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The map label for this gene is gloB [H]

Identifier: 41406495

GI number: 41406495

Start: 421403

End: 422206

Strand: Direct

Name: gloB [H]

Synonym: MAP0397

Alternate gene names: 41406495

Gene position: 421403-422206 (Clockwise)

Preceding gene: 41406494

Following gene: 41406498

Centisome position: 8.73

GC content: 70.9

Gene sequence:

>804_bases
GTGACCGAAGTTGCCGCGTCGCCGACCCATCCCGCATACGGCAGGTTGCGGGCGGTCACCGACACGGCCTCGGTGCTGCT
GGCCGACAATCCCGGTTTGCTGACGCTGGAGGGCACCAACACCTGGGTGCTGCGCGGGCGGGGCAGCGACGAGCTGGTGA
TCGTGGACCCCGGGCCGGACGACGACGAGCATATCGCGCGGATCGCCGCGCTGGGCCGCATCGCGCTGGTGCTGATCAGC
CACCGGCACGGCGACCACACCGACGGCATCGACAAGCTGGTCGGGCGCACCGGTGCCATCGTGCGCTCGGCGGGCAGCGG
CTTTCTGCGCGGCCTGGGCGGTGAGCTCACCGACGGCGAGGTGATCGACGCGGCCGGGCTGAGGATCAAGGTGATGGCCA
CGCCCGGGCACACCGCCGATTCGCTGTGCTTCCTGCTCGACGACGCCGTGCTGACCGCCGACACCGTGCTGGGCCGCGGC
ACCACCGTCCTCGACAAGGAGGACGGCAGCCTGACGGACTACCTGGAATCGCTGCGGCGGCTGCGCGGCCTGGGCCGGCG
GGCGGTGCTGCCCGGCCACGGCCCGGACCTGACCGACCTGGAAAGCGTCGCGCAGGGCTACCTGGAACACCGGCGGGAGC
GGCTGGACCAGGTGCGATCGGCGGTGCGGGAGCTGGGCGAGGACGTCAGTGCCCGCCGGATCGTCGAACACGTCTACGTC
GATGTCGATGAGAAGCTGTGGGACGCCGCCGAGTGGTCGGTGCAGGTGCAGTTGAATCACCTGCGCTCGGAGCCATCGAC
GTAA

Upstream 100 bases:

>100_bases
GCGAACATGGCGCGCATGCGCGCTCGGCGGTCGGGGTCGGTGAGCTGCCGCTGGATGCGCCGGTGGAAGTGGAGCTGATC
GTGGAGGTCGGCGCGCGGCC

Downstream 100 bases:

>100_bases
CCGCCTTGGCGTGAGTCACTCCGGCCCCATGGGTCCCGGCCCCGAAGGGACGGAGTGCGTCAGAGTTCCGCTAGCGCCGC
CGCTAGCGGATTTCGAAGTC

Product: hypothetical protein

Products: NA

Alternate protein names: Glyoxalase II; Glx II [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MTEVAASPTHPAYGRLRAVTDTASVLLADNPGLLTLEGTNTWVLRGRGSDELVIVDPGPDDDEHIARIAALGRIALVLIS
HRHGDHTDGIDKLVGRTGAIVRSAGSGFLRGLGGELTDGEVIDAAGLRIKVMATPGHTADSLCFLLDDAVLTADTVLGRG
TTVLDKEDGSLTDYLESLRRLRGLGRRAVLPGHGPDLTDLESVAQGYLEHRRERLDQVRSAVRELGEDVSARRIVEHVYV
DVDEKLWDAAEWSVQVQLNHLRSEPST

Sequences:

>Translated_267_residues
MTEVAASPTHPAYGRLRAVTDTASVLLADNPGLLTLEGTNTWVLRGRGSDELVIVDPGPDDDEHIARIAALGRIALVLIS
HRHGDHTDGIDKLVGRTGAIVRSAGSGFLRGLGGELTDGEVIDAAGLRIKVMATPGHTADSLCFLLDDAVLTADTVLGRG
TTVLDKEDGSLTDYLESLRRLRGLGRRAVLPGHGPDLTDLESVAQGYLEHRRERLDQVRSAVRELGEDVSARRIVEHVYV
DVDEKLWDAAEWSVQVQLNHLRSEPST
>Mature_266_residues
TEVAASPTHPAYGRLRAVTDTASVLLADNPGLLTLEGTNTWVLRGRGSDELVIVDPGPDDDEHIARIAALGRIALVLISH
RHGDHTDGIDKLVGRTGAIVRSAGSGFLRGLGGELTDGEVIDAAGLRIKVMATPGHTADSLCFLLDDAVLTADTVLGRGT
TVLDKEDGSLTDYLESLRRLRGLGRRAVLPGHGPDLTDLESVAQGYLEHRRERLDQVRSAVRELGEDVSARRIVEHVYVD
VDEKLWDAAEWSVQVQLNHLRSEPST

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI7705793, Length=256, Percent_Identity=30.078125, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI193205216, Length=263, Percent_Identity=28.8973384030418, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17537503, Length=263, Percent_Identity=28.8973384030418, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20129357, Length=275, Percent_Identity=28.3636363636364, Blast_Score=107, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR017782 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.2.6 [H]

Molecular weight: Translated: 28809; Mature: 28678

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVAASPTHPAYGRLRAVTDTASVLLADNPGLLTLEGTNTWVLRGRGSDELVIVDPGPD
CCCCCCCCCCCCHHHEEEEECCEEEEEECCCCEEEEECCCEEEEEECCCCCEEEECCCCC
DDEHIARIAALGRIALVLISHRHGDHTDGIDKLVGRTGAIVRSAGSGFLRGLGGELTDGE
CHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHCCCCHHHHHCCCHHHHHCCCCCCCCC
VIDAAGLRIKVMATPGHTADSLCFLLDDAVLTADTVLGRGTTVLDKEDGSLTDYLESLRR
EEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHH
LRGLGRRAVLPGHGPDLTDLESVAQGYLEHRRERLDQVRSAVRELGEDVSARRIVEHVYV
HHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
DVDEKLWDAAEWSVQVQLNHLRSEPST
CCCHHHHCCCCEEEEEEEEHHCCCCCC
>Mature Secondary Structure 
TEVAASPTHPAYGRLRAVTDTASVLLADNPGLLTLEGTNTWVLRGRGSDELVIVDPGPD
CCCCCCCCCCCHHHEEEEECCEEEEEECCCCEEEEECCCEEEEEECCCCCEEEECCCCC
DDEHIARIAALGRIALVLISHRHGDHTDGIDKLVGRTGAIVRSAGSGFLRGLGGELTDGE
CHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHCCCCHHHHHCCCHHHHHCCCCCCCCC
VIDAAGLRIKVMATPGHTADSLCFLLDDAVLTADTVLGRGTTVLDKEDGSLTDYLESLRR
EEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHH
LRGLGRRAVLPGHGPDLTDLESVAQGYLEHRRERLDQVRSAVRELGEDVSARRIVEHVYV
HHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
DVDEKLWDAAEWSVQVQLNHLRSEPST
CCCHHHHCCCCEEEEEEEEHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA