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The map label for this gene is cobH [H]

Identifier: 39998090

GI number: 39998090

Start: 3292653

End: 3293294

Strand: Reverse

Name: cobH [H]

Synonym: GSU2999

Alternate gene names: 39998090

Gene position: 3293294-3292653 (Counterclockwise)

Preceding gene: 39998091

Following gene: 39998089

Centisome position: 86.34

GC content: 68.07

Gene sequence:

>642_bases
ATGTCGGTCCACCTCCGCCCCGAGGAGATCGAGGCCGAGTCGTTCCGGATCATCGATGCCGAAGCGGGCTCCCACTCCTG
GGGGCCGGACCAGTGGCCGGTGGTGCGCCGCGTCATCCATACCTCCGCCGATTTCGACTATGCCCGGAGCATGGTCTTCT
CCCCCGACGCCGTGCCGCGCGCCCTGGCCGCGCTCAAGGCGGGAAGAGGCATCGTCACCGACACCACCATGGCCCTGTCG
GGCATCGCCAAGCCGCGCCTGGAGCGATTCGGCATCTCCGTCTCCTGTTTCGTGGCTGATCCCGATGTGGCACGCCGGGC
CCGGGAGCAGGGGATCACCCGCTCTATCCTGGCTCTACGTGCGGGGGCGTCGGACCGGGGTAACGGCATCTTCGTCATCG
GCAACGCACCCACGGCCCTCTTCGAGCTGATCCGCCTGGTGCGGGAAGAGGGTCTGCGTCCCGACTTGGTGGTGGGCTTG
CCGGTGGGGTTCGTTGGGGCCGCGGAGAGCAAAGAGGCGCTCCTGGCCCTGGAGCATGAGGTCCCGGAAGTCCCCTTCAT
CACCAACCGGGGACGCAAGGGGGGGTCCAACGTGGCGGCGGCGGTGGTGAACGCCCTGCTCATCATGGCTATGGAGGGGT
AA

Upstream 100 bases:

>100_bases
TGGAGTTCGCCATGGGAGGGCATCTGGGCGTGCACCGCAAGCTGGCCGAGGTGGCGGCTGACCGGATCGCCGAAGCCCTC
GCCGCCACGGGGTGGCGCTG

Downstream 100 bases:

>100_bases
TGCGCAAAGCCAACAAGCGAATCACCGATTTCGACATCATCCGCCGGATGCTCGACACCTGTCACGTGGGGCGGCTCGGC
ACCCTGGGAGCCGACGGCTG

Product: precorrin-8X methylmutase

Products: hydrogenobyrinate

Alternate protein names: Cobalt-precorrin isomerase; HBA synthase [H]

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MSVHLRPEEIEAESFRIIDAEAGSHSWGPDQWPVVRRVIHTSADFDYARSMVFSPDAVPRALAALKAGRGIVTDTTMALS
GIAKPRLERFGISVSCFVADPDVARRAREQGITRSILALRAGASDRGNGIFVIGNAPTALFELIRLVREEGLRPDLVVGL
PVGFVGAAESKEALLALEHEVPEVPFITNRGRKGGSNVAAAVVNALLIMAMEG

Sequences:

>Translated_213_residues
MSVHLRPEEIEAESFRIIDAEAGSHSWGPDQWPVVRRVIHTSADFDYARSMVFSPDAVPRALAALKAGRGIVTDTTMALS
GIAKPRLERFGISVSCFVADPDVARRAREQGITRSILALRAGASDRGNGIFVIGNAPTALFELIRLVREEGLRPDLVVGL
PVGFVGAAESKEALLALEHEVPEVPFITNRGRKGGSNVAAAVVNALLIMAMEG
>Mature_212_residues
SVHLRPEEIEAESFRIIDAEAGSHSWGPDQWPVVRRVIHTSADFDYARSMVFSPDAVPRALAALKAGRGIVTDTTMALSG
IAKPRLERFGISVSCFVADPDVARRAREQGITRSILALRAGASDRGNGIFVIGNAPTALFELIRLVREEGLRPDLVVGLP
VGFVGAAESKEALLALEHEVPEVPFITNRGRKGGSNVAAAVVNALLIMAMEG

Specific function: Catalyzes the conversion of cobalt-precorrin-8X to cobyrinic acid; a methyl migration reaction during the transformation of cobalt-precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: 5.4.1.2

Molecular weight: Translated: 22806; Mature: 22675

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVHLRPEEIEAESFRIIDAEAGSHSWGPDQWPVVRRVIHTSADFDYARSMVFSPDAVPR
CCCCCCHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCHHHH
ALAALKAGRGIVTDTTMALSGIAKPRLERFGISVSCFVADPDVARRAREQGITRSILALR
HHHHHHCCCCCEEHHHHHHHHCCHHHHHHHCCEEEEEEECHHHHHHHHHCCHHHHHHHHH
AGASDRGNGIFVIGNAPTALFELIRLVREEGLRPDLVVGLPVGFVGAAESKEALLALEHE
CCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHEEECCC
VPEVPFITNRGRKGGSNVAAAVVNALLIMAMEG
CCCCCEECCCCCCCCCHHHHHHHHHHHHHEECC
>Mature Secondary Structure 
SVHLRPEEIEAESFRIIDAEAGSHSWGPDQWPVVRRVIHTSADFDYARSMVFSPDAVPR
CCCCCHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCHHHH
ALAALKAGRGIVTDTTMALSGIAKPRLERFGISVSCFVADPDVARRAREQGITRSILALR
HHHHHHCCCCCEEHHHHHHHHCCHHHHHHHCCEEEEEEECHHHHHHHHHCCHHHHHHHHH
AGASDRGNGIFVIGNAPTALFELIRLVREEGLRPDLVVGLPVGFVGAAESKEALLALEHE
CCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHEEECCC
VPEVPFITNRGRKGGSNVAAAVVNALLIMAMEG
CCCCCEECCCCCCCCCHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 8X

Specific reaction: precorrin-8X = hydrogenobyrinate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]