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The map label for this gene is nuoH-1

Identifier: 39995454

GI number: 39995454

Start: 375402

End: 376448

Strand: Direct

Name: nuoH-1

Synonym: GSU0345

Alternate gene names: 39995454

Gene position: 375402-376448 (Clockwise)

Preceding gene: 39995453

Following gene: 39995455

Centisome position: 9.84

GC content: 52.05

Gene sequence:

>1047_bases
ATGGGATACGAACTGTTCGGACTGCCAATGATCTACTACATCTCCATGGTAGCAAAGGTCCTTGTGGTATTCGTGTTCGT
CCTGCTCACCGTTGCATATGCAACCTACGCAGAGCGGAAGATCATCGGCCACATGCAGGTGCGGCTTGGACCAATGCGAA
CGGGCTGGCATGGGCTTCTGCAGCCGATTGCTGACGGCCTTAAGCTTTTCTTCAAGGAAGAGATTGTCCCCAGCCAAGCG
GATAAGTTTGCGTTTCTGATTGCGCCGATCATTGCGTTGGTTCCGGCCTTTATTGGATTTGCCGTCATCCCCTTCGGTGA
AACTATTGAAGTGGCTGGATACAAAATTCCCCTGCAGATTGCCGGCTACTATGACACTGTCTCAGGACAGGTAGTCGACA
TGAACGTCGGAGTGCTGTATATCCTCGCACTTGCGTCCATCGGTGTCTATGGAATCGTTCTGGCGGGGTGGTCTTCTAAC
AGCAAGTACTCTCTCCTCGGTGGACTGAGATCGTCGGCGCAGATGATCTCCTACGAATTGGCTGCAGGGTTGGCGATTAT
ATCGGTCTTCATGCTTTCCGAGTCACTCTCGTTGCAGAAGATCGTAGCCGACCAGGCTAATGGAGCATGGTACTGTTTCA
AACAGCCGCTCGCCTTCATTCTCTTCTTCATCTGCTCTCTCGCAGAAATCAACCGGACGCCGTTCGACCTGCCTGAGGCG
GAAACGGAGCTGGTATCAGGCTTCTGCACTGAATATTCAAGTATGAAGTACGCGATGTTCTTTATGGCAGAATATGCGAA
CATGGTGACCGTCTGCGCTGTGACAACCACTCTTTTCCTCGGTGGATGGCATGGTCCGGCCTTCCTTCCCGGGTGGGCAT
GGTTCATCGCCAAGGTCTACTTCCTGATTTTTGTCTGCATGTGGATTCGGGCGACCTATCCGCGCTACCGGTACGATCAA
CTGATGCGTTTGGGTTGGAAGGTCTTCCTCCCGCTTACCTTGGTGAATATTATTGTCACGGGTATAGTAGTGTCGCTCCA
ATCGTAA

Upstream 100 bases:

>100_bases
TCGCTGACGGGCGCCACGGCTATTACGTGGATAACTATCAGTAAGTAGCAGGTAATAGCCACCAGTTTCCTAACAAAAGA
CAGAAGAGGAAGAGGAACAC

Downstream 100 bases:

>100_bases
CTCCACTACGAGGTCACAGCCATGATAATGCCGTTAATTAATGGACTCAAAATCACGTTAAAGCATATGTTCATGAAGCC
GGTAACGCTCCAGTACCCTG

Product: NADH dehydrogenase I subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H 1; NDH-1 subunit H 1

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MGYELFGLPMIYYISMVAKVLVVFVFVLLTVAYATYAERKIIGHMQVRLGPMRTGWHGLLQPIADGLKLFFKEEIVPSQA
DKFAFLIAPIIALVPAFIGFAVIPFGETIEVAGYKIPLQIAGYYDTVSGQVVDMNVGVLYILALASIGVYGIVLAGWSSN
SKYSLLGGLRSSAQMISYELAAGLAIISVFMLSESLSLQKIVADQANGAWYCFKQPLAFILFFICSLAEINRTPFDLPEA
ETELVSGFCTEYSSMKYAMFFMAEYANMVTVCAVTTTLFLGGWHGPAFLPGWAWFIAKVYFLIFVCMWIRATYPRYRYDQ
LMRLGWKVFLPLTLVNIIVTGIVVSLQS

Sequences:

>Translated_348_residues
MGYELFGLPMIYYISMVAKVLVVFVFVLLTVAYATYAERKIIGHMQVRLGPMRTGWHGLLQPIADGLKLFFKEEIVPSQA
DKFAFLIAPIIALVPAFIGFAVIPFGETIEVAGYKIPLQIAGYYDTVSGQVVDMNVGVLYILALASIGVYGIVLAGWSSN
SKYSLLGGLRSSAQMISYELAAGLAIISVFMLSESLSLQKIVADQANGAWYCFKQPLAFILFFICSLAEINRTPFDLPEA
ETELVSGFCTEYSSMKYAMFFMAEYANMVTVCAVTTTLFLGGWHGPAFLPGWAWFIAKVYFLIFVCMWIRATYPRYRYDQ
LMRLGWKVFLPLTLVNIIVTGIVVSLQS
>Mature_347_residues
GYELFGLPMIYYISMVAKVLVVFVFVLLTVAYATYAERKIIGHMQVRLGPMRTGWHGLLQPIADGLKLFFKEEIVPSQAD
KFAFLIAPIIALVPAFIGFAVIPFGETIEVAGYKIPLQIAGYYDTVSGQVVDMNVGVLYILALASIGVYGIVLAGWSSNS
KYSLLGGLRSSAQMISYELAAGLAIISVFMLSESLSLQKIVADQANGAWYCFKQPLAFILFFICSLAEINRTPFDLPEAE
TELVSGFCTEYSSMKYAMFFMAEYANMVTVCAVTTTLFLGGWHGPAFLPGWAWFIAKVYFLIFVCMWIRATYPRYRYDQL
MRLGWKVFLPLTLVNIIVTGIVVSLQS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=306, Percent_Identity=41.8300653594771, Blast_Score=229, Evalue=3e-60,
Organism=Escherichia coli, GI1788618, Length=332, Percent_Identity=41.566265060241, Blast_Score=268, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH1_GEOSL (Q74GA1)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_951405.1
- GeneID:   2687263
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU0345
- NMPDR:   fig|243231.1.peg.343
- TIGR:   GSU0345
- HOGENOM:   HBG727670
- OMA:   NMCWKIM
- ProtClustDB:   CLSK827768
- BioCyc:   GSUL243231:GSU_0345-MONOMER
- BRENDA:   1.6.99.5
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 38718; Mature: 38587

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb002784)-; HASH(0xc979b98)-; HASH(0xcb3c8a4)-; HASH(0xc7c1304)-; HASH(0xb21e310)-; HASH(0xc8a19bc)-; HASH(0xc302fdc)-; HASH(0xbb07d44)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYELFGLPMIYYISMVAKVLVVFVFVLLTVAYATYAERKIIGHMQVRLGPMRTGWHGLL
CCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHH
QPIADGLKLFFKEEIVPSQADKFAFLIAPIIALVPAFIGFAVIPFGETIEVAGYKIPLQI
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEEEEEEE
AGYYDTVSGQVVDMNVGVLYILALASIGVYGIVLAGWSSNSKYSLLGGLRSSAQMISYEL
ECEEECCCCEEEEECHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
AAGLAIISVFMLSESLSLQKIVADQANGAWYCFKQPLAFILFFICSLAEINRTPFDLPEA
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCH
ETELVSGFCTEYSSMKYAMFFMAEYANMVTVCAVTTTLFLGGWHGPAFLPGWAWFIAKVY
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
FLIFVCMWIRATYPRYRYDQLMRLGWKVFLPLTLVNIIVTGIVVSLQS
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
GYELFGLPMIYYISMVAKVLVVFVFVLLTVAYATYAERKIIGHMQVRLGPMRTGWHGLL
CCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHH
QPIADGLKLFFKEEIVPSQADKFAFLIAPIIALVPAFIGFAVIPFGETIEVAGYKIPLQI
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEEEEEEE
AGYYDTVSGQVVDMNVGVLYILALASIGVYGIVLAGWSSNSKYSLLGGLRSSAQMISYEL
ECEEECCCCEEEEECHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
AAGLAIISVFMLSESLSLQKIVADQANGAWYCFKQPLAFILFFICSLAEINRTPFDLPEA
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCH
ETELVSGFCTEYSSMKYAMFFMAEYANMVTVCAVTTTLFLGGWHGPAFLPGWAWFIAKVY
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
FLIFVCMWIRATYPRYRYDQLMRLGWKVFLPLTLVNIIVTGIVVSLQS
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA