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The map label for this gene is hoxU

Identifier: 38637754

GI number: 38637754

Start: 81517

End: 82221

Strand: Direct

Name: hoxU

Synonym: PHG089

Alternate gene names: 38637754

Gene position: 81517-82221 (Clockwise)

Preceding gene: 38637753

Following gene: 38637755

Centisome position: 18.03

GC content: 60.71

Gene sequence:

>705_bases
ATGAGCATTCAAATTACGATCGACGGCAAGACGCTCACGACCGAGGAAGGACGAACGCTGGTGGATGTTGCCGCAGAGAA
CGGCGTTTACATCCCGACGCTGTGCTACCTCAAGGACAAGCCCTGCCTCGGCACCTGCCGGGTGTGTTCGGTCAAGGTGA
ATGGCAATGTCGCCGCGGCATGTACGGTGCGGGTCTCGAAGGGCCTGAATGTCGAGGTCAACGACCCCGAATTGGTCGAC
ATGCGCAAGGCGCTGGTCGAATTCCTGTTCGCGGAAGGCAACCACAACTGCCCGAGTTGCGAGAAGAGCGGCCGTTGCCA
GTTGCAGGCGGTCGGCTACGAGGTGGACATGATGGTCTCGCGCTTTCCGTACCGGTTCCCGGTCCGCGTGGTGGACCACG
CGTCCGAAAAGATCTGGCTCGAGCGGGATCGGTGCATCTTCTGTCAGCGCTGTGTCGAGTTCATCCGCGACAAGGCAAGC
GGCCGGAAGATCTTCAGCATCAGCCATCGGGGTCCCGAGTCGCGCATCGAGATCGATGCCGAACTGGCGAACGCCATGCC
GCCGGAGCAAGTCAAAGAGGCGGTTGCGATCTGCCCGGTGGGCACCATTCTCGAGAAACGGGTCGGTTATGACGATCCCA
TCGGACGACGCAAGTACGAAATCCAGTCGGTGCGCGCACGCGCGCTGGAAGGAGAAGACAAATGA

Upstream 100 bases:

>100_bases
AGCTGGTGAGGCACGAGGGCCCGCTGCTGCCATCGTTCGATCTCGATACCGCCTTGGGCGGGTATGAGAAGGCGCTGAAG
GATCTGGAAGAGGTGACAAG

Downstream 100 bases:

>100_bases
GAGCCCCCCACAAAGACGAGATTGCGTCGCACGAATTGCCTGCGACGCCGATGGATCCGGCGCTGGCCGCGAACCGTGAA
GGCAAGATCAAGGTGGCCAC

Product: NAD-reducing hydrogenase diaphorase moiety small subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MSIQITIDGKTLTTEEGRTLVDVAAENGVYIPTLCYLKDKPCLGTCRVCSVKVNGNVAAACTVRVSKGLNVEVNDPELVD
MRKALVEFLFAEGNHNCPSCEKSGRCQLQAVGYEVDMMVSRFPYRFPVRVVDHASEKIWLERDRCIFCQRCVEFIRDKAS
GRKIFSISHRGPESRIEIDAELANAMPPEQVKEAVAICPVGTILEKRVGYDDPIGRRKYEIQSVRARALEGEDK

Sequences:

>Translated_234_residues
MSIQITIDGKTLTTEEGRTLVDVAAENGVYIPTLCYLKDKPCLGTCRVCSVKVNGNVAAACTVRVSKGLNVEVNDPELVD
MRKALVEFLFAEGNHNCPSCEKSGRCQLQAVGYEVDMMVSRFPYRFPVRVVDHASEKIWLERDRCIFCQRCVEFIRDKAS
GRKIFSISHRGPESRIEIDAELANAMPPEQVKEAVAICPVGTILEKRVGYDDPIGRRKYEIQSVRARALEGEDK
>Mature_233_residues
SIQITIDGKTLTTEEGRTLVDVAAENGVYIPTLCYLKDKPCLGTCRVCSVKVNGNVAAACTVRVSKGLNVEVNDPELVDM
RKALVEFLFAEGNHNCPSCEKSGRCQLQAVGYEVDMMVSRFPYRFPVRVVDHASEKIWLERDRCIFCQRCVEFIRDKASG
RKIFSISHRGPESRIEIDAELANAMPPEQVKEAVAICPVGTILEKRVGYDDPIGRRKYEIQSVRARALEGEDK

Specific function: Subunits alpha and gamma of hoxS constitute an NADH-- oxidoreductase

COG id: COG1034

COG function: function code C; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain

Homologues:

Organism=Homo sapiens, GI33519475, Length=225, Percent_Identity=28.8888888888889, Blast_Score=88, Evalue=8e-18,
Organism=Escherichia coli, GI145693161, Length=213, Percent_Identity=28.169014084507, Blast_Score=88, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI193209088, Length=224, Percent_Identity=27.6785714285714, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI32566231, Length=224, Percent_Identity=27.6785714285714, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17565758, Length=224, Percent_Identity=27.6785714285714, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24640559, Length=236, Percent_Identity=26.6949152542373, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24640557, Length=236, Percent_Identity=26.6949152542373, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): HOXU_CUPNH (P22318)

Other databases:

- EMBL:   M55230
- EMBL:   AY305378
- PIR:   B35385
- RefSeq:   NP_942728.1
- ProteinModelPortal:   P22318
- SMR:   P22318
- GeneID:   2656815
- GenomeReviews:   AY305378_GR
- KEGG:   reh:PHG089
- eggNOG:   COG1034
- HOGENOM:   HBG583502
- OMA:   DEIEGAH
- ProtClustDB:   CLSK923808
- BioCyc:   MetaCyc:HOXUALCA-MONOMER
- BioCyc:   REUT381666:PHG089-MONOMER
- BRENDA:   1.12.1.2
- GO:   GO:0005737
- GO:   GO:0016020
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR016214
- InterPro:   IPR000283
- InterPro:   IPR019574
- Gene3D:   G3DSA:3.10.20.30
- PIRSF:   PIRSF000309
- SMART:   SM00929

Pfam domain/function: PF00111 Fer2; PF10588 NADH-G_4Fe-4S_3; SSF54292 Ferredoxin

EC number: =1.12.1.2

Molecular weight: Translated: 26173; Mature: 26042

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00197 2FE2S_FER_1; PS51085 2FE2S_FER_2; PS00641 COMPLEX1_75K_1; PS00642 COMPLEX1_75K_2; PS00643 COMPLEX1_75K_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
5.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIQITIDGKTLTTEEGRTLVDVAAENGVYIPTLCYLKDKPCLGTCRVCSVKVNGNVAAA
CEEEEEECCCEEECCCCCEEEEEECCCCEEEEEEEEECCCCCCCEEEEEEEEECCCEEEE
CTVRVSKGLNVEVNDPELVDMRKALVEFLFAEGNHNCPSCEKSGRCQLQAVGYEVDMMVS
EEEEECCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECEEEEHHHH
RFPYRFPVRVVDHASEKIWLERDRCIFCQRCVEFIRDKASGRKIFSISHRGPESRIEIDA
HCCCCCCCCEECCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEH
ELANAMPPEQVKEAVAICPVGTILEKRVGYDDPIGRRKYEIQSVRARALEGEDK
HHHHCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SIQITIDGKTLTTEEGRTLVDVAAENGVYIPTLCYLKDKPCLGTCRVCSVKVNGNVAAA
EEEEEECCCEEECCCCCEEEEEECCCCEEEEEEEEECCCCCCCEEEEEEEEECCCEEEE
CTVRVSKGLNVEVNDPELVDMRKALVEFLFAEGNHNCPSCEKSGRCQLQAVGYEVDMMVS
EEEEECCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECEEEEHHHH
RFPYRFPVRVVDHASEKIWLERDRCIFCQRCVEFIRDKASGRKIFSISHRGPESRIEIDA
HCCCCCCCCEECCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEH
ELANAMPPEQVKEAVAICPVGTILEKRVGYDDPIGRRKYEIQSVRARALEGEDK
HHHHCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2188945; 12948488; 2496982