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The map label for this gene is msrA

Identifier: 39998251

GI number: 39998251

Start: 3467663

End: 3468151

Strand: Direct

Name: msrA

Synonym: GSU3161

Alternate gene names: 39998251

Gene position: 3467663-3468151 (Clockwise)

Preceding gene: 39998250

Following gene: 39998252

Centisome position: 90.92

GC content: 64.83

Gene sequence:

>489_bases
ATGGGAGAGAATACGAGTCTTGAGAAGGCTACCTTCGGGGCCGGCTGTTTCTGGCATGTGGAAGAGGAGTTCCGCCGCGT
GCCCGGAGTCGTCTCAACCCTGGCGGGATATATGGGGGGATGGAAGGAACACCCCACCTACGAGGAGGTCTGCTCCAAGA
CCACCGGCCACGCCGAGGTGGTGGAGGTGACCTTTGACCCCGCCGCCGTCACCTATGACCACCTGCTGCGGGTCTTCTGG
GACTGCCACGACCCGACCCAGCTCAACCGGCAGGGCCCCGACATCGGCACCAACTACCGCTCCGTCATCTTTTACCACTC
GCCGGACCAAGAGCGGGCGGCCCGGGCCTCCCTAGAGCACGAGCAGCGTTCCGGGCGCCATGCCCGCCCCATCGTTACCG
AGATCGTTCCGGCTGCCACCTTCTGGTGGGCCGAGGAATACCACCAGCACTACCTGGAAAAACGGGGCGGCGGCAGTTGC
CGCTGGTAG

Upstream 100 bases:

>100_bases
GCCTGCGCCGCCTTGATTTTTGCCGTGGCGGCGCGTATGGTACGCGCAGGGACAACCATTGCGCGCTGTGTTACTCTTTT
CAGGCAGGGAGGTACATGTC

Downstream 100 bases:

>100_bases
GCCGGCGGATATTCTCCGCGAGCCCGGCGCGTGAACTCCCGCCCACGGGCAAATGACCCGACGCACGCACACTATCCCCA
TCCCACGAGGATCCCATGAA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MGENTSLEKATFGAGCFWHVEEEFRRVPGVVSTLAGYMGGWKEHPTYEEVCSKTTGHAEVVEVTFDPAAVTYDHLLRVFW
DCHDPTQLNRQGPDIGTNYRSVIFYHSPDQERAARASLEHEQRSGRHARPIVTEIVPAATFWWAEEYHQHYLEKRGGGSC
RW

Sequences:

>Translated_162_residues
MGENTSLEKATFGAGCFWHVEEEFRRVPGVVSTLAGYMGGWKEHPTYEEVCSKTTGHAEVVEVTFDPAAVTYDHLLRVFW
DCHDPTQLNRQGPDIGTNYRSVIFYHSPDQERAARASLEHEQRSGRHARPIVTEIVPAATFWWAEEYHQHYLEKRGGGSC
RW
>Mature_161_residues
GENTSLEKATFGAGCFWHVEEEFRRVPGVVSTLAGYMGGWKEHPTYEEVCSKTTGHAEVVEVTFDPAAVTYDHLLRVFWD
CHDPTQLNRQGPDIGTNYRSVIFYHSPDQERAARASLEHEQRSGRHARPIVTEIVPAATFWWAEEYHQHYLEKRGGGSCR
W

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=155, Percent_Identity=49.0322580645161, Blast_Score=149, Evalue=9e-37,
Organism=Homo sapiens, GI208609995, Length=155, Percent_Identity=49.0322580645161, Blast_Score=149, Evalue=1e-36,
Organism=Homo sapiens, GI208609993, Length=108, Percent_Identity=49.0740740740741, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=52.6315789473684, Blast_Score=158, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=36.551724137931, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=38.8535031847134, Blast_Score=99, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24664627, Length=152, Percent_Identity=38.8157894736842, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24664631, Length=152, Percent_Identity=37.5, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=38.2978723404255, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_GEOSL (Q747V4)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_954202.1
- HSSP:   P0A744
- ProteinModelPortal:   Q747V4
- SMR:   Q747V4
- GeneID:   2686767
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU3161
- NMPDR:   fig|243231.1.peg.3140
- TIGR:   GSU3161
- HOGENOM:   HBG748152
- OMA:   NYRSVIF
- ProtClustDB:   PRK14054
- BioCyc:   GSUL243231:GSU_3161-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 18553; Mature: 18421

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: ACT_SITE 16-16

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGENTSLEKATFGAGCFWHVEEEFRRVPGVVSTLAGYMGGWKEHPTYEEVCSKTTGHAEV
CCCCCCCCHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEE
VEVTFDPAAVTYDHLLRVFWDCHDPTQLNRQGPDIGTNYRSVIFYHSPDQERAARASLEH
EEEEECCHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHH
EQRSGRHARPIVTEIVPAATFWWAEEYHQHYLEKRGGGSCRW
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GENTSLEKATFGAGCFWHVEEEFRRVPGVVSTLAGYMGGWKEHPTYEEVCSKTTGHAEV
CCCCCCCHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEE
VEVTFDPAAVTYDHLLRVFWDCHDPTQLNRQGPDIGTNYRSVIFYHSPDQERAARASLEH
EEEEECCHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHH
EQRSGRHARPIVTEIVPAATFWWAEEYHQHYLEKRGGGSCRW
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA