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The map label for this gene is hemN [H]

Identifier: 39995141

GI number: 39995141

Start: 39428

End: 40585

Strand: Direct

Name: hemN [H]

Synonym: GSU0030

Alternate gene names: 39995141

Gene position: 39428-40585 (Clockwise)

Preceding gene: 39995133

Following gene: 39995142

Centisome position: 1.03

GC content: 64.77

Gene sequence:

>1158_bases
ATGAACGAGCCGCTGCATCTCTACGTCCATATCCCTTTCTGCCTGAAGAAGTGCCGTTATTGCTCTTTCGTTTCACGGTC
GGACGCACCCCTGGCGATCGACGACTACGCATCACTCGTGGCCCGGGAGATGGAGATGCGGGTCGCGGCGGCGAATCCCC
TCCCCCTCTCTCCAGCGACTACCCTCTATCTTGGCGGAGGGACCCCGTCGCTTCTGTCGCCGGCGGCCCTGGAGCGCATC
ATCGATGCGGCAGCGCGCAGCTATGGCCTTGGCCCCGGCGCGGAGATAACCCTGGAGGCCAATCCCGGCACCGTCACCTT
CCAGCGGCTCGCCGATTTCCGCTCCGCGGGCGTGAATCGCCTCTCCCTGGGCGTCCAGTCCTTCGACGACGGGATGCTGG
TCCTGCTGGGCCGGCTCCACACCGCCCGCCAAGCGAGAGAGGCCGTTGCGGCGACCCGTCGTGCCGGCTTCGACAATATC
GGCATCGACCTCATCCACTCGCTTCCCGGCCAGACGCCCGACCAATGGCGCGAGCAACTGGCCTGCGCCGTGGCTCTTAA
TCCTGATCACGTTTCGGCCTACGGTCTCACGGTTGAGGAGGGCACCCCCTTCGCGGCCATGGAGGAGCGGGGAGAACTGG
TGCTGCCCGACGAAGAGCAGTCGGCCCTCATGTTCGAAGCGACGACGGACGTGCTGGTCTCAGCCGGCTTCGAGCACTAT
GAGATCGCCAATTTTGCCCGTCCGCACCGGCGTTCACGCCACAATCAGGTTTACTGGCTCCGCCGAAACTACCTGGGATT
CGGCGCGGGCGCCCATTCCTTTCTGCGCGCTCCGGCCTTTGGCGTGCGCTGGAAGAATACCGACGACCTGGAACTCTATC
GCGACACTCTTGCGGCGGCGGAGCTTCCCGGGGAGGAGCGGACGGTCCTTTCCCGTGCCGACGCTATGGCCGAGTTTTTT
TTCCTCGGGCTCCGGCTGCTGGACGGGGTGCGGGAAGAGGACTTCGTCCGGGAGTTCGGCGATACGATGGAAAACGTGTA
CGGCCGCGAAATGGAACGCCTCTGCTCGGCAGGACTCCTCATGCGCGAGGGGGGCAGGTTGAAGCTCTCCCGCCGGGGAG
TCATCCTCGCCAACCGGGTATTCGCCTCCTTTCTCTGA

Upstream 100 bases:

>100_bases
CAAACCCTGTGGATGACGAACGAGTGTACCGTCAACCCGCTTATATTTCAACTCAATAGATGGTGGACGGCCGGCTGGGC
AGTGGCGTATCATGGGGGAC

Downstream 100 bases:

>100_bases
CCCGCCTGCGTAACTCGTGTATTCCCCCCTTCAGAAACGGGAAACCCCCTTGACAAAGCGGGGGTCGGTTGTTACCTTAG
CAACCAGTTAGCACTCACGT

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MNEPLHLYVHIPFCLKKCRYCSFVSRSDAPLAIDDYASLVAREMEMRVAAANPLPLSPATTLYLGGGTPSLLSPAALERI
IDAAARSYGLGPGAEITLEANPGTVTFQRLADFRSAGVNRLSLGVQSFDDGMLVLLGRLHTARQAREAVAATRRAGFDNI
GIDLIHSLPGQTPDQWREQLACAVALNPDHVSAYGLTVEEGTPFAAMEERGELVLPDEEQSALMFEATTDVLVSAGFEHY
EIANFARPHRRSRHNQVYWLRRNYLGFGAGAHSFLRAPAFGVRWKNTDDLELYRDTLAAAELPGEERTVLSRADAMAEFF
FLGLRLLDGVREEDFVREFGDTMENVYGREMERLCSAGLLMREGGRLKLSRRGVILANRVFASFL

Sequences:

>Translated_385_residues
MNEPLHLYVHIPFCLKKCRYCSFVSRSDAPLAIDDYASLVAREMEMRVAAANPLPLSPATTLYLGGGTPSLLSPAALERI
IDAAARSYGLGPGAEITLEANPGTVTFQRLADFRSAGVNRLSLGVQSFDDGMLVLLGRLHTARQAREAVAATRRAGFDNI
GIDLIHSLPGQTPDQWREQLACAVALNPDHVSAYGLTVEEGTPFAAMEERGELVLPDEEQSALMFEATTDVLVSAGFEHY
EIANFARPHRRSRHNQVYWLRRNYLGFGAGAHSFLRAPAFGVRWKNTDDLELYRDTLAAAELPGEERTVLSRADAMAEFF
FLGLRLLDGVREEDFVREFGDTMENVYGREMERLCSAGLLMREGGRLKLSRRGVILANRVFASFL
>Mature_385_residues
MNEPLHLYVHIPFCLKKCRYCSFVSRSDAPLAIDDYASLVAREMEMRVAAANPLPLSPATTLYLGGGTPSLLSPAALERI
IDAAARSYGLGPGAEITLEANPGTVTFQRLADFRSAGVNRLSLGVQSFDDGMLVLLGRLHTARQAREAVAATRRAGFDNI
GIDLIHSLPGQTPDQWREQLACAVALNPDHVSAYGLTVEEGTPFAAMEERGELVLPDEEQSALMFEATTDVLVSAGFEHY
EIANFARPHRRSRHNQVYWLRRNYLGFGAGAHSFLRAPAFGVRWKNTDDLELYRDTLAAAELPGEERTVLSRADAMAEFF
FLGLRLLDGVREEDFVREFGDTMENVYGREMERLCSAGLLMREGGRLKLSRRGVILANRVFASFL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=269, Percent_Identity=40.5204460966543, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1789325, Length=383, Percent_Identity=33.9425587467363, Blast_Score=211, Evalue=6e-56,
Organism=Escherichia coli, GI87082341, Length=251, Percent_Identity=31.8725099601594, Blast_Score=126, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 42600; Mature: 42600

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEPLHLYVHIPFCLKKCRYCSFVSRSDAPLAIDDYASLVAREMEMRVAAANPLPLSPAT
CCCCEEEEEECHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHEECCCCCCCCCC
TLYLGGGTPSLLSPAALERIIDAAARSYGLGPGAEITLEANPGTVTFQRLADFRSAGVNR
EEEECCCCCHHCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEHHHHHHHHHHCCCCE
LSLGVQSFDDGMLVLLGRLHTARQAREAVAATRRAGFDNIGIDLIHSLPGQTPDQWREQL
EECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHH
ACAVALNPDHVSAYGLTVEEGTPFAAMEERGELVLPDEEQSALMFEATTDVLVSAGFEHY
EEEEEECCCCEEEEEEEEECCCCCHHHHCCCCEECCCCCCCEEEEEHHHHHHHHCCCCHH
EIANFARPHRRSRHNQVYWLRRNYLGFGAGAHSFLRAPAFGVRWKNTDDLELYRDTLAAA
HHHHHHCHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCCCEECCCCCHHHHHHHHHHHH
ELPGEERTVLSRADAMAEFFFLGLRLLDGVREEDFVREFGDTMENVYGREMERLCSAGLL
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
MREGGRLKLSRRGVILANRVFASFL
ECCCCEEEEECCCEEEHHHHHHHCC
>Mature Secondary Structure
MNEPLHLYVHIPFCLKKCRYCSFVSRSDAPLAIDDYASLVAREMEMRVAAANPLPLSPAT
CCCCEEEEEECHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHEECCCCCCCCCC
TLYLGGGTPSLLSPAALERIIDAAARSYGLGPGAEITLEANPGTVTFQRLADFRSAGVNR
EEEECCCCCHHCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEHHHHHHHHHHCCCCE
LSLGVQSFDDGMLVLLGRLHTARQAREAVAATRRAGFDNIGIDLIHSLPGQTPDQWREQL
EECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHH
ACAVALNPDHVSAYGLTVEEGTPFAAMEERGELVLPDEEQSALMFEATTDVLVSAGFEHY
EEEEEECCCCEEEEEEEEECCCCCHHHHCCCCEECCCCCCCEEEEEHHHHHHHHCCCCHH
EIANFARPHRRSRHNQVYWLRRNYLGFGAGAHSFLRAPAFGVRWKNTDDLELYRDTLAAA
HHHHHHCHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCCCEECCCCCHHHHHHHHHHHH
ELPGEERTVLSRADAMAEFFFLGLRLLDGVREEDFVREFGDTMENVYGREMERLCSAGLL
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
MREGGRLKLSRRGVILANRVFASFL
ECCCCEEEEECCCEEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]