Click here to switch to the map view.

The map label for this gene is pepA

Identifier: 39995441

GI number: 39995441

Start: 362976

End: 364466

Strand: Direct

Name: pepA

Synonym: GSU0332

Alternate gene names: 39995441

Gene position: 362976-364466 (Clockwise)

Preceding gene: 39995440

Following gene: 39995447

Centisome position: 9.52

GC content: 59.83

Gene sequence:

>1491_bases
ATGGTTATTTCAGTAGAGGCTGCCGATTATACAGCGTTTCCCTGTGCGGCGCTGCTGGTTGGCTGCCGTGAAGACAACCC
CTTGGAGGACTCCCTTCTGGCACGTATCGACCAGCTTCTCCAGGGTGCCATTGCGTCGCTTGTTCAAAGCCGCGAGATTA
CCGGAGAGCTGAATCGGGTTACGATTCTTCATACGCTGGGGCGGCTCCCTGCTGAGCGCATTGTTCTTGTGGGGCTCGGC
AACTCCGGTGCGCTGACTTCTGATCGGCTGCGCCAAGTGGGAGGGAGCGCCGTAAAAGCCTTGAAAGGTGCCGGCGTCAC
CCGTGCCGCCTCTGTCGTGCATCGGGCTGCTGGTGTCCCTCCCACGTCAGTAGCAGATATTGCCCAAGGATTGTCCCTTG
GGGATTATTCCTTCGATATCTACAAAACGAAGCCGGGCACTACGGTCCCCGTGACGGAACTAGTCAATCTCTTTGAGCCG
GGGACGGATACTGCCGATGCCGAACGTCTGCTCGCAGCTGATGCAACTATCTGTGAGGCTGTCTCCTTTGCCCGCGATCT
CGTTTCTCAGCCCGGCAACGTGGCTACTCCCCTCTTTCTGGCGGAGAAGGCCCTTGAGTTTTCGGCCCGCCTCGGCATTG
CCTGTACGGTCCTCGACCGTGACGAGATGGAGCGTCAGGGCATGGAGGGAATCCTCTCAGTTGCCAAGGGATCGCATCAG
CTTCCCCGTTTCATTGTTCTCGAATATCGAGGAGGAAGTGCGGATAAGCGCCCCACGGTCCTGGTAGGAAAGGGGATCAC
GTTCGACTCGGGTGGTATATCGCTCAAACCCCGCGAGGGCATGGAGCGGATGAAAGACGACATGGCAGGCGCAGCGGCCG
TTATGGGGGCTGTGATGGCCGTGGCGGGGCTACGACTGCCGGTGAACGTCATCGGGCTCATCCCGGCAGCTGAAAACCTG
CCCGGGGGAGGGGCGTACAAACCGGGCGACATCGTCCGGACCATGTCCGGTCAAACCGTGGAAATCGTAAATACTGACGC
CGAGGGTCGAATGATACTCAGCGATGCCCTGTTTTATGCTCAGCGCTTCAAGCCTGCCGCGGTAATCGATCTTGCAACCC
TGACGGGAGCCTGCCTTGTGGCGCTCGGGAGTGCCGTATCGGGAGTCATGGGAAATGACGCCGCCCTTGTCAAGCTGCTC
CGCAGGGCAGGGGAGGCGACGGGCGAACGTTTATGGGAACTGCCCTTGTGGGACGAGTATGGCGAGATTATGAAAAGTGA
TGTGGCTGACCTGAAAAACGCGGGTGGCCCCCACGCAGGAACCATTACCGCTGCATGGTTCCTGCAGCGTTTCGTGGGCA
AGAGCCGGTGGGCTCATGTTGATATCGCCGGCACCGCGTGGGAGGAAAAGGGGCGGCCGTATCAGCCGAAAGGTGCCACC
GGTGTCGGGGTGCGGCTGCTGGTCGAGTATCTGAAGGCAACCGTACGGTAG

Upstream 100 bases:

>100_bases
CTTCCTGGCAATCCGGGTCGAATAGCCTGGCTTCATACTTCAGAAGAAGGGGCATGTCTGCGGACATGCCCCTTCTTTAT
TGATTACAAGGAGATATCCT

Downstream 100 bases:

>100_bases
TCAAATCAGGGATAACGGATGAAAAAAGGGTGGAGCCGTCAGGCCCCACCCTTTTTGTCTCGACGGAAGGACTGTCCTTA
CTTAACGACAGCCTTGGCAA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MVISVEAADYTAFPCAALLVGCREDNPLEDSLLARIDQLLQGAIASLVQSREITGELNRVTILHTLGRLPAERIVLVGLG
NSGALTSDRLRQVGGSAVKALKGAGVTRAASVVHRAAGVPPTSVADIAQGLSLGDYSFDIYKTKPGTTVPVTELVNLFEP
GTDTADAERLLAADATICEAVSFARDLVSQPGNVATPLFLAEKALEFSARLGIACTVLDRDEMERQGMEGILSVAKGSHQ
LPRFIVLEYRGGSADKRPTVLVGKGITFDSGGISLKPREGMERMKDDMAGAAAVMGAVMAVAGLRLPVNVIGLIPAAENL
PGGGAYKPGDIVRTMSGQTVEIVNTDAEGRMILSDALFYAQRFKPAAVIDLATLTGACLVALGSAVSGVMGNDAALVKLL
RRAGEATGERLWELPLWDEYGEIMKSDVADLKNAGGPHAGTITAAWFLQRFVGKSRWAHVDIAGTAWEEKGRPYQPKGAT
GVGVRLLVEYLKATVR

Sequences:

>Translated_496_residues
MVISVEAADYTAFPCAALLVGCREDNPLEDSLLARIDQLLQGAIASLVQSREITGELNRVTILHTLGRLPAERIVLVGLG
NSGALTSDRLRQVGGSAVKALKGAGVTRAASVVHRAAGVPPTSVADIAQGLSLGDYSFDIYKTKPGTTVPVTELVNLFEP
GTDTADAERLLAADATICEAVSFARDLVSQPGNVATPLFLAEKALEFSARLGIACTVLDRDEMERQGMEGILSVAKGSHQ
LPRFIVLEYRGGSADKRPTVLVGKGITFDSGGISLKPREGMERMKDDMAGAAAVMGAVMAVAGLRLPVNVIGLIPAAENL
PGGGAYKPGDIVRTMSGQTVEIVNTDAEGRMILSDALFYAQRFKPAAVIDLATLTGACLVALGSAVSGVMGNDAALVKLL
RRAGEATGERLWELPLWDEYGEIMKSDVADLKNAGGPHAGTITAAWFLQRFVGKSRWAHVDIAGTAWEEKGRPYQPKGAT
GVGVRLLVEYLKATVR
>Mature_496_residues
MVISVEAADYTAFPCAALLVGCREDNPLEDSLLARIDQLLQGAIASLVQSREITGELNRVTILHTLGRLPAERIVLVGLG
NSGALTSDRLRQVGGSAVKALKGAGVTRAASVVHRAAGVPPTSVADIAQGLSLGDYSFDIYKTKPGTTVPVTELVNLFEP
GTDTADAERLLAADATICEAVSFARDLVSQPGNVATPLFLAEKALEFSARLGIACTVLDRDEMERQGMEGILSVAKGSHQ
LPRFIVLEYRGGSADKRPTVLVGKGITFDSGGISLKPREGMERMKDDMAGAAAVMGAVMAVAGLRLPVNVIGLIPAAENL
PGGGAYKPGDIVRTMSGQTVEIVNTDAEGRMILSDALFYAQRFKPAAVIDLATLTGACLVALGSAVSGVMGNDAALVKLL
RRAGEATGERLWELPLWDEYGEIMKSDVADLKNAGGPHAGTITAAWFLQRFVGKSRWAHVDIAGTAWEEKGRPYQPKGAT
GVGVRLLVEYLKATVR

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=499, Percent_Identity=37.875751503006, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI47155554, Length=346, Percent_Identity=34.6820809248555, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI1790710, Length=498, Percent_Identity=40.5622489959839, Blast_Score=343, Evalue=2e-95,
Organism=Escherichia coli, GI87082123, Length=322, Percent_Identity=36.0248447204969, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=313, Percent_Identity=34.8242811501597, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=258, Percent_Identity=28.6821705426357, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355725, Length=378, Percent_Identity=35.7142857142857, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24661038, Length=375, Percent_Identity=35.2, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI20129969, Length=470, Percent_Identity=31.9148936170213, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI21355645, Length=466, Percent_Identity=31.9742489270386, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24662223, Length=466, Percent_Identity=31.9742489270386, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI161077148, Length=470, Percent_Identity=30.2127659574468, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI20130057, Length=470, Percent_Identity=30.2127659574468, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI20129963, Length=467, Percent_Identity=32.762312633833, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24662227, Length=466, Percent_Identity=30.0429184549356, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI19922386, Length=470, Percent_Identity=30.2127659574468, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI221379063, Length=318, Percent_Identity=33.9622641509434, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI221379062, Length=318, Percent_Identity=33.9622641509434, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21357381, Length=318, Percent_Identity=33.9622641509434, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646701, Length=260, Percent_Identity=29.2307692307692, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646703, Length=260, Percent_Identity=29.2307692307692, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21358201, Length=260, Percent_Identity=29.2307692307692, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_GEOSL (Q74GB4)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_951392.1
- ProteinModelPortal:   Q74GB4
- SMR:   Q74GB4
- MEROPS:   M17.003
- GeneID:   2686847
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU0332
- NMPDR:   fig|243231.1.peg.330
- TIGR:   GSU0332
- HOGENOM:   HBG742580
- OMA:   ELHKPCE
- ProtClustDB:   PRK00913
- BioCyc:   GSUL243231:GSU_0332-MONOMER
- BRENDA:   3.4.11.1
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 52229; Mature: 52229

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 276-276 ACT_SITE 350-350

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVISVEAADYTAFPCAALLVGCREDNPLEDSLLARIDQLLQGAIASLVQSREITGELNRV
CEEEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
TILHTLGRLPAERIVLVGLGNSGALTSDRLRQVGGSAVKALKGAGVTRAASVVHRAAGVP
HHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHCCCC
PTSVADIAQGLSLGDYSFDIYKTKPGTTVPVTELVNLFEPGTDTADAERLLAADATICEA
CCHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
VSFARDLVSQPGNVATPLFLAEKALEFSARLGIACTVLDRDEMERQGMEGILSVAKGSHQ
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHCCCCC
LPRFIVLEYRGGSADKRPTVLVGKGITFDSGGISLKPREGMERMKDDMAGAAAVMGAVMA
CCEEEEEEECCCCCCCCCEEEEECCEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHHH
VAGLRLPVNVIGLIPAAENLPGGGAYKPGDIVRTMSGQTVEIVNTDAEGRMILSDALFYA
HHCCCCCEEHEEECCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCHHHHHHHHH
QRFKPAAVIDLATLTGACLVALGSAVSGVMGNDAALVKLLRRAGEATGERLWELPLWDEY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHEECCCCHHHH
GEIMKSDVADLKNAGGPHAGTITAAWFLQRFVGKSRWAHVDIAGTAWEEKGRPYQPKGAT
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHCCCCCCCCCCC
GVGVRLLVEYLKATVR
CHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVISVEAADYTAFPCAALLVGCREDNPLEDSLLARIDQLLQGAIASLVQSREITGELNRV
CEEEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
TILHTLGRLPAERIVLVGLGNSGALTSDRLRQVGGSAVKALKGAGVTRAASVVHRAAGVP
HHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHCCCC
PTSVADIAQGLSLGDYSFDIYKTKPGTTVPVTELVNLFEPGTDTADAERLLAADATICEA
CCHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
VSFARDLVSQPGNVATPLFLAEKALEFSARLGIACTVLDRDEMERQGMEGILSVAKGSHQ
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHCCCCC
LPRFIVLEYRGGSADKRPTVLVGKGITFDSGGISLKPREGMERMKDDMAGAAAVMGAVMA
CCEEEEEEECCCCCCCCCEEEEECCEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHHH
VAGLRLPVNVIGLIPAAENLPGGGAYKPGDIVRTMSGQTVEIVNTDAEGRMILSDALFYA
HHCCCCCEEHEEECCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCHHHHHHHHH
QRFKPAAVIDLATLTGACLVALGSAVSGVMGNDAALVKLLRRAGEATGERLWELPLWDEY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHEECCCCHHHH
GEIMKSDVADLKNAGGPHAGTITAAWFLQRFVGKSRWAHVDIAGTAWEEKGRPYQPKGAT
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHCCCCCCCCCCC
GVGVRLLVEYLKATVR
CHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA