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The map label for this gene is truC [H]

Identifier: 39998250

GI number: 39998250

Start: 3466826

End: 3467578

Strand: Direct

Name: truC [H]

Synonym: GSU3160

Alternate gene names: 39998250

Gene position: 3466826-3467578 (Clockwise)

Preceding gene: 39998249

Following gene: 39998251

Centisome position: 90.89

GC content: 68.79

Gene sequence:

>753_bases
GTGGAGATCCTCTTTCGCGACCAATACCTGGTGGCCGTGCACAAGCCGGCCGGGCTCCTGGTGCACCGAAGCCCCATCGA
CCGCCATGAAACCCGTTTCGCCCTCCAGGAGGTGCGCGACCTCCTCGGCCGCCGGGTCTATCCCGTTCATCGCCTCGACA
AGCCCACCTCCGGCGTCCTGGTGTTCGCCCTGGACCCGGCAACGGCCCGTTCGCTCGGCGATGCCTTCGCCGGCGGCCGG
GTGAACAAGACCTACCTGGCGGTCACCCGGGGGATTGTCCCGCCGGAGGGAATCATTGACCACTCCCTGAGCGAAGAACC
GGACCGGCTGGACGGTGCGAAGAGCTCACCAGCAGCGCCTCAGCCGGCGGTCACCGTTTTCCGGCGACTCGCGGAAGCAG
AACTGCCCGTGGTAACGGGGCGCTATGCCTCCTCCCGCTACTCACTTGCGGAACTAACACCCCACACCGGCCGCCGCCAC
CAGCTGCGGCGCCACATGAAGCACATCTTCCACCCGATCATCGGCGACACCACCTACGGCGAAGGGCGCCACAACCGCTT
CTTCCGGGAAGAGTTCGGCTGCGGCCGTCTCCTGCTCCATGCCGCGGAGCTTTCGCTGCCGCATCCCGCAAGCGGAGAAA
CCCTGACCATCGCCGCACCGCCGGACCGGGAGCTCGCCCGCCTCCTGGATCGCCTCGGCTGGCTGGCTGCGGCGACCGGT
CGCGGGCGGCCGGGCATGCCTGCGCCGCCTTGA

Upstream 100 bases:

>100_bases
TCATCCTTCCCGTGTCAGGAAAGCCGGTCCTGTGGGGGATCACCTACCGGCTCGTGATGCAGTTCCTGGCCCTCCTCGGC
AAGGCACGGGGATGAGCGCC

Downstream 100 bases:

>100_bases
TTTTTGCCGTGGCGGCGCGTATGGTACGCGCAGGGACAACCATTGCGCGCTGTGTTACTCTTTTCAGGCAGGGAGGTACA
TGTCATGGGAGAGAATACGA

Product: RNA pseudouridine synthase

Products: NA

Alternate protein names: tRNA pseudouridylate synthase C; tRNA-uridine isomerase C [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MEILFRDQYLVAVHKPAGLLVHRSPIDRHETRFALQEVRDLLGRRVYPVHRLDKPTSGVLVFALDPATARSLGDAFAGGR
VNKTYLAVTRGIVPPEGIIDHSLSEEPDRLDGAKSSPAAPQPAVTVFRRLAEAELPVVTGRYASSRYSLAELTPHTGRRH
QLRRHMKHIFHPIIGDTTYGEGRHNRFFREEFGCGRLLLHAAELSLPHPASGETLTIAAPPDRELARLLDRLGWLAAATG
RGRPGMPAPP

Sequences:

>Translated_250_residues
MEILFRDQYLVAVHKPAGLLVHRSPIDRHETRFALQEVRDLLGRRVYPVHRLDKPTSGVLVFALDPATARSLGDAFAGGR
VNKTYLAVTRGIVPPEGIIDHSLSEEPDRLDGAKSSPAAPQPAVTVFRRLAEAELPVVTGRYASSRYSLAELTPHTGRRH
QLRRHMKHIFHPIIGDTTYGEGRHNRFFREEFGCGRLLLHAAELSLPHPASGETLTIAAPPDRELARLLDRLGWLAAATG
RGRPGMPAPP
>Mature_250_residues
MEILFRDQYLVAVHKPAGLLVHRSPIDRHETRFALQEVRDLLGRRVYPVHRLDKPTSGVLVFALDPATARSLGDAFAGGR
VNKTYLAVTRGIVPPEGIIDHSLSEEPDRLDGAKSSPAAPQPAVTVFRRLAEAELPVVTGRYASSRYSLAELTPHTGRRH
QLRRHMKHIFHPIIGDTTYGEGRHNRFFREEFGCGRLLLHAAELSLPHPASGETLTIAAPPDRELARLLDRLGWLAAATG
RGRPGMPAPP

Specific function: Responsible for synthesis of pseudouridine from uracil- 65 in transfer RNAs [H]

COG id: COG0564

COG function: function code J; Pseudouridylate synthases, 23S RNA-specific

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yqcC in the N-terminal section [H]

Homologues:

Organism=Homo sapiens, GI221316663, Length=273, Percent_Identity=29.6703296703297, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI17158025, Length=182, Percent_Identity=34.0659340659341, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI221316667, Length=256, Percent_Identity=29.296875, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI23308689, Length=186, Percent_Identity=29.0322580645161, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1789155, Length=235, Percent_Identity=49.3617021276596, Blast_Score=232, Evalue=1e-62,
Organism=Escherichia coli, GI1786244, Length=226, Percent_Identity=35.3982300884956, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787327, Length=236, Percent_Identity=32.2033898305085, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788946, Length=239, Percent_Identity=28.4518828451883, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320168, Length=185, Percent_Identity=29.1891891891892, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324506, Length=186, Percent_Identity=29.0322580645161, Blast_Score=79, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321608, Length=189, Percent_Identity=29.1005291005291, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24583449, Length=244, Percent_Identity=27.8688524590164, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24583447, Length=244, Percent_Identity=27.8688524590164, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24583445, Length=244, Percent_Identity=27.8688524590164, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI19921090, Length=185, Percent_Identity=30.8108108108108, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007384
- InterPro:   IPR020103
- InterPro:   IPR006224
- InterPro:   IPR006145 [H]

Pfam domain/function: PF04287 DUF446; PF00849 PseudoU_synth_2 [H]

EC number: NA

Molecular weight: Translated: 27631; Mature: 27631

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: PS01129 PSI_RLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILFRDQYLVAVHKPAGLLVHRSPIDRHETRFALQEVRDLLGRRVYPVHRLDKPTSGVL
CCEEEECCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEE
VFALDPATARSLGDAFAGGRVNKTYLAVTRGIVPPEGIIDHSLSEEPDRLDGAKSSPAAP
EEEECCHHHHHHHHHHCCCCCCHHHEEEECCCCCCCCHHHCCCCCCCHHHCCCCCCCCCC
QPAVTVFRRLAEAELPVVTGRYASSRYSLAELTPHTGRRHQLRRHMKHIFHPIIGDTTYG
CHHHHHHHHHHHHCCCEEECCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
EGRHNRFFREEFGCGRLLLHAAELSLPHPASGETLTIAAPPDRELARLLDRLGWLAAATG
CCCCCCHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCC
RGRPGMPAPP
CCCCCCCCCC
>Mature Secondary Structure
MEILFRDQYLVAVHKPAGLLVHRSPIDRHETRFALQEVRDLLGRRVYPVHRLDKPTSGVL
CCEEEECCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEE
VFALDPATARSLGDAFAGGRVNKTYLAVTRGIVPPEGIIDHSLSEEPDRLDGAKSSPAAP
EEEECCHHHHHHHHHHCCCCCCHHHEEEECCCCCCCCHHHCCCCCCCHHHCCCCCCCCCC
QPAVTVFRRLAEAELPVVTGRYASSRYSLAELTPHTGRRHQLRRHMKHIFHPIIGDTTYG
CHHHHHHHHHHHHCCCEEECCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
EGRHNRFFREEFGCGRLLLHAAELSLPHPASGETLTIAAPPDRELARLLDRLGWLAAATG
CCCCCCHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCC
RGRPGMPAPP
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA