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The map label for this gene is mutT [H]

Identifier: 39995976

GI number: 39995976

Start: 926968

End: 927381

Strand: Direct

Name: mutT [H]

Synonym: GSU0870

Alternate gene names: 39995976

Gene position: 926968-927381 (Clockwise)

Preceding gene: 39995975

Following gene: 39995977

Centisome position: 24.3

GC content: 63.77

Gene sequence:

>414_bases
ATGTACCCGCTCCTCGTCACCGCCGCCATTATCGAGCACAACGGCCTGATTCTCCTGACCCGGCGGAAGCCCGATGCGCC
CTATCCCTTGCTCTGGGAATTCCCGGGAGGGAAGGTGGAACCCGAAGAGCATCCCGAGGCGTGCATCGTCAGGGAGGTGC
TGGAGGAGCTTGCCATGGAGGTGGCGGTTGAGGGGATCTACGACGTAATCTACTACCGTTATCCCGAACGGGCCGTGATA
GTGCTGGCCTACCGCTGCACCTGGACCGGCGGCGAGCTGCAGGAACGCGACGTGGCCGGACACCGGTGGGTCGCCCCGGC
GGAGGTGCCCGCCTTCGACCTTCTTCCCGCGGATATTCCGCTCGCGGCCAGGATAGCACGGGAATTCGGCAATGCAGGTT
CTTCTCGCCTATAA

Upstream 100 bases:

>100_bases
CCTTGCCAACGATACCCTCGGCGTTGGCCTGTTGAAGTAGCACCTGTCGGTCAATCATTCCAAAATCCGGTCCGTGGACC
GGATTTTTTTTTGAGGCACC

Downstream 100 bases:

>100_bases
ATCCCACCATGCTGGGGCGCGGGATCCCTTTGCGTCGCTGCTGCCCACGGGGCTCGGCTACCTGAATGGGCTCCTGCGGG
CACAGGGCTTCGCTTCCCGC

Product: mutator mutT protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MYPLLVTAAIIEHNGLILLTRRKPDAPYPLLWEFPGGKVEPEEHPEACIVREVLEELAMEVAVEGIYDVIYYRYPERAVI
VLAYRCTWTGGELQERDVAGHRWVAPAEVPAFDLLPADIPLAARIAREFGNAGSSRL

Sequences:

>Translated_137_residues
MYPLLVTAAIIEHNGLILLTRRKPDAPYPLLWEFPGGKVEPEEHPEACIVREVLEELAMEVAVEGIYDVIYYRYPERAVI
VLAYRCTWTGGELQERDVAGHRWVAPAEVPAFDLLPADIPLAARIAREFGNAGSSRL
>Mature_137_residues
MYPLLVTAAIIEHNGLILLTRRKPDAPYPLLWEFPGGKVEPEEHPEACIVREVLEELAMEVAVEGIYDVIYYRYPERAVI
VLAYRCTWTGGELQERDVAGHRWVAPAEVPAFDLLPADIPLAARIAREFGNAGSSRL

Specific function: Specific for pyrimidine substrates. Acts on 5-methyl- dCTP, CTP and dCTP in decreasing order [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=122, Percent_Identity=40.9836065573771, Blast_Score=74, Evalue=5e-15,
Organism=Escherichia coli, GI1786288, Length=128, Percent_Identity=30.46875, Blast_Score=63, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 15384; Mature: 15384

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPLLVTAAIIEHNGLILLTRRKPDAPYPLLWEFPGGKVEPEEHPEACIVREVLEELAME
CCHHHEEEEECCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
VAVEGIYDVIYYRYPERAVIVLAYRCTWTGGELQERDVAGHRWVAPAEVPAFDLLPADIP
HHHHHHHHHHEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LAARIAREFGNAGSSRL
HHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MYPLLVTAAIIEHNGLILLTRRKPDAPYPLLWEFPGGKVEPEEHPEACIVREVLEELAME
CCHHHEEEEECCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
VAVEGIYDVIYYRYPERAVIVLAYRCTWTGGELQERDVAGHRWVAPAEVPAFDLLPADIP
HHHHHHHHHHEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LAARIAREFGNAGSSRL
HHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 11053429 [H]