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The map label for this gene is moaA [H]

Identifier: 38233119

GI number: 38233119

Start: 476407

End: 477438

Strand: Reverse

Name: moaA [H]

Synonym: DIP0507

Alternate gene names: 38233119

Gene position: 477438-476407 (Counterclockwise)

Preceding gene: 38233120

Following gene: 38233118

Centisome position: 19.18

GC content: 49.71

Gene sequence:

>1032_bases
ATGCGTTCTGCTCCTCACCCAACCTATGATCTGATTGATTCTTTTGGAAGAACCGCAACTGATCTTCGCGTTTCCCTTAC
AGATAAATGCAACCTTCGCTGCACCTACTGTATGCCGGCAGAAGGTCTTCAGTGGATGCCCAGCCCGCAGGTTCTTACGG
ATGACGAGGTTATCAGGCTTGTCAGCATTGCAGTTACTCGCCTGAATGTCACCTCTGTTCGTTTTACTGGCGGAGAACCT
CTGTTAAGAAAATCGCTTGAGAGTATTGTTTCTACTACTAGCTCTTTGCGCACGCCGCAAGGCACGTCGCCAAGCATTGC
GTTGACGACGAATGGACTAGGTCTTGATAAAAGAATCACTGGCCTTGTGGATGCGGGATTAGATCGCATCAATATTTCTC
TCGATTCTCTTGATCCACAGCGCTATGCGGAGTTAAGTAGGCGTGCTCGTCTTGATGATGTGTTAAAGGGGATCGACGCT
GCTGTGCGCACTGGAATCGCACCGATCAAAATTAATACTGTGGTCATGCCTGGGGTCAATGAAGATGATATTGTGCCGCT
GGCGCGATATTGCTTGAGCACAGGGCTGCAATTACGGTTTATTGAGCAGATGCCTATTGGCGCTGAGGGGAACTGGGATA
AATCATCTATGATCACAGCAGCCCAAATTCTGGAGGTTCTTTCGAGTGAGATTGAATTATCGGAAGCCTCGCAGCCGCGC
GGTCATGCGCCTGCTGAGTTGTGGAACGCTTCTTATCAGGGGATACAGGGCAGCATTGGTGTGATCGCAGCAGTCACGCA
GCCCTTCTGTGGTGCTTGTGATCGTACAAGGCTCACTGCGGATGGTTCCATCCGTAATTGTTTGTTTGCTCATGATGAGT
TCTCACTCCGGGATCTCATGCGTGATGGTGCTAGTGATGATGAGTTAGCGCAAGCATGGAAGGGGCACGCGTACATTAAA
GCAGCAGGCCATGGAATTAATGACCTAGGTTTTCTTAAACCAACCCGCACTATGTCTGCCATTGGTGGCTAA

Upstream 100 bases:

>100_bases
CGTAAAGCGAGTTTTTAGCGCACCAATGTTAGTATTAACACCAATTTTTCAAATAAAATCCATCTTAGTAGATTTCCTTC
AATGCTAGGTTACCTTTTGT

Downstream 100 bases:

>100_bases
TAAGCAAGGAGTTTCCCTTTTTCATGCTCACCCCCAAGATTTATCGTGAAACATGCATCGATCTTGCCCACAGCTTGGCA
CAGGCACGCACTGGCACGAT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MRSAPHPTYDLIDSFGRTATDLRVSLTDKCNLRCTYCMPAEGLQWMPSPQVLTDDEVIRLVSIAVTRLNVTSVRFTGGEP
LLRKSLESIVSTTSSLRTPQGTSPSIALTTNGLGLDKRITGLVDAGLDRINISLDSLDPQRYAELSRRARLDDVLKGIDA
AVRTGIAPIKINTVVMPGVNEDDIVPLARYCLSTGLQLRFIEQMPIGAEGNWDKSSMITAAQILEVLSSEIELSEASQPR
GHAPAELWNASYQGIQGSIGVIAAVTQPFCGACDRTRLTADGSIRNCLFAHDEFSLRDLMRDGASDDELAQAWKGHAYIK
AAGHGINDLGFLKPTRTMSAIGG

Sequences:

>Translated_343_residues
MRSAPHPTYDLIDSFGRTATDLRVSLTDKCNLRCTYCMPAEGLQWMPSPQVLTDDEVIRLVSIAVTRLNVTSVRFTGGEP
LLRKSLESIVSTTSSLRTPQGTSPSIALTTNGLGLDKRITGLVDAGLDRINISLDSLDPQRYAELSRRARLDDVLKGIDA
AVRTGIAPIKINTVVMPGVNEDDIVPLARYCLSTGLQLRFIEQMPIGAEGNWDKSSMITAAQILEVLSSEIELSEASQPR
GHAPAELWNASYQGIQGSIGVIAAVTQPFCGACDRTRLTADGSIRNCLFAHDEFSLRDLMRDGASDDELAQAWKGHAYIK
AAGHGINDLGFLKPTRTMSAIGG
>Mature_343_residues
MRSAPHPTYDLIDSFGRTATDLRVSLTDKCNLRCTYCMPAEGLQWMPSPQVLTDDEVIRLVSIAVTRLNVTSVRFTGGEP
LLRKSLESIVSTTSSLRTPQGTSPSIALTTNGLGLDKRITGLVDAGLDRINISLDSLDPQRYAELSRRARLDDVLKGIDA
AVRTGIAPIKINTVVMPGVNEDDIVPLARYCLSTGLQLRFIEQMPIGAEGNWDKSSMITAAQILEVLSSEIELSEASQPR
GHAPAELWNASYQGIQGSIGVIAAVTQPFCGACDRTRLTADGSIRNCLFAHDEFSLRDLMRDGASDDELAQAWKGHAYIK
AAGHGINDLGFLKPTRTMSAIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=343, Percent_Identity=37.9008746355685, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI22027536, Length=343, Percent_Identity=37.9008746355685, Blast_Score=225, Evalue=5e-59,
Organism=Escherichia coli, GI1786999, Length=340, Percent_Identity=34.1176470588235, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI32566329, Length=339, Percent_Identity=38.6430678466077, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17561210, Length=339, Percent_Identity=38.9380530973451, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI32566331, Length=322, Percent_Identity=38.1987577639752, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI28574488, Length=336, Percent_Identity=40.1785714285714, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI28574490, Length=299, Percent_Identity=41.8060200668896, Blast_Score=218, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37086; Mature: 37086

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00136 SUBTILASE_ASP ; PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSAPHPTYDLIDSFGRTATDLRVSLTDKCNLRCTYCMPAEGLQWMPSPQVLTDDEVIRL
CCCCCCCCHHHHHHHCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHH
VSIAVTRLNVTSVRFTGGEPLLRKSLESIVSTTSSLRTPQGTSPSIALTTNGLGLDKRIT
HHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHH
GLVDAGLDRINISLDSLDPQRYAELSRRARLDDVLKGIDAAVRTGIAPIKINTVVMPGVN
HHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCC
EDDIVPLARYCLSTGLQLRFIEQMPIGAEGNWDKSSMITAAQILEVLSSEIELSEASQPR
CCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
GHAPAELWNASYQGIQGSIGVIAAVTQPFCGACDRTRLTADGSIRNCLFAHDEFSLRDLM
CCCCHHHHCCHHCCCCCCCCEEEEHHCHHCCCCCCCEEECCCCHHHEEEECCCHHHHHHH
RDGASDDELAQAWKGHAYIKAAGHGINDLGFLKPTRTMSAIGG
HCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHCCC
>Mature Secondary Structure
MRSAPHPTYDLIDSFGRTATDLRVSLTDKCNLRCTYCMPAEGLQWMPSPQVLTDDEVIRL
CCCCCCCCHHHHHHHCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHH
VSIAVTRLNVTSVRFTGGEPLLRKSLESIVSTTSSLRTPQGTSPSIALTTNGLGLDKRIT
HHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHH
GLVDAGLDRINISLDSLDPQRYAELSRRARLDDVLKGIDAAVRTGIAPIKINTVVMPGVN
HHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCC
EDDIVPLARYCLSTGLQLRFIEQMPIGAEGNWDKSSMITAAQILEVLSSEIELSEASQPR
CCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
GHAPAELWNASYQGIQGSIGVIAAVTQPFCGACDRTRLTADGSIRNCLFAHDEFSLRDLM
CCCCHHHHCCHHCCCCCCCCEEEEHHCHHCCCCCCCEEECCCCHHHEEEECCCHHHHHHH
RDGASDDELAQAWKGHAYIKAAGHGINDLGFLKPTRTMSAIGG
HCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA