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The map label for this gene is ldh2 [H]

Identifier: 38233041

GI number: 38233041

Start: 391490

End: 392440

Strand: Reverse

Name: ldh2 [H]

Synonym: DIP0427

Alternate gene names: 38233041

Gene position: 392440-391490 (Counterclockwise)

Preceding gene: 38233042

Following gene: 38233035

Centisome position: 15.77

GC content: 57.2

Gene sequence:

>951_bases
ATGAACAAGCTAGTAGTGATAGGCCTCGGCCATGTGGGTTCATACGTACTGAGCTACGCCATGGCATCGGGGTTGTATGC
AGAAATTGCCACAATCGACACAAACCCAGGAGTAGCGCTCGGCGAGGCTATTGACCTAGCTCAAGCCACCGGCGTTCCGG
GAACCACCAACACCTACTGCCACGAGGGCACCTACGCAGACTGCGCCGATGCCGACGTTATTATCTGCGCAGCCGGCGAA
TCGATCGTCCCAGACCCTAACGATCCAACCCGTATGCCAGACCGCTCTGAACTCGCACAGATCAGCGGCGCAGTTATCCG
CGATGTAATGACAAATATCACCGCGAATGTCGGCGAGAATCCACCGGTACTCATTTTGATTACCAATCCGCTGGACGCAA
TGGTTCACATCGCAGCCACCGAGTTCGGTTACCCCAAGGTCTTTGGCACGGGCACCATGCTGGACTCCGCACGCCTACGC
TACATCATCGGCACTGAGCTGGGCATTGATCCCAAGTCCGTTACCGGCTACATGATGGGCGAACACGGCTCTACCTCCGT
ACCGATCCTCTCCCAGGTCAACGTCCAAGGCCTGCGCTGGGAGGAGCTAGAAGCTTGGCACGGAAAGCCACTACCAACTG
CTCCAGAGATGCAAGAAAAGGTCGTTCGCGCGGCTTACGACGTCCTCCTGTCAAAGGGCTGGACCAATGCTGGCGTAGCC
CGCTCGGCCAATGAGCTAGCCAAGTGCGTACTACTCAACGAGCGCGCTGTACACCCCATCTGTACCCCACTCCACGGCGA
GTACGGCCTCGAGGATGTTTCGCTCTCCATCCCCACCGAGATCACCCACGAAGGTGCTGGACGCAAAATGCTGCCCCAGC
TCAACGAATGGGAGCTAGAGCAGCTGCATAAGTCCGCAGAATTTATCCGCGAGACTGTTAGGAAGGCTTAA

Upstream 100 bases:

>100_bases
GAGGAAGACAAAGACATCGTGGCCCGCGCGTGGCGAGCAGCCGGTTGGGGTGTGACAAAAATCCGTGGCGGGTCCCCACT
GTGGGACTAAGCTCGATGGC

Downstream 100 bases:

>100_bases
CAGCCGAGTGAAGAGCCACGATGCCGAGGCTGAGATTTTGCCAGCCGGCATCGTGCCAGCCGTTTTCATTGATGGCCGCG
GCGAGTTCTTCTCGCTCCGG

Product: putative lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH 2 [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MNKLVVIGLGHVGSYVLSYAMASGLYAEIATIDTNPGVALGEAIDLAQATGVPGTTNTYCHEGTYADCADADVIICAAGE
SIVPDPNDPTRMPDRSELAQISGAVIRDVMTNITANVGENPPVLILITNPLDAMVHIAATEFGYPKVFGTGTMLDSARLR
YIIGTELGIDPKSVTGYMMGEHGSTSVPILSQVNVQGLRWEELEAWHGKPLPTAPEMQEKVVRAAYDVLLSKGWTNAGVA
RSANELAKCVLLNERAVHPICTPLHGEYGLEDVSLSIPTEITHEGAGRKMLPQLNEWELEQLHKSAEFIRETVRKA

Sequences:

>Translated_316_residues
MNKLVVIGLGHVGSYVLSYAMASGLYAEIATIDTNPGVALGEAIDLAQATGVPGTTNTYCHEGTYADCADADVIICAAGE
SIVPDPNDPTRMPDRSELAQISGAVIRDVMTNITANVGENPPVLILITNPLDAMVHIAATEFGYPKVFGTGTMLDSARLR
YIIGTELGIDPKSVTGYMMGEHGSTSVPILSQVNVQGLRWEELEAWHGKPLPTAPEMQEKVVRAAYDVLLSKGWTNAGVA
RSANELAKCVLLNERAVHPICTPLHGEYGLEDVSLSIPTEITHEGAGRKMLPQLNEWELEQLHKSAEFIRETVRKA
>Mature_316_residues
MNKLVVIGLGHVGSYVLSYAMASGLYAEIATIDTNPGVALGEAIDLAQATGVPGTTNTYCHEGTYADCADADVIICAAGE
SIVPDPNDPTRMPDRSELAQISGAVIRDVMTNITANVGENPPVLILITNPLDAMVHIAATEFGYPKVFGTGTMLDSARLR
YIIGTELGIDPKSVTGYMMGEHGSTSVPILSQVNVQGLRWEELEAWHGKPLPTAPEMQEKVVRAAYDVLLSKGWTNAGVA
RSANELAKCVLLNERAVHPICTPLHGEYGLEDVSLSIPTEITHEGAGRKMLPQLNEWELEQLHKSAEFIRETVRKA

Specific function: Unknown

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI47059044, Length=320, Percent_Identity=31.5625, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI221136809, Length=320, Percent_Identity=31.5625, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI15082234, Length=320, Percent_Identity=30.3125, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI291575128, Length=312, Percent_Identity=31.4102564102564, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI4557032, Length=312, Percent_Identity=31.4102564102564, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI5031857, Length=312, Percent_Identity=31.4102564102564, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI260099723, Length=312, Percent_Identity=31.4102564102564, Blast_Score=138, Evalue=5e-33,
Organism=Homo sapiens, GI9257228, Length=311, Percent_Identity=31.8327974276527, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4504973, Length=311, Percent_Identity=31.8327974276527, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI207028494, Length=187, Percent_Identity=36.3636363636364, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI260099727, Length=230, Percent_Identity=29.5652173913043, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI260099725, Length=206, Percent_Identity=30.5825242718447, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17535107, Length=251, Percent_Identity=31.8725099601594, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI17136226, Length=328, Percent_Identity=30.7926829268293, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45550422, Length=319, Percent_Identity=26.9592476489028, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 33945; Mature: 33945

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKLVVIGLGHVGSYVLSYAMASGLYAEIATIDTNPGVALGEAIDLAQATGVPGTTNTYC
CCCEEEEECCHHHHHHHHHHHHCCCEEEEEEEECCCCEEHHHHHHHHHHCCCCCCCCCEE
HEGTYADCADADVIICAAGESIVPDPNDPTRMPDRSELAQISGAVIRDVMTNITANVGEN
CCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PPVLILITNPLDAMVHIAATEFGYPKVFGTGTMLDSARLRYIIGTELGIDPKSVTGYMMG
CCEEEEEECCHHHHHHHHHHCCCCCEEEECCCEECCCCEEEEEECCCCCCCCCCEEEEEC
EHGSTSVPILSQVNVQGLRWEELEAWHGKPLPTAPEMQEKVVRAAYDVLLSKGWTNAGVA
CCCCCCCCEEEECCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH
RSANELAKCVLLNERAVHPICTPLHGEYGLEDVSLSIPTEITHEGAGRKMLPQLNEWELE
HCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCHHCCCCCCCCCCCCCCHHHHH
QLHKSAEFIRETVRKA
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKLVVIGLGHVGSYVLSYAMASGLYAEIATIDTNPGVALGEAIDLAQATGVPGTTNTYC
CCCEEEEECCHHHHHHHHHHHHCCCEEEEEEEECCCCEEHHHHHHHHHHCCCCCCCCCEE
HEGTYADCADADVIICAAGESIVPDPNDPTRMPDRSELAQISGAVIRDVMTNITANVGEN
CCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PPVLILITNPLDAMVHIAATEFGYPKVFGTGTMLDSARLRYIIGTELGIDPKSVTGYMMG
CCEEEEEECCHHHHHHHHHHCCCCCEEEECCCEECCCCEEEEEECCCCCCCCCCEEEEEC
EHGSTSVPILSQVNVQGLRWEELEAWHGKPLPTAPEMQEKVVRAAYDVLLSKGWTNAGVA
CCCCCCCCEEEECCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH
RSANELAKCVLLNERAVHPICTPLHGEYGLEDVSLSIPTEITHEGAGRKMLPQLNEWELE
HCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCHHCCCCCCCCCCCCCCHHHHH
QLHKSAEFIRETVRKA
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]