Click here to switch to the map view.

The map label for this gene is cobU [H]

Identifier: 39998101

GI number: 39998101

Start: 3302370

End: 3302888

Strand: Reverse

Name: cobU [H]

Synonym: GSU3010

Alternate gene names: 39998101

Gene position: 3302888-3302370 (Counterclockwise)

Preceding gene: 39998102

Following gene: 39998100

Centisome position: 86.6

GC content: 64.93

Gene sequence:

>519_bases
ATGGCACAGATCATTTTCTTAACGGGCGGCGCCCGTAGCGGCAAAAGCCGCTTGGCCGAAGAACTGGCAACCAGGCGGGG
TACTCCCCTCGGCTACCTGGCCACCGGCTCTGCCGGTGACGGGGAGATGGCCGAGCGGATCGCCCGGCACCGGGAGCGCC
GCGGCGATGCCTGGACCACCATCGAAGAACCCCTGGCCCTTGCCGAGTCCCTGGCGGCCCATGACGGCCGGTTCGCCGCA
ATCCTCGTGGATTGCGTCACCCTCTGGCTCTCCAATCTCCTCTTTTCCCTGGACGATCCAGCCCGCGTGCTCAAAGAAGT
CGAACTATTGACACGGACATTCTCCTCCCTCCGGACTCCGCTCATCATCGTATCCAACGAGGTGGGCATGGGGATAGTGC
CGGAGAACCGCCTGGCGCGCCAGTTCCGTGACCTGGCCGGCGAGGCCAACGAGCGGATCGCCGCCGCGGCCGACGAAGTC
TATGTGACATTCAGCGGGCTCCCGCTACGCCTGAAATGA

Upstream 100 bases:

>100_bases
GCATGAGCAGCGGCCTCCGAGGAAGAGGTGCCGAAGCCATCGTCAATTCATCCACGGTATTCGAGCCCCGCCCCTTGTCA
GGAGGCGGGGTTTTTCATTC

Downstream 100 bases:

>100_bases
ACCCTGAAAGACGAGGTACCCCATGACGCTGCTGACCGAAGCCCTGTCAAAAATATGTCCCGTAGATGCCGAACTCATGG
CCCAGGCCCAGGCGCGGCTT

Product: bifunctional cobalamin biosynthesis protein CobU

Products: NA

Alternate protein names: Adenosylcobinamide kinase; Adenosylcobinamide-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MAQIIFLTGGARSGKSRLAEELATRRGTPLGYLATGSAGDGEMAERIARHRERRGDAWTTIEEPLALAESLAAHDGRFAA
ILVDCVTLWLSNLLFSLDDPARVLKEVELLTRTFSSLRTPLIIVSNEVGMGIVPENRLARQFRDLAGEANERIAAAADEV
YVTFSGLPLRLK

Sequences:

>Translated_172_residues
MAQIIFLTGGARSGKSRLAEELATRRGTPLGYLATGSAGDGEMAERIARHRERRGDAWTTIEEPLALAESLAAHDGRFAA
ILVDCVTLWLSNLLFSLDDPARVLKEVELLTRTFSSLRTPLIIVSNEVGMGIVPENRLARQFRDLAGEANERIAAAADEV
YVTFSGLPLRLK
>Mature_171_residues
AQIIFLTGGARSGKSRLAEELATRRGTPLGYLATGSAGDGEMAERIARHRERRGDAWTTIEEPLALAESLAAHDGRFAAI
LVDCVTLWLSNLLFSLDDPARVLKEVELLTRTFSSLRTPLIIVSNEVGMGIVPENRLARQFRDLAGEANERIAAAADEVY
VTFSGLPLRLK

Specific function: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate [H]

COG id: COG2087

COG function: function code H; Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788302, Length=181, Percent_Identity=41.4364640883978, Blast_Score=129, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003203 [H]

Pfam domain/function: PF02283 CobU [H]

EC number: =2.7.1.156; =2.7.7.62 [H]

Molecular weight: Translated: 18763; Mature: 18632

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQIIFLTGGARSGKSRLAEELATRRGTPLGYLATGSAGDGEMAERIARHRERRGDAWTT
CCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCHH
IEEPLALAESLAAHDGRFAAILVDCVTLWLSNLLFSLDDPARVLKEVELLTRTFSSLRTP
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
LIIVSNEVGMGIVPENRLARQFRDLAGEANERIAAAADEVYVTFSGLPLRLK
EEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCEEEEEECCCEEEEC
>Mature Secondary Structure 
AQIIFLTGGARSGKSRLAEELATRRGTPLGYLATGSAGDGEMAERIARHRERRGDAWTT
CEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCHH
IEEPLALAESLAAHDGRFAAILVDCVTLWLSNLLFSLDDPARVLKEVELLTRTFSSLRTP
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
LIIVSNEVGMGIVPENRLARQFRDLAGEANERIAAAADEVYVTFSGLPLRLK
EEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCEEEEEECCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655697; 1655696 [H]