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The map label for this gene is ctpA [H]

Identifier: 38233019

GI number: 38233019

Start: 370197

End: 372722

Strand: Direct

Name: ctpA [H]

Synonym: DIP0405

Alternate gene names: 38233019

Gene position: 370197-372722 (Clockwise)

Preceding gene: 38233017

Following gene: 38233021

Centisome position: 14.88

GC content: 54.75

Gene sequence:

>2526_bases
GTGTGGTCCGTGACTGATTCGCCGCTTGACGACGCCATCCAGGAAGCCAAATCCGCTGCGCAGAAGGCGGGATTTGATAC
CGAAACTTTTGCCGCTGTGCAGTCGAAGGAGGGGCGTACTTCTTTCGCTTTTGAATTGGAGGGGTTAGGTAGTGCCTCTT
CGGTTTCGGAGTTGGAAGAAGCGATCGAGCAGATCGAAGGAGTGGATGCCAAGATCGTTTATCCTTCGGCGATGGCGTGG
ATTAGCGCCAGTCGCACGTTGGATCCGACGCTCATTGTGGATGCTTTTCAGCAGCATGGCGTGACGGCTACGTTGACGGA
TTCTTCGCTGCGTCGTCGATTGGCGTGGACGGACGTGGAGGAGGGTCGGTATCGCCGCGCGCGTGCTCGCCGCTTTGGTT
CGCGTGTCGACGAAGAATCGCGCCGCTTCGAAATTGCTCGGCGCGAAGGGTTTTTGCACAAGCGCGACGAAACCACACGG
GTGGTGGAAACCACGGAGGTGTTGTTCACTGCGCGTTCGTTGATGACTAAAGCTCGCCTTTTTACTTCTATTGCCTGCAC
GATTCCTGTTTTAGCGGTGAGCTTTTGGCGGGAACTGCAGTTTGATTATTGGCAGTGGGCACTGGCGGCGCTGTCGCTTC
CTGTGGTGCTCTATGGTGCGTGGCCGTTTCACCGTGCCACGATTGGTGGTGCGCGCAGGGGAATGTCGGCTCTGGATAGT
GCCTCCTCCGTTGCCATTTTGATGGCGTGGGGTTGGTCTATCGTGATGATGCTGTTTTCTTCGGTGGGTGATCCTACGTA
CCGTGCGCAGCCGAAGTGGATTGCGATTGATCCCACGAAGTTTGTTTCGGGTGCACTGTTTTTCGATGTTGCATGCGGCA
TGACCGTGATCTTGTTGGCGGGACGTATCTTGGTGCGTCGTGCGCGTTCGGATCTTTTGGAAGATTTGAAACGTTATCGC
CCGAATCCGTCGTCAACAGTGACGGTGGTGGGAAAGAACCGTAAGACGGGTGAGGTTCGTAAGGAAGAAGTTGCGATTCA
GAAGCTCAACGTGGGTGACGATATCCTCATTGCTCCTTATGCGTTGATCCCTGCCGACGGCTATGTTGTTGGTGGCGCTT
CTACGATCGATGGCACTGCTTTGGGCATTGGCCGATTGAAGGTCAAGGTCAACGACCATGTTTATGCTGGTTGTGTCAAT
GGTTCTAATCCGCTGAAGATTCGTGTGCTTCAAACTGGTCACCGCACATGGTTTGCGGGCATTACGCGGTGGGTGTCGCA
GGCAAGTGTGCATCAAAACCATGCGGATGCGGTGGCAACGAGGGCGGCGTCGATGTTGGTGCCTGTCTCTTTTGTTATTG
CGGCTACGGATTTTGCGTTGTGGGCGCTGATTACTAATAACCTAAACCAAGCTTTTGCTACCGCGCTGGCGGTATTGGGG
TGTGTTTCTCCGGTGGCTCTGGCTACCTCGGCTTCTCTGGCTATGCGTAAGAGCATTGAAGACGCCGCCCGTCAGGGTGT
GTTGATCCAAAGTGGTGAGACGTTGCGTGTGATCGATACTGTCGACACAGTAATTTTCAACCGAGTGGGTGCGTTGTCTA
AGGCAGGCATGTCGGTAGAAAAGGTCACGGCAGACCGCGGTGAAAATCCAGATTTGGTGCTGCGTGTTGCAGGCGCGTTG
GCGATGGAAAGCGATCACCCCGTATCCCGGGCGTTGGTGCGTGCGGCTCGTGAGGCTCGCGATGCTTCGACGGATGATTC
GATCCCCGGCTGGATTGACGTGACGCATTCGGAAATCGATGAGGAAGGTAGTTTCCGCGGTTTTGTGGAACTTCCTGTTG
GTGAGGAGGCGCGCTCTGTGGAGGCCGTGTTGTGGCGTCCTCGCAGCCTATCGGCACTTGATGGTCGTCTTGCTGCTGCC
GCGGAGTCGGGTAGTTCTCCGTTGGTGGTGCGCTGGAAGAACAAGGATCGTGGTGTTATCACCTTGTTTAATGCGGTTAA
AGATGATGCCGTGGACGCGGTGGATGATTTGGAAGCCCAAGGCATCGAGACGATGATGCTGAGCCGTGATACCTATCCGG
TGGCGCGTCGATACGGCGATAGCGTGGGTGTTTCTCACGTGTTGGCTGGCATTCAGCCTGGTCAAAAGCCGCAGACCGTT
CGTTCTGTGCGCAACCACGGTGCCACGATTGCGGTGGTGGGAGATGATTCCATCAATGATTGTTTTCGCGTGGCTAATGT
AGGCATTTTGATTGATGCAATGTCGAAGAGCTCGGCAGCTATTGAGCACCCTGTTGCTAATGTCATCATGCTCAAAAATG
ATGTTGCGCCTATCCCACGCTTGTTCACCTTTGCGCGTCGACTCAATCGTCGTATTCGCTCAAACTTGGGTTTTGCGTGG
GTATATAACGTGGCGGCGATTGTTGCCGCTATTTCTGGGGTGTTGCACCCGATGATCGCAAGCCTGTTTATGTTGGGTGC
GACCATCGTGATTGAGGTGCGTTCTACGTGGACGAGGAATTTGTAA

Upstream 100 bases:

>100_bases
CAGGGCTGGTTTTTGGCTGATGGTTGTTTGTCCATTGCTTGTGGCGTGGCGGCGATCATTGGTTTGATTTTTGCGCAGAA
GAAGGAGTCGCTGGAGTGGG

Downstream 100 bases:

>100_bases
GCTGAAGCGTTGGTCCGTATGACAGCCTGCGGTGGAGCCATTCGAATGGCCCTCGCAGGTTTTTCTTTTCTAGTAGGCAG
GCCAGCAGCAGTGTGATCAG

Product: putative cation transport protein

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 841; Mature: 841

Protein sequence:

>841_residues
MWSVTDSPLDDAIQEAKSAAQKAGFDTETFAAVQSKEGRTSFAFELEGLGSASSVSELEEAIEQIEGVDAKIVYPSAMAW
ISASRTLDPTLIVDAFQQHGVTATLTDSSLRRRLAWTDVEEGRYRRARARRFGSRVDEESRRFEIARREGFLHKRDETTR
VVETTEVLFTARSLMTKARLFTSIACTIPVLAVSFWRELQFDYWQWALAALSLPVVLYGAWPFHRATIGGARRGMSALDS
ASSVAILMAWGWSIVMMLFSSVGDPTYRAQPKWIAIDPTKFVSGALFFDVACGMTVILLAGRILVRRARSDLLEDLKRYR
PNPSSTVTVVGKNRKTGEVRKEEVAIQKLNVGDDILIAPYALIPADGYVVGGASTIDGTALGIGRLKVKVNDHVYAGCVN
GSNPLKIRVLQTGHRTWFAGITRWVSQASVHQNHADAVATRAASMLVPVSFVIAATDFALWALITNNLNQAFATALAVLG
CVSPVALATSASLAMRKSIEDAARQGVLIQSGETLRVIDTVDTVIFNRVGALSKAGMSVEKVTADRGENPDLVLRVAGAL
AMESDHPVSRALVRAAREARDASTDDSIPGWIDVTHSEIDEEGSFRGFVELPVGEEARSVEAVLWRPRSLSALDGRLAAA
AESGSSPLVVRWKNKDRGVITLFNAVKDDAVDAVDDLEAQGIETMMLSRDTYPVARRYGDSVGVSHVLAGIQPGQKPQTV
RSVRNHGATIAVVGDDSINDCFRVANVGILIDAMSKSSAAIEHPVANVIMLKNDVAPIPRLFTFARRLNRRIRSNLGFAW
VYNVAAIVAAISGVLHPMIASLFMLGATIVIEVRSTWTRNL

Sequences:

>Translated_841_residues
MWSVTDSPLDDAIQEAKSAAQKAGFDTETFAAVQSKEGRTSFAFELEGLGSASSVSELEEAIEQIEGVDAKIVYPSAMAW
ISASRTLDPTLIVDAFQQHGVTATLTDSSLRRRLAWTDVEEGRYRRARARRFGSRVDEESRRFEIARREGFLHKRDETTR
VVETTEVLFTARSLMTKARLFTSIACTIPVLAVSFWRELQFDYWQWALAALSLPVVLYGAWPFHRATIGGARRGMSALDS
ASSVAILMAWGWSIVMMLFSSVGDPTYRAQPKWIAIDPTKFVSGALFFDVACGMTVILLAGRILVRRARSDLLEDLKRYR
PNPSSTVTVVGKNRKTGEVRKEEVAIQKLNVGDDILIAPYALIPADGYVVGGASTIDGTALGIGRLKVKVNDHVYAGCVN
GSNPLKIRVLQTGHRTWFAGITRWVSQASVHQNHADAVATRAASMLVPVSFVIAATDFALWALITNNLNQAFATALAVLG
CVSPVALATSASLAMRKSIEDAARQGVLIQSGETLRVIDTVDTVIFNRVGALSKAGMSVEKVTADRGENPDLVLRVAGAL
AMESDHPVSRALVRAAREARDASTDDSIPGWIDVTHSEIDEEGSFRGFVELPVGEEARSVEAVLWRPRSLSALDGRLAAA
AESGSSPLVVRWKNKDRGVITLFNAVKDDAVDAVDDLEAQGIETMMLSRDTYPVARRYGDSVGVSHVLAGIQPGQKPQTV
RSVRNHGATIAVVGDDSINDCFRVANVGILIDAMSKSSAAIEHPVANVIMLKNDVAPIPRLFTFARRLNRRIRSNLGFAW
VYNVAAIVAAISGVLHPMIASLFMLGATIVIEVRSTWTRNL
>Mature_841_residues
MWSVTDSPLDDAIQEAKSAAQKAGFDTETFAAVQSKEGRTSFAFELEGLGSASSVSELEEAIEQIEGVDAKIVYPSAMAW
ISASRTLDPTLIVDAFQQHGVTATLTDSSLRRRLAWTDVEEGRYRRARARRFGSRVDEESRRFEIARREGFLHKRDETTR
VVETTEVLFTARSLMTKARLFTSIACTIPVLAVSFWRELQFDYWQWALAALSLPVVLYGAWPFHRATIGGARRGMSALDS
ASSVAILMAWGWSIVMMLFSSVGDPTYRAQPKWIAIDPTKFVSGALFFDVACGMTVILLAGRILVRRARSDLLEDLKRYR
PNPSSTVTVVGKNRKTGEVRKEEVAIQKLNVGDDILIAPYALIPADGYVVGGASTIDGTALGIGRLKVKVNDHVYAGCVN
GSNPLKIRVLQTGHRTWFAGITRWVSQASVHQNHADAVATRAASMLVPVSFVIAATDFALWALITNNLNQAFATALAVLG
CVSPVALATSASLAMRKSIEDAARQGVLIQSGETLRVIDTVDTVIFNRVGALSKAGMSVEKVTADRGENPDLVLRVAGAL
AMESDHPVSRALVRAAREARDASTDDSIPGWIDVTHSEIDEEGSFRGFVELPVGEEARSVEAVLWRPRSLSALDGRLAAA
AESGSSPLVVRWKNKDRGVITLFNAVKDDAVDAVDDLEAQGIETMMLSRDTYPVARRYGDSVGVSHVLAGIQPGQKPQTV
RSVRNHGATIAVVGDDSINDCFRVANVGILIDAMSKSSAAIEHPVANVIMLKNDVAPIPRLFTFARRLNRRIRSNLGFAW
VYNVAAIVAAISGVLHPMIASLFMLGATIVIEVRSTWTRNL

Specific function: Involved In Copper Efflux. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=677, Percent_Identity=23.781388478582, Blast_Score=154, Evalue=4e-37,
Organism=Homo sapiens, GI55743073, Length=572, Percent_Identity=23.7762237762238, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI115529486, Length=404, Percent_Identity=21.2871287128713, Blast_Score=94, Evalue=5e-19,
Organism=Escherichia coli, GI1786691, Length=632, Percent_Identity=24.2088607594937, Blast_Score=126, Evalue=7e-30,
Organism=Escherichia coli, GI1789879, Length=519, Percent_Identity=25.0481695568401, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17556548, Length=697, Percent_Identity=24.6771879483501, Blast_Score=118, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320475, Length=934, Percent_Identity=23.0192719486081, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319772, Length=592, Percent_Identity=23.1418918918919, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221329854, Length=588, Percent_Identity=20.9183673469388, Blast_Score=83, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR000579
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 91405; Mature: 91405

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWSVTDSPLDDAIQEAKSAAQKAGFDTETFAAVQSKEGRTSFAFELEGLGSASSVSELEE
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHH
AIEQIEGVDAKIVYPSAMAWISASRTLDPTLIVDAFQQHGVTATLTDSSLRRRLAWTDVE
HHHHHCCCCEEEECCHHHHHHHCCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHCCCCCH
EGRYRRARARRFGSRVDEESRRFEIARREGFLHKRDETTRVVETTEVLFTARSLMTKARL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FTSIACTIPVLAVSFWRELQFDYWQWALAALSLPVVLYGAWPFHRATIGGARRGMSALDS
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCEEEEECCCHHHHHHCHHHHCHHHHCC
ASSVAILMAWGWSIVMMLFSSVGDPTYRAQPKWIAIDPTKFVSGALFFDVACGMTVILLA
CCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHH
GRILVRRARSDLLEDLKRYRPNPSSTVTVVGKNRKTGEVRKEEVAIQKLNVGDDILIAPY
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHEECCCCCEEECCE
ALIPADGYVVGGASTIDGTALGIGRLKVKVNDHVYAGCVNGSNPLKIRVLQTGHRTWFAG
EEECCCCEEECCCCCCCCCEEEEEEEEEEECCEEEEEEECCCCCEEEEEEECCCHHHHHH
ITRWVSQASVHQNHADAVATRAASMLVPVSFVIAATDFALWALITNNLNQAFATALAVLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
CVSPVALATSASLAMRKSIEDAARQGVLIQSGETLRVIDTVDTVIFNRVGALSKAGMSVE
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEHHHHHHHHHHHHHHHHHCCCCHH
KVTADRGENPDLVLRVAGALAMESDHPVSRALVRAAREARDASTDDSIPGWIDVTHSEID
HHHHCCCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHCC
EEGSFRGFVELPVGEEARSVEAVLWRPRSLSALDGRLAAAAESGSSPLVVRWKNKDRGVI
CCCCCCEEEECCCCCCHHHHHHHHCCCCCCHHHCCHHHHHHCCCCCCEEEEECCCCCCEE
TLFNAVKDDAVDAVDDLEAQGIETMMLSRDTYPVARRYGDSVGVSHVLAGIQPGQKPQTV
EEEHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHCCCCCCHHHHHHCCCCCCCCHHH
RSVRNHGATIAVVGDDSINDCFRVANVGILIDAMSKSSAAIEHPVANVIMLKNDVAPIPR
HHHHHCCCEEEEECCCCHHHHHHHHCCCEEEEECCCCCCHHHCCCCEEEEEECCCCCHHH
LFTFARRLNRRIRSNLGFAWVYNVAAIVAAISGVLHPMIASLFMLGATIVIEVRSTWTRN
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECHHCCC
L
C
>Mature Secondary Structure
MWSVTDSPLDDAIQEAKSAAQKAGFDTETFAAVQSKEGRTSFAFELEGLGSASSVSELEE
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHH
AIEQIEGVDAKIVYPSAMAWISASRTLDPTLIVDAFQQHGVTATLTDSSLRRRLAWTDVE
HHHHHCCCCEEEECCHHHHHHHCCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHCCCCCH
EGRYRRARARRFGSRVDEESRRFEIARREGFLHKRDETTRVVETTEVLFTARSLMTKARL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FTSIACTIPVLAVSFWRELQFDYWQWALAALSLPVVLYGAWPFHRATIGGARRGMSALDS
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCEEEEECCCHHHHHHCHHHHCHHHHCC
ASSVAILMAWGWSIVMMLFSSVGDPTYRAQPKWIAIDPTKFVSGALFFDVACGMTVILLA
CCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHH
GRILVRRARSDLLEDLKRYRPNPSSTVTVVGKNRKTGEVRKEEVAIQKLNVGDDILIAPY
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHEECCCCCEEECCE
ALIPADGYVVGGASTIDGTALGIGRLKVKVNDHVYAGCVNGSNPLKIRVLQTGHRTWFAG
EEECCCCEEECCCCCCCCCEEEEEEEEEEECCEEEEEEECCCCCEEEEEEECCCHHHHHH
ITRWVSQASVHQNHADAVATRAASMLVPVSFVIAATDFALWALITNNLNQAFATALAVLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
CVSPVALATSASLAMRKSIEDAARQGVLIQSGETLRVIDTVDTVIFNRVGALSKAGMSVE
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEHHHHHHHHHHHHHHHHHCCCCHH
KVTADRGENPDLVLRVAGALAMESDHPVSRALVRAAREARDASTDDSIPGWIDVTHSEID
HHHHCCCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHCC
EEGSFRGFVELPVGEEARSVEAVLWRPRSLSALDGRLAAAAESGSSPLVVRWKNKDRGVI
CCCCCCEEEECCCCCCHHHHHHHHCCCCCCHHHCCHHHHHHCCCCCCEEEEECCCCCCEE
TLFNAVKDDAVDAVDDLEAQGIETMMLSRDTYPVARRYGDSVGVSHVLAGIQPGQKPQTV
EEEHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHCCCCCCHHHHHHCCCCCCCCHHH
RSVRNHGATIAVVGDDSINDCFRVANVGILIDAMSKSSAAIEHPVANVIMLKNDVAPIPR
HHHHHCCCEEEEECCCCHHHHHHHHCCCEEEEECCCCCCHHHCCCCEEEEEECCCCCHHH
LFTFARRLNRRIRSNLGFAWVYNVAAIVAAISGVLHPMIASLFMLGATIVIEVRSTWTRN
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECHHCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]