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The map label for this gene is serC [H]

Identifier: 37679635

GI number: 37679635

Start: 1485785

End: 1486930

Strand: Direct

Name: serC [H]

Synonym: VV1451

Alternate gene names: 37679635

Gene position: 1485785-1486930 (Clockwise)

Preceding gene: 37679634

Following gene: 37679641

Centisome position: 44.29

GC content: 45.29

Gene sequence:

>1146_bases
GTGATATTACTTGCAGAGTTTTTATTACATCTAGCAGGAGCAAAGAGCGTCATGGAACAAAATACGGATAACGTATTTAA
CTTTAGTGCCGGACCAGCAGCACTACCGAAGCCTGTTATGCAGCAGGCGCAACAAGAATTGTTGAACTGGCAAGGGCTAG
GCACTTCCGTTATGGAAATCAGCCACCGTAGCAAAGAGTTTATTGCAGTCGCAGAGCAATCTGAGCAAGATCTCCGCGAT
TTACTGAATATCCCTGATAATTACAAAGTTCTTTTCTGCCAAGGTGGTGCGCGCGCTCAATTTGCGGCCGTGCCGCTGAA
TCTGCTAGGTGACGCGACGACGGCGACCTACATTGATGCGGGCTATTGGGCAGAAAGTGCTGTCGAAGAAGCGAAAAAAT
ACTGTCAGCCGGATGTCTTTGTTGCCAAAGCAGAAAAAGACGGTAAGCAAGCGGTACTACCTGCCTCAGAATGGCAAATT
CATCCTGATGCGGCTTACGTGCATTTTTGTCCCAATGAAACCATTGATGGCATTGAGATCAATGATCTTCCAGTGACGGA
TAAGCCGATCGTTGCCGATATGTCTTCGACCATTTTGTCGCGTGAAATTGATGTATCAAAATACGGTGTGATTTACGCAG
GAGCGCAAAAAAATATCGGTCCTTCTGGTATTGCGATTGCCATTGTACGTGACGATTTGCTTGGTTTGGCGAAAGAAGTA
TTGCCAAGTATTCTCAATTACAAAGTGTTGGCAGAACAAGACTCGATGTTTAACACGCCACCAACTTTTGCCTGGTACTT
GTCTGGCCTTGTTTTCAAATGGTTGAAAGCGCAGGGTGGGGTAAAAGCGATTGAGCAAGTAAACCGTGAGAAAGCGGCGA
TTTTGTATAACTACATTGATGAGTCCGATTTTTACATCAACAATGTACATCCAGATAACCGTTCATTAATGAATGTGCCG
TTCCAAATGGTGAAACCAGAGCTAGACGCAAAATTCTTGAAAGAAGCTGAAGCATTGGGTCTCAAATCACTAAAAGGTCA
CCGAGTAGTGGGTGGCATGCGCGCCTCCATTTACAACGCAATGCCAATTGAAGGTGTGAAGGCGTTAGTCGATTTCATGC
GCCAATTTGAGCAAGAAAACGCGTAA

Upstream 100 bases:

>100_bases
GCTATTGATGCCTGCGCTAATGCAATAATTGTGGATTCATTTGCTTAGAATAAAAAAGAGGTCGTAAGACCTCTTTTCTT
GTTTTTCAACAGCGAAAAAC

Downstream 100 bases:

>100_bases
TTTCAGTGCGATAGATGAGAAAAACAAAGGGAAGTGCGTAAGCACTTCCCTTTTTCTTGTTTGCCATTGTCCTATTGATG
GCTGAGTAATACTGCCCAGC

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MILLAEFLLHLAGAKSVMEQNTDNVFNFSAGPAALPKPVMQQAQQELLNWQGLGTSVMEISHRSKEFIAVAEQSEQDLRD
LLNIPDNYKVLFCQGGARAQFAAVPLNLLGDATTATYIDAGYWAESAVEEAKKYCQPDVFVAKAEKDGKQAVLPASEWQI
HPDAAYVHFCPNETIDGIEINDLPVTDKPIVADMSSTILSREIDVSKYGVIYAGAQKNIGPSGIAIAIVRDDLLGLAKEV
LPSILNYKVLAEQDSMFNTPPTFAWYLSGLVFKWLKAQGGVKAIEQVNREKAAILYNYIDESDFYINNVHPDNRSLMNVP
FQMVKPELDAKFLKEAEALGLKSLKGHRVVGGMRASIYNAMPIEGVKALVDFMRQFEQENA

Sequences:

>Translated_381_residues
MILLAEFLLHLAGAKSVMEQNTDNVFNFSAGPAALPKPVMQQAQQELLNWQGLGTSVMEISHRSKEFIAVAEQSEQDLRD
LLNIPDNYKVLFCQGGARAQFAAVPLNLLGDATTATYIDAGYWAESAVEEAKKYCQPDVFVAKAEKDGKQAVLPASEWQI
HPDAAYVHFCPNETIDGIEINDLPVTDKPIVADMSSTILSREIDVSKYGVIYAGAQKNIGPSGIAIAIVRDDLLGLAKEV
LPSILNYKVLAEQDSMFNTPPTFAWYLSGLVFKWLKAQGGVKAIEQVNREKAAILYNYIDESDFYINNVHPDNRSLMNVP
FQMVKPELDAKFLKEAEALGLKSLKGHRVVGGMRASIYNAMPIEGVKALVDFMRQFEQENA
>Mature_381_residues
MILLAEFLLHLAGAKSVMEQNTDNVFNFSAGPAALPKPVMQQAQQELLNWQGLGTSVMEISHRSKEFIAVAEQSEQDLRD
LLNIPDNYKVLFCQGGARAQFAAVPLNLLGDATTATYIDAGYWAESAVEEAKKYCQPDVFVAKAEKDGKQAVLPASEWQI
HPDAAYVHFCPNETIDGIEINDLPVTDKPIVADMSSTILSREIDVSKYGVIYAGAQKNIGPSGIAIAIVRDDLLGLAKEV
LPSILNYKVLAEQDSMFNTPPTFAWYLSGLVFKWLKAQGGVKAIEQVNREKAAILYNYIDESDFYINNVHPDNRSLMNVP
FQMVKPELDAKFLKEAEALGLKSLKGHRVVGGMRASIYNAMPIEGVKALVDFMRQFEQENA

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine [H]

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily [H]

Homologues:

Organism=Homo sapiens, GI17402893, Length=361, Percent_Identity=47.3684210526316, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI10863955, Length=357, Percent_Identity=42.296918767507, Blast_Score=286, Evalue=2e-77,
Organism=Escherichia coli, GI1787136, Length=359, Percent_Identity=66.8523676880223, Blast_Score=509, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17506897, Length=361, Percent_Identity=44.0443213296399, Blast_Score=308, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6324758, Length=386, Percent_Identity=43.7823834196891, Blast_Score=285, Evalue=7e-78,
Organism=Drosophila melanogaster, GI21356589, Length=364, Percent_Identity=46.1538461538462, Blast_Score=335, Evalue=2e-92,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.6.1.52 [H]

Molecular weight: Translated: 42075; Mature: 42075

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLAEFLLHLAGAKSVMEQNTDNVFNFSAGPAALPKPVMQQAQQELLNWQGLGTSVMEI
CEEHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
SHRSKEFIAVAEQSEQDLRDLLNIPDNYKVLFCQGGARAQFAAVPLNLLGDATTATYIDA
HHCCHHHEEEHHCCHHHHHHHHCCCCCCEEEEEECCCCCEEEECCHHHHCCCCHHEEEEC
GYWAESAVEEAKKYCQPDVFVAKAEKDGKQAVLPASEWQIHPDAAYVHFCPNETIDGIEI
CHHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCCCCEECCCCEEEEECCCCCCCCEEE
NDLPVTDKPIVADMSSTILSREIDVSKYGVIYAGAQKNIGPSGIAIAIVRDDLLGLAKEV
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEEEHHHHHHHHHHH
LPSILNYKVLAEQDSMFNTPPTFAWYLSGLVFKWLKAQGGVKAIEQVNREKAAILYNYID
HHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHEEECC
ESDFYINNVHPDNRSLMNVPFQMVKPELDAKFLKEAEALGLKSLKGHRVVGGMRASIYNA
CCCCEEECCCCCCCCHHHCCHHHHCCCHHHHHHHHHHHHCHHHCCCCEEECCHHHHHHCC
MPIEGVKALVDFMRQFEQENA
CCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MILLAEFLLHLAGAKSVMEQNTDNVFNFSAGPAALPKPVMQQAQQELLNWQGLGTSVMEI
CEEHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
SHRSKEFIAVAEQSEQDLRDLLNIPDNYKVLFCQGGARAQFAAVPLNLLGDATTATYIDA
HHCCHHHEEEHHCCHHHHHHHHCCCCCCEEEEEECCCCCEEEECCHHHHCCCCHHEEEEC
GYWAESAVEEAKKYCQPDVFVAKAEKDGKQAVLPASEWQIHPDAAYVHFCPNETIDGIEI
CHHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCCCCEECCCCEEEEECCCCCCCCEEE
NDLPVTDKPIVADMSSTILSREIDVSKYGVIYAGAQKNIGPSGIAIAIVRDDLLGLAKEV
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEEEHHHHHHHHHHH
LPSILNYKVLAEQDSMFNTPPTFAWYLSGLVFKWLKAQGGVKAIEQVNREKAAILYNYID
HHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHEEECC
ESDFYINNVHPDNRSLMNVPFQMVKPELDAKFLKEAEALGLKSLKGHRVVGGMRASIYNA
CCCCEEECCCCCCCCHHHCCHHHHCCCHHHHHHHHHHHHCHHHCCCCEEECCHHHHHHCC
MPIEGVKALVDFMRQFEQENA
CCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA