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The map label for this gene is moaE2 [H]

Identifier: 38233118

GI number: 38233118

Start: 475157

End: 476383

Strand: Reverse

Name: moaE2 [H]

Synonym: DIP0506

Alternate gene names: 38233118

Gene position: 476383-475157 (Counterclockwise)

Preceding gene: 38233119

Following gene: 38233117

Centisome position: 19.14

GC content: 54.77

Gene sequence:

>1227_bases
ATGCTCACCCCCAAGATTTATCGTGAAACATGCATCGATCTTGCCCACAGCTTGGCACAGGCACGCACTGGCACGATCAC
TGTATCCCCTCATGATGCTGCAATTGATTGCCTGACTCTTGCCCACGATATTCATGCTGTGTTGCCCATCCCTCCCATGG
ATAATTCCGCGATGGATGGTTTTCTCGTGCGCACTGCTGATCTTGTTGGTTCTGCACCGTGGAGCTTCCCTGTGGCGGGA
GATGTCCCTGCTGGTGCAGCCCCCATGGAGGTGCCCCCTGGTCGCGCTGTGCGAATTATGACTGGCGCCGAAGTTATCGG
TGAGAACGTCACTGTCATTCCGGTGGAAAAGACCAATATTCCCGCAGGCCCTACCACCTGCCCGTCGCATATTGTGGTCC
ATGAGGCCGATGCCCAACCGCGGCATATTCGTCGTCGTGGGGAAAATGTTCAGCCGGGTCAGTGCATTGCTACACGTGGT
CAGCGTGTTGATGCAGGTACGCTCGCAGCGATTGTGTCCTGTGGTGTCCGCGAGATTGAGGTTTTACCGCGTCTGCGTGT
GACTGTGATTGCTACTGGCAATGAGCTAGGTGATAGTGACGCCGATTCTCTCAAGCGCGCCCATATTCCTGATTCTAATT
CACCGATGATCGCGCAGCTGGTGCACGATACTGGCTTGGCCACTGTAAACATCGTACGCATGTGCGATGATATTGCTGCT
TTTGGCAGCGCGATAAGTGCAGCCGCTAATTCCTCTGATCTCATTATCACTACTGGTGGTATTTCTGCGGGAGCCTTTGA
TGTGGTCAAAGAATCGCTTTCATCCCATAAGGATTCCACCATGTGGTTTGGCGCAGTTGCCATGCAACCAGGTAAGCCGC
AGGGTCATGGACGAGTTGGCAACACCATGATTACGTGTCTACCGGGTAATCCTGTGAGTGCTTTTGTGTCTTTCCAGCTC
TTTGTTCGCCCTGCGCTGTACACACTTGCGGGGCTGCAGCCGCCAGCGTTGGGGTATCTAGAAGCTGACATTCAGGGTAC
ACTGCCTACCCCACGGGGCCGGGATATATTTGTGCCTGCGACGGTGACCTACGTCGATACGTGGCAGGCGCAGCCAGCGG
CTTTCGGCTCGCATTTTATTGGCTCACTGGTGGGGGTTAATGCGCTCATTCATGTGCCAGCCGACGCCCACCGCGTAGCG
CCTCGTGTTATCCCTCTAACTTTTTAA

Upstream 100 bases:

>100_bases
TTAAAGCAGCAGGCCATGGAATTAATGACCTAGGTTTTCTTAAACCAACCCGCACTATGTCTGCCATTGGTGGCTAATAA
GCAAGGAGTTTCCCTTTTTC

Downstream 100 bases:

>100_bases
TCAAGGACTTTTATTATGTTTACACATCTTAATAACAACGGTTCCGCCTACATGGTGGATGTAACGCATAAGCAAGTATC
GGTGCGCAGCGCTACCGCGG

Product: putative molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase 2 [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MLTPKIYRETCIDLAHSLAQARTGTITVSPHDAAIDCLTLAHDIHAVLPIPPMDNSAMDGFLVRTADLVGSAPWSFPVAG
DVPAGAAPMEVPPGRAVRIMTGAEVIGENVTVIPVEKTNIPAGPTTCPSHIVVHEADAQPRHIRRRGENVQPGQCIATRG
QRVDAGTLAAIVSCGVREIEVLPRLRVTVIATGNELGDSDADSLKRAHIPDSNSPMIAQLVHDTGLATVNIVRMCDDIAA
FGSAISAAANSSDLIITTGGISAGAFDVVKESLSSHKDSTMWFGAVAMQPGKPQGHGRVGNTMITCLPGNPVSAFVSFQL
FVRPALYTLAGLQPPALGYLEADIQGTLPTPRGRDIFVPATVTYVDTWQAQPAAFGSHFIGSLVGVNALIHVPADAHRVA
PRVIPLTF

Sequences:

>Translated_408_residues
MLTPKIYRETCIDLAHSLAQARTGTITVSPHDAAIDCLTLAHDIHAVLPIPPMDNSAMDGFLVRTADLVGSAPWSFPVAG
DVPAGAAPMEVPPGRAVRIMTGAEVIGENVTVIPVEKTNIPAGPTTCPSHIVVHEADAQPRHIRRRGENVQPGQCIATRG
QRVDAGTLAAIVSCGVREIEVLPRLRVTVIATGNELGDSDADSLKRAHIPDSNSPMIAQLVHDTGLATVNIVRMCDDIAA
FGSAISAAANSSDLIITTGGISAGAFDVVKESLSSHKDSTMWFGAVAMQPGKPQGHGRVGNTMITCLPGNPVSAFVSFQL
FVRPALYTLAGLQPPALGYLEADIQGTLPTPRGRDIFVPATVTYVDTWQAQPAAFGSHFIGSLVGVNALIHVPADAHRVA
PRVIPLTF
>Mature_408_residues
MLTPKIYRETCIDLAHSLAQARTGTITVSPHDAAIDCLTLAHDIHAVLPIPPMDNSAMDGFLVRTADLVGSAPWSFPVAG
DVPAGAAPMEVPPGRAVRIMTGAEVIGENVTVIPVEKTNIPAGPTTCPSHIVVHEADAQPRHIRRRGENVQPGQCIATRG
QRVDAGTLAAIVSCGVREIEVLPRLRVTVIATGNELGDSDADSLKRAHIPDSNSPMIAQLVHDTGLATVNIVRMCDDIAA
FGSAISAAANSSDLIITTGGISAGAFDVVKESLSSHKDSTMWFGAVAMQPGKPQGHGRVGNTMITCLPGNPVSAFVSFQL
FVRPALYTLAGLQPPALGYLEADIQGTLPTPRGRDIFVPATVTYVDTWQAQPAAFGSHFIGSLVGVNALIHVPADAHRVA
PRVIPLTF

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=305, Percent_Identity=32.1311475409836, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI10880983, Length=305, Percent_Identity=32.1311475409836, Blast_Score=132, Evalue=7e-31,
Organism=Escherichia coli, GI1787049, Length=323, Percent_Identity=32.1981424148607, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25147659, Length=370, Percent_Identity=27.2972972972973, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17136978, Length=365, Percent_Identity=27.3972602739726, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24638841, Length=365, Percent_Identity=27.3972602739726, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42807; Mature: 42807

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTPKIYRETCIDLAHSLAQARTGTITVSPHDAAIDCLTLAHDIHAVLPIPPMDNSAMDG
CCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHEEECCCCCCCCCCCC
FLVRTADLVGSAPWSFPVAGDVPAGAAPMEVPPGRAVRIMTGAEVIGENVTVIPVEKTNI
EEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHCCCEEEEEEECCCC
PAGPTTCPSHIVVHEADAQPRHIRRRGENVQPGQCIATRGQRVDAGTLAAIVSCGVREIE
CCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCHHEE
VLPRLRVTVIATGNELGDSDADSLKRAHIPDSNSPMIAQLVHDTGLATVNIVRMCDDIAA
CCCCEEEEEEEECCCCCCCCHHHHHHCCCCCCCCCHHHEEHHHCCCHHHHHHHHHHHHHH
FGSAISAAANSSDLIITTGGISAGAFDVVKESLSSHKDSTMWFGAVAMQPGKPQGHGRVG
HHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCC
NTMITCLPGNPVSAFVSFQLFVRPALYTLAGLQPPALGYLEADIQGTLPTPRGRDIFVPA
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCEEEEEE
TVTYVDTWQAQPAAFGSHFIGSLVGVNALIHVPADAHRVAPRVIPLTF
EEEEEECCCCCCHHHHHHHHHHHHHCCEEEECCCCHHHCCCEEEEECC
>Mature Secondary Structure
MLTPKIYRETCIDLAHSLAQARTGTITVSPHDAAIDCLTLAHDIHAVLPIPPMDNSAMDG
CCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHEEECCCCCCCCCCCC
FLVRTADLVGSAPWSFPVAGDVPAGAAPMEVPPGRAVRIMTGAEVIGENVTVIPVEKTNI
EEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHCCCEEEEEEECCCC
PAGPTTCPSHIVVHEADAQPRHIRRRGENVQPGQCIATRGQRVDAGTLAAIVSCGVREIE
CCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCHHEE
VLPRLRVTVIATGNELGDSDADSLKRAHIPDSNSPMIAQLVHDTGLATVNIVRMCDDIAA
CCCCEEEEEEEECCCCCCCCHHHHHHCCCCCCCCCHHHEEHHHCCCHHHHHHHHHHHHHH
FGSAISAAANSSDLIITTGGISAGAFDVVKESLSSHKDSTMWFGAVAMQPGKPQGHGRVG
HHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCC
NTMITCLPGNPVSAFVSFQLFVRPALYTLAGLQPPALGYLEADIQGTLPTPRGRDIFVPA
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCEEEEEE
TVTYVDTWQAQPAAFGSHFIGSLVGVNALIHVPADAHRVAPRVIPLTF
EEEEEECCCCCCHHHHHHHHHHHHHCCEEEECCCCHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]