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The map label for this gene is nth

Identifier: 41406498

GI number: 41406498

Start: 423627

End: 424424

Strand: Direct

Name: nth

Synonym: MAP0400

Alternate gene names: 41406498

Gene position: 423627-424424 (Clockwise)

Preceding gene: 41406495

Following gene: 41406499

Centisome position: 8.77

GC content: 68.67

Gene sequence:

>798_bases
GTGACAACGGCTAAGTCGTCGGGGCGTGCGAAGTCGACCCCGGCCCCGCCCGGCGACGCCGCCGCCCGGCGCTGGTCGAC
CGAATCCCGAGTTGCCTTGGTGCGACGGGCGCGGCGGATGAATCGCATTCTGGCACAAGCGTTTCCGGAAGCGCACTGCG
AGCTGGACTTCACCACGCCGCTGGAGCTGACGGTCGCCACCATCCTGTCGGCGCAGAGCACCGACAAACGGGTGAACCTG
ACGACGCCGGCCTTGTTCAAGCGCTACACCTGCGCGCTGGATTACGCCCGGGCCGACCGCGACGAGCTGGAGAACCTGAT
CCGCCCGACCGGCTTCTTCCGCAACAAGGCCTCCGCGCTGATCCGTCTCGGCCAGGCCCTGGTGGAACGGTTCGACGGTG
AGGTGCCCGCCACCATGGCCGAGCTGGTCACCCTGCCCGGTGTGGGCCGCAAGACCGCGAACGTCATCCTGGGCAACGCC
TTCGGTGTCCCCGGTATCACCGTCGACACCCATTTCGCCCGGCTGGTGCACCGCTGGCGCTGGACCGCCGAGAAGGATCC
GGTCAAAATCGAGCACGCCGTAGGCGAGCTGATCGAACGCAGCGAGTGGACCATGCTCAGCCACCGGGTCATCTTCCACG
GCCGCCGGGTGTGTCACTCGCGCAAACCGGCCTGCGGGGTATGCCTGCTCGCCAAGGACTGCCCCTCGTTCGGGCTGGGT
CCCACCGAACCGCCGCTGGCCGCGCAGTTGGTGCGCGGGCCGGAAACCGAGCATCTGCTCGCCCTGGCCGGGCTGTAA

Upstream 100 bases:

>100_bases
GGTACACCGGCCACCAGCAACCACGACACACGAAGAGTAAACATGGCCTTGCATGAACACGAGGTCTCGGCCGGATCACG
AAATAAGTACTCTGTCGTAG

Downstream 100 bases:

>100_bases
CCGCGCCGACAGCACGGGGACCGCATGCCCATCCCGAGGCCGACGCTGACCCGGAAGGTTCGCTGGCACATCGCGATTCT
CACGGTGGTGGTGGCGCTGA

Product: hypothetical protein

Products: NA

Alternate protein names: DNA-(apurinic or apyrimidinic site) lyase [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MTTAKSSGRAKSTPAPPGDAAARRWSTESRVALVRRARRMNRILAQAFPEAHCELDFTTPLELTVATILSAQSTDKRVNL
TTPALFKRYTCALDYARADRDELENLIRPTGFFRNKASALIRLGQALVERFDGEVPATMAELVTLPGVGRKTANVILGNA
FGVPGITVDTHFARLVHRWRWTAEKDPVKIEHAVGELIERSEWTMLSHRVIFHGRRVCHSRKPACGVCLLAKDCPSFGLG
PTEPPLAAQLVRGPETEHLLALAGL

Sequences:

>Translated_265_residues
MTTAKSSGRAKSTPAPPGDAAARRWSTESRVALVRRARRMNRILAQAFPEAHCELDFTTPLELTVATILSAQSTDKRVNL
TTPALFKRYTCALDYARADRDELENLIRPTGFFRNKASALIRLGQALVERFDGEVPATMAELVTLPGVGRKTANVILGNA
FGVPGITVDTHFARLVHRWRWTAEKDPVKIEHAVGELIERSEWTMLSHRVIFHGRRVCHSRKPACGVCLLAKDCPSFGLG
PTEPPLAAQLVRGPETEHLLALAGL
>Mature_264_residues
TTAKSSGRAKSTPAPPGDAAARRWSTESRVALVRRARRMNRILAQAFPEAHCELDFTTPLELTVATILSAQSTDKRVNLT
TPALFKRYTCALDYARADRDELENLIRPTGFFRNKASALIRLGQALVERFDGEVPATMAELVTLPGVGRKTANVILGNAF
GVPGITVDTHFARLVHRWRWTAEKDPVKIEHAVGELIERSEWTMLSHRVIFHGRRVCHSRKPACGVCLLAKDCPSFGLGP
TEPPLAAQLVRGPETEHLLALAGL

Specific function: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site [H]

COG id: COG0177

COG function: function code L; Predicted EndoIII-related endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI4505471, Length=193, Percent_Identity=32.6424870466321, Blast_Score=101, Evalue=6e-22,
Organism=Escherichia coli, GI1787920, Length=203, Percent_Identity=35.4679802955665, Blast_Score=132, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17554540, Length=181, Percent_Identity=33.7016574585635, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324530, Length=217, Percent_Identity=30.4147465437788, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319304, Length=195, Percent_Identity=27.1794871794872, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI45550361, Length=175, Percent_Identity=33.1428571428571, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR005759
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00730 HhH-GPD [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 29164; Mature: 29033

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAKSSGRAKSTPAPPGDAAARRWSTESRVALVRRARRMNRILAQAFPEAHCELDFTTP
CCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHCEECCCCC
LELTVATILSAQSTDKRVNLTTPALFKRYTCALDYARADRDELENLIRPTGFFRNKASAL
HHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHH
IRLGQALVERFDGEVPATMAELVTLPGVGRKTANVILGNAFGVPGITVDTHFARLVHRWR
HHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHEEEECCCCCCCCCHHHHHHHHHHHHH
WTAEKDPVKIEHAVGELIERSEWTMLSHRVIFHGRRVCHSRKPACGVCLLAKDCPSFGLG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCC
PTEPPLAAQLVRGPETEHLLALAGL
CCCCHHHHHHHCCCCHHHHHHCCCC
>Mature Secondary Structure 
TTAKSSGRAKSTPAPPGDAAARRWSTESRVALVRRARRMNRILAQAFPEAHCELDFTTP
CCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHCEECCCCC
LELTVATILSAQSTDKRVNLTTPALFKRYTCALDYARADRDELENLIRPTGFFRNKASAL
HHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHH
IRLGQALVERFDGEVPATMAELVTLPGVGRKTANVILGNAFGVPGITVDTHFARLVHRWR
HHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHEEEECCCCCCCCCHHHHHHHHHHHHH
WTAEKDPVKIEHAVGELIERSEWTMLSHRVIFHGRRVCHSRKPACGVCLLAKDCPSFGLG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCC
PTEPPLAAQLVRGPETEHLLALAGL
CCCCHHHHHHHCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]