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The map label for this gene is hoxH

Identifier: 38637756

GI number: 38637756

Start: 82865

End: 84331

Strand: Direct

Name: hoxH

Synonym: PHG091

Alternate gene names: 38637756

Gene position: 82865-84331 (Clockwise)

Preceding gene: 38637755

Following gene: 38637757

Centisome position: 18.33

GC content: 61.35

Gene sequence:

>1467_bases
ATGAGCAGAAAACTGGTTATCGACCCGGTGACCCGCATCGAGGGTCACGGCAAGGTGGTGGTGCACCTGGATGACGACAA
CAAGGTCGTCGACGCAAAGCTGCACGTCGTGGAGTTCCGGGGCTTTGAAAAGTTCGTTCAGGGCCATCCCTTCTGGGAGG
CGCCGATGTTCCTGCAGCGCATCTGCGGCATCTGTTTCGTCAGTCACCATCTGTGCGGGGCCAAGGCGCTGGATGACATG
GTCGGCGTCGGCTTGAAGTCCGGCATCCATGTCACCCCGACGGCGGAGAAAATGCGCCGGCTCGGCCACTACGCGCAGAT
GCTCCAGTCCCATACGACCGCCTATTTCTACCTGATCGTGCCGGAGATGCTGTTTGGCATGGACGCGCCGCCCGCACAGC
GCAACGTGCTCGGCCTGATCGAGGCCAATCCCGACTTGGTGAAGCGCGTCGTGATGTTGCGCAAATGGGGACAGGAAGTC
ATCAAGGCGGTGTTCGGCAAGAAGATGCACGGCATCAATTCGGTGCCGGGAGGCGTCAACAACAACCTGAGCATCGCCGA
GCGCGACCGTTTCCTGAACGGGGAGGAGGGCCTTCTGTCGGTGGATCAGGTCATCGATTACGCGCAGGATGGCCTGCGCC
TGTTCTACGACTTCCATCAGAAACACCGGGCGCAGGTCGATAGTTTCGCGGACGTGCCCGCGCTCAGCATGTGCCTGGTC
GGCGACGACGACAACGTGGACTACTACCACGGCAGGCTGAGGATCATCGACGACGACAAGCACATCGTCCGTGAATTCGA
CTATCACGACTATCTGGATCATTTCTCCGAAGCGGTGGAGGAATGGAGCTACATGAAGTTCCCCTACCTCAAGGAGCTTG
GGAGAGAGCAGGGATCGGTGCGCGTGGGGCCGCTTGGCCGCATGAACGTGACGAAGTCGCTCCCGACACCGCTCGCGCAG
GAGGCGCTGGAACGGTTCCACGCCTACACGAAGGGGCGGACGAACAACATGACGCTGCATACTAACTGGGCACGGGCCAT
CGAGATCCTCCACGCCGCGGAGGTGGTCAAAGAACTGCTGCATGACCCGGACCTGCAGAAGGATCAGCTGGTGTTGACAC
CGCCCCCCAATGCGTGGACAGGTGAAGGCGTCGGCGTGGTCGAAGCGCCACGCGGTACCTTGCTTCACCATTATCGTGCC
GATGAGCGCGGCAATATCACGTTCGCCAACCTGGTCGTCGCCACCACCCAGAACAACCAGGTCATGAATCGCACGGTGCG
CAGCGTCGCCGAGGACTACCTGGGCGGACATGGCGAAATCACCGAGGGCATGATGAATGCCATCGAGGTGGGTATTCGCG
CCTACGATCCATGCCTGAGCTGCGCGACACACGCCCTGGGGCAGATGCCGCTGGTGGTCTCGGTCTTTGACGCGGCGGGG
CGCCTGATCGATGAACGCGCCCGCTGA

Upstream 100 bases:

>100_bases
GAGATGCCATCTTCAAGGTGCTGGACGATCTGGTGAATGGACGGCCATTCGATTTGCCGAGCTCGATCAATCGCTACGAT
TGATTAACGGAGGGTTTGTT

Downstream 100 bases:

>100_bases
GTTTCCCTATGTGACCCTTGCCGATTTCGATGATCCGTCGACGCTGATCTACGGAATCGGCAACGTGGGTCGGCAGGACG
ACGGATTGGGGTGGGCTTTC

Product: NAD-reducing hydrogenase moiety large subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MSRKLVIDPVTRIEGHGKVVVHLDDDNKVVDAKLHVVEFRGFEKFVQGHPFWEAPMFLQRICGICFVSHHLCGAKALDDM
VGVGLKSGIHVTPTAEKMRRLGHYAQMLQSHTTAYFYLIVPEMLFGMDAPPAQRNVLGLIEANPDLVKRVVMLRKWGQEV
IKAVFGKKMHGINSVPGGVNNNLSIAERDRFLNGEEGLLSVDQVIDYAQDGLRLFYDFHQKHRAQVDSFADVPALSMCLV
GDDDNVDYYHGRLRIIDDDKHIVREFDYHDYLDHFSEAVEEWSYMKFPYLKELGREQGSVRVGPLGRMNVTKSLPTPLAQ
EALERFHAYTKGRTNNMTLHTNWARAIEILHAAEVVKELLHDPDLQKDQLVLTPPPNAWTGEGVGVVEAPRGTLLHHYRA
DERGNITFANLVVATTQNNQVMNRTVRSVAEDYLGGHGEITEGMMNAIEVGIRAYDPCLSCATHALGQMPLVVSVFDAAG
RLIDERAR

Sequences:

>Translated_488_residues
MSRKLVIDPVTRIEGHGKVVVHLDDDNKVVDAKLHVVEFRGFEKFVQGHPFWEAPMFLQRICGICFVSHHLCGAKALDDM
VGVGLKSGIHVTPTAEKMRRLGHYAQMLQSHTTAYFYLIVPEMLFGMDAPPAQRNVLGLIEANPDLVKRVVMLRKWGQEV
IKAVFGKKMHGINSVPGGVNNNLSIAERDRFLNGEEGLLSVDQVIDYAQDGLRLFYDFHQKHRAQVDSFADVPALSMCLV
GDDDNVDYYHGRLRIIDDDKHIVREFDYHDYLDHFSEAVEEWSYMKFPYLKELGREQGSVRVGPLGRMNVTKSLPTPLAQ
EALERFHAYTKGRTNNMTLHTNWARAIEILHAAEVVKELLHDPDLQKDQLVLTPPPNAWTGEGVGVVEAPRGTLLHHYRA
DERGNITFANLVVATTQNNQVMNRTVRSVAEDYLGGHGEITEGMMNAIEVGIRAYDPCLSCATHALGQMPLVVSVFDAAG
RLIDERAR
>Mature_487_residues
SRKLVIDPVTRIEGHGKVVVHLDDDNKVVDAKLHVVEFRGFEKFVQGHPFWEAPMFLQRICGICFVSHHLCGAKALDDMV
GVGLKSGIHVTPTAEKMRRLGHYAQMLQSHTTAYFYLIVPEMLFGMDAPPAQRNVLGLIEANPDLVKRVVMLRKWGQEVI
KAVFGKKMHGINSVPGGVNNNLSIAERDRFLNGEEGLLSVDQVIDYAQDGLRLFYDFHQKHRAQVDSFADVPALSMCLVG
DDDNVDYYHGRLRIIDDDKHIVREFDYHDYLDHFSEAVEEWSYMKFPYLKELGREQGSVRVGPLGRMNVTKSLPTPLAQE
ALERFHAYTKGRTNNMTLHTNWARAIEILHAAEVVKELLHDPDLQKDQLVLTPPPNAWTGEGVGVVEAPRGTLLHHYRAD
ERGNITFANLVVATTQNNQVMNRTVRSVAEDYLGGHGEITEGMMNAIEVGIRAYDPCLSCATHALGQMPLVVSVFDAAGR
LIDERAR

Specific function: This Is One Of Three E.Coli Hydrogenases Synthesized In Response To Different Physiological Conditions. Hyd1 Is Believed To Have A Role In Hydrogen Cycling During Fermentative Growth. [C]

COG id: COG3259

COG function: function code C; Coenzyme F420-reducing hydrogenase, alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family

Homologues:

Organism=Escherichia coli, GI1787207, Length=89, Percent_Identity=37.0786516853933, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HOXH_CUPNH (P22320)

Other databases:

- EMBL:   M55230
- EMBL:   AY305378
- PIR:   D35385
- RefSeq:   NP_942730.1
- ProteinModelPortal:   P22320
- SMR:   P22320
- GeneID:   2656817
- GenomeReviews:   AY305378_GR
- KEGG:   reh:PHG091
- HOGENOM:   HBG287963
- OMA:   FFHLSSP
- PhylomeDB:   P22320
- ProtClustDB:   CLSK2761122
- BioCyc:   MetaCyc:HOXHALCA-MONOMER
- BioCyc:   REUT381666:PHG091-MONOMER
- BRENDA:   1.12.1.2
- GO:   GO:0005737
- InterPro:   IPR001501
- InterPro:   IPR018194

Pfam domain/function: PF00374 NiFeSe_Hases

EC number: =1.12.1.2

Molecular weight: Translated: 54864; Mature: 54732

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00507 NI_HGENASE_L_1; PS00508 NI_HGENASE_L_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKLVIDPVTRIEGHGKVVVHLDDDNKVVDAKLHVVEFRGFEKFVQGHPFWEAPMFLQR
CCCCEEECHHHHCCCCCEEEEEECCCCEEEEEEEEEEECCCHHHHHCCCCCCCHHHHHHH
ICGICFVSHHLCGAKALDDMVGVGLKSGIHVTPTAEKMRRLGHYAQMLQSHTTAYFYLIV
HHHHHHHHHHHCCHHHHHHHHHCHHHCCEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEH
PEMLFGMDAPPAQRNVLGLIEANPDLVKRVVMLRKWGQEVIKAVFGKKMHGINSVPGGVN
HHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
NNLSIAERDRFLNGEEGLLSVDQVIDYAQDGLRLFYDFHQKHRAQVDSFADVPALSMCLV
CCCCHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEE
GDDDNVDYYHGRLRIIDDDKHIVREFDYHDYLDHFSEAVEEWSYMKFPYLKELGREQGSV
CCCCCCCEEECEEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCE
RVGPLGRMNVTKSLPTPLAQEALERFHAYTKGRTNNMTLHTNWARAIEILHAAEVVKELL
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHH
HDPDLQKDQLVLTPPPNAWTGEGVGVVEAPRGTLLHHYRADERGNITFANLVVATTQNNQ
CCCCCCCCCEEEECCCCCCCCCCCEEEECCCCCEEHHCCCCCCCCEEEEEEEEEECCCCH
VMNRTVRSVAEDYLGGHGEITEGMMNAIEVGIRAYDPCLSCATHALGQMPLVVSVFDAAG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RLIDERAR
HHHHHCCC
>Mature Secondary Structure 
SRKLVIDPVTRIEGHGKVVVHLDDDNKVVDAKLHVVEFRGFEKFVQGHPFWEAPMFLQR
CCCEEECHHHHCCCCCEEEEEECCCCEEEEEEEEEEECCCHHHHHCCCCCCCHHHHHHH
ICGICFVSHHLCGAKALDDMVGVGLKSGIHVTPTAEKMRRLGHYAQMLQSHTTAYFYLIV
HHHHHHHHHHHCCHHHHHHHHHCHHHCCEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEH
PEMLFGMDAPPAQRNVLGLIEANPDLVKRVVMLRKWGQEVIKAVFGKKMHGINSVPGGVN
HHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
NNLSIAERDRFLNGEEGLLSVDQVIDYAQDGLRLFYDFHQKHRAQVDSFADVPALSMCLV
CCCCHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEE
GDDDNVDYYHGRLRIIDDDKHIVREFDYHDYLDHFSEAVEEWSYMKFPYLKELGREQGSV
CCCCCCCEEECEEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCE
RVGPLGRMNVTKSLPTPLAQEALERFHAYTKGRTNNMTLHTNWARAIEILHAAEVVKELL
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHH
HDPDLQKDQLVLTPPPNAWTGEGVGVVEAPRGTLLHHYRADERGNITFANLVVATTQNNQ
CCCCCCCCCEEEECCCCCCCCCCCEEEECCCCCEEHHCCCCCCCCEEEEEEEEEECCCCH
VMNRTVRSVAEDYLGGHGEITEGMMNAIEVGIRAYDPCLSCATHALGQMPLVVSVFDAAG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RLIDERAR
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2188945; 12948488; 2496982