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The map label for this gene is glpK

Identifier: 41406451

GI number: 41406451

Start: 377404

End: 378951

Strand: Direct

Name: glpK

Synonym: MAP0353

Alternate gene names: 41406451

Gene position: 377404-378951 (Clockwise)

Preceding gene: 41406449

Following gene: 41406453

Centisome position: 7.81

GC content: 68.6

Gene sequence:

>1548_bases
GTGTCACCGAACAGGAGAGCTGTGGCCGAATTCGCCGAATTCATCGCCGCCATCGACCAGGGCACCACCAGCACGCGCTG
CATGATCTTCGATCACCAGGGTGCCGAGGTGGCCCGCCATCAGCTCGAGCACGAGCAGATCCTGCCCCGGGCGGGCTGGG
TCGAGCACGACCCGATCGAGATCTGGGAGCGCACCTCCTCGGTGTTGACGTCGGTGCTCAACCGGGCCAACCTGTCCGCG
GAAAACCTTGCCGCGCTGGGCATCACGAATCAGCGCGAGACCACCCTGGTATGGAACCGCAAGACCGGCCGGCCCTATTA
CAACGCGATCGTCTGGCAGGACACCCGGACCGACCGGATCGCGTCGGCGCTCGACCGCGACGGCCGCGGCCAGGTGATCC
GCCGCAAGGCGGGCCTGCCCCCGGCGACCTACTTCTCCGGGGCGAAGTTGCAATGGATCCTGGACAACGTCGACGGGGTG
CGCGAGGCGGCCGAGCGCGGCGACGCGTTGTTCGGCACTGCCGACAGCTGGGTGTTGTGGCAGCTCACCGGGGGGCCGCG
GGGCGGGGTGCACGCCACCGACGTGACCAACGCCAGCCGGACCATGCTGATGGACTTGGAGACGCTGGACTGGGACGACG
AGCTGCTGTCGTTCTTCACCATCCCGCGCGCCATGCTGCCCGAGATCGGGCCGTCGTCGTCGCCGCGGCCGTTCGGGGTG
ACCTCGGACACCGGGCCGGCCGGCGGCCGGATACCGATCACCGCCGTGCTGGGGGATCAGCACGCGGCGATGGTGGGCCA
GGTCTGCCTGGCCGAGGGCGAAGCCAAAAATACCTACGGCACCGGGAATTTCCTGCTGCTCAACACCGGTGAGAGCATCG
TGCGGTCCGAGCACGGATTGCTCACCACCGTGTGTTACCAGTTCGGCGACGCCAAACCCGTTTACGCACTTGAGGGTTCG
ATCGCGGTCACCGGCGCCGCCGTGCAGTGGCTGCGCGACCAGTTGGGCATCATCAGCGGCGCCGCGCAGAGCGAATCGCT
TGCGCGGCAGGTCGACGACAACGGCGGCGTCTATTTCGTCCCCGCCTTTTCCGGGCTGTTCGCGCCCTACTGGCGTTCGG
ATGCGCGCGGCGCGATCGTCGGGCTGTCGCGGTTCAACACCAATGCCCACCTGGCGCGGGCGACGCTGGAGGCGATCTGC
TATCAGAGCCGTGACGTGGTGGACGCGATGGCAGCGGATTCTGGTGTGCGCCTTGAGGTTTTGAAGGTCGACGGCGGCAT
CACCGGAAACGACCTGTGCATGCAGATCCAGGCCGATGTGTTGGGCGTGGACGTGGTGCGGCCGGTGGTGGCCGAGACCA
CCGCGCTGGGCGCGGCGTACGCGGCCGGGCTGGCGGTGGGGTTCTGGGCCGACCCGGGCGAGCTGCGGGCCAACTGGCGC
GAAGACAAGCGCTGGACGCCGGCCTGGAGCGACGAGCAGCGCACCGCGGGTTACGCGGGCTGGCACAAGGCCGTGCAGCG
GACCCTGGATTGGGCCGACGTCACGTGA

Upstream 100 bases:

>100_bases
GACCTCTTCGCCCACACCGCAGATGCAACAGGGTTACCGCCGGTAACGCAAGCTTGGTCGGCGGTGAGCGGGTAGACCAT
GATGGACTTCTGCCGCCGAC

Downstream 100 bases:

>100_bases
CGTGACCCGATCCAGGGCCCGCTCAAGGCAACTCAGTCCTCGCCGAGAATGCCGTAGATCTCGCGCCGCGCATTGTTGAG
GATGTCGACGATGCGCTGCT

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MSPNRRAVAEFAEFIAAIDQGTTSTRCMIFDHQGAEVARHQLEHEQILPRAGWVEHDPIEIWERTSSVLTSVLNRANLSA
ENLAALGITNQRETTLVWNRKTGRPYYNAIVWQDTRTDRIASALDRDGRGQVIRRKAGLPPATYFSGAKLQWILDNVDGV
REAAERGDALFGTADSWVLWQLTGGPRGGVHATDVTNASRTMLMDLETLDWDDELLSFFTIPRAMLPEIGPSSSPRPFGV
TSDTGPAGGRIPITAVLGDQHAAMVGQVCLAEGEAKNTYGTGNFLLLNTGESIVRSEHGLLTTVCYQFGDAKPVYALEGS
IAVTGAAVQWLRDQLGIISGAAQSESLARQVDDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLEAIC
YQSRDVVDAMAADSGVRLEVLKVDGGITGNDLCMQIQADVLGVDVVRPVVAETTALGAAYAAGLAVGFWADPGELRANWR
EDKRWTPAWSDEQRTAGYAGWHKAVQRTLDWADVT

Sequences:

>Translated_515_residues
MSPNRRAVAEFAEFIAAIDQGTTSTRCMIFDHQGAEVARHQLEHEQILPRAGWVEHDPIEIWERTSSVLTSVLNRANLSA
ENLAALGITNQRETTLVWNRKTGRPYYNAIVWQDTRTDRIASALDRDGRGQVIRRKAGLPPATYFSGAKLQWILDNVDGV
REAAERGDALFGTADSWVLWQLTGGPRGGVHATDVTNASRTMLMDLETLDWDDELLSFFTIPRAMLPEIGPSSSPRPFGV
TSDTGPAGGRIPITAVLGDQHAAMVGQVCLAEGEAKNTYGTGNFLLLNTGESIVRSEHGLLTTVCYQFGDAKPVYALEGS
IAVTGAAVQWLRDQLGIISGAAQSESLARQVDDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLEAIC
YQSRDVVDAMAADSGVRLEVLKVDGGITGNDLCMQIQADVLGVDVVRPVVAETTALGAAYAAGLAVGFWADPGELRANWR
EDKRWTPAWSDEQRTAGYAGWHKAVQRTLDWADVT
>Mature_514_residues
SPNRRAVAEFAEFIAAIDQGTTSTRCMIFDHQGAEVARHQLEHEQILPRAGWVEHDPIEIWERTSSVLTSVLNRANLSAE
NLAALGITNQRETTLVWNRKTGRPYYNAIVWQDTRTDRIASALDRDGRGQVIRRKAGLPPATYFSGAKLQWILDNVDGVR
EAAERGDALFGTADSWVLWQLTGGPRGGVHATDVTNASRTMLMDLETLDWDDELLSFFTIPRAMLPEIGPSSSPRPFGVT
SDTGPAGGRIPITAVLGDQHAAMVGQVCLAEGEAKNTYGTGNFLLLNTGESIVRSEHGLLTTVCYQFGDAKPVYALEGSI
AVTGAAVQWLRDQLGIISGAAQSESLARQVDDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLEAICY
QSRDVVDAMAADSGVRLEVLKVDGGITGNDLCMQIQADVLGVDVVRPVVAETTALGAAYAAGLAVGFWADPGELRANWRE
DKRWTPAWSDEQRTAGYAGWHKAVQRTLDWADVT

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI42794763, Length=524, Percent_Identity=47.7099236641221, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI4504007, Length=522, Percent_Identity=47.7011494252874, Blast_Score=487, Evalue=1e-138,
Organism=Homo sapiens, GI189409120, Length=522, Percent_Identity=47.7011494252874, Blast_Score=487, Evalue=1e-137,
Organism=Homo sapiens, GI41393575, Length=509, Percent_Identity=47.5442043222004, Blast_Score=478, Evalue=1e-135,
Organism=Homo sapiens, GI88196792, Length=530, Percent_Identity=32.0754716981132, Blast_Score=298, Evalue=6e-81,
Organism=Escherichia coli, GI1790361, Length=502, Percent_Identity=53.1872509960159, Blast_Score=539, Evalue=1e-154,
Organism=Escherichia coli, GI1790005, Length=490, Percent_Identity=23.469387755102, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1789987, Length=492, Percent_Identity=24.7967479674797, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17535599, Length=509, Percent_Identity=43.811394891945, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71986140, Length=521, Percent_Identity=22.8406909788868, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI71986147, Length=272, Percent_Identity=27.2058823529412, Blast_Score=103, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321755, Length=553, Percent_Identity=39.0596745027125, Blast_Score=332, Evalue=7e-92,
Organism=Drosophila melanogaster, GI17864214, Length=514, Percent_Identity=48.443579766537, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24654573, Length=443, Percent_Identity=50.5643340857788, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24655555, Length=517, Percent_Identity=40.2321083172147, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24655560, Length=517, Percent_Identity=40.2321083172147, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24655570, Length=517, Percent_Identity=40.2321083172147, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24655574, Length=517, Percent_Identity=40.2321083172147, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24655565, Length=517, Percent_Identity=40.2321083172147, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI19922058, Length=541, Percent_Identity=33.826247689464, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24652871, Length=497, Percent_Identity=33.6016096579477, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI21357867, Length=536, Percent_Identity=30.5970149253731, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24656367, Length=522, Percent_Identity=30.6513409961686, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24656372, Length=377, Percent_Identity=31.5649867374005, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI45552909, Length=318, Percent_Identity=29.874213836478, Blast_Score=125, Evalue=1e-28,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55902; Mature: 55771

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPNRRAVAEFAEFIAAIDQGTTSTRCMIFDHQGAEVARHQLEHEQILPRAGWVEHDPIE
CCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHH
IWERTSSVLTSVLNRANLSAENLAALGITNQRETTLVWNRKTGRPYYNAIVWQDTRTDRI
HHHHHHHHHHHHHHHCCCCHHHEEEEECCCCCCEEEEEECCCCCCEEEEEEECCCCHHHH
ASALDRDGRGQVIRRKAGLPPATYFSGAKLQWILDNVDGVREAAERGDALFGTADSWVLW
HHHHCCCCCCCEEHHHCCCCCHHHCCCCEEEEEECCHHHHHHHHHCCCEEEECCCCEEEE
QLTGGPRGGVHATDVTNASRTMLMDLETLDWDDELLSFFTIPRAMLPEIGPSSSPRPFGV
EECCCCCCCEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHHCCCCCCCCCCCCCCC
TSDTGPAGGRIPITAVLGDQHAAMVGQVCLAEGEAKNTYGTGNFLLLNTGESIVRSEHGL
CCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHHHCCCCH
LTTVCYQFGDAKPVYALEGSIAVTGAAVQWLRDQLGIISGAAQSESLARQVDDNGGVYFV
HHHHHHHCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEE
PAFSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLEAICYQSRDVVDAMAADSGVRLEV
ECCCCHHCHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEE
LKVDGGITGNDLCMQIQADVLGVDVVRPVVAETTALGAAYAAGLAVGFWADPGELRANWR
EEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHCCCCC
EDKRWTPAWSDEQRTAGYAGWHKAVQRTLDWADVT
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHCCC
>Mature Secondary Structure 
SPNRRAVAEFAEFIAAIDQGTTSTRCMIFDHQGAEVARHQLEHEQILPRAGWVEHDPIE
CCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHH
IWERTSSVLTSVLNRANLSAENLAALGITNQRETTLVWNRKTGRPYYNAIVWQDTRTDRI
HHHHHHHHHHHHHHHCCCCHHHEEEEECCCCCCEEEEEECCCCCCEEEEEEECCCCHHHH
ASALDRDGRGQVIRRKAGLPPATYFSGAKLQWILDNVDGVREAAERGDALFGTADSWVLW
HHHHCCCCCCCEEHHHCCCCCHHHCCCCEEEEEECCHHHHHHHHHCCCEEEECCCCEEEE
QLTGGPRGGVHATDVTNASRTMLMDLETLDWDDELLSFFTIPRAMLPEIGPSSSPRPFGV
EECCCCCCCEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHHCCCCCCCCCCCCCCC
TSDTGPAGGRIPITAVLGDQHAAMVGQVCLAEGEAKNTYGTGNFLLLNTGESIVRSEHGL
CCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHHHCCCCH
LTTVCYQFGDAKPVYALEGSIAVTGAAVQWLRDQLGIISGAAQSESLARQVDDNGGVYFV
HHHHHHHCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEE
PAFSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLEAICYQSRDVVDAMAADSGVRLEV
ECCCCHHCHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEE
LKVDGGITGNDLCMQIQADVLGVDVVRPVVAETTALGAAYAAGLAVGFWADPGELRANWR
EEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHCCCCC
EDKRWTPAWSDEQRTAGYAGWHKAVQRTLDWADVT
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA