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The map label for this gene is hoxF

Identifier: 38637753

GI number: 38637753

Start: 79712

End: 81520

Strand: Direct

Name: hoxF

Synonym: PHG088

Alternate gene names: 38637753

Gene position: 79712-81520 (Clockwise)

Preceding gene: 38637752

Following gene: 38637754

Centisome position: 17.63

GC content: 59.87

Gene sequence:

>1809_bases
ATGGATAGTCGTATCACGACAATACTCGAGCGCTACCGCTCAGACCGTACACGGCTGATCGACATACTTTGGGATGTTCA
GCATGAGTATGGGCACATTCCCGATGCGGTACTGCCGCAACTGGGGGCTGGGTTGAAGCTGTCCCCGCTGGACATTCGCG
AAACGGCGTCGTTCTACCACTTTTTCCTTGACAAGCCGTCGGGCAAGTATCGGATTTACTTGTGCAATTCCGTGATTGCC
AAGATCAACGGCTATCAGGCGGTGCGTGAGGCGCTCGAACGCGAGACTGGGATTCGCTTCGGCGAAACCGACCCGAATGG
GATGTTTGGCCTGTTCGACACCCCCTGTATCGGACTCAGCGATCAGGAACCGGCGATGCTGATCGATAAGGTGGTATTCA
CCCGCCTGCGACCCGGAAAGATCACGGACATCATCGCGCAGTTGAAACAAGGACGATCGCCGGCCGAGATCGCGAACCCG
GCCGGTTTGCCCAGTCAGGACATCGCCTATGTCGATGCCATGGTCGAGTCCAATGTCCGCACCAAGGGGCCGGTGTTCTT
CCGTGGCCGGACGGATTTGAGATCTTTGCTCGACCAATGCCTGCTGCTCAAGCCCGAACAAGTGATTGAGACCATCGTCG
ACTCCAGGCTGCGCGGACGTGGCGGCGCAGGGTTCTCGACCGGGCTGAAGTGGCGGCTGTGTCGGGATGCCGAAAGCGAG
CAGAAGTATGTAATCTGCAACGCCGACGAAGGTGAGCCCGGCACGTTCAAGGATAGGGTCCTCCTGACACGCGCTCCCAA
GAAGGTTTTCGTCGGAATGGTTATCGCCGCGTATGCGATCGGCTGCCGCAAGGGTATCGTCTATCTGCGGGGGGAATACT
TCTACCTCAAGGATTATCTGGAGCGACAGCTTCAGGAACTTCGGGAGGACGGGTTGCTGGGGCGCGCTATCGGTGGCCGG
GCGGGCTTTGATTTCGATATCCGTATTCAGATGGGGGCCGGCGCTTATATCTGCGGCGACGAATCGGCGCTCATCGAGTC
CTGCGAGGGGAAACGGGGCACGCCACGGGTGAAACCTCCGTTCCCGGTGCAGCAAGGGTATCTGGGCAAGCCCACCAGCG
TCAACAACGTTGAGACCTTTGCCGCCGTGTCGCGGATCATGGAGGAAGGCGCGGACTGGTTCCGGGCGATGGGAACGCCA
GACTCGGCCGGCACCCGGCTGCTGAGCGTGGCTGGCGATTGCAGCAAGCCTGGCATCTACGAGGTGGAATGGGGGGTCAC
CCTCAACGAAGTGCTGGCGATGGTCGGAGCGCGGGACGCGCGGGCCGTCCAGATCAGCGGTCCTTCCGGTGAATGCGTGT
CGGTGGCAAAGGACGGTGAGCGCAAGCTCGCGTACGAAGATCTTTCGTGCAATGGCGCCTTCACCATTTTCAACTGCAAG
CGCGACCTGCTGGAAATCGTGCGTGACCACATGCAGTTCTTCGTCGAAGAGTCCTGCGGCATTTGTGTGCCATGTCGCGC
CGGCAACGTTGATCTGCACCGGAAGGTCGAATGGGTCATCGCGGGCAAGGCCTGCCAGAAGGATCTGGACGATATGGTCA
GTTGGGGAGCGCTGGTGCGGAGGACCAGTCGATGTGGCCTTGGGGCCACATCGCCCAAGCCCATCCTGACGACGCTGGAG
AAATTCCCCGAGATCTATCAGAACAAGCTGGTGAGGCACGAGGGCCCGCTGCTGCCATCGTTCGATCTCGATACCGCCTT
GGGCGGGTATGAGAAGGCGCTGAAGGATCTGGAAGAGGTGACAAGATGA

Upstream 100 bases:

>100_bases
TTCCCTTAGGCCCTGCGAAATTGGCGCACATCCTGCGTTCCACCTGCGCATCGAAGTGACGCACCAAGCAAGGGGCGAAC
ATTAGTAAGGAGGAGACAAC

Downstream 100 bases:

>100_bases
GCATTCAAATTACGATCGACGGCAAGACGCTCACGACCGAGGAAGGACGAACGCTGGTGGATGTTGCCGCAGAGAACGGC
GTTTACATCCCGACGCTGTG

Product: NAD-reducing hydrogenase diaphorase moiety large subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MDSRITTILERYRSDRTRLIDILWDVQHEYGHIPDAVLPQLGAGLKLSPLDIRETASFYHFFLDKPSGKYRIYLCNSVIA
KINGYQAVREALERETGIRFGETDPNGMFGLFDTPCIGLSDQEPAMLIDKVVFTRLRPGKITDIIAQLKQGRSPAEIANP
AGLPSQDIAYVDAMVESNVRTKGPVFFRGRTDLRSLLDQCLLLKPEQVIETIVDSRLRGRGGAGFSTGLKWRLCRDAESE
QKYVICNADEGEPGTFKDRVLLTRAPKKVFVGMVIAAYAIGCRKGIVYLRGEYFYLKDYLERQLQELREDGLLGRAIGGR
AGFDFDIRIQMGAGAYICGDESALIESCEGKRGTPRVKPPFPVQQGYLGKPTSVNNVETFAAVSRIMEEGADWFRAMGTP
DSAGTRLLSVAGDCSKPGIYEVEWGVTLNEVLAMVGARDARAVQISGPSGECVSVAKDGERKLAYEDLSCNGAFTIFNCK
RDLLEIVRDHMQFFVEESCGICVPCRAGNVDLHRKVEWVIAGKACQKDLDDMVSWGALVRRTSRCGLGATSPKPILTTLE
KFPEIYQNKLVRHEGPLLPSFDLDTALGGYEKALKDLEEVTR

Sequences:

>Translated_602_residues
MDSRITTILERYRSDRTRLIDILWDVQHEYGHIPDAVLPQLGAGLKLSPLDIRETASFYHFFLDKPSGKYRIYLCNSVIA
KINGYQAVREALERETGIRFGETDPNGMFGLFDTPCIGLSDQEPAMLIDKVVFTRLRPGKITDIIAQLKQGRSPAEIANP
AGLPSQDIAYVDAMVESNVRTKGPVFFRGRTDLRSLLDQCLLLKPEQVIETIVDSRLRGRGGAGFSTGLKWRLCRDAESE
QKYVICNADEGEPGTFKDRVLLTRAPKKVFVGMVIAAYAIGCRKGIVYLRGEYFYLKDYLERQLQELREDGLLGRAIGGR
AGFDFDIRIQMGAGAYICGDESALIESCEGKRGTPRVKPPFPVQQGYLGKPTSVNNVETFAAVSRIMEEGADWFRAMGTP
DSAGTRLLSVAGDCSKPGIYEVEWGVTLNEVLAMVGARDARAVQISGPSGECVSVAKDGERKLAYEDLSCNGAFTIFNCK
RDLLEIVRDHMQFFVEESCGICVPCRAGNVDLHRKVEWVIAGKACQKDLDDMVSWGALVRRTSRCGLGATSPKPILTTLE
KFPEIYQNKLVRHEGPLLPSFDLDTALGGYEKALKDLEEVTR
>Mature_602_residues
MDSRITTILERYRSDRTRLIDILWDVQHEYGHIPDAVLPQLGAGLKLSPLDIRETASFYHFFLDKPSGKYRIYLCNSVIA
KINGYQAVREALERETGIRFGETDPNGMFGLFDTPCIGLSDQEPAMLIDKVVFTRLRPGKITDIIAQLKQGRSPAEIANP
AGLPSQDIAYVDAMVESNVRTKGPVFFRGRTDLRSLLDQCLLLKPEQVIETIVDSRLRGRGGAGFSTGLKWRLCRDAESE
QKYVICNADEGEPGTFKDRVLLTRAPKKVFVGMVIAAYAIGCRKGIVYLRGEYFYLKDYLERQLQELREDGLLGRAIGGR
AGFDFDIRIQMGAGAYICGDESALIESCEGKRGTPRVKPPFPVQQGYLGKPTSVNNVETFAAVSRIMEEGADWFRAMGTP
DSAGTRLLSVAGDCSKPGIYEVEWGVTLNEVLAMVGARDARAVQISGPSGECVSVAKDGERKLAYEDLSCNGAFTIFNCK
RDLLEIVRDHMQFFVEESCGICVPCRAGNVDLHRKVEWVIAGKACQKDLDDMVSWGALVRRTSRCGLGATSPKPILTTLE
KFPEIYQNKLVRHEGPLLPSFDLDTALGGYEKALKDLEEVTR

Specific function: Subunits alpha and gamma of hoxS constitute an NADH-- oxidoreductase

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family

Homologues:

Organism=Homo sapiens, GI260656005, Length=383, Percent_Identity=35.2480417754569, Blast_Score=236, Evalue=7e-62,
Organism=Homo sapiens, GI20149568, Length=383, Percent_Identity=35.2480417754569, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI222080062, Length=153, Percent_Identity=28.1045751633987, Blast_Score=83, Evalue=7e-16,
Organism=Escherichia coli, GI1788620, Length=329, Percent_Identity=40.4255319148936, Blast_Score=251, Evalue=1e-67,
Organism=Escherichia coli, GI1788621, Length=141, Percent_Identity=32.6241134751773, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17531727, Length=434, Percent_Identity=33.4101382488479, Blast_Score=232, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI17561328, Length=154, Percent_Identity=29.8701298701299, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19920794, Length=381, Percent_Identity=34.1207349081365, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI45550452, Length=382, Percent_Identity=34.2931937172775, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24653819, Length=341, Percent_Identity=33.4310850439883, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24653817, Length=316, Percent_Identity=31.3291139240506, Blast_Score=155, Evalue=1e-37,
Organism=Drosophila melanogaster, GI18859877, Length=151, Percent_Identity=27.1523178807947, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21355353, Length=161, Percent_Identity=25.4658385093168, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HOXF_CUPNH (P22317)

Other databases:

- EMBL:   M55230
- EMBL:   AY305378
- PIR:   A35385
- RefSeq:   NP_942727.1
- ProteinModelPortal:   P22317
- SMR:   P22317
- GeneID:   2656814
- GenomeReviews:   AY305378_GR
- KEGG:   reh:PHG088
- eggNOG:   COG1894
- HOGENOM:   HBG669338
- OMA:   FCTPCRV
- PhylomeDB:   P22317
- ProtClustDB:   CLSK923807
- BioCyc:   MetaCyc:HOXFALCA-MONOMER
- BioCyc:   REUT381666:PHG088-MONOMER
- BRENDA:   1.12.1.2
- GO:   GO:0005737
- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR002023
- InterPro:   IPR011538
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- SMART:   SM00928

Pfam domain/function: PF01257 Complex1_24kDa; PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; SSF52833 Thiordxn-like_fd

EC number: =1.12.1.2

Molecular weight: Translated: 66784; Mature: 66784

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00644 COMPLEX1_51K_1; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSRITTILERYRSDRTRLIDILWDVQHEYGHIPDAVLPQLGAGLKLSPLDIRETASFYH
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEECCCCHHHHHHHHH
FFLDKPSGKYRIYLCNSVIAKINGYQAVREALERETGIRFGETDPNGMFGLFDTPCIGLS
HEEECCCCCEEEEEEHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCC
DQEPAMLIDKVVFTRLRPGKITDIIAQLKQGRSPAEIANPAGLPSQDIAYVDAMVESNVR
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHCCCC
TKGPVFFRGRTDLRSLLDQCLLLKPEQVIETIVDSRLRGRGGAGFSTGLKWRLCRDAESE
CCCCEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCC
QKYVICNADEGEPGTFKDRVLLTRAPKKVFVGMVIAAYAIGCRKGIVYLRGEYFYLKDYL
CCEEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHH
ERQLQELREDGLLGRAIGGRAGFDFDIRIQMGAGAYICGDESALIESCEGKRGTPRVKPP
HHHHHHHHHCCCEEEECCCCCCCCEEEEEEECCCEEEECCCHHHHHHCCCCCCCCCCCCC
FPVQQGYLGKPTSVNNVETFAAVSRIMEEGADWFRAMGTPDSAGTRLLSVAGDCSKPGIY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCEEEEECCCCCCCCEE
EVEWGVTLNEVLAMVGARDARAVQISGPSGECVSVAKDGERKLAYEDLSCNGAFTIFNCK
EEECCCCHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCEEEEECCCCCCCEEEECCH
RDLLEIVRDHMQFFVEESCGICVPCRAGNVDLHRKVEWVIAGKACQKDLDDMVSWGALVR
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHEEEEEEEECHHHHHHHHHHHHHHHHHH
RTSRCGLGATSPKPILTTLEKFPEIYQNKLVRHEGPLLPSFDLDTALGGYEKALKDLEEV
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHH
TR
CC
>Mature Secondary Structure
MDSRITTILERYRSDRTRLIDILWDVQHEYGHIPDAVLPQLGAGLKLSPLDIRETASFYH
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEECCCCHHHHHHHHH
FFLDKPSGKYRIYLCNSVIAKINGYQAVREALERETGIRFGETDPNGMFGLFDTPCIGLS
HEEECCCCCEEEEEEHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCC
DQEPAMLIDKVVFTRLRPGKITDIIAQLKQGRSPAEIANPAGLPSQDIAYVDAMVESNVR
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHCCCC
TKGPVFFRGRTDLRSLLDQCLLLKPEQVIETIVDSRLRGRGGAGFSTGLKWRLCRDAESE
CCCCEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCC
QKYVICNADEGEPGTFKDRVLLTRAPKKVFVGMVIAAYAIGCRKGIVYLRGEYFYLKDYL
CCEEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHH
ERQLQELREDGLLGRAIGGRAGFDFDIRIQMGAGAYICGDESALIESCEGKRGTPRVKPP
HHHHHHHHHCCCEEEECCCCCCCCEEEEEEECCCEEEECCCHHHHHHCCCCCCCCCCCCC
FPVQQGYLGKPTSVNNVETFAAVSRIMEEGADWFRAMGTPDSAGTRLLSVAGDCSKPGIY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCEEEEECCCCCCCCEE
EVEWGVTLNEVLAMVGARDARAVQISGPSGECVSVAKDGERKLAYEDLSCNGAFTIFNCK
EEECCCCHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCEEEEECCCCCCCEEEECCH
RDLLEIVRDHMQFFVEESCGICVPCRAGNVDLHRKVEWVIAGKACQKDLDDMVSWGALVR
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHEEEEEEEECHHHHHHHHHHHHHHHHHH
RTSRCGLGATSPKPILTTLEKFPEIYQNKLVRHEGPLLPSFDLDTALGGYEKALKDLEEV
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHH
TR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2188945; 12948488; 2496982