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The map label for this gene is hisD

Identifier: 37679535

GI number: 37679535

Start: 1376741

End: 1378036

Strand: Direct

Name: hisD

Synonym: VV1351

Alternate gene names: 37679535

Gene position: 1376741-1378036 (Clockwise)

Preceding gene: 37679534

Following gene: 37679536

Centisome position: 41.04

GC content: 48.23

Gene sequence:

>1296_bases
ATGAGAACGGTTGTTTGGCAATCTCTTAGTGAGACGCAACAAGACGCTATTTTGGAACGTCCAGCGATAACAGAAGGTGC
GAATATTACCGCTGCAGTGGCAGAAGTGATTGCGAAAGTCAGAGCAGAAGGCGATGCGGCACTGTTCGAACTCACGGAAA
AGTTTGATCGCATTAAACCAGAATCGATTCGAGTGACTGAACAAGAAATCGAGGAGGCTTCTGCTCGCTTAACTGCAAAA
ATGAAGCAAGCGCTTGAGCAGGCTTACGCCAATATCGCGAAGTTCCACAATGCCCAGAAACCGACGCCAATTAAAGTCGA
AACACAACCGGGTGTGGTGTGTGAACAAGTCACTCGCCCGATACAAAAAGTGGGTTTATACATTCCTGGTGGCAGTGCAC
CGCTGCCTTCAACGGTATTGATGTTGGGTGTTCCTGCGCAAATCGCGGGTTGCCGCAAAGTGGTTTTATGTTCACCACCA
CCGATTGCCGATGAGATTCTCTATGTGGCAAAGCTTTGTAATATTGATGAAGTTTACAATGTTGGCGGTGGGCAAGCGGT
AGCGGCGATGGCCTATGGGACAGAAAGTGTCACTAAGGTGGACAAAATATTTGGTCCTGGCAATGCGTATGTCACAGAAG
CAAAACGCCAAGTGAGCAATGACTTTCGTGGTGCCGCCATTGATATGCCCGCTGGGCCATCAGAAGTGTTGGTGATTGCT
GATGAAACTGCAGATGCCGATTTTATCGCCGCCGATTTACTTAGCCAAGCCGAGCACGGACCAGACTCGCAAGTGGTTTT
AGTGACGCCATCTGTCTTGATTGCAGATCAAGTAACGGATGCTGTACAGAAACAGTTGAAGCAGTTATCACGCGCCTCTA
TTGCTGAAAAAGCACTGGCGTCGAGCTTGATTATTATTGCTGACTCCTTAACCCAAGCGGTTTCTATTTCAAATTATTAC
GGTCCAGAGCATTTAATTGTTCAGACCAAAAATCCTCGAGAGTTGTTGCCATTGCTGGATAACGCAGGTTCCATTTTCTT
GGGTGATTGGTCGCCTGAATCGGCGGGTGATTATGCGTCAGGAACCAACCACGTGTTGCCAACGTATGGGTACACCCGTA
CCTACTCAAGCCTTGGATTGGCTGATTTTTCTAAACGCATGACGGTACAAGAACTCTCTGCGGAAGGGCTGAAAAACCTT
GCTCCAACGGTGGTGACGATGGCGGAAGCAGAAGGATTGGACGCACACAAACGAGCGGTCACAATTCGTGTTGAAAAATT
AACTGCGCGTAGCTAA

Upstream 100 bases:

>100_bases
GTACAGAAAACCTATTCTGGGAAACGATGGAACAGCTCAAAGAACTTGGCGCGAGCTCTATTCTTGTTTTACCAATTGAA
AAAATGATGGAGTAAGGCTC

Downstream 100 bases:

>100_bases
GGAAAAGACGATGGAAAAGCTTGCTCGTAAAAGTGTACAGAAACTGACGCCTTATCTTTCGGCGCGCCGCATCGGTGGAA
CCGGCGATGTTTGGTTGAAT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MRTVVWQSLSETQQDAILERPAITEGANITAAVAEVIAKVRAEGDAALFELTEKFDRIKPESIRVTEQEIEEASARLTAK
MKQALEQAYANIAKFHNAQKPTPIKVETQPGVVCEQVTRPIQKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPP
PIADEILYVAKLCNIDEVYNVGGGQAVAAMAYGTESVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DETADADFIAADLLSQAEHGPDSQVVLVTPSVLIADQVTDAVQKQLKQLSRASIAEKALASSLIIIADSLTQAVSISNYY
GPEHLIVQTKNPRELLPLLDNAGSIFLGDWSPESAGDYASGTNHVLPTYGYTRTYSSLGLADFSKRMTVQELSAEGLKNL
APTVVTMAEAEGLDAHKRAVTIRVEKLTARS

Sequences:

>Translated_431_residues
MRTVVWQSLSETQQDAILERPAITEGANITAAVAEVIAKVRAEGDAALFELTEKFDRIKPESIRVTEQEIEEASARLTAK
MKQALEQAYANIAKFHNAQKPTPIKVETQPGVVCEQVTRPIQKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPP
PIADEILYVAKLCNIDEVYNVGGGQAVAAMAYGTESVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DETADADFIAADLLSQAEHGPDSQVVLVTPSVLIADQVTDAVQKQLKQLSRASIAEKALASSLIIIADSLTQAVSISNYY
GPEHLIVQTKNPRELLPLLDNAGSIFLGDWSPESAGDYASGTNHVLPTYGYTRTYSSLGLADFSKRMTVQELSAEGLKNL
APTVVTMAEAEGLDAHKRAVTIRVEKLTARS
>Mature_431_residues
MRTVVWQSLSETQQDAILERPAITEGANITAAVAEVIAKVRAEGDAALFELTEKFDRIKPESIRVTEQEIEEASARLTAK
MKQALEQAYANIAKFHNAQKPTPIKVETQPGVVCEQVTRPIQKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPP
PIADEILYVAKLCNIDEVYNVGGGQAVAAMAYGTESVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DETADADFIAADLLSQAEHGPDSQVVLVTPSVLIADQVTDAVQKQLKQLSRASIAEKALASSLIIIADSLTQAVSISNYY
GPEHLIVQTKNPRELLPLLDNAGSIFLGDWSPESAGDYASGTNHVLPTYGYTRTYSSLGLADFSKRMTVQELSAEGLKNL
APTVVTMAEAEGLDAHKRAVTIRVEKLTARS

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=422, Percent_Identity=64.218009478673, Blast_Score=558, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6319819, Length=419, Percent_Identity=52.2673031026253, Blast_Score=419, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46069; Mature: 46069

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTVVWQSLSETQQDAILERPAITEGANITAAVAEVIAKVRAEGDAALFELTEKFDRIKP
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
ESIRVTEQEIEEASARLTAKMKQALEQAYANIAKFHNAQKPTPIKVETQPGVVCEQVTRP
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHH
IQKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPPPIADEILYVAKLCNIDEVYN
HHHCCEEECCCCCCCCCEEEEECCCHHHCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHC
VGGGQAVAAMAYGTESVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
CCCCCEEEEEHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEE
DETADADFIAADLLSQAEHGPDSQVVLVTPSVLIADQVTDAVQKQLKQLSRASIAEKALA
ECCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLIIIADSLTQAVSISNYYGPEHLIVQTKNPRELLPLLDNAGSIFLGDWSPESAGDYAS
HHHHEEEHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCEEEECCCCCCCCCCCC
GTNHVLPTYGYTRTYSSLGLADFSKRMTVQELSAEGLKNLAPTVVTMAEAEGLDAHKRAV
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEHHCCCCCCHHEEE
TIRVEKLTARS
EEEEECCCCCC
>Mature Secondary Structure
MRTVVWQSLSETQQDAILERPAITEGANITAAVAEVIAKVRAEGDAALFELTEKFDRIKP
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
ESIRVTEQEIEEASARLTAKMKQALEQAYANIAKFHNAQKPTPIKVETQPGVVCEQVTRP
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHH
IQKVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPPPIADEILYVAKLCNIDEVYN
HHHCCEEECCCCCCCCCEEEEECCCHHHCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHC
VGGGQAVAAMAYGTESVTKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
CCCCCEEEEEHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEE
DETADADFIAADLLSQAEHGPDSQVVLVTPSVLIADQVTDAVQKQLKQLSRASIAEKALA
ECCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLIIIADSLTQAVSISNYYGPEHLIVQTKNPRELLPLLDNAGSIFLGDWSPESAGDYAS
HHHHEEEHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCEEEECCCCCCCCCCCC
GTNHVLPTYGYTRTYSSLGLADFSKRMTVQELSAEGLKNLAPTVVTMAEAEGLDAHKRAV
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEHHCCCCCCHHEEE
TIRVEKLTARS
EEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]