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The map label for this gene is cobT

Identifier: 39998100

GI number: 39998100

Start: 3301289

End: 3302347

Strand: Reverse

Name: cobT

Synonym: GSU3009

Alternate gene names: 39998100

Gene position: 3302347-3301289 (Counterclockwise)

Preceding gene: 39998101

Following gene: 39998099

Centisome position: 86.58

GC content: 64.59

Gene sequence:

>1059_bases
ATGACGCTGCTGACCGAAGCCCTGTCAAAAATATGTCCCGTAGATGCCGAACTCATGGCCCAGGCCCAGGCGCGGCTTGA
CAACAAGACCAAACCCATTGGCTCCCTCGGACGGTTGGAGGAGTTCGCCCGGCGCATGGTGGCCATCACCGGCAGCGTTG
CGCCCGATACGAAGAAGAAGGTGGTCTTCACCTTTGCCGGTGATCATGGCGTGACCGATGAAGGTGTGTCGGCCTTTCCC
CGGGAAGTGACCCCCCAGATGGTCTATAATTTCCTGCGGGGAGGAGCCGGCATCAATGTCCTTGCGCGCCACGTGGGAGC
CCAGGTACGGGTGGTCGACATCGGGGTGGATCACGATTTCGGCGACACCCCCGGCCTCATTGTCCGGAAGGTGGCCCGGG
GCACCCGTAATTTCGCTCGAGGCCCGGCCATGACCAGGGAGGAGGCGGTCGCCGCCCTGGAGGTGGGGATAGATCTGGCG
AATGAGGCCAAGCGGGAAGGGATCGCCCTGGTCGGTACCGGCGAGATGGGTATCGGTAACACTACCCCGTCGGCTGCCAT
TATCGCCGCCTTCTCGGGGCTGCCGGTCCCGGCGGTGACCCACCGGGGGACCGGCATCGGCGATGAGGCCCTTGCCAACA
AGGTCCGGGTTATCGAGGCGGGGCTGGCCCTGAACCAACCCGATCCGAAAGATCCTATCGATGTGCTGGCAAAAGTCGGA
GGACTGGAGATCGCCGGCATTGCAGGCCTGATCCTCGGCTGCGCCGCAAACCGGCTGCCGGTGGTGGTGGACGGCTTCAT
CTCCACGGCCGGGGCCCTGGTGGCCTGCGAGCTCAATCCCCATGTGCGGGATTACCTCTTTGCGGCCCACCAGTCGGTGG
AAGTGGGGCACCGGGTCATGCTCGACCGCATCGGCGCCGCCCCGATCCTGGACCTCCAGCTGCGGCTCGGCGAGGGGACT
GGTGGGGCACTGGCCATGGGACTCATCGAGGCCGGAGTCAGAATTTTGACGGAAATGGCCACCTTTGAGGAAGCGGGCGT
GGCGGAAGGGGACTATTGA

Upstream 100 bases:

>100_bases
GAGGCCAACGAGCGGATCGCCGCCGCGGCCGACGAAGTCTATGTGACATTCAGCGGGCTCCCGCTACGCCTGAAATGAAC
CCTGAAAGACGAGGTACCCC

Downstream 100 bases:

>100_bases
AACTCTATTTCATCGCCCTTCAGTTTCTGACCGTCGTCCCGCTGCCGTTCCGGCTGCGCTGGGACGAGCGCGCCCTGGGA
CGCTCCATGGCATTCTTCCC

Product: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MTLLTEALSKICPVDAELMAQAQARLDNKTKPIGSLGRLEEFARRMVAITGSVAPDTKKKVVFTFAGDHGVTDEGVSAFP
REVTPQMVYNFLRGGAGINVLARHVGAQVRVVDIGVDHDFGDTPGLIVRKVARGTRNFARGPAMTREEAVAALEVGIDLA
NEAKREGIALVGTGEMGIGNTTPSAAIIAAFSGLPVPAVTHRGTGIGDEALANKVRVIEAGLALNQPDPKDPIDVLAKVG
GLEIAGIAGLILGCAANRLPVVVDGFISTAGALVACELNPHVRDYLFAAHQSVEVGHRVMLDRIGAAPILDLQLRLGEGT
GGALAMGLIEAGVRILTEMATFEEAGVAEGDY

Sequences:

>Translated_352_residues
MTLLTEALSKICPVDAELMAQAQARLDNKTKPIGSLGRLEEFARRMVAITGSVAPDTKKKVVFTFAGDHGVTDEGVSAFP
REVTPQMVYNFLRGGAGINVLARHVGAQVRVVDIGVDHDFGDTPGLIVRKVARGTRNFARGPAMTREEAVAALEVGIDLA
NEAKREGIALVGTGEMGIGNTTPSAAIIAAFSGLPVPAVTHRGTGIGDEALANKVRVIEAGLALNQPDPKDPIDVLAKVG
GLEIAGIAGLILGCAANRLPVVVDGFISTAGALVACELNPHVRDYLFAAHQSVEVGHRVMLDRIGAAPILDLQLRLGEGT
GGALAMGLIEAGVRILTEMATFEEAGVAEGDY
>Mature_351_residues
TLLTEALSKICPVDAELMAQAQARLDNKTKPIGSLGRLEEFARRMVAITGSVAPDTKKKVVFTFAGDHGVTDEGVSAFPR
EVTPQMVYNFLRGGAGINVLARHVGAQVRVVDIGVDHDFGDTPGLIVRKVARGTRNFARGPAMTREEAVAALEVGIDLAN
EAKREGIALVGTGEMGIGNTTPSAAIIAAFSGLPVPAVTHRGTGIGDEALANKVRVIEAGLALNQPDPKDPIDVLAKVGG
LEIAGIAGLILGCAANRLPVVVDGFISTAGALVACELNPHVRDYLFAAHQSVEVGHRVMLDRIGAAPILDLQLRLGEGTG
GALAMGLIEAGVRILTEMATFEEAGVAEGDY

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family

Homologues:

Organism=Escherichia coli, GI1788300, Length=348, Percent_Identity=42.2413793103448, Blast_Score=275, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBT_GEOSL (Q748J3)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_954051.1
- HSSP:   Q7SIC7
- ProteinModelPortal:   Q748J3
- SMR:   Q748J3
- GeneID:   2686694
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU3009
- NMPDR:   fig|243231.1.peg.2989
- TIGR:   GSU3009
- HOGENOM:   HBG634399
- OMA:   NEMATFS
- ProtClustDB:   PRK00105
- BioCyc:   GSUL243231:GSU_3009-MONOMER
- BRENDA:   2.4.2.21
- HAMAP:   MF_00230
- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846
- Gene3D:   G3DSA:1.10.1610.10
- TIGRFAMs:   TIGR03160

Pfam domain/function: PF02277 DBI_PRT; SSF52733 NN:DBI_PRT

EC number: =2.4.2.21

Molecular weight: Translated: 36619; Mature: 36488

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: ACT_SITE 318-318

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLTEALSKICPVDAELMAQAQARLDNKTKPIGSLGRLEEFARRMVAITGSVAPDTKKK
CCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCE
VVFTFAGDHGVTDEGVSAFPREVTPQMVYNFLRGGAGINVLARHVGAQVRVVDIGVDHDF
EEEEEECCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCHHHHHHHCCCEEEEEEEECCCCC
GDTPGLIVRKVARGTRNFARGPAMTREEAVAALEVGIDLANEAKREGIALVGTGEMGIGN
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHCCEEEEECCCCCCCC
TTPSAAIIAAFSGLPVPAVTHRGTGIGDEALANKVRVIEAGLALNQPDPKDPIDVLAKVG
CCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHC
GLEIAGIAGLILGCAANRLPVVVDGFISTAGALVACELNPHVRDYLFAAHQSVEVGHRVM
CCCHHHHHHHHHHHCCCCCCEEEEHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
LDRIGAAPILDLQLRLGEGTGGALAMGLIEAGVRILTEMATFEEAGVAEGDY
HHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TLLTEALSKICPVDAELMAQAQARLDNKTKPIGSLGRLEEFARRMVAITGSVAPDTKKK
CHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCE
VVFTFAGDHGVTDEGVSAFPREVTPQMVYNFLRGGAGINVLARHVGAQVRVVDIGVDHDF
EEEEEECCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCHHHHHHHCCCEEEEEEEECCCCC
GDTPGLIVRKVARGTRNFARGPAMTREEAVAALEVGIDLANEAKREGIALVGTGEMGIGN
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHCCEEEEECCCCCCCC
TTPSAAIIAAFSGLPVPAVTHRGTGIGDEALANKVRVIEAGLALNQPDPKDPIDVLAKVG
CCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHC
GLEIAGIAGLILGCAANRLPVVVDGFISTAGALVACELNPHVRDYLFAAHQSVEVGHRVM
CCCHHHHHHHHHHHCCCCCCEEEEHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
LDRIGAAPILDLQLRLGEGTGGALAMGLIEAGVRILTEMATFEEAGVAEGDY
HHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA