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The map label for this gene is hypE1

Identifier: 38637685

GI number: 38637685

Start: 12614

End: 13669

Strand: Direct

Name: hypE1

Synonym: PHG017

Alternate gene names: 38637685

Gene position: 12614-13669 (Clockwise)

Preceding gene: 38637684

Following gene: 38637686

Centisome position: 2.79

GC content: 63.35

Gene sequence:

>1056_bases
ATGAGCGGCACCGTTAAACTGGGCTATCAACGGCCCCTGAACATCAAGAGCGGCAGAATCGACATGGGCCACGGCGCGGG
GGGGCGCGCAGCCGCACAACTTATCCAGGAACTGTTCGTTGCTGCGTTTGACAATGAGTGGCTGCGCCAGGGCAACGACC
AGGCGGCTTTCGCCATGCCTGCCGGGGCCAGAATGGTGATGGCCACCGACGCGCACGTGGTGTCGCCGCTATTCTTCCCC
GGGGGTGACATCGGTAGCCTGTCGGTGCACGGCACCATTAACGATGTGGCGATGGCCGGTGCCAAACCGCTGTATCTGGC
CGCGAGTTTCATCCTCGAGGAAGGGTTTCCGCTAGCGGATCTTAAGCGCATTGTCGAATCGATGGCCGGGGCTGCGCGTG
AGGCTGGCGTGCCTATCGTGACGGGTGACACGAAAGTGGTCGAGCAAGGCAAGGGTGATGGCGTATTCATTACCACTACC
GGCGTCGGCGTGGTGCCAGCGGGCATTCTAATCGACGGCGCCGGGGCCAGGCCCGGCGACGCTATTCTGCTCTCTGGCAC
TATGGGGGAGCATGGCGTAGCGATCCTGTCCAAACGCGAGTCGCTTGAATTTGACACTGAGATCCGCTCGGACAGCGCCG
CGCTGCACGACTTGGTGGCACAGATGCTGGCCGTGGTGCCGGGGGTACGAGTGCTGCGGGATCCTACGCGCGGCGGACTG
GCGACCACGCTCAACGAAATTTCCAGTCAATCGGGAGTGGGCATGGTGTTGGACGAAGCGGCGATCCCCGTCCTGCCACA
GGTGGACGCGGCATGCGAGCTGCTCGGGCTTGATCCGCTGTACGTGGCGAACGAAGGTAAATTGGTTGCCATTTGCGCAG
CTGCGGACGCGGATGCCCTGCTTGCCGCCATGCGGGGGCATCCGCTCGGTCGCGAGGCACGGCGCATCGGAGAGGTCATC
GAGGACGGGCGCCACTTTGTGCAGATGCGCACAAAATTCGGCGGGATGCGCGTGGTGGACTGGCTGTCCGGCGAGCAGCT
TCCGCGCATTTGTTGA

Upstream 100 bases:

>100_bases
CCCCGGAGAATCCGATGGGGTCGTGCATGGTATCCAGCGAAGGTGCCTGCGCCGCGCACTATTCGTATGGGCGGTTCAAG
GATATCCCCTTGGTGGCAGC

Downstream 100 bases:

>100_bases
GCGAGTCGGCTATGCGCATATTGCTCCTCACCCATAGCTTCAACAGTCTGACGCAGCGACTGTTTGTCGAGTTGCGCCAG
CGCGGCCACCTGGTGTCGGT

Product: HypE1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSGTVKLGYQRPLNIKSGRIDMGHGAGGRAAAQLIQELFVAAFDNEWLRQGNDQAAFAMPAGARMVMATDAHVVSPLFFP
GGDIGSLSVHGTINDVAMAGAKPLYLAASFILEEGFPLADLKRIVESMAGAAREAGVPIVTGDTKVVEQGKGDGVFITTT
GVGVVPAGILIDGAGARPGDAILLSGTMGEHGVAILSKRESLEFDTEIRSDSAALHDLVAQMLAVVPGVRVLRDPTRGGL
ATTLNEISSQSGVGMVLDEAAIPVLPQVDAACELLGLDPLYVANEGKLVAICAAADADALLAAMRGHPLGREARRIGEVI
EDGRHFVQMRTKFGGMRVVDWLSGEQLPRIC

Sequences:

>Translated_351_residues
MSGTVKLGYQRPLNIKSGRIDMGHGAGGRAAAQLIQELFVAAFDNEWLRQGNDQAAFAMPAGARMVMATDAHVVSPLFFP
GGDIGSLSVHGTINDVAMAGAKPLYLAASFILEEGFPLADLKRIVESMAGAAREAGVPIVTGDTKVVEQGKGDGVFITTT
GVGVVPAGILIDGAGARPGDAILLSGTMGEHGVAILSKRESLEFDTEIRSDSAALHDLVAQMLAVVPGVRVLRDPTRGGL
ATTLNEISSQSGVGMVLDEAAIPVLPQVDAACELLGLDPLYVANEGKLVAICAAADADALLAAMRGHPLGREARRIGEVI
EDGRHFVQMRTKFGGMRVVDWLSGEQLPRIC
>Mature_350_residues
SGTVKLGYQRPLNIKSGRIDMGHGAGGRAAAQLIQELFVAAFDNEWLRQGNDQAAFAMPAGARMVMATDAHVVSPLFFPG
GDIGSLSVHGTINDVAMAGAKPLYLAASFILEEGFPLADLKRIVESMAGAAREAGVPIVTGDTKVVEQGKGDGVFITTTG
VGVVPAGILIDGAGARPGDAILLSGTMGEHGVAILSKRESLEFDTEIRSDSAALHDLVAQMLAVVPGVRVLRDPTRGGLA
TTLNEISSQSGVGMVLDEAAIPVLPQVDAACELLGLDPLYVANEGKLVAICAAADADALLAAMRGHPLGREARRIGEVIE
DGRHFVQMRTKFGGMRVVDWLSGEQLPRIC

Specific function: Unknown

COG id: COG0309

COG function: function code O; Hydrogenase maturation factor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hypE family

Homologues:

Organism=Escherichia coli, GI226510967, Length=337, Percent_Identity=49.2581602373887, Blast_Score=304, Evalue=6e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HYPE_CUPNH (P31905)

Other databases:

- EMBL:   X70183
- EMBL:   X74670
- EMBL:   AY305378
- PIR:   S29979
- RefSeq:   NP_942659.1
- ProteinModelPortal:   P31905
- SMR:   P31905
- IntAct:   P31905
- GeneID:   2656438
- GenomeReviews:   AY305378_GR
- KEGG:   reh:PHG017
- eggNOG:   COG0611
- HOGENOM:   HBG287946
- OMA:   AMRDPTR
- PhylomeDB:   P31905
- ProtClustDB:   CLSK648203
- BioCyc:   REUT381666:PHG017-MONOMER
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR011854
- InterPro:   IPR016188
- PIRSF:   PIRSF005644
- TIGRFAMs:   TIGR02124

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: NA

Molecular weight: Translated: 36597; Mature: 36465

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTVKLGYQRPLNIKSGRIDMGHGAGGRAAAQLIQELFVAAFDNEWLRQGNDQAAFAMP
CCCCEEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEECC
AGARMVMATDAHVVSPLFFPGGDIGSLSVHGTINDVAMAGAKPLYLAASFILEEGFPLAD
CCCEEEEEECCHHHCEEECCCCCCCCEEECCCHHHHHHCCCCHHHHHHHHHHHCCCCHHH
LKRIVESMAGAAREAGVPIVTGDTKVVEQGKGDGVFITTTGVGVVPAGILIDGAGARPGD
HHHHHHHHHCHHHHCCCCEEECCHHHHHCCCCCEEEEEECCCCCCCCCEEEECCCCCCCC
AILLSGTMGEHGVAILSKRESLEFDTEIRSDSAALHDLVAQMLAVVPGVRVLRDPTRGGL
EEEEECCCCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCH
ATTLNEISSQSGVGMVLDEAAIPVLPQVDAACELLGLDPLYVANEGKLVAICAAADADAL
HHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHCCCCCEEEECCCCEEEEEECCCHHHH
LAAMRGHPLGREARRIGEVIEDGRHFVQMRTKFGGMRVVDWLSGEQLPRIC
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure 
SGTVKLGYQRPLNIKSGRIDMGHGAGGRAAAQLIQELFVAAFDNEWLRQGNDQAAFAMP
CCCEEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEECC
AGARMVMATDAHVVSPLFFPGGDIGSLSVHGTINDVAMAGAKPLYLAASFILEEGFPLAD
CCCEEEEEECCHHHCEEECCCCCCCCEEECCCHHHHHHCCCCHHHHHHHHHHHCCCCHHH
LKRIVESMAGAAREAGVPIVTGDTKVVEQGKGDGVFITTTGVGVVPAGILIDGAGARPGD
HHHHHHHHHCHHHHCCCCEEECCHHHHHCCCCCEEEEEECCCCCCCCCEEEECCCCCCCC
AILLSGTMGEHGVAILSKRESLEFDTEIRSDSAALHDLVAQMLAVVPGVRVLRDPTRGGL
EEEEECCCCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCH
ATTLNEISSQSGVGMVLDEAAIPVLPQVDAACELLGLDPLYVANEGKLVAICAAADADAL
HHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHCCCCCEEEECCCCEEEEEECCCHHHH
LAAMRGHPLGREARRIGEVIEDGRHFVQMRTKFGGMRVVDWLSGEQLPRIC
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8352644; 12948488; 8021224