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The map label for this gene is trpE [H]

Identifier: 39997478

GI number: 39997478

Start: 2611347

End: 2612822

Strand: Reverse

Name: trpE [H]

Synonym: GSU2383

Alternate gene names: 39997478

Gene position: 2612822-2611347 (Counterclockwise)

Preceding gene: 39997479

Following gene: 39997477

Centisome position: 68.5

GC content: 66.94

Gene sequence:

>1476_bases
GTGTATTTCCCCGATGTGGATACCTTTCGCGCCCTGGGCGCCCGGGGTAACCTGATTCCCGTCTGCCGCGAGATCATGGC
GGATATGGACACCCCGGTCAGTGCCTTCCGCAAGCTCGACGACGGCCGCTATGCCTTCCTCCTGGAGAGTATCGAGGGGG
GCGAAAAGTGGGCCCGCTATACCTTCCTCGGCGCCAGCCCCTCCACGGTCATCCGGAGCCGGGGCACCACCGTCGAGATC
ATCACCAACGGCGAGACCCGTTCCGTGACGACGGACGACCCCCTCGGCTTTGTCCGCGATTTCCTGGCCCGGTTCCGGCC
CGTGGAGATCCCCGGGCTTCCCCGCTTCTTCGGCGGCGCCGTGGGGTACCTCGGCTACGACATGGTCCGCCAATTCGAGC
GGCTTCCCACGGACAAACCCGCCGTGATCGGCGCCTGGGACTCCTGTTTCCTCATCACCGACACCATCGTGATTTTCGAC
AATATGCGCCAGAAGATCACGGTGGTCTCCAATGCCCACCTGGACGAGGGCGTTTCCGTCGAAGCGGCCTATGCCGACGC
CGTTGCCCGGATCGACGGGATCATTGCCCGGCTCAAGGCGCCGCTGCCGGCCCAGCCCGCCGCGGCCGCGGCCCGGAAGG
TCTCCTTTTCTTCCAACATCACCCGGGAGGCGTTCGAGGATGCCGTGGAACGGGCCAAGGAGTACGTCCGGGCCGGCGAC
ATCATCCAGGTGGTCCTGTCCCAGCGTTTTTCCGGCGAGCTCACCGTGGACCCTCTCGACATCTACCGGGTATTGCGGAC
CCTGAACCCGTCGCCCTACATGTTTTTCCTCCGCCTGGACGATACCCTGGTGGTGGGCGCCTCTCCCGAAGTCATGGTGC
GTCGGGAGGGGAACCGGGTGGAGCTCCGCCCCATCGCCGGCACCCGCCCCCGGGGCGCCACGCCGGAACAGGACGAGCAA
CTGGCGGAGGAACTCCTGGCCGACCCCAAGGAGCGGGCCGAGCACGTGATGCTCGTGGACCTGGGGCGCAACGACCTGGG
GCGGGTCTGCCGCACCGGCACCGTGAAGGTGTCGGAGCTCATGGTGATCGAGCGCTACTCCCACGTGATGCACATCGTTT
CCAACGTCCAGGGCGAACTGGCCGAGGGGAGGGACGCCTTCGACGTGGTGCGGGCCACCTTCCCGGCCGGCACCCTCTCC
GGCGCCCCCAAGGTGCGGGCCATGGAGATCATCGACGAGCTGGAGCCGGTGCGCCGGGAAGTCTACGGCGGCGCCGTGGG
CTACTTCTCCTTCTCCGGCACCATGGACCTGGCCATCGCCATCCGCACTCTCGTCATCCGCGACGGCGTGGTGCACCTCC
AGGCCGGGGCCGGCATCGTGGCCGACTCTGATCCGGCCTCCGAGTACCAGGAGACGGTCAACAAGGCCATGGCCGTGGTA
AAGGCCATCGAGACCGCGGAAAAGGGGTTGGACTGA

Upstream 100 bases:

>100_bases
CGTTTCTTGACACCCCGTTGTTCCCCGTGCTAGTTTAACCCATTCTAAAAAGGGTCTTTTTTCGTTCCACCTCCCTTGCC
GACCCGTTCCGGAGCCTCCC

Downstream 100 bases:

>100_bases
CATGCTCCTGATGATTGACAATTATGATTCCTTCACCTTCAATATCGTCCAGTATTTCGGCGAGCTGGGCGAGGATGTGC
GGGTCTTCCGCAACGACGGC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MYFPDVDTFRALGARGNLIPVCREIMADMDTPVSAFRKLDDGRYAFLLESIEGGEKWARYTFLGASPSTVIRSRGTTVEI
ITNGETRSVTTDDPLGFVRDFLARFRPVEIPGLPRFFGGAVGYLGYDMVRQFERLPTDKPAVIGAWDSCFLITDTIVIFD
NMRQKITVVSNAHLDEGVSVEAAYADAVARIDGIIARLKAPLPAQPAAAAARKVSFSSNITREAFEDAVERAKEYVRAGD
IIQVVLSQRFSGELTVDPLDIYRVLRTLNPSPYMFFLRLDDTLVVGASPEVMVRREGNRVELRPIAGTRPRGATPEQDEQ
LAEELLADPKERAEHVMLVDLGRNDLGRVCRTGTVKVSELMVIERYSHVMHIVSNVQGELAEGRDAFDVVRATFPAGTLS
GAPKVRAMEIIDELEPVRREVYGGAVGYFSFSGTMDLAIAIRTLVIRDGVVHLQAGAGIVADSDPASEYQETVNKAMAVV
KAIETAEKGLD

Sequences:

>Translated_491_residues
MYFPDVDTFRALGARGNLIPVCREIMADMDTPVSAFRKLDDGRYAFLLESIEGGEKWARYTFLGASPSTVIRSRGTTVEI
ITNGETRSVTTDDPLGFVRDFLARFRPVEIPGLPRFFGGAVGYLGYDMVRQFERLPTDKPAVIGAWDSCFLITDTIVIFD
NMRQKITVVSNAHLDEGVSVEAAYADAVARIDGIIARLKAPLPAQPAAAAARKVSFSSNITREAFEDAVERAKEYVRAGD
IIQVVLSQRFSGELTVDPLDIYRVLRTLNPSPYMFFLRLDDTLVVGASPEVMVRREGNRVELRPIAGTRPRGATPEQDEQ
LAEELLADPKERAEHVMLVDLGRNDLGRVCRTGTVKVSELMVIERYSHVMHIVSNVQGELAEGRDAFDVVRATFPAGTLS
GAPKVRAMEIIDELEPVRREVYGGAVGYFSFSGTMDLAIAIRTLVIRDGVVHLQAGAGIVADSDPASEYQETVNKAMAVV
KAIETAEKGLD
>Mature_491_residues
MYFPDVDTFRALGARGNLIPVCREIMADMDTPVSAFRKLDDGRYAFLLESIEGGEKWARYTFLGASPSTVIRSRGTTVEI
ITNGETRSVTTDDPLGFVRDFLARFRPVEIPGLPRFFGGAVGYLGYDMVRQFERLPTDKPAVIGAWDSCFLITDTIVIFD
NMRQKITVVSNAHLDEGVSVEAAYADAVARIDGIIARLKAPLPAQPAAAAARKVSFSSNITREAFEDAVERAKEYVRAGD
IIQVVLSQRFSGELTVDPLDIYRVLRTLNPSPYMFFLRLDDTLVVGASPEVMVRREGNRVELRPIAGTRPRGATPEQDEQ
LAEELLADPKERAEHVMLVDLGRNDLGRVCRTGTVKVSELMVIERYSHVMHIVSNVQGELAEGRDAFDVVRATFPAGTLS
GAPKVRAMEIIDELEPVRREVYGGAVGYFSFSGTMDLAIAIRTLVIRDGVVHLQAGAGIVADSDPASEYQETVNKAMAVV
KAIETAEKGLD

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=472, Percent_Identity=37.0762711864407, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1787518, Length=382, Percent_Identity=41.0994764397906, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1786809, Length=280, Percent_Identity=30, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI87082077, Length=263, Percent_Identity=28.8973384030418, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6320935, Length=505, Percent_Identity=42.5742574257426, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6324361, Length=404, Percent_Identity=26.4851485148515, Blast_Score=123, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 53938; Mature: 53938

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYFPDVDTFRALGARGNLIPVCREIMADMDTPVSAFRKLDDGRYAFLLESIEGGEKWARY
CCCCCCHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEECCCCCCCEEEE
TFLGASPSTVIRSRGTTVEIITNGETRSVTTDDPLGFVRDFLARFRPVEIPGLPRFFGGA
EEECCCHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
VGYLGYDMVRQFERLPTDKPAVIGAWDSCFLITDTIVIFDNMRQKITVVSNAHLDEGVSV
HHHHHHHHHHHHHHCCCCCCCEEECCCCEEEHHHHHHEECCCCCEEEEEECCCCCCCCEE
EAAYADAVARIDGIIARLKAPLPAQPAAAAARKVSFSSNITREAFEDAVERAKEYVRAGD
EHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
IIQVVLSQRFSGELTVDPLDIYRVLRTLNPSPYMFFLRLDDTLVVGASPEVMVRREGNRV
HHHHHHHHCCCCCEEECHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCCEEEEECCCEE
ELRPIAGTRPRGATPEQDEQLAEELLADPKERAEHVMLVDLGRNDLGRVCRTGTVKVSEL
EEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHCCEEEEEECCCCHHHHHHCCCCEEHHHH
MVIERYSHVMHIVSNVQGELAEGRDAFDVVRATFPAGTLSGAPKVRAMEIIDELEPVRRE
HHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
VYGGAVGYFSFSGTMDLAIAIRTLVIRDGVVHLQAGAGIVADSDPASEYQETVNKAMAVV
HHCCEEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCEEECCCCHHHHHHHHHHHHHHH
KAIETAEKGLD
HHHHHHHHCCC
>Mature Secondary Structure
MYFPDVDTFRALGARGNLIPVCREIMADMDTPVSAFRKLDDGRYAFLLESIEGGEKWARY
CCCCCCHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEECCCCCCCEEEE
TFLGASPSTVIRSRGTTVEIITNGETRSVTTDDPLGFVRDFLARFRPVEIPGLPRFFGGA
EEECCCHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
VGYLGYDMVRQFERLPTDKPAVIGAWDSCFLITDTIVIFDNMRQKITVVSNAHLDEGVSV
HHHHHHHHHHHHHHCCCCCCCEEECCCCEEEHHHHHHEECCCCCEEEEEECCCCCCCCEE
EAAYADAVARIDGIIARLKAPLPAQPAAAAARKVSFSSNITREAFEDAVERAKEYVRAGD
EHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
IIQVVLSQRFSGELTVDPLDIYRVLRTLNPSPYMFFLRLDDTLVVGASPEVMVRREGNRV
HHHHHHHHCCCCCEEECHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCCEEEEECCCEE
ELRPIAGTRPRGATPEQDEQLAEELLADPKERAEHVMLVDLGRNDLGRVCRTGTVKVSEL
EEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHCCEEEEEECCCCHHHHHHCCCCEEHHHH
MVIERYSHVMHIVSNVQGELAEGRDAFDVVRATFPAGTLSGAPKVRAMEIIDELEPVRRE
HHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
VYGGAVGYFSFSGTMDLAIAIRTLVIRDGVVHLQAGAGIVADSDPASEYQETVNKAMAVV
HHCCEEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCEEECCCCHHHHHHHHHHHHHHH
KAIETAEKGLD
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2732211 [H]