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The map label for this gene is hoxC [H]

Identifier: 38637689

GI number: 38637689

Start: 17976

End: 19433

Strand: Direct

Name: hoxC [H]

Synonym: PHG021

Alternate gene names: 38637689

Gene position: 17976-19433 (Clockwise)

Preceding gene: 38637688

Following gene: 38637690

Centisome position: 3.98

GC content: 65.09

Gene sequence:

>1458_bases
ATGGAACGTTTGGTGGTGGGGCCGTTCAACCGCGTTGAGGGCGACCTCGAGGTGAACCTCGAGGTCGCCAGCGGTCGGGT
ATGCTCAGCACGTGTGAATGCCACGATGTACCGCGGATTGGAACAGATCCTGCTACACCGGCATCCGCTTGACGCGCTGG
TCTATGCGCCGCGTGTGTGCGGTATCTGCTCGGTGTCCCAGTCGGTCGCGGCCAGCCGCGCATTGGCGGATCTTGCCGGC
GTGACGGTACCCGCTAACGGTATGCTGGCGATGAACTTGATGCTGGCGACCGAGAATCTGGCCGACCATCTGACGCACTT
CTATCTGTTCTTCATGCCGGATTTCACGCGCGAGATATATGCTGGCCGCCCCTGGCACACCGACGCGACGGCACGTTTTT
CGCCCACGCATGGTAAGCACCACAGGCTGGCGATTGCCGCAAGGCAGCGATGGTTTACCTTGATGGGCACCCTGGGCGGC
AAATGGCCGCACACAGAATCGGTGCAGCCCGGTGGTTCGTCGCGCGCCATCGACGCCGCTGAGCGCGTTCGCCTGCTGGG
CCGGGTGCGCGAATTCCGGTGCTTTCTCGAGCAGACACTGTATGCCGCACCGCTCGAGGACGTCGTCGCGCTCGACAGCG
AAGTCGCGTTGTGGCGCTGGCATGCGCAGGCGCCGCAGGCCGGAGACCTGCGATGTTTCCTCACGATCGCGCAGGATGCG
GCGCTGGACCAGATGGGGCCCGGCCCGGGTACGTATCTGTCATATGGCGCCTACCCCCAGCCCGAAGGCGGTTTTTGCTT
CGCACAAGGTGTGTGGCGTAGCGCGCAAGGGCGGCTCGACGCGCTTGATCTTGCCGCGATCAGCGAAGATGCCACCTCCG
CCTGGTTAGTCGACCAAGGGGGGGCGCGTCATCCTGCCAATGGCCTGACCGCGCCAGCACCTGACAAGGTGGGCGCCTAT
ACCTGGAACAAGGCCCCTCGATTGGCCGGCGCCGTGCTGGAGACCGGTGCGATCGCCCGGCAGTTGGCCGGCGCACAGCC
CTTGGTGCGTGACGCGGTGGCGCGCTGCGGCGCCACCGTCTATACGCGCGTATTGGCGCGACTGGTTGAACTGGCGCGAG
TGGTGCCGTTGATGGAAGACTGGTTACAGTCCCTAGAAATCGGGGCCCCATATTGGGCGTCGGCCCACCTGCCGGATCAG
GGCGCTGGCGTTGGCCTTACGGAGGCGGCGCGCGGCAGCCTGGGGCACTGGGTGTCGGTGCGCGATGGGCGAATCGACAA
TTACCAGATCGTCGCACCCACGTCCTGGAACTTCTCGCCGCGCGATATAGCCGGCCAGCCCGGGGCCGTGGAGAAAGCAC
TCGAGGGTGCGCCTGTGCTGCAAGGCGAAACAACGCCGGTCGCCGTTCAGCACATTGTCCGCTCCTTCGATCCCTGCATG
GTGTGCACCGTGCATTGA

Upstream 100 bases:

>100_bases
CAAGTCAGCCACGCCCAAGCGAGTGAAACTTAATGCCACGGCAGATCATCCGCTGATCGCGCCAGCCATTCGCAAGACGC
GGCTGAAATAGGAGGCGAGC

Downstream 100 bases:

>100_bases
GCATGCACCTCAATCACCACGATCATATGGCACGGGCAAGCCGAAGCCGACGTGGCAACGTTGCGTCGCATCCTCGGGCA
CCTGATTGCCATTATCGCCA

Product: regulatory [NiFe] hydrogenase large subunit

Products: NA

Alternate protein names: NiFe hydrogenlyase large chain [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MERLVVGPFNRVEGDLEVNLEVASGRVCSARVNATMYRGLEQILLHRHPLDALVYAPRVCGICSVSQSVAASRALADLAG
VTVPANGMLAMNLMLATENLADHLTHFYLFFMPDFTREIYAGRPWHTDATARFSPTHGKHHRLAIAARQRWFTLMGTLGG
KWPHTESVQPGGSSRAIDAAERVRLLGRVREFRCFLEQTLYAAPLEDVVALDSEVALWRWHAQAPQAGDLRCFLTIAQDA
ALDQMGPGPGTYLSYGAYPQPEGGFCFAQGVWRSAQGRLDALDLAAISEDATSAWLVDQGGARHPANGLTAPAPDKVGAY
TWNKAPRLAGAVLETGAIARQLAGAQPLVRDAVARCGATVYTRVLARLVELARVVPLMEDWLQSLEIGAPYWASAHLPDQ
GAGVGLTEAARGSLGHWVSVRDGRIDNYQIVAPTSWNFSPRDIAGQPGAVEKALEGAPVLQGETTPVAVQHIVRSFDPCM
VCTVH

Sequences:

>Translated_485_residues
MERLVVGPFNRVEGDLEVNLEVASGRVCSARVNATMYRGLEQILLHRHPLDALVYAPRVCGICSVSQSVAASRALADLAG
VTVPANGMLAMNLMLATENLADHLTHFYLFFMPDFTREIYAGRPWHTDATARFSPTHGKHHRLAIAARQRWFTLMGTLGG
KWPHTESVQPGGSSRAIDAAERVRLLGRVREFRCFLEQTLYAAPLEDVVALDSEVALWRWHAQAPQAGDLRCFLTIAQDA
ALDQMGPGPGTYLSYGAYPQPEGGFCFAQGVWRSAQGRLDALDLAAISEDATSAWLVDQGGARHPANGLTAPAPDKVGAY
TWNKAPRLAGAVLETGAIARQLAGAQPLVRDAVARCGATVYTRVLARLVELARVVPLMEDWLQSLEIGAPYWASAHLPDQ
GAGVGLTEAARGSLGHWVSVRDGRIDNYQIVAPTSWNFSPRDIAGQPGAVEKALEGAPVLQGETTPVAVQHIVRSFDPCM
VCTVH
>Mature_485_residues
MERLVVGPFNRVEGDLEVNLEVASGRVCSARVNATMYRGLEQILLHRHPLDALVYAPRVCGICSVSQSVAASRALADLAG
VTVPANGMLAMNLMLATENLADHLTHFYLFFMPDFTREIYAGRPWHTDATARFSPTHGKHHRLAIAARQRWFTLMGTLGG
KWPHTESVQPGGSSRAIDAAERVRLLGRVREFRCFLEQTLYAAPLEDVVALDSEVALWRWHAQAPQAGDLRCFLTIAQDA
ALDQMGPGPGTYLSYGAYPQPEGGFCFAQGVWRSAQGRLDALDLAAISEDATSAWLVDQGGARHPANGLTAPAPDKVGAY
TWNKAPRLAGAVLETGAIARQLAGAQPLVRDAVARCGATVYTRVLARLVELARVVPLMEDWLQSLEIGAPYWASAHLPDQ
GAGVGLTEAARGSLGHWVSVRDGRIDNYQIVAPTSWNFSPRDIAGQPGAVEKALEGAPVLQGETTPVAVQHIVRSFDPCM
VCTVH

Specific function: This Is One Of Three E.Coli Hydrogenases Synthesized In Response To Different Physiological Conditions. Hyd2 Is Involved In Hydrogen Uptake. [C]

COG id: COG0374

COG function: function code C; Ni,Fe-hydrogenase I large subunit

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789368, Length=573, Percent_Identity=26.5270506108202, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1787207, Length=574, Percent_Identity=28.7456445993031, Blast_Score=174, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001501
- InterPro:   IPR018194 [H]

Pfam domain/function: PF00374 NiFeSe_Hases [H]

EC number: =1.12.2.1 [H]

Molecular weight: Translated: 52434; Mature: 52434

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00507 NI_HGENASE_L_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERLVVGPFNRVEGDLEVNLEVASGRVCSARVNATMYRGLEQILLHRHPLDALVYAPRVC
CCCEEECCHHHCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHH
GICSVSQSVAASRALADLAGVTVPANGMLAMNLMLATENLADHLTHFYLFFMPDFTREIY
HHHHHHHHHHHHHHHHHHHCCEECCCCEEEEEEHHHHHHHHHHHHHHHHEECCCHHHHHH
AGRPWHTDATARFSPTHGKHHRLAIAARQRWFTLMGTLGGKWPHTESVQPGGSSRAIDAA
CCCCCCCCCCCEECCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
ERVRLLGRVREFRCFLEQTLYAAPLEDVVALDSEVALWRWHAQAPQAGDLRCFLTIAQDA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEHHHH
ALDQMGPGPGTYLSYGAYPQPEGGFCFAQGVWRSAQGRLDALDLAAISEDATSAWLVDQG
HHHHCCCCCCCCEECCCCCCCCCCEEEHHHHHHHCCCCCCHHHHHHHCCCCCCEEEECCC
GARHPANGLTAPAPDKVGAYTWNKAPRLAGAVLETGAIARQLAGAQPLVRDAVARCGATV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHH
YTRVLARLVELARVVPLMEDWLQSLEIGAPYWASAHLPDQGAGVGLTEAARGSLGHWVSV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEEEE
RDGRIDNYQIVAPTSWNFSPRDIAGQPGAVEKALEGAPVLQGETTPVAVQHIVRSFDPCM
ECCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEE
VCTVH
EEEEC
>Mature Secondary Structure
MERLVVGPFNRVEGDLEVNLEVASGRVCSARVNATMYRGLEQILLHRHPLDALVYAPRVC
CCCEEECCHHHCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHH
GICSVSQSVAASRALADLAGVTVPANGMLAMNLMLATENLADHLTHFYLFFMPDFTREIY
HHHHHHHHHHHHHHHHHHHCCEECCCCEEEEEEHHHHHHHHHHHHHHHHEECCCHHHHHH
AGRPWHTDATARFSPTHGKHHRLAIAARQRWFTLMGTLGGKWPHTESVQPGGSSRAIDAA
CCCCCCCCCCCEECCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
ERVRLLGRVREFRCFLEQTLYAAPLEDVVALDSEVALWRWHAQAPQAGDLRCFLTIAQDA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEHHHH
ALDQMGPGPGTYLSYGAYPQPEGGFCFAQGVWRSAQGRLDALDLAAISEDATSAWLVDQG
HHHHCCCCCCCCEECCCCCCCCCCEEEHHHHHHHCCCCCCHHHHHHHCCCCCCEEEECCC
GARHPANGLTAPAPDKVGAYTWNKAPRLAGAVLETGAIARQLAGAQPLVRDAVARCGATV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHH
YTRVLARLVELARVVPLMEDWLQSLEIGAPYWASAHLPDQGAGVGLTEAARGSLGHWVSV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEEEE
RDGRIDNYQIVAPTSWNFSPRDIAGQPGAVEKALEGAPVLQGETTPVAVQHIVRSFDPCM
ECCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEE
VCTVH
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2227457; 2154378 [H]