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The map label for this gene is nadC [H]

Identifier: 38234795

GI number: 38234795

Start: 2351642

End: 2352469

Strand: Direct

Name: nadC [H]

Synonym: DIP2259

Alternate gene names: 38234795

Gene position: 2351642-2352469 (Clockwise)

Preceding gene: 38234794

Following gene: 38234797

Centisome position: 94.5

GC content: 46.38

Gene sequence:

>828_bases
ATGGATGTTATAAACAATGCCCTTAATGAAGATCTATGTTATGGTCCTGACGTCACAACAGAAGCAATTTTTGGGCTAGA
AAAAGCCGAGGTGCAATTTGCAGCACGTGCCCATGGGGTTCTGGCCGGATCTAGGATAGCAGAGGAAGTTTTTCGCACGT
ACGCTACGCAATTGAAAATGCGAATTGACACCGAAGTTCTGATTGAGGACGGCGAGGTGGTCGCCCCAGGAGACGTCATC
TTAAGGATTTCTGGCCCGCTGCGTGTTCTTCTTACCGCAGAGCGCGTTGCACTCAACATAGTTTCACATTTATCAGGAAT
AGCTACACATACCTCGAAATGGGTCAAGCAAGTCGCAGGTACAGAAACTCGCATTCGAGATACACGCAAAACGCTGCCTG
GACTTAGGCAGTTGCAAAAATATGCTGTGGTATGCGGTGGAGGAATAAATCATCGCATGGGGCTTGGGGATGCTGCCTTG
ATCAAAGATAACCACATAGCTTATCGGGGGATTAAAGATTGTGTATCTATTATTCGTAAAGCACATCCACACATATCGAT
TGAAGTCGAATGTGACACGTTGACACAGGTTGCTGAAGCCCTTGACTCGGGAGTGCGACTCATTTTGCTCGATAATATGT
CTGTTGACCAAGTAAAAATCGCCGTAGATATGTGCCGAAAAGCTCCACACCCTGTAGAAATAGAAGCTTCAGGCGGTTTA
ACGCTAGATGTTGCTTTATCTTATGCGCAGACTGGTGTTAACTATTTAGCGGTGGGAGAGCTTACGCATTCGGTGCGAGC
ACTAGATATCGGTTGTGATGTGAATTAG

Upstream 100 bases:

>100_bases
AAAACCATGAATACACAAAACCCACTCCGCGTGCGCGCGTTATGGAAAATCTCGATGCATGTAATCTTCGTTTGGTTAAA
GAAGCGGTAGGACAGCAGCC

Downstream 100 bases:

>100_bases
TTTTCGGAAATGGGAGCTGTGTAATTCTAGATATCTAAGTTTTAACGGGCTGATTCCGATATTTCATCGGTTTCAGACCG
TTAATTGTTGGTAGTACCGC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MDVINNALNEDLCYGPDVTTEAIFGLEKAEVQFAARAHGVLAGSRIAEEVFRTYATQLKMRIDTEVLIEDGEVVAPGDVI
LRISGPLRVLLTAERVALNIVSHLSGIATHTSKWVKQVAGTETRIRDTRKTLPGLRQLQKYAVVCGGGINHRMGLGDAAL
IKDNHIAYRGIKDCVSIIRKAHPHISIEVECDTLTQVAEALDSGVRLILLDNMSVDQVKIAVDMCRKAPHPVEIEASGGL
TLDVALSYAQTGVNYLAVGELTHSVRALDIGCDVN

Sequences:

>Translated_275_residues
MDVINNALNEDLCYGPDVTTEAIFGLEKAEVQFAARAHGVLAGSRIAEEVFRTYATQLKMRIDTEVLIEDGEVVAPGDVI
LRISGPLRVLLTAERVALNIVSHLSGIATHTSKWVKQVAGTETRIRDTRKTLPGLRQLQKYAVVCGGGINHRMGLGDAAL
IKDNHIAYRGIKDCVSIIRKAHPHISIEVECDTLTQVAEALDSGVRLILLDNMSVDQVKIAVDMCRKAPHPVEIEASGGL
TLDVALSYAQTGVNYLAVGELTHSVRALDIGCDVN
>Mature_275_residues
MDVINNALNEDLCYGPDVTTEAIFGLEKAEVQFAARAHGVLAGSRIAEEVFRTYATQLKMRIDTEVLIEDGEVVAPGDVI
LRISGPLRVLLTAERVALNIVSHLSGIATHTSKWVKQVAGTETRIRDTRKTLPGLRQLQKYAVVCGGGINHRMGLGDAAL
IKDNHIAYRGIKDCVSIIRKAHPHISIEVECDTLTQVAEALDSGVRLILLDNMSVDQVKIAVDMCRKAPHPVEIEASGGL
TLDVALSYAQTGVNYLAVGELTHSVRALDIGCDVN

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=279, Percent_Identity=31.1827956989247, Blast_Score=129, Evalue=3e-30,
Organism=Escherichia coli, GI1786299, Length=274, Percent_Identity=39.4160583941606, Blast_Score=171, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6321162, Length=254, Percent_Identity=33.4645669291339, Blast_Score=121, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29740; Mature: 29740

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVINNALNEDLCYGPDVTTEAIFGLEKAEVQFAARAHGVLAGSRIAEEVFRTYATQLKM
CCHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIDTEVLIEDGEVVAPGDVILRISGPLRVLLTAERVALNIVSHLSGIATHTSKWVKQVAG
EECEEEEEECCCEECCCCEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TETRIRDTRKTLPGLRQLQKYAVVCGGGINHRMGLGDAALIKDNHIAYRGIKDCVSIIRK
CHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEEECCCCHHHCHHHHHHHHHH
AHPHISIEVECDTLTQVAEALDSGVRLILLDNMSVDQVKIAVDMCRKAPHPVEIEASGGL
CCCCEEEEEEHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCE
TLDVALSYAQTGVNYLAVGELTHSVRALDIGCDVN
EEEEEHHHHHCCCCEEEEHHHHHCEEEEEECCCCC
>Mature Secondary Structure
MDVINNALNEDLCYGPDVTTEAIFGLEKAEVQFAARAHGVLAGSRIAEEVFRTYATQLKM
CCHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIDTEVLIEDGEVVAPGDVILRISGPLRVLLTAERVALNIVSHLSGIATHTSKWVKQVAG
EECEEEEEECCCEECCCCEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TETRIRDTRKTLPGLRQLQKYAVVCGGGINHRMGLGDAALIKDNHIAYRGIKDCVSIIRK
CHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEEECCCCHHHCHHHHHHHHHH
AHPHISIEVECDTLTQVAEALDSGVRLILLDNMSVDQVKIAVDMCRKAPHPVEIEASGGL
CCCCEEEEEEHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCE
TLDVALSYAQTGVNYLAVGELTHSVRALDIGCDVN
EEEEEHHHHHCCCCEEEEHHHHHCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036; 9862811 [H]