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The map label for this gene is gmk

Identifier: 39997336

GI number: 39997336

Start: 2453113

End: 2453724

Strand: Reverse

Name: gmk

Synonym: GSU2238

Alternate gene names: 39997336

Gene position: 2453724-2453113 (Counterclockwise)

Preceding gene: 39997337

Following gene: 39997335

Centisome position: 64.33

GC content: 55.23

Gene sequence:

>612_bases
ATGAAACGTGAAGGGGTTTTATACATACTGTCGGCACCGTCGGGGGCGGGTAAAACCACGCTGTGCAGAGAAATAATTGA
CATTTTTCCACAGCTGCGGCATTCTGTCAGTTACACTACGCGCACGCCACGGCCCGGCGAAATCCATGGCAAAGACTATT
TTTTTGTTTCCATGGATGAGTTTCACCGGATGATCGATGCTGATGAGTTCGCGGAGTGGGCAGAGGTTCACGGCAACTGC
TACGGCACCTCCATCCGGACCCTTGAGGAGAATCGTGCCGCAGGCGTGGACCTTATCCTGGATATCGATATCCAGGGGGC
ACGCCAGCTCCAGGAGCGGTTTGCGGGCGGCGTTTATATCTTTATTCTCCCCCCAAGCTTTGAGGAGTTGCGTCGTCGGC
TCAACGGGCGCTCCTCGGACAGCGACGAGGTTATCAGCCGGCGGATAAACGCTGCTGCCGGCGAGATCCGGGAATCCCGC
TGGTACGACTACATTATCGTCAACGATCAATTCAGCCGGGCGGTGGAAGAGCTCAAATCGGTCATCATTGCCGAGCAGTG
TCGTACCGCCAGGGTGCTGGATGCGGTTTCAGAGATTTTTTCCATGGATTGA

Upstream 100 bases:

>100_bases
CGGACACCGCAGCGCTGGTGGTGGAGCTCAAGGCCGAGTTGGAGAAGATTCGCGAGCAGGTCCAGAATATTGAATAGCGT
TTGCCACGAGCGGGGTCTTG

Downstream 100 bases:

>100_bases
GTGACCCCGTTGCGGGTCGGATTTTACACACGTTACCGTCCCCGTCGCCAGCGGGTGCCGGTTGCACGAAAGGAGTAATA
ATGGCACGAGTAACCGTTGA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MKREGVLYILSAPSGAGKTTLCREIIDIFPQLRHSVSYTTRTPRPGEIHGKDYFFVSMDEFHRMIDADEFAEWAEVHGNC
YGTSIRTLEENRAAGVDLILDIDIQGARQLQERFAGGVYIFILPPSFEELRRRLNGRSSDSDEVISRRINAAAGEIRESR
WYDYIIVNDQFSRAVEELKSVIIAEQCRTARVLDAVSEIFSMD

Sequences:

>Translated_203_residues
MKREGVLYILSAPSGAGKTTLCREIIDIFPQLRHSVSYTTRTPRPGEIHGKDYFFVSMDEFHRMIDADEFAEWAEVHGNC
YGTSIRTLEENRAAGVDLILDIDIQGARQLQERFAGGVYIFILPPSFEELRRRLNGRSSDSDEVISRRINAAAGEIRESR
WYDYIIVNDQFSRAVEELKSVIIAEQCRTARVLDAVSEIFSMD
>Mature_203_residues
MKREGVLYILSAPSGAGKTTLCREIIDIFPQLRHSVSYTTRTPRPGEIHGKDYFFVSMDEFHRMIDADEFAEWAEVHGNC
YGTSIRTLEENRAAGVDLILDIDIQGARQLQERFAGGVYIFILPPSFEELRRRLNGRSSDSDEVISRRINAAAGEIRESR
WYDYIIVNDQFSRAVEELKSVIIAEQCRTARVLDAVSEIFSMD

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=191, Percent_Identity=38.2198952879581, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI4504221, Length=191, Percent_Identity=38.2198952879581, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI226874831, Length=191, Percent_Identity=38.2198952879581, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI14780902, Length=194, Percent_Identity=27.319587628866, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI38570142, Length=179, Percent_Identity=31.2849162011173, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI21361598, Length=185, Percent_Identity=29.7297297297297, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI262118259, Length=172, Percent_Identity=26.7441860465116, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4505237, Length=172, Percent_Identity=26.7441860465116, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI262118263, Length=172, Percent_Identity=26.7441860465116, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI262118255, Length=172, Percent_Identity=26.7441860465116, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI111154074, Length=160, Percent_Identity=31.25, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI52630447, Length=201, Percent_Identity=28.8557213930348, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1790080, Length=190, Percent_Identity=52.1052631578947, Blast_Score=195, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI193203132, Length=188, Percent_Identity=35.6382978723404, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17508835, Length=175, Percent_Identity=37.7142857142857, Blast_Score=127, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17556244, Length=126, Percent_Identity=30.952380952381, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71988041, Length=183, Percent_Identity=24.0437158469945, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71988048, Length=183, Percent_Identity=24.0437158469945, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=187, Percent_Identity=43.8502673796791, Blast_Score=163, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21356141, Length=181, Percent_Identity=40.3314917127072, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24640542, Length=179, Percent_Identity=28.4916201117318, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161077626, Length=179, Percent_Identity=28.4916201117318, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45554489, Length=179, Percent_Identity=28.4916201117318, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI116007136, Length=179, Percent_Identity=28.4916201117318, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45554481, Length=179, Percent_Identity=28.4916201117318, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI85724806, Length=179, Percent_Identity=28.4916201117318, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648808, Length=177, Percent_Identity=25.9887005649718, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330162, Length=192, Percent_Identity=29.1666666666667, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281362230, Length=177, Percent_Identity=25.9887005649718, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330166, Length=192, Percent_Identity=29.1666666666667, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161078487, Length=177, Percent_Identity=25.9887005649718, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330164, Length=192, Percent_Identity=28.125, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161078485, Length=177, Percent_Identity=25.9887005649718, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24648810, Length=177, Percent_Identity=25.9887005649718, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281362232, Length=177, Percent_Identity=25.9887005649718, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_GEOSL (P60551)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_953287.1
- ProteinModelPortal:   P60551
- SMR:   P60551
- GeneID:   2687509
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU2238
- NMPDR:   fig|243231.1.peg.2225
- TIGR:   GSU2238
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BioCyc:   GSUL243231:GSU_2238-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23171; Mature: 23171

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKREGVLYILSAPSGAGKTTLCREIIDIFPQLRHSVSYTTRTPRPGEIHGKDYFFVSMDE
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHH
FHRMIDADEFAEWAEVHGNCYGTSIRTLEENRAAGVDLILDIDIQGARQLQERFAGGVYI
HHHHHCHHHHHHHHHHCCCEECCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHCCCEEE
FILPPSFEELRRRLNGRSSDSDEVISRRINAAAGEIRESRWYDYIIVNDQFSRAVEELKS
EEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHH
VIIAEQCRTARVLDAVSEIFSMD
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKREGVLYILSAPSGAGKTTLCREIIDIFPQLRHSVSYTTRTPRPGEIHGKDYFFVSMDE
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHH
FHRMIDADEFAEWAEVHGNCYGTSIRTLEENRAAGVDLILDIDIQGARQLQERFAGGVYI
HHHHHCHHHHHHHHHHCCCEECCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHCCCEEE
FILPPSFEELRRRLNGRSSDSDEVISRRINAAAGEIRESRWYDYIIVNDQFSRAVEELKS
EEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHH
VIIAEQCRTARVLDAVSEIFSMD
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA