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The map label for this gene is menB [H]

Identifier: 38233035

GI number: 38233035

Start: 386100

End: 386966

Strand: Reverse

Name: menB [H]

Synonym: DIP0421

Alternate gene names: 38233035

Gene position: 386966-386100 (Counterclockwise)

Preceding gene: 38233041

Following gene: 38233034

Centisome position: 15.55

GC content: 59.52

Gene sequence:

>867_bases
ATGAATCCAGAACTTTGGAAGCCAGTCGAAGGCTTTGACAACCTCACCGACATCACGTACCACCGCCACCGCGAAGAAGG
CATCGTCCGCATCGCCTTCGACCGCCCCGAAGTACGCAACGCTTTTCGGCCGCACACCGTCGACGAGCTCTACCGCGCGC
TCGATCACGCCCGCCAAACCTCCGACGTAGGCACCGTGCTTCTTACCGGCAACGGCCCCTCCCCTAAAGACGGCGGCTGG
GCATTTTGCTCTGGCGGCGACCAACGCATCCGCGGACGTGCAGGCTACCAGTACGAGGGCGACCCCGCACAAGCCGGCCG
CCTCCACATTCTCGAAGTACAACGCCTGATTCGCACCATGCCCAAGGTTGTCATCGCAGTAGTCAACGGTTGGGCCGCAG
GCGGCGGACACTCCCTTCACGTCGTTTGCGACATGACCATCGCGTCTCGCGAACACGCCAAATTTAAGCAGACCGACGCC
GATGTCGGATCCTTCGACGCTGGATATGGCTCCGCGTACCTCGCCAAAATGGTGGGCCAGAAATTCGCCCGCGAAATTTT
CTTCCTAGGCCGCACCTACGATGCCGAAACTATGCAACGGATGGGTGCCGTCAACATCGTCGTTGACCATGCCGATCTCG
AAGACGAAGCCATCCAGGTCGGACGCGAAATCAACGGCAAATCCCCTACCGCGCAACGCATGCTGAAATTTGCCTTCAAC
CTCACCGACGACGGACTCATGGGACAGCAAGTCTTCGCAGGCGAGGCCACCCGATTGGCCTACATGACCGACGAGGCCGT
AGAAGGCCGCGACTCCTTCCTTGAAAAACGCGACCCCGATTGGTCACGCTTCCCTTATTACTTCTAA

Upstream 100 bases:

>100_bases
CTCGCGGACCATTATGCCGCGAAACTTCACCCGCATGGGGAGGGCAACCACATGAGCACGTTCGAGAATTTCGTCCATAG
GGGCGACTATAGTCACCCTT

Downstream 100 bases:

>100_bases
AATTTTCAGCATGATCCTCGAACCCCTCATCGTCCCCGCATATCCCAATGAGATCCTCGATGAGCTCGAGGCCGCGATAG
CTGGCGAACGCTGCTACCTG

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MNPELWKPVEGFDNLTDITYHRHREEGIVRIAFDRPEVRNAFRPHTVDELYRALDHARQTSDVGTVLLTGNGPSPKDGGW
AFCSGGDQRIRGRAGYQYEGDPAQAGRLHILEVQRLIRTMPKVVIAVVNGWAAGGGHSLHVVCDMTIASREHAKFKQTDA
DVGSFDAGYGSAYLAKMVGQKFAREIFFLGRTYDAETMQRMGAVNIVVDHADLEDEAIQVGREINGKSPTAQRMLKFAFN
LTDDGLMGQQVFAGEATRLAYMTDEAVEGRDSFLEKRDPDWSRFPYYF

Sequences:

>Translated_288_residues
MNPELWKPVEGFDNLTDITYHRHREEGIVRIAFDRPEVRNAFRPHTVDELYRALDHARQTSDVGTVLLTGNGPSPKDGGW
AFCSGGDQRIRGRAGYQYEGDPAQAGRLHILEVQRLIRTMPKVVIAVVNGWAAGGGHSLHVVCDMTIASREHAKFKQTDA
DVGSFDAGYGSAYLAKMVGQKFAREIFFLGRTYDAETMQRMGAVNIVVDHADLEDEAIQVGREINGKSPTAQRMLKFAFN
LTDDGLMGQQVFAGEATRLAYMTDEAVEGRDSFLEKRDPDWSRFPYYF
>Mature_288_residues
MNPELWKPVEGFDNLTDITYHRHREEGIVRIAFDRPEVRNAFRPHTVDELYRALDHARQTSDVGTVLLTGNGPSPKDGGW
AFCSGGDQRIRGRAGYQYEGDPAQAGRLHILEVQRLIRTMPKVVIAVVNGWAAGGGHSLHVVCDMTIASREHAKFKQTDA
DVGSFDAGYGSAYLAKMVGQKFAREIFFLGRTYDAETMQRMGAVNIVVDHADLEDEAIQVGREINGKSPTAQRMLKFAFN
LTDDGLMGQQVFAGEATRLAYMTDEAVEGRDSFLEKRDPDWSRFPYYF

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=287, Percent_Identity=28.2229965156794, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI31542718, Length=268, Percent_Identity=28.7313432835821, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4502327, Length=270, Percent_Identity=26.2962962962963, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788597, Length=284, Percent_Identity=49.2957746478873, Blast_Score=250, Evalue=6e-68,
Organism=Escherichia coli, GI221142681, Length=268, Percent_Identity=27.2388059701493, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787659, Length=269, Percent_Identity=26.3940520446097, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1787660, Length=261, Percent_Identity=27.9693486590038, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082183, Length=257, Percent_Identity=25.6809338521401, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=258, Percent_Identity=27.1317829457364, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17540714, Length=218, Percent_Identity=27.0642201834862, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI25145438, Length=265, Percent_Identity=27.1698113207547, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI20129971, Length=253, Percent_Identity=26.8774703557312, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24653477, Length=253, Percent_Identity=26.8774703557312, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24653139, Length=264, Percent_Identity=25.3787878787879, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 32253; Mature: 32253

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPELWKPVEGFDNLTDITYHRHREEGIVRIAFDRPEVRNAFRPHTVDELYRALDHARQT
CCCCCCCCHHCCCCHHHHHHHHHCCCCEEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHC
SDVGTVLLTGNGPSPKDGGWAFCSGGDQRIRGRAGYQYEGDPAQAGRLHILEVQRLIRTM
CCCCEEEEECCCCCCCCCCEEEECCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
PKVVIAVVNGWAAGGGHSLHVVCDMTIASREHAKFKQTDADVGSFDAGYGSAYLAKMVGQ
HHHHHHHHHCCCCCCCCEEEEEEEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
KFAREIFFLGRTYDAETMQRMGAVNIVVDHADLEDEAIQVGREINGKSPTAQRMLKFAFN
HHHHHHHHHCCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHC
LTDDGLMGQQVFAGEATRLAYMTDEAVEGRDSFLEKRDPDWSRFPYYF
CCCCCCCCCHHHCCCCEEEEEECCHHHCCHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNPELWKPVEGFDNLTDITYHRHREEGIVRIAFDRPEVRNAFRPHTVDELYRALDHARQT
CCCCCCCCHHCCCCHHHHHHHHHCCCCEEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHC
SDVGTVLLTGNGPSPKDGGWAFCSGGDQRIRGRAGYQYEGDPAQAGRLHILEVQRLIRTM
CCCCEEEEECCCCCCCCCCEEEECCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
PKVVIAVVNGWAAGGGHSLHVVCDMTIASREHAKFKQTDADVGSFDAGYGSAYLAKMVGQ
HHHHHHHHHCCCCCCCCEEEEEEEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
KFAREIFFLGRTYDAETMQRMGAVNIVVDHADLEDEAIQVGREINGKSPTAQRMLKFAFN
HHHHHHHHHCCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHC
LTDDGLMGQQVFAGEATRLAYMTDEAVEGRDSFLEKRDPDWSRFPYYF
CCCCCCCCCHHHCCCCEEEEEECCHHHCCHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA