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The map label for this gene is mtrB [H]

Identifier: 38233302

GI number: 38233302

Start: 669450

End: 670892

Strand: Direct

Name: mtrB [H]

Synonym: DIP0695

Alternate gene names: 38233302

Gene position: 669450-670892 (Clockwise)

Preceding gene: 38233301

Following gene: 38233303

Centisome position: 26.9

GC content: 52.95

Gene sequence:

>1443_bases
TTGGTCAGTTTTGTTACCCAGCGATTGGTTAACACAAAACTGGATGTTGCCAGTTCTGAAATCGATCGAGCCCGTGCTTC
AGTCGAGCAACAGATTGAATCAACAGGCTCATCGAGCAGCGTGCAAGTTCGACTCAATTCCGCGCGCGCGGTACTGACCA
GTAGGGCAACAAGCGCGGACGATACGGCTGCCTATGAGCCTGTTCTTGTGGTGTCTAACCCCGATGGATCCACTGTTACT
TCTCCTGAAGGCTACCGCATTCCTGAACGATTGCGTAGCTTTGTAGACCAAGGGCAAGTCTCGTATCAATTTGCCACTAT
TGACCGTGTTGATGGCAGCACATACAAAGCCCTCATCATTGGTAGCCCTACGGCTTCTGATATTCCCAACACCCAGGTGT
ATTTGGTGTTGTCGATGGAATCGGATGAGGCAACTCTTGCGCTGCTACGCGGCCTATTTTCCGGTGCAGCGGTAGTCCTT
GTTGTGCTCCTCGTGGGAATCACATGGTTGCTCACGCAGCAGGTGATTACTCCTGTGCGTTCGGCTTCGCGTATTGCCGA
GCGTTTCAGTTCGGGTCATCTGCGCGAACGCATGGTGGTTACGGGTGAAGATGAGATGGCACGACTAGCGATGAGCTTTA
ACTCGATGGCGGAGTCTTTGTCGCGGCAGATTCATCAGCTGGAAGAATACGGCAACCTGCAAAAACAGTTTACGTCGGAT
GTCTCACATGAGTTGCGTACACCGTTGACAACGGTACGTATGGCTGCTGATCTCATTGTGGACGAAGCCGATGACCTTTC
TCCTGGCACTCGACGAGCCTCGGAGTTGATGGTGCGTGAACTTGATCGCTTTGAGGCGTTGTTGGCGGATCTGCTGGAGA
TCTCGCGACATGATGCCGGTGTAGCTGATCTTGCCGAAACAACCCTCGATATTCGAATTTGTATTTCTTCAGCGCATCAG
CAAGTAGACCATCTTGCCCAAGAGCTCGGTGTAGACATCATCATTGATGTCCCTGAAAAACCGGTAGAGATTAAGGGCGA
TTCCCGTCGTATCGAGCGAATCCTTCGTAATCTTTTGGCCAACGCAATTGACCATTCTGAGGGAAAACCAGTCACCTTGC
TGTGCCGTGAAAATGACGAGGCTGTATCCGTCGCGGTTATCGACCACGGGGTGGGCCTGAAGCCTGGTCAAGAAGACCTA
GTATTTAATCGCTTTTGGCGAGCGGATCCTTCTCGAGTCCGCCACTCCGGAGGCACCGGTTTGGGCCTTGCCATCTCCCG
AGAAGACGCCATTTTGCATGGTGGCCAGCTCAGTGCTGCGGGCCGCCCAGGGGTTGGATCTATGTTCCTGTTGACGGTCC
CTCGTGTGCCTAAACGATCATTTACCGAAACCCCTATTGAGTTAGCTGCCCCAGAGCCCCCGTTGGAGGACACCGATGCG
TAA

Upstream 100 bases:

>100_bases
TCATCGCATTGCAGAACTGTGGCGTACCTCGTTGCAATTTAAGGTTCTAGGCTCCATTTTTGCCGCTTCACTCGTGGTGA
TGATGGTGCTGGCATTTGTC

Downstream 100 bases:

>100_bases
CCATGTTTCGAGGTATCTCACAGCATTGATCGCTGTGGGTTGTGCCGCAACAACCGCTGCATGTACATCGTTGCCGTCGA
ACTCGGAACCTCAGGCGTTA

Product: putative two component system sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MVSFVTQRLVNTKLDVASSEIDRARASVEQQIESTGSSSSVQVRLNSARAVLTSRATSADDTAAYEPVLVVSNPDGSTVT
SPEGYRIPERLRSFVDQGQVSYQFATIDRVDGSTYKALIIGSPTASDIPNTQVYLVLSMESDEATLALLRGLFSGAAVVL
VVLLVGITWLLTQQVITPVRSASRIAERFSSGHLRERMVVTGEDEMARLAMSFNSMAESLSRQIHQLEEYGNLQKQFTSD
VSHELRTPLTTVRMAADLIVDEADDLSPGTRRASELMVRELDRFEALLADLLEISRHDAGVADLAETTLDIRICISSAHQ
QVDHLAQELGVDIIIDVPEKPVEIKGDSRRIERILRNLLANAIDHSEGKPVTLLCRENDEAVSVAVIDHGVGLKPGQEDL
VFNRFWRADPSRVRHSGGTGLGLAISREDAILHGGQLSAAGRPGVGSMFLLTVPRVPKRSFTETPIELAAPEPPLEDTDA

Sequences:

>Translated_480_residues
MVSFVTQRLVNTKLDVASSEIDRARASVEQQIESTGSSSSVQVRLNSARAVLTSRATSADDTAAYEPVLVVSNPDGSTVT
SPEGYRIPERLRSFVDQGQVSYQFATIDRVDGSTYKALIIGSPTASDIPNTQVYLVLSMESDEATLALLRGLFSGAAVVL
VVLLVGITWLLTQQVITPVRSASRIAERFSSGHLRERMVVTGEDEMARLAMSFNSMAESLSRQIHQLEEYGNLQKQFTSD
VSHELRTPLTTVRMAADLIVDEADDLSPGTRRASELMVRELDRFEALLADLLEISRHDAGVADLAETTLDIRICISSAHQ
QVDHLAQELGVDIIIDVPEKPVEIKGDSRRIERILRNLLANAIDHSEGKPVTLLCRENDEAVSVAVIDHGVGLKPGQEDL
VFNRFWRADPSRVRHSGGTGLGLAISREDAILHGGQLSAAGRPGVGSMFLLTVPRVPKRSFTETPIELAAPEPPLEDTDA
>Mature_480_residues
MVSFVTQRLVNTKLDVASSEIDRARASVEQQIESTGSSSSVQVRLNSARAVLTSRATSADDTAAYEPVLVVSNPDGSTVT
SPEGYRIPERLRSFVDQGQVSYQFATIDRVDGSTYKALIIGSPTASDIPNTQVYLVLSMESDEATLALLRGLFSGAAVVL
VVLLVGITWLLTQQVITPVRSASRIAERFSSGHLRERMVVTGEDEMARLAMSFNSMAESLSRQIHQLEEYGNLQKQFTSD
VSHELRTPLTTVRMAADLIVDEADDLSPGTRRASELMVRELDRFEALLADLLEISRHDAGVADLAETTLDIRICISSAHQ
QVDHLAQELGVDIIIDVPEKPVEIKGDSRRIERILRNLLANAIDHSEGKPVTLLCRENDEAVSVAVIDHGVGLKPGQEDL
VFNRFWRADPSRVRHSGGTGLGLAISREDAILHGGQLSAAGRPGVGSMFLLTVPRVPKRSFTETPIELAAPEPPLEDTDA

Specific function: Member of the two-component regulatory system mtrA/mtrB. Seems to function as a membrane-associated protein kinase that phosphorylates mtrA in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=340, Percent_Identity=27.3529411764706, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787894, Length=278, Percent_Identity=32.3741007194245, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790346, Length=284, Percent_Identity=29.2253521126761, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=27.7580071174377, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789149, Length=372, Percent_Identity=24.1935483870968, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786912, Length=262, Percent_Identity=31.2977099236641, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI145693157, Length=244, Percent_Identity=28.2786885245902, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786600, Length=234, Percent_Identity=27.7777777777778, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87081816, Length=346, Percent_Identity=26.878612716763, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=27.8026905829596, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=300, Percent_Identity=23.6666666666667, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1788549, Length=245, Percent_Identity=26.1224489795918, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788713, Length=229, Percent_Identity=26.6375545851528, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=25.4464285714286, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082128, Length=307, Percent_Identity=23.4527687296417, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790551, Length=214, Percent_Identity=28.5046728971963, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1789403, Length=222, Percent_Identity=29.2792792792793, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790861, Length=294, Percent_Identity=25.1700680272109, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1789808, Length=301, Percent_Identity=24.5847176079734, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52252; Mature: 52252

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSFVTQRLVNTKLDVASSEIDRARASVEQQIESTGSSSSVQVRLNSARAVLTSRATSAD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCCCC
DTAAYEPVLVVSNPDGSTVTSPEGYRIPERLRSFVDQGQVSYQFATIDRVDGSTYKALII
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEE
GSPTASDIPNTQVYLVLSMESDEATLALLRGLFSGAAVVLVVLLVGITWLLTQQVITPVR
ECCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SASRIAERFSSGHLRERMVVTGEDEMARLAMSFNSMAESLSRQIHQLEEYGNLQKQFTSD
HHHHHHHHHHCCCCHHCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSHELRTPLTTVRMAADLIVDEADDLSPGTRRASELMVRELDRFEALLADLLEISRHDAG
HHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VADLAETTLDIRICISSAHQQVDHLAQELGVDIIIDVPEKPVEIKGDSRRIERILRNLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCHHHHHHHHHHHHH
NAIDHSEGKPVTLLCRENDEAVSVAVIDHGVGLKPGQEDLVFNRFWRADPSRVRHSGGTG
HHHCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCC
LGLAISREDAILHGGQLSAAGRPGVGSMFLLTVPRVPKRSFTETPIELAAPEPPLEDTDA
EEEEEECCCCEEECCEECCCCCCCCCCEEEEECCCCCCCCCCCCCCEECCCCCCCCCCCC
>Mature Secondary Structure
MVSFVTQRLVNTKLDVASSEIDRARASVEQQIESTGSSSSVQVRLNSARAVLTSRATSAD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCCCC
DTAAYEPVLVVSNPDGSTVTSPEGYRIPERLRSFVDQGQVSYQFATIDRVDGSTYKALII
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEE
GSPTASDIPNTQVYLVLSMESDEATLALLRGLFSGAAVVLVVLLVGITWLLTQQVITPVR
ECCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SASRIAERFSSGHLRERMVVTGEDEMARLAMSFNSMAESLSRQIHQLEEYGNLQKQFTSD
HHHHHHHHHHCCCCHHCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSHELRTPLTTVRMAADLIVDEADDLSPGTRRASELMVRELDRFEALLADLLEISRHDAG
HHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VADLAETTLDIRICISSAHQQVDHLAQELGVDIIIDVPEKPVEIKGDSRRIERILRNLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCHHHHHHHHHHHHH
NAIDHSEGKPVTLLCRENDEAVSVAVIDHGVGLKPGQEDLVFNRFWRADPSRVRHSGGTG
HHHCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCC
LGLAISREDAILHGGQLSAAGRPGVGSMFLLTVPRVPKRSFTETPIELAAPEPPLEDTDA
EEEEEECCCCEEECCEECCCCCCCCCCEEEEECCCCCCCCCCCCCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA