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The map label for this gene is hrcA

Identifier: 39995142

GI number: 39995142

Start: 40721

End: 41749

Strand: Direct

Name: hrcA

Synonym: GSU0031

Alternate gene names: 39995142

Gene position: 40721-41749 (Clockwise)

Preceding gene: 39995141

Following gene: 39995143

Centisome position: 1.07

GC content: 60.93

Gene sequence:

>1029_bases
ATGACAGATATATCCGAGCGCAACAAGCTTATCCTCGAAGCCATCATCGAGGATTACATCACGACGGCGGAGCCGGTCGG
CAGCCGCGCCGTGACCAAGCGGCACGGCCTGACCCTCTCGCCGGCAACGGTGCGCAACGTCATGGCCGACCTGGAGGAGA
TGGGGTATCTCGTCTCTCCCCATACTTCGGCGGGGCGGGTTCCCACCGACAAGGCCTATCGGCTCTACGTGGACTCGCTT
CTGGCGGTTCGGCGCATCGACAAGGTGGAGCGGGAGCGGATCCGCAAGCGCTACGCGGAGGCCGGCCGGGATATTGGCGC
AGTCCTTCATGAAACGAGCCGATTGCTCTCCTCGGTCTCCCACTACACGGGGATCGTCCTCGCCCCCCGCTTCTCCGCCA
CCATTTTCCGGCACATTGAGTTCGTAAAGCTGGGAGGGCGCCGTATCCTCGTCATCCTGGTGGCCGACAACGGCACCGTC
CAGAATCGGCTCATCGAATCCGACGAGGAGTTTTCCTCCGAAGAACTGATCAGGATGTCCAACTACCTGAATGAGCTTCT
GGTGGGGGTGCCGGTGGGCCAGGTCCGCACGCGGATACTGGAGGAGATGAGAAACGAGAAGGTCCTTTACGACAAGCTCC
TCGCCCGTGCGCTCCAGCTTTCCGAGCAGAGCCTGAATGACGACGGCGCCCAGATCTTCATCGAGGGACAGACCAATATC
CTTGAACAGCCCGAGTTCGCCGACTCGCGGCGGATGAGGGATCTCTTCCGGGCGTTCGAGGAAAAGAACCAACTGGTGGG
GCTCCTGGACCGGTGCCTCAATGCCCAGGGCGTGCAGATATTTATCGGCGCCGAAACCCATCTCAGCCAGATGGAGGGTT
TGAGCATCATCACCTCCACGTACCTCACGGGAAAGAACACTCTCGGCGTTCTGGGGGTCATCGGACCGACCCGGATGGGC
TATGCCAAGGTGATCCCCATCGTCGACTATACCGCGAAGCTGGTCAGCAGGCTCCTGGAAGGGGAATAG

Upstream 100 bases:

>100_bases
AACGGGAAACCCCCTTGACAAAGCGGGGGTCGGTTGTTACCTTAGCAACCAGTTAGCACTCACGTCCCTTGAGTGCTAAT
CTGCTTTGTGGGGCCGAGAG

Downstream 100 bases:

>100_bases
GAGCGGTTCGGCAGATATTCGCAGGGAGGAACTATCAGCGTGGATAAAAAGAAACACGGCACCGTACAGAGTGCAGATGA
AACCATCGCGGCCGCCGGGT

Product: heat-inducible transcription repressor HrcA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MTDISERNKLILEAIIEDYITTAEPVGSRAVTKRHGLTLSPATVRNVMADLEEMGYLVSPHTSAGRVPTDKAYRLYVDSL
LAVRRIDKVERERIRKRYAEAGRDIGAVLHETSRLLSSVSHYTGIVLAPRFSATIFRHIEFVKLGGRRILVILVADNGTV
QNRLIESDEEFSSEELIRMSNYLNELLVGVPVGQVRTRILEEMRNEKVLYDKLLARALQLSEQSLNDDGAQIFIEGQTNI
LEQPEFADSRRMRDLFRAFEEKNQLVGLLDRCLNAQGVQIFIGAETHLSQMEGLSIITSTYLTGKNTLGVLGVIGPTRMG
YAKVIPIVDYTAKLVSRLLEGE

Sequences:

>Translated_342_residues
MTDISERNKLILEAIIEDYITTAEPVGSRAVTKRHGLTLSPATVRNVMADLEEMGYLVSPHTSAGRVPTDKAYRLYVDSL
LAVRRIDKVERERIRKRYAEAGRDIGAVLHETSRLLSSVSHYTGIVLAPRFSATIFRHIEFVKLGGRRILVILVADNGTV
QNRLIESDEEFSSEELIRMSNYLNELLVGVPVGQVRTRILEEMRNEKVLYDKLLARALQLSEQSLNDDGAQIFIEGQTNI
LEQPEFADSRRMRDLFRAFEEKNQLVGLLDRCLNAQGVQIFIGAETHLSQMEGLSIITSTYLTGKNTLGVLGVIGPTRMG
YAKVIPIVDYTAKLVSRLLEGE
>Mature_341_residues
TDISERNKLILEAIIEDYITTAEPVGSRAVTKRHGLTLSPATVRNVMADLEEMGYLVSPHTSAGRVPTDKAYRLYVDSLL
AVRRIDKVERERIRKRYAEAGRDIGAVLHETSRLLSSVSHYTGIVLAPRFSATIFRHIEFVKLGGRRILVILVADNGTVQ
NRLIESDEEFSSEELIRMSNYLNELLVGVPVGQVRTRILEEMRNEKVLYDKLLARALQLSEQSLNDDGAQIFIEGQTNIL
EQPEFADSRRMRDLFRAFEEKNQLVGLLDRCLNAQGVQIFIGAETHLSQMEGLSIITSTYLTGKNTLGVLGVIGPTRMGY
AKVIPIVDYTAKLVSRLLEGE

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_GEOSL (Q74H61)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_951093.1
- ProteinModelPortal:   Q74H61
- SMR:   Q74H61
- GeneID:   2685607
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU0031
- NMPDR:   fig|243231.1.peg.31
- TIGR:   GSU0031
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   CLSK827600
- BioCyc:   GSUL243231:GSU_0031-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR005104
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF03444 DUF293; PF01628 HrcA

EC number: NA

Molecular weight: Translated: 38375; Mature: 38244

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDISERNKLILEAIIEDYITTAEPVGSRAVTKRHGLTLSPATVRNVMADLEEMGYLVSP
CCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEECHHHHHHHHHHHHHCCCEECC
HTSAGRVPTDKAYRLYVDSLLAVRRIDKVERERIRKRYAEAGRDIGAVLHETSRLLSSVS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
HYTGIVLAPRFSATIFRHIEFVKLGGRRILVILVADNGTVQNRLIESDEEFSSEELIRMS
HHCCEEECCCHHHHHHHHHHHHEECCCEEEEEEEECCCCHHHHHHCCCHHCCHHHHHHHH
NYLNELLVGVPVGQVRTRILEEMRNEKVLYDKLLARALQLSEQSLNDDGAQIFIEGQTNI
HHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
LEQPEFADSRRMRDLFRAFEEKNQLVGLLDRCLNAQGVQIFIGAETHLSQMEGLSIITST
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHCCHHHHHHH
YLTGKNTLGVLGVIGPTRMGYAKVIPIVDYTAKLVSRLLEGE
HCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDISERNKLILEAIIEDYITTAEPVGSRAVTKRHGLTLSPATVRNVMADLEEMGYLVSP
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEECHHHHHHHHHHHHHCCCEECC
HTSAGRVPTDKAYRLYVDSLLAVRRIDKVERERIRKRYAEAGRDIGAVLHETSRLLSSVS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
HYTGIVLAPRFSATIFRHIEFVKLGGRRILVILVADNGTVQNRLIESDEEFSSEELIRMS
HHCCEEECCCHHHHHHHHHHHHEECCCEEEEEEEECCCCHHHHHHCCCHHCCHHHHHHHH
NYLNELLVGVPVGQVRTRILEEMRNEKVLYDKLLARALQLSEQSLNDDGAQIFIEGQTNI
HHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
LEQPEFADSRRMRDLFRAFEEKNQLVGLLDRCLNAQGVQIFIGAETHLSQMEGLSIITST
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHCCHHHHHHH
YLTGKNTLGVLGVIGPTRMGYAKVIPIVDYTAKLVSRLLEGE
HCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA