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The map label for this gene is pbpE [H]

Identifier: 39996480

GI number: 39996480

Start: 1506745

End: 1507758

Strand: Direct

Name: pbpE [H]

Synonym: GSU1378

Alternate gene names: 39996480

Gene position: 1506745-1507758 (Clockwise)

Preceding gene: 39996477

Following gene: 39996481

Centisome position: 39.5

GC content: 70.02

Gene sequence:

>1014_bases
ATGGGCACCCTGCTCGCCGGCCTCCCCGACGGGTGCGGCGCGGCCGCGCTGGCCCTCAGGCGCGGTGACGTTATCCTGCA
GGCCGGCGTTAATCTTTCCTCGGACCATTCAACCGGCCCCGGCTCACCGGCGCCCCTGTTTCTGGCCTACAGCTGCACCA
AGACCTTCATTGCCGCCCTGGTGCTCCGGTTGGGCGAGGAAGGACGCCTTGCCCTGACGGATCCCGTTTCCCGCTGGTTT
CCCGATCTCCCGCACTCCTCCGCCATCACCGTGCGCCACCTGCTCAACCATACCTCGGGCCTGCCCGACTACGGGCCGCT
TGCGGCGTACCACCAGGCCGTTCGCCGGACGCCGTCCCGGCCGTGGAATTCCGACGAGTTCCTGGCGCGGACCCTGGCGC
AGGGGGTGCTGTTCGAGCCGGGGAAGGGGTGGAGCTACTCGAATATCGGCTATCTGCTGCTCAGGATGATCGTCGAGACG
CTGACCGGCGAGCGGCTGGCCGGGTTGCTGGCGGCGCGTTTTTTCCACCCCCTCGGCCTGGGGGACACGTTCGTGCCCGA
GACCGTGGCTGATCTTGGGCGGCTGCAGCCGTCCCGATCCGGACTGGTGGCCGAGGAGGGGGCCGTCGATGTCCGCCGCG
TCTACCACCCGGGCTGGGTTTCCCACGGTGTTGTCGCCTCGACCCCGGCCGACATGGCCGAGTTCTGCCGCCGCCTGTTC
ACCGGCGCGGTCCTGTCCCGCGACTCCCTGGCAGCCATGACCACCCTGACCCCGGTGCCGGGTGCGCCGCCACGCTATGG
CCGGCCCTGCTACGGTCTCGGTATCATGGCTGACTGCGCATCCCGGTTCGGGATGCTCCTGGGGCACAACGGCGGCGGCC
CCGGCTACGGGGCCAGCGTATTCCACGCCCCGGACCACCACGGCGGCCCCCTGACGGTCTGCGCCATGGTCGCGTGCGAG
GCGCCGGATCTGGCCGAACGGCTGGTCATGGCCGTTCTGGAGGAAACAGCGTGA

Upstream 100 bases:

>100_bases
TTGCGGCCAGGGGCGAGGAGACACCCACCGTCCGGCACCGCGGGCGCCGACGGTTTCCCGGACGCCATGGAGGCATGTAA
GCGTGCTTACTCCCGAACAG

Downstream 100 bases:

>100_bases
GAACCGGCCTTCAGACCTGGGGACGCGAAGTGAATGTGCGACCGTTCGTCGCCCCGGGTCGGGTGAGGCTTCGTTAATCG
CTCTCATCTAAGTGATATTT

Product: beta-lactamase

Products: NA

Alternate protein names: PBP 4*; PBP 4A; Penicillin-binding protein E [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MGTLLAGLPDGCGAAALALRRGDVILQAGVNLSSDHSTGPGSPAPLFLAYSCTKTFIAALVLRLGEEGRLALTDPVSRWF
PDLPHSSAITVRHLLNHTSGLPDYGPLAAYHQAVRRTPSRPWNSDEFLARTLAQGVLFEPGKGWSYSNIGYLLLRMIVET
LTGERLAGLLAARFFHPLGLGDTFVPETVADLGRLQPSRSGLVAEEGAVDVRRVYHPGWVSHGVVASTPADMAEFCRRLF
TGAVLSRDSLAAMTTLTPVPGAPPRYGRPCYGLGIMADCASRFGMLLGHNGGGPGYGASVFHAPDHHGGPLTVCAMVACE
APDLAERLVMAVLEETA

Sequences:

>Translated_337_residues
MGTLLAGLPDGCGAAALALRRGDVILQAGVNLSSDHSTGPGSPAPLFLAYSCTKTFIAALVLRLGEEGRLALTDPVSRWF
PDLPHSSAITVRHLLNHTSGLPDYGPLAAYHQAVRRTPSRPWNSDEFLARTLAQGVLFEPGKGWSYSNIGYLLLRMIVET
LTGERLAGLLAARFFHPLGLGDTFVPETVADLGRLQPSRSGLVAEEGAVDVRRVYHPGWVSHGVVASTPADMAEFCRRLF
TGAVLSRDSLAAMTTLTPVPGAPPRYGRPCYGLGIMADCASRFGMLLGHNGGGPGYGASVFHAPDHHGGPLTVCAMVACE
APDLAERLVMAVLEETA
>Mature_336_residues
GTLLAGLPDGCGAAALALRRGDVILQAGVNLSSDHSTGPGSPAPLFLAYSCTKTFIAALVLRLGEEGRLALTDPVSRWFP
DLPHSSAITVRHLLNHTSGLPDYGPLAAYHQAVRRTPSRPWNSDEFLARTLAQGVLFEPGKGWSYSNIGYLLLRMIVETL
TGERLAGLLAARFFHPLGLGDTFVPETVADLGRLQPSRSGLVAEEGAVDVRRVYHPGWVSHGVVASTPADMAEFCRRLFT
GAVLSRDSLAAMTTLTPVPGAPPRYGRPCYGLGIMADCASRFGMLLGHNGGGPGYGASVFHAPDHHGGPLTVCAMVACEA
PDLAERLVMAVLEETA

Specific function: Probably involved in peptidoglycan modification during cortex synthesis [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Escherichia coli, GI1786574, Length=281, Percent_Identity=27.4021352313167, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466
- InterPro:   IPR021860 [H]

Pfam domain/function: PF00144 Beta-lactamase; PF11954 DUF3471 [H]

EC number: NA

Molecular weight: Translated: 35631; Mature: 35500

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTLLAGLPDGCGAAALALRRGDVILQAGVNLSSDHSTGPGSPAPLFLAYSCTKTFIAAL
CCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHH
VLRLGEEGRLALTDPVSRWFPDLPHSSAITVRHLLNHTSGLPDYGPLAAYHQAVRRTPSR
HHHHCCCCCEEEECCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
PWNSDEFLARTLAQGVLFEPGKGWSYSNIGYLLLRMIVETLTGERLAGLLAARFFHPLGL
CCCCHHHHHHHHHHCCEECCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCC
GDTFVPETVADLGRLQPSRSGLVAEEGAVDVRRVYHPGWVSHGVVASTPADMAEFCRRLF
CCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
TGAVLSRDSLAAMTTLTPVPGAPPRYGRPCYGLGIMADCASRFGMLLGHNGGGPGYGASV
HHHHHCCCHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCCE
FHAPDHHGGPLTVCAMVACEAPDLAERLVMAVLEETA
EECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GTLLAGLPDGCGAAALALRRGDVILQAGVNLSSDHSTGPGSPAPLFLAYSCTKTFIAAL
CCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHH
VLRLGEEGRLALTDPVSRWFPDLPHSSAITVRHLLNHTSGLPDYGPLAAYHQAVRRTPSR
HHHHCCCCCEEEECCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
PWNSDEFLARTLAQGVLFEPGKGWSYSNIGYLLLRMIVETLTGERLAGLLAARFFHPLGL
CCCCHHHHHHHHHHCCEECCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCC
GDTFVPETVADLGRLQPSRSGLVAEEGAVDVRRVYHPGWVSHGVVASTPADMAEFCRRLF
CCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
TGAVLSRDSLAAMTTLTPVPGAPPRYGRPCYGLGIMADCASRFGMLLGHNGGGPGYGASV
HHHHHCCCHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCCE
FHAPDHHGGPLTVCAMVACEAPDLAERLVMAVLEETA
EECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8491712; 9384377 [H]