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The map label for this gene is tcmR [H]

Identifier: 41406449

GI number: 41406449

Start: 375742

End: 376338

Strand: Direct

Name: tcmR [H]

Synonym: MAP0351

Alternate gene names: 41406449

Gene position: 375742-376338 (Clockwise)

Preceding gene: 41406448

Following gene: 41406451

Centisome position: 7.78

GC content: 69.51

Gene sequence:

>597_bases
ATGACACCGGAATCGCTGCGTGACCGGCAGCGCGCACAGATCCGGGCCGACATCCGGCGCGCGGCGTTCCGGTTGTTCGT
CGAGCGCGGGTACGATGCGGTGACAACCGAGGAAATCGCCACGGCCGCAGGTGTTTCCCCGCGCACCTTCTTCCGGCACG
TGCCGGCGAAGGAGGAACTTCTGCTCGCGCCGGTGCGCTACGGCGGCGCCGCGATCGTCCATCTCCTCGAGGGCCGCCCG
GCCGGCGAATCACCCGACGTCGCGCTGATCAACGCCATCATCACCCGCACCCGCTCGTTCGAGCCGGCCGACACCGAGGA
GTGGCGTCAGGCCCTGCTGGTGGCCCCCGGCCTGCTGGACAAGGTGACCGTGCACCGGCCTGCCGACAAGGAACGCGCCA
CCAAGCTCATCGCCGACCGGATGCGAGTCGACCCCCACACCGACATCCGCCCCGGCCTGCTGGTCCAACTGGCCTTCGCC
GCCGCCGATTTCGGCTTTCAGCAGTGGGTGCTCCAGTCCGGGCGGCGGTGGCCGCTGGACCGCTACGTCGCCGAAGCGCT
CAAGGCCGTCAAAAGTCCGCACTGGAGGCGGAAATGA

Upstream 100 bases:

>100_bases
GCACCGACGTGGGTGCGCTGGTGGCCTTCCTGCTCAGCACCGACGCCACCTTCATCACCGGGCAGACCATCCACGTCGAC
GGCGGGATCGGCTGCTTCCG

Downstream 100 bases:

>100_bases
ACGCGCTCAATCTCGTTGCAGCACTTCGTGATTGGCGATCCGGATCGGGGTGCCGTCCAGCCAGGCCAGCACGGATTCCA
CGGTGTCGGCGTAGAACGCG

Product: hypothetical protein

Products: NA

Alternate protein names: Tetracenomycin C transcriptional repressor [H]

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MTPESLRDRQRAQIRADIRRAAFRLFVERGYDAVTTEEIATAAGVSPRTFFRHVPAKEELLLAPVRYGGAAIVHLLEGRP
AGESPDVALINAIITRTRSFEPADTEEWRQALLVAPGLLDKVTVHRPADKERATKLIADRMRVDPHTDIRPGLLVQLAFA
AADFGFQQWVLQSGRRWPLDRYVAEALKAVKSPHWRRK

Sequences:

>Translated_198_residues
MTPESLRDRQRAQIRADIRRAAFRLFVERGYDAVTTEEIATAAGVSPRTFFRHVPAKEELLLAPVRYGGAAIVHLLEGRP
AGESPDVALINAIITRTRSFEPADTEEWRQALLVAPGLLDKVTVHRPADKERATKLIADRMRVDPHTDIRPGLLVQLAFA
AADFGFQQWVLQSGRRWPLDRYVAEALKAVKSPHWRRK
>Mature_197_residues
TPESLRDRQRAQIRADIRRAAFRLFVERGYDAVTTEEIATAAGVSPRTFFRHVPAKEELLLAPVRYGGAAIVHLLEGRPA
GESPDVALINAIITRTRSFEPADTEEWRQALLVAPGLLDKVTVHRPADKERATKLIADRMRVDPHTDIRPGLLVQLAFAA
ADFGFQQWVLQSGRRWPLDRYVAEALKAVKSPHWRRK

Specific function: Represses transcription of the divergently oriented tcmR and tcmA (tetracenomycin C resistance and export) genes by binding to an intergenic operator region. This binding is inhibited by tetracenomycin C [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 22364; Mature: 22233

Theoretical pI: Translated: 10.72; Mature: 10.72

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPESLRDRQRAQIRADIRRAAFRLFVERGYDAVTTEEIATAAGVSPRTFFRHVPAKEEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHE
LLAPVRYGGAAIVHLLEGRPAGESPDVALINAIITRTRSFEPADTEEWRQALLVAPGLLD
EEECHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHH
KVTVHRPADKERATKLIADRMRVDPHTDIRPGLLVQLAFAAADFGFQQWVLQSGRRWPLD
HHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCHH
RYVAEALKAVKSPHWRRK
HHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TPESLRDRQRAQIRADIRRAAFRLFVERGYDAVTTEEIATAAGVSPRTFFRHVPAKEEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHE
LLAPVRYGGAAIVHLLEGRPAGESPDVALINAIITRTRSFEPADTEEWRQALLVAPGLLD
EEECHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHH
KVTVHRPADKERATKLIADRMRVDPHTDIRPGLLVQLAFAAADFGFQQWVLQSGRRWPLD
HHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCHH
RYVAEALKAVKSPHWRRK
HHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1592819; 1592820 [H]