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The map label for this gene is argC

Identifier: 38233757

GI number: 38233757

Start: 1159280

End: 1160323

Strand: Direct

Name: argC

Synonym: DIP1167

Alternate gene names: 38233757

Gene position: 1159280-1160323 (Clockwise)

Preceding gene: 38233756

Following gene: 38233758

Centisome position: 46.58

GC content: 47.7

Gene sequence:

>1044_bases
ATGAATATAAAGGTAGCTATCGTTGGGGCGAGTGGATATGCCGGAGGAGAAATCCTTCGGCTTTTACTGCAACATCCGTT
GTATTTATCGGGTCAGCTGAGCATTGGAGCGCTGATGGGCTCTTCAACTGTTGGCCAGACAGTTAGCGAACTCATGCCGC
ATCTTCCCGAATTGTCGGATCGTGTTGTCGAGCCGACTGATGTTGAGACACTAAAAAGTCATGATGTCGTATTTTTAGCG
TTGCCACATGGGTTTTCTGCGGAAATTGCTCAGCAGCTTCCTGCTGAAATTACGGTGATTGACTGTGCTGCAGATTTTCG
ACTTAAAGATCAAAAAGACTGGGATGCGTACTATGGGGGAAAACATGCAGGTTCATGGCCGTATGGCATCCCAGAAATGC
CTGGGCATAGGGATTTGATTGCATCATCAAAGCGTATTGCGGTGCCGGGATGTTTTCCGACAGGTGCAACGCTTGCACTT
TTGCCGGCAATTGCCGCTCACATTATTGAACCTGACGTTTCTGTTGTCTCAATTACCGGAGTGTCTGGAGCTGGTAAAAA
GGCATCAGTTGCCATGCTGGGCGCAGAGACAATGGGTTCGTTGAAGGCCTATAACGTGGCCGGAAAGCATCGACATACCC
CTGAGATATCACAAAATCTTAGTGAATATGCAGACCAAAAAATTGTCGTTAGCTTTACTCCTGTTTTGGCTCCGCTTCCT
CGTGGAATTCTTACTACCGCAACGGCAAAGTTAACTAGCGGGATTACGCTTGATGAAATTCGGGAGATCTACCTCAATGC
GTATGAGAATGAGCCCTTTGTTCATATATTGCCGTCGGGCCAGCAGCCGCAGACCCAGGCAGTCGTAGGTTCCAATATGT
GTCACATTCAAGTTGATGCGGACGATAATTCGAAAAAACTAGTCGTTACCTCTGCGATTGACAATCTAACAAAGGGTACA
GCTGGGGCTGCAGTTCAATGTATGAATTTATCCCTCGGGGTTTCCGAAACTTCAGGTCTACCTTGTGGTGGTGTTGCGCC
ATAG

Upstream 100 bases:

>100_bases
CCCCATGTCAATGAAGTAATTTTTCACTGGCACGGGGATTTTATTATATTAATGGCGAATACTTTACATTTGAATGCATA
GTATGTGTATGATGGCTGCT

Downstream 100 bases:

>100_bases
GGAATTGAAAATCCTCCACTATGAGATTAAACGGGGTAGCGTACAACACAACTGGCAATGCGAAGGGAATTAACATGAGT
TCACGAGGAGTAACTGCTCC

Product: N-acetyl-gamma-glutamyl-phosphate reductase

Products: NA

Alternate protein names: AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MNIKVAIVGASGYAGGEILRLLLQHPLYLSGQLSIGALMGSSTVGQTVSELMPHLPELSDRVVEPTDVETLKSHDVVFLA
LPHGFSAEIAQQLPAEITVIDCAADFRLKDQKDWDAYYGGKHAGSWPYGIPEMPGHRDLIASSKRIAVPGCFPTGATLAL
LPAIAAHIIEPDVSVVSITGVSGAGKKASVAMLGAETMGSLKAYNVAGKHRHTPEISQNLSEYADQKIVVSFTPVLAPLP
RGILTTATAKLTSGITLDEIREIYLNAYENEPFVHILPSGQQPQTQAVVGSNMCHIQVDADDNSKKLVVTSAIDNLTKGT
AGAAVQCMNLSLGVSETSGLPCGGVAP

Sequences:

>Translated_347_residues
MNIKVAIVGASGYAGGEILRLLLQHPLYLSGQLSIGALMGSSTVGQTVSELMPHLPELSDRVVEPTDVETLKSHDVVFLA
LPHGFSAEIAQQLPAEITVIDCAADFRLKDQKDWDAYYGGKHAGSWPYGIPEMPGHRDLIASSKRIAVPGCFPTGATLAL
LPAIAAHIIEPDVSVVSITGVSGAGKKASVAMLGAETMGSLKAYNVAGKHRHTPEISQNLSEYADQKIVVSFTPVLAPLP
RGILTTATAKLTSGITLDEIREIYLNAYENEPFVHILPSGQQPQTQAVVGSNMCHIQVDADDNSKKLVVTSAIDNLTKGT
AGAAVQCMNLSLGVSETSGLPCGGVAP
>Mature_347_residues
MNIKVAIVGASGYAGGEILRLLLQHPLYLSGQLSIGALMGSSTVGQTVSELMPHLPELSDRVVEPTDVETLKSHDVVFLA
LPHGFSAEIAQQLPAEITVIDCAADFRLKDQKDWDAYYGGKHAGSWPYGIPEMPGHRDLIASSKRIAVPGCFPTGATLAL
LPAIAAHIIEPDVSVVSITGVSGAGKKASVAMLGAETMGSLKAYNVAGKHRHTPEISQNLSEYADQKIVVSFTPVLAPLP
RGILTTATAKLTSGITLDEIREIYLNAYENEPFVHILPSGQQPQTQAVVGSNMCHIQVDADDNSKKLVVTSAIDNLTKGT
AGAAVQCMNLSLGVSETSGLPCGGVAP

Specific function: Arginine biosynthesis; third step. [C]

COG id: COG0002

COG function: function code E; Acetylglutamate semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1790396, Length=350, Percent_Identity=37.1428571428571, Blast_Score=174, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6320913, Length=343, Percent_Identity=29.4460641399417, Blast_Score=118, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGC_CORDI (Q6NHH0)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939524.1
- ProteinModelPortal:   Q6NHH0
- SMR:   Q6NHH0
- GeneID:   2648567
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1167
- NMPDR:   fig|257309.1.peg.1115
- HOGENOM:   HBG294213
- OMA:   VCRIAVH
- PhylomeDB:   Q6NHH0
- ProtClustDB:   PRK00436
- BioCyc:   CDIP257309:DIP1167-MONOMER
- BRENDA:   1.2.1.38
- GO:   GO:0005737
- HAMAP:   MF_00150
- InterPro:   IPR023013
- InterPro:   IPR000706
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280
- Gene3D:   G3DSA:3.40.50.720
- SMART:   SM00859
- TIGRFAMs:   TIGR01850

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC

EC number: =1.2.1.38

Molecular weight: Translated: 36437; Mature: 36437

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS01224 ARGC

Important sites: ACT_SITE 151-151

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKVAIVGASGYAGGEILRLLLQHPLYLSGQLSIGALMGSSTVGQTVSELMPHLPELSD
CCEEEEEEECCCCCHHHHHHHHHHCCCEEECCEEEEEEECCCHHHHHHHHHHHCCCCHHH
RVVEPTDVETLKSHDVVFLALPHGFSAEIAQQLPAEITVIDCAADFRLKDQKDWDAYYGG
HCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHCCCEEEEEEEECCCEECCCCCCHHHCCC
KHAGSWPYGIPEMPGHRDLIASSKRIAVPGCFPTGATLALLPAIAAHIIEPDVSVVSITG
CCCCCCCCCCCCCCCCHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEC
VSGAGKKASVAMLGAETMGSLKAYNVAGKHRHTPEISQNLSEYADQKIVVSFTPVLAPLP
CCCCCCCCEEEEECHHHHCCEEEEECCCCCCCCCHHHHHHHHHCCCEEEEEECCHHHHCC
RGILTTATAKLTSGITLDEIREIYLNAYENEPFVHILPSGQQPQTQAVVGSNMCHIQVDA
CCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHCCCEEEEEEEC
DDNSKKLVVTSAIDNLTKGTAGAAVQCMNLSLGVSETSGLPCGGVAP
CCCCCEEEEEECHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MNIKVAIVGASGYAGGEILRLLLQHPLYLSGQLSIGALMGSSTVGQTVSELMPHLPELSD
CCEEEEEEECCCCCHHHHHHHHHHCCCEEECCEEEEEEECCCHHHHHHHHHHHCCCCHHH
RVVEPTDVETLKSHDVVFLALPHGFSAEIAQQLPAEITVIDCAADFRLKDQKDWDAYYGG
HCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHCCCEEEEEEEECCCEECCCCCCHHHCCC
KHAGSWPYGIPEMPGHRDLIASSKRIAVPGCFPTGATLALLPAIAAHIIEPDVSVVSITG
CCCCCCCCCCCCCCCCHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEC
VSGAGKKASVAMLGAETMGSLKAYNVAGKHRHTPEISQNLSEYADQKIVVSFTPVLAPLP
CCCCCCCCEEEEECHHHHCCEEEEECCCCCCCCCHHHHHHHHHCCCEEEEEECCHHHHCC
RGILTTATAKLTSGITLDEIREIYLNAYENEPFVHILPSGQQPQTQAVVGSNMCHIQVDA
CCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHCCCEEEEEEEC
DDNSKKLVVTSAIDNLTKGTAGAAVQCMNLSLGVSETSGLPCGGVAP
CCCCCEEEEEECHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910