACCCGGTAAGCTGGCACGTC

Downstream 100 bases:

>100_bases
ATGGCGGGCAACTCGCGACGCCGCGGCGCGGTACGCAAAGCCGGCACCAAGAAGGGCCCGACCGTGGGTTCAGGGGGCCA
GCGTCGCCGCGGGCTGGAGG

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MTDRPRLRLHDTAAGAVRDFVPLRDGHVSIYLCGATVQGLPHIGHVRSGVAFDILRRWLIALGYDVAFIRNVTDIDDKIL
NKAAAAGRPWWEWAATYERAFSAAYDALDVLPPSAEPRATGHITQMVELIERLIEKGHAYTGDGDVYFDVLSYPEYGQLS
GHRIDDVHQGEGVASGKRDQRDFTLWKGAKPGEPSWPTPWGRGRPGWHTECVAMAHEYLGPEFDIHCGGMDLVFPHHENE
IAQSRAAGDGFARYWLHNGWVTMGGEKMSKSLGNVLAIPAMLQRVRPAELRYYLGSAHYRSMLEFSDTALQDAVKAYVGV
EEFLHRVRVRVGAVEPGEPNPRFADALNDDLAVPAALAEVHQARAEGNRALDSGDHEGALRQARSIRAMMGILGCDPLHE
RWETRDETSAALAAVDVLVRAELQNREKAREQRNWALADEIRNRLKQAGIEVTDTADGPQWTLGGDGK

Sequences:

>Translated_468_residues
MTDRPRLRLHDTAAGAVRDFVPLRDGHVSIYLCGATVQGLPHIGHVRSGVAFDILRRWLIALGYDVAFIRNVTDIDDKIL
NKAAAAGRPWWEWAATYERAFSAAYDALDVLPPSAEPRATGHITQMVELIERLIEKGHAYTGDGDVYFDVLSYPEYGQLS
GHRIDDVHQGEGVASGKRDQRDFTLWKGAKPGEPSWPTPWGRGRPGWHTECVAMAHEYLGPEFDIHCGGMDLVFPHHENE
IAQSRAAGDGFARYWLHNGWVTMGGEKMSKSLGNVLAIPAMLQRVRPAELRYYLGSAHYRSMLEFSDTALQDAVKAYVGV
EEFLHRVRVRVGAVEPGEPNPRFADALNDDLAVPAALAEVHQARAEGNRALDSGDHEGALRQARSIRAMMGILGCDPLHE
RWETRDETSAALAAVDVLVRAELQNREKAREQRNWALADEIRNRLKQAGIEVTDTADGPQWTLGGDGK
>Mature_467_residues
TDRPRLRLHDTAAGAVRDFVPLRDGHVSIYLCGATVQGLPHIGHVRSGVAFDILRRWLIALGYDVAFIRNVTDIDDKILN
KAAAAGRPWWEWAATYERAFSAAYDALDVLPPSAEPRATGHITQMVELIERLIEKGHAYTGDGDVYFDVLSYPEYGQLSG
HRIDDVHQGEGVASGKRDQRDFTLWKGAKPGEPSWPTPWGRGRPGWHTECVAMAHEYLGPEFDIHCGGMDLVFPHHENEI
AQSRAAGDGFARYWLHNGWVTMGGEKMSKSLGNVLAIPAMLQRVRPAELRYYLGSAHYRSMLEFSDTALQDAVKAYVGVE
EFLHRVRVRVGAVEPGEPNPRFADALNDDLAVPAALAEVHQARAEGNRALDSGDHEGALRQARSIRAMMGILGCDPLHER
WETRDETSAALAAVDVLVRAELQNREKAREQRNWALADEIRNRLKQAGIEVTDTADGPQWTLGGDGK

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI13375695, Length=460, Percent_Identity=35.6521739130435, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI62240992, Length=296, Percent_Identity=37.5, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI10835051, Length=296, Percent_Identity=37.5, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI303304987, Length=296, Percent_Identity=37.5, Blast_Score=195, Evalue=8e-50,
Organism=Homo sapiens, GI21269877, Length=296, Percent_Identity=37.5, Blast_Score=195, Evalue=8e-50,
Organism=Escherichia coli, GI1786737, Length=463, Percent_Identity=42.548596112311, Blast_Score=327, Evalue=7e-91,
Organism=Caenorhabditis elegans, GI17509797, Length=260, Percent_Identity=36.5384615384615, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17509795, Length=260, Percent_Identity=36.5384615384615, Blast_Score=174, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6324082, Length=352, Percent_Identity=31.8181818181818, Blast_Score=206, Evalue=9e-54,
Organism=Drosophila melanogaster, GI19922218, Length=493, Percent_Identity=30.6288032454361, Blast_Score=222, Evalue=5e-58,
Organism=Drosophila melanogaster, GI19922364, Length=315, Percent_Identity=36.1904761904762, Blast_Score=189, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080 [H]

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e [H]

EC number: =6.1.1.16 [H]

Molecular weight: Translated: 51930; Mature: 51799

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRPRLRLHDTAAGAVRDFVPLRDGHVSIYLCGATVQGLPHIGHVRSGVAFDILRRWLI
CCCCCCEEEECCHHHHHHHHCCCCCCCEEEEEECCHHCCCCCHHHHHCCHHHHHHHHHHH
ALGYDVAFIRNVTDIDDKILNKAAAAGRPWWEWAATYERAFSAAYDALDVLPPSAEPRAT
HHCCHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
GHITQMVELIERLIEKGHAYTGDGDVYFDVLSYPEYGQLSGHRIDDVHQGEGVASGKRDQ
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RDFTLWKGAKPGEPSWPTPWGRGRPGWHTECVAMAHEYLGPEFDIHCGGMDLVFPHHENE
CCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCEEEECCCCCHH
IAQSRAAGDGFARYWLHNGWVTMGGEKMSKSLGNVLAIPAMLQRVRPAELRYYLGSAHYR
HHHHHCCCCHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SMLEFSDTALQDAVKAYVGVEEFLHRVRVRVGAVEPGEPNPRFADALNDDLAVPAALAEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHHHHHH
HQARAEGNRALDSGDHEGALRQARSIRAMMGILGCDPLHERWETRDETSAALAAVDVLVR
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHH
AELQNREKAREQRNWALADEIRNRLKQAGIEVTDTADGPQWTLGGDGK
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCCEECCCCCCC
>Mature Secondary Structure 
TDRPRLRLHDTAAGAVRDFVPLRDGHVSIYLCGATVQGLPHIGHVRSGVAFDILRRWLI
CCCCCEEEECCHHHHHHHHCCCCCCCEEEEEECCHHCCCCCHHHHHCCHHHHHHHHHHH
ALGYDVAFIRNVTDIDDKILNKAAAAGRPWWEWAATYERAFSAAYDALDVLPPSAEPRAT
HHCCHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
GHITQMVELIERLIEKGHAYTGDGDVYFDVLSYPEYGQLSGHRIDDVHQGEGVASGKRDQ
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RDFTLWKGAKPGEPSWPTPWGRGRPGWHTECVAMAHEYLGPEFDIHCGGMDLVFPHHENE
CCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCEEEECCCCCHH
IAQSRAAGDGFARYWLHNGWVTMGGEKMSKSLGNVLAIPAMLQRVRPAELRYYLGSAHYR
HHHHHCCCCHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SMLEFSDTALQDAVKAYVGVEEFLHRVRVRVGAVEPGEPNPRFADALNDDLAVPAALAEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHHHHHH
HQARAEGNRALDSGDHEGALRQARSIRAMMGILGCDPLHERWETRDETSAALAAVDVLVR
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHH
AELQNREKAREQRNWALADEIRNRLKQAGIEVTDTADGPQWTLGGDGK
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA