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The map label for this gene is hisC [H]

Identifier: 37679536

GI number: 37679536

Start: 1378047

End: 1379087

Strand: Direct

Name: hisC [H]

Synonym: VV1352

Alternate gene names: 37679536

Gene position: 1378047-1379087 (Clockwise)

Preceding gene: 37679535

Following gene: 37679537

Centisome position: 41.08

GC content: 46.59

Gene sequence:

>1041_bases
ATGGAAAAGCTTGCTCGTAAAAGTGTACAGAAACTGACGCCTTATCTTTCGGCGCGCCGCATCGGTGGAACCGGCGATGT
TTGGTTGAATGCCAATGAATCGCCATTTGACAATGAATACCGCACAAACTTTGCGCGCTTGAACCGTTACAGTGATTGTC
AGCCGAAAGCATTGATTGCAGCCTACGCTGCCTATGCAGGTGTTAAACCAGAACAAACTCTTACATCGCGTGGCGCGGAT
GAGGGTATCGAATTGCTGATTCGCGCTTTCTGCGAACCAAATGAAGATGCCATTCTTTACTGTCCTCCTACGTATGGCAT
GTATTCTGTGAGCGCTGAAACCATTGGCGTTGAGCGTAAAACCGTACCGCTGACAGAGGATTGGCAATTAGACCTTTCAG
GTATTGAAGCCAATTTGGACAAGGTTAAGTTGGTCTTTGTTTGTTCACCAAACAATCCAACAGGCAACTTAGTGAAGCGA
GAAGACATCATCGCCTTGCTAGAGATGACAAAAGACAGAGCCATCGTTGTGATGGATGAAGCGTATATCGATTTTTGTCC
AGAGGCCTCAACTGTCGATTTACTTGCGCAGTACTCAAACCTTGCGATTTTGCGTACTTTGTCGAAAGCCTTTGCATTAG
CTGGCTTGCGTTGTGGATTCACACTTGCGAATGAAGAGCTGATTAATGTACTTCTAAAAGTTATCGCGCCCTATCCGGTA
CCAGTGCCTGTCGCAGAAATTGCGACACAAGCATTGTCAGAAGCTGGCTTGGCTCGTGCTAAGTTCCAAGTGCTCGACCT
CAATGCAAACCGTGCCTATTTGCAAGTGGGATTATCAATGATCGCAGGTTTAGAAGTGTTTGAAGGGTGGGGCAATTATC
TGCTGGTGAAATTCCCTAATGGCGACGAGCTATTTAAGGCGGCTTGGGAGTCCGGCATCATCTTGCGAAACTCGCCAATC
AAAGATTGCGTAAGAATCAGTGTTGGCAGCCGAGATGAGTGTGAGAAAACTCTGGGTTTCATTAGAAACTACTACTCATA
A

Upstream 100 bases:

>100_bases
ACGGTGGTGACGATGGCGGAAGCAGAAGGATTGGACGCACACAAACGAGCGGTCACAATTCGTGTTGAAAAATTAACTGC
GCGTAGCTAAGGAAAAGACG

Downstream 100 bases:

>100_bases
GTAGAGAAAGAATGAATTGCATTCGCTAAACAGCGAGAGCGCCAAAAGAATAGCAATAAGGAAGTTCGAGTGAGCAAACA
ACAAAAAATCCTTTTTATCG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MEKLARKSVQKLTPYLSARRIGGTGDVWLNANESPFDNEYRTNFARLNRYSDCQPKALIAAYAAYAGVKPEQTLTSRGAD
EGIELLIRAFCEPNEDAILYCPPTYGMYSVSAETIGVERKTVPLTEDWQLDLSGIEANLDKVKLVFVCSPNNPTGNLVKR
EDIIALLEMTKDRAIVVMDEAYIDFCPEASTVDLLAQYSNLAILRTLSKAFALAGLRCGFTLANEELINVLLKVIAPYPV
PVPVAEIATQALSEAGLARAKFQVLDLNANRAYLQVGLSMIAGLEVFEGWGNYLLVKFPNGDELFKAAWESGIILRNSPI
KDCVRISVGSRDECEKTLGFIRNYYS

Sequences:

>Translated_346_residues
MEKLARKSVQKLTPYLSARRIGGTGDVWLNANESPFDNEYRTNFARLNRYSDCQPKALIAAYAAYAGVKPEQTLTSRGAD
EGIELLIRAFCEPNEDAILYCPPTYGMYSVSAETIGVERKTVPLTEDWQLDLSGIEANLDKVKLVFVCSPNNPTGNLVKR
EDIIALLEMTKDRAIVVMDEAYIDFCPEASTVDLLAQYSNLAILRTLSKAFALAGLRCGFTLANEELINVLLKVIAPYPV
PVPVAEIATQALSEAGLARAKFQVLDLNANRAYLQVGLSMIAGLEVFEGWGNYLLVKFPNGDELFKAAWESGIILRNSPI
KDCVRISVGSRDECEKTLGFIRNYYS
>Mature_346_residues
MEKLARKSVQKLTPYLSARRIGGTGDVWLNANESPFDNEYRTNFARLNRYSDCQPKALIAAYAAYAGVKPEQTLTSRGAD
EGIELLIRAFCEPNEDAILYCPPTYGMYSVSAETIGVERKTVPLTEDWQLDLSGIEANLDKVKLVFVCSPNNPTGNLVKR
EDIIALLEMTKDRAIVVMDEAYIDFCPEASTVDLLAQYSNLAILRTLSKAFALAGLRCGFTLANEELINVLLKVIAPYPV
PVPVAEIATQALSEAGLARAKFQVLDLNANRAYLQVGLSMIAGLEVFEGWGNYLLVKFPNGDELFKAAWESGIILRNSPI
KDCVRISVGSRDECEKTLGFIRNYYS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=344, Percent_Identity=61.046511627907, Blast_Score=425, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322075, Length=382, Percent_Identity=31.9371727748691, Blast_Score=157, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38257; Mature: 38257

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLARKSVQKLTPYLSARRIGGTGDVWLNANESPFDNEYRTNFARLNRYSDCQPKALIA
CCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHH
AYAAYAGVKPEQTLTSRGADEGIELLIRAFCEPNEDAILYCPPTYGMYSVSAETIGVERK
HHHHHCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEEECHHHCCCCCC
TVPLTEDWQLDLSGIEANLDKVKLVFVCSPNNPTGNLVKREDIIALLEMTKDRAIVVMDE
CCCCCCCCEEEECCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEC
AYIDFCPEASTVDLLAQYSNLAILRTLSKAFALAGLRCGFTLANEELINVLLKVIAPYPV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHCCCCC
PVPVAEIATQALSEAGLARAKFQVLDLNANRAYLQVGLSMIAGLEVFEGWGNYLLVKFPN
CCCHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
GDELFKAAWESGIILRNSPIKDCVRISVGSRDECEKTLGFIRNYYS
CHHHHHHHHHCCEEEECCCHHHHHEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKLARKSVQKLTPYLSARRIGGTGDVWLNANESPFDNEYRTNFARLNRYSDCQPKALIA
CCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHH
AYAAYAGVKPEQTLTSRGADEGIELLIRAFCEPNEDAILYCPPTYGMYSVSAETIGVERK
HHHHHCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEEECHHHCCCCCC
TVPLTEDWQLDLSGIEANLDKVKLVFVCSPNNPTGNLVKREDIIALLEMTKDRAIVVMDE
CCCCCCCCEEEECCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEC
AYIDFCPEASTVDLLAQYSNLAILRTLSKAFALAGLRCGFTLANEELINVLLKVIAPYPV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHCCCCC
PVPVAEIATQALSEAGLARAKFQVLDLNANRAYLQVGLSMIAGLEVFEGWGNYLLVKFPN
CCCHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
GDELFKAAWESGIILRNSPIKDCVRISVGSRDECEKTLGFIRNYYS
CHHHHHHHHHCCEEEECCCHHHHHEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA