Click here to switch to the map view.

The map label for this gene is hemE

Identifier: 38233021

GI number: 38233021

Start: 373884

End: 374918

Strand: Direct

Name: hemE

Synonym: DIP0407

Alternate gene names: 38233021

Gene position: 373884-374918 (Clockwise)

Preceding gene: 38233019

Following gene: 38233022

Centisome position: 15.02

GC content: 54.49

Gene sequence:

>1035_bases
ATGGTGAGCATGCCCAATCCTATTCTTGACGCCGCGGCGGGTGTGACTCCGCACCGCCGCCCTGTTTGGTTCATGCGCCA
GGCTGGACGTTCCTTGCCCGAGTACCGTGAGATTCGTGAGGGGGTCAGCATGTTGGACAGTTGCTTCCGCCCCGACATGC
TGGCGGAAATCACGTTGCAGCCGGTGCGACGCCACGATGTGGATGCTGCGATTTTGTTCTCTGACATTGTGGTGCCACTT
AAAGCTGCAGGTGTTCGTGTAGAGATCGTCCCTGGCCGTGGCCCGGTCATGGATCATCCGTTGCTTACTCGCCAAGATAT
TGAGAACCTGCCCATTTTGGACCACGATGTCCACGAGGTTGCTGAAGGCATTGGCATCATTCGCGAGGAGCTGAACGACG
CGCAAACGCTGATTGGTTTTGCTGGTGCGCCTTTTACGTTGGCGAGCTACTTGGTTGAAGGTGGCCCGAGTAAGAACCAT
GAGAAGACTAAGTCGCTGATGCACCAAGACCCTGAGTCGTGGCATCTACTGATGCGGCGTTTGGTTCCTACTATTGTGCA
GTTTTTGCGTACTCAGATTGATGCCGGTGTGCAGGCTATGCAGTTGTTTGATTCGTGGGCTGGCTTTTTGTCTGAGCGGG
ATTATCGTGAGTTTGTGCTGCCCTATTCTATGGAGATCCTTGCGCAGGTTGGCGATGTTCCTCGTATTCACTTTGGTGTG
GGCACTGGGGAGTTGCTGACGGCGATGAGTGAGGCTGGTAGCGAAGTGGTGGGCGTCGATTGGCGGGTGCCGCTTGATGT
GGCTGCGCAGCGGATGGTGTCGCCGAAGGTGCTGCAGGGTAATTTGGATCCGGCTATTTTGTTTGCTGGTGAGGATGTTA
TGCGTCGTGAGATCGCTCGTATTTGTGCAGAGGCGGATCGTGCGATTGCTGCGGGTCATGCAACTGGCCATATTTTTAAT
CTTGGACATGGCGTTTTGCCGAATACTGATCCCGATGCGATTACTCGTGCTGTCGAGATAATCCATACTTTCTAG

Upstream 100 bases:

>100_bases
TCGGGGGCCATCATGCGGGGTCGTTTTTGATCCATGGGTTAGATACTAAGGCATCCAAGTAGGTACGCCTTGCTTTCATA
TCATCCAAAAGTTGGGCATG

Downstream 100 bases:

>100_bases
AGAAGGACTTTCAACGTGCGTATTGCGATCATTGGTGCGGGGCTTGCGGGTTTGACTGCGGCGTATCGTCTTCGTGACCA
TGATGTTTCGGTTTTCGAGG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MVSMPNPILDAAAGVTPHRRPVWFMRQAGRSLPEYREIREGVSMLDSCFRPDMLAEITLQPVRRHDVDAAILFSDIVVPL
KAAGVRVEIVPGRGPVMDHPLLTRQDIENLPILDHDVHEVAEGIGIIREELNDAQTLIGFAGAPFTLASYLVEGGPSKNH
EKTKSLMHQDPESWHLLMRRLVPTIVQFLRTQIDAGVQAMQLFDSWAGFLSERDYREFVLPYSMEILAQVGDVPRIHFGV
GTGELLTAMSEAGSEVVGVDWRVPLDVAAQRMVSPKVLQGNLDPAILFAGEDVMRREIARICAEADRAIAAGHATGHIFN
LGHGVLPNTDPDAITRAVEIIHTF

Sequences:

>Translated_344_residues
MVSMPNPILDAAAGVTPHRRPVWFMRQAGRSLPEYREIREGVSMLDSCFRPDMLAEITLQPVRRHDVDAAILFSDIVVPL
KAAGVRVEIVPGRGPVMDHPLLTRQDIENLPILDHDVHEVAEGIGIIREELNDAQTLIGFAGAPFTLASYLVEGGPSKNH
EKTKSLMHQDPESWHLLMRRLVPTIVQFLRTQIDAGVQAMQLFDSWAGFLSERDYREFVLPYSMEILAQVGDVPRIHFGV
GTGELLTAMSEAGSEVVGVDWRVPLDVAAQRMVSPKVLQGNLDPAILFAGEDVMRREIARICAEADRAIAAGHATGHIFN
LGHGVLPNTDPDAITRAVEIIHTF
>Mature_344_residues
MVSMPNPILDAAAGVTPHRRPVWFMRQAGRSLPEYREIREGVSMLDSCFRPDMLAEITLQPVRRHDVDAAILFSDIVVPL
KAAGVRVEIVPGRGPVMDHPLLTRQDIENLPILDHDVHEVAEGIGIIREELNDAQTLIGFAGAPFTLASYLVEGGPSKNH
EKTKSLMHQDPESWHLLMRRLVPTIVQFLRTQIDAGVQAMQLFDSWAGFLSERDYREFVLPYSMEILAQVGDVPRIHFGV
GTGELLTAMSEAGSEVVGVDWRVPLDVAAQRMVSPKVLQGNLDPAILFAGEDVMRREIARICAEADRAIAAGHATGHIFN
LGHGVLPNTDPDAITRAVEIIHTF

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=349, Percent_Identity=38.9684813753582, Blast_Score=231, Evalue=8e-61,
Organism=Escherichia coli, GI2367337, Length=331, Percent_Identity=39.8791540785499, Blast_Score=243, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6320252, Length=364, Percent_Identity=35.989010989011, Blast_Score=216, Evalue=3e-57,
Organism=Drosophila melanogaster, GI221330099, Length=349, Percent_Identity=36.9627507163324, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI19921920, Length=349, Percent_Identity=36.9627507163324, Blast_Score=216, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_CORDI (Q6NJJ4)

Other databases:

- EMBL:   BX248355
- RefSeq:   NP_938788.1
- HSSP:   P06132
- ProteinModelPortal:   Q6NJJ4
- SMR:   Q6NJJ4
- GeneID:   2649507
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0407
- NMPDR:   fig|257309.1.peg.379
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q6NJJ4
- ProtClustDB:   PRK00115
- BioCyc:   CDIP257309:DIP0407-MONOMER
- BRENDA:   4.1.1.37
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37972; Mature: 37972

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 75-75 BINDING 150-150 BINDING 205-205 BINDING 323-323

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSMPNPILDAAAGVTPHRRPVWFMRQAGRSLPEYREIREGVSMLDSCFRPDMLAEITLQ
CCCCCCHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
PVRRHDVDAAILFSDIVVPLKAAGVRVEIVPGRGPVMDHPLLTRQDIENLPILDHDVHEV
HHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCHHHHH
AEGIGIIREELNDAQTLIGFAGAPFTLASYLVEGGPSKNHEKTKSLMHQDPESWHLLMRR
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHH
LVPTIVQFLRTQIDAGVQAMQLFDSWAGFLSERDYREFVLPYSMEILAQVGDVPRIHFGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHCCCCEEEEEC
GTGELLTAMSEAGSEVVGVDWRVPLDVAAQRMVSPKVLQGNLDPAILFAGEDVMRREIAR
CCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHCCCHHHCCCCCCEEEECCHHHHHHHHHH
ICAEADRAIAAGHATGHIFNLGHGVLPNTDPDAITRAVEIIHTF
HHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MVSMPNPILDAAAGVTPHRRPVWFMRQAGRSLPEYREIREGVSMLDSCFRPDMLAEITLQ
CCCCCCHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
PVRRHDVDAAILFSDIVVPLKAAGVRVEIVPGRGPVMDHPLLTRQDIENLPILDHDVHEV
HHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCHHHHH
AEGIGIIREELNDAQTLIGFAGAPFTLASYLVEGGPSKNHEKTKSLMHQDPESWHLLMRR
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHH
LVPTIVQFLRTQIDAGVQAMQLFDSWAGFLSERDYREFVLPYSMEILAQVGDVPRIHFGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHCCCCEEEEEC
GTGELLTAMSEAGSEVVGVDWRVPLDVAAQRMVSPKVLQGNLDPAILFAGEDVMRREIAR
CCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHCCCHHHCCCCCCEEEECCHHHHHHHHHH
ICAEADRAIAAGHATGHIFNLGHGVLPNTDPDAITRAVEIIHTF
HHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910