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The map label for this gene is hisB [H]

Identifier: 37679537

GI number: 37679537

Start: 1379157

End: 1380230

Strand: Direct

Name: hisB [H]

Synonym: VV1353

Alternate gene names: 37679537

Gene position: 1379157-1380230 (Clockwise)

Preceding gene: 37679536

Following gene: 37679538

Centisome position: 41.11

GC content: 46.83

Gene sequence:

>1074_bases
GTGAGCAAACAACAAAAAATCCTTTTTATCGACCGTGACGGCACTTTGATCGTGGAACCACCTGTCGATTTTCAAGTAGA
CCGTTTAGATAAGCTAAAACTAGAGCCATTTGTTATCCCAAGCCTGTTGTCGTTGCAAGATGCAGGATACCGTCTAGTGA
TGGTCACCAACCAAGACGGCCTTGGAACAGACAGCTATCCGCAAGAAGATTTTGATGCTCCACACAATATGATGATGGAG
ATCTTTGAATCTCAAGGTGTGAAATTTGATGATGTTCTGATCTGTCCTCACTTTGAAAAAGACAATTGCTCTTGTCGCAA
ACCGAAATTGGGCTTAGTAAAAGAGTACCTTCAAGCGGGTAAAGTGGATTTCCAGAACTCGTTCGTGATTGGCGATCGTC
AAACCGATCTTCAACTTGCAGAGAACATGGCTATTCGTGGCATTCAATACAACCCAGAAACCATGGGTTGGAAACAGATC
CTGAAAGATCTGACGGTGAAAGCGCGTGTTGCTGAAGTGGTTCGCACCACGAAAGAAACGGACATCAAAGTATTCGTTAA
TCTTGATGAACAAGGCGGTAACGCGATATCAACCGGTCTTGGTTTCTTCGACCACATGTTGGATCAAATCGCCACTCACG
GTGGCTTCCAGATGGTGTGCAAAGTGGAAGGTGACTTGCACATTGATGATCACCACACGGTAGAAGATACCGCTCTCGCG
TTGGGGCAAGCATTGAAAGAAGCACTGGGTGACAAGCGTGGTATTGGCCGCTTTGGCTTCAGCCTGCCAATGGATGAGTG
CTTGGCACAATGTGCACTAGACCTATCTGGCCGTCCTTACCTTAAGTTTGACGCGCAGTTCAGCCGTGAGCAGGTCGGTG
ACTTATCCACTGAGATGGTGGTTCATTTCTTCCGTTCTTTGACGGATACCCTAGCGTGTACGCTGCACCTTTCTTCTGCG
GGCAACAATGATCACCACATCATTGAAAGTCTATTCAAAGCGTTTGGTCGTACTCTGCGCCAAGCAATCAAAGTAGAAGG
CACTGAGCTACCAAGTAGTAAAGGCGTGCTGTAA

Upstream 100 bases:

>100_bases
TCTGGGTTTCATTAGAAACTACTACTCATAAGTAGAGAAAGAATGAATTGCATTCGCTAAACAGCGAGAGCGCCAAAAGA
ATAGCAATAAGGAAGTTCGA

Downstream 100 bases:

>100_bases
GGCGAGCGTAAGCAAGGAGAAAAACAGTGACAGAACAGAAAGTTGTCATTATCGATACTGGCTGTGCCAACGTTTCTTCG
GTGAAGTTTGCCATTGAACG

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSKQQKILFIDRDGTLIVEPPVDFQVDRLDKLKLEPFVIPSLLSLQDAGYRLVMVTNQDGLGTDSYPQEDFDAPHNMMME
IFESQGVKFDDVLICPHFEKDNCSCRKPKLGLVKEYLQAGKVDFQNSFVIGDRQTDLQLAENMAIRGIQYNPETMGWKQI
LKDLTVKARVAEVVRTTKETDIKVFVNLDEQGGNAISTGLGFFDHMLDQIATHGGFQMVCKVEGDLHIDDHHTVEDTALA
LGQALKEALGDKRGIGRFGFSLPMDECLAQCALDLSGRPYLKFDAQFSREQVGDLSTEMVVHFFRSLTDTLACTLHLSSA
GNNDHHIIESLFKAFGRTLRQAIKVEGTELPSSKGVL

Sequences:

>Translated_357_residues
MSKQQKILFIDRDGTLIVEPPVDFQVDRLDKLKLEPFVIPSLLSLQDAGYRLVMVTNQDGLGTDSYPQEDFDAPHNMMME
IFESQGVKFDDVLICPHFEKDNCSCRKPKLGLVKEYLQAGKVDFQNSFVIGDRQTDLQLAENMAIRGIQYNPETMGWKQI
LKDLTVKARVAEVVRTTKETDIKVFVNLDEQGGNAISTGLGFFDHMLDQIATHGGFQMVCKVEGDLHIDDHHTVEDTALA
LGQALKEALGDKRGIGRFGFSLPMDECLAQCALDLSGRPYLKFDAQFSREQVGDLSTEMVVHFFRSLTDTLACTLHLSSA
GNNDHHIIESLFKAFGRTLRQAIKVEGTELPSSKGVL
>Mature_356_residues
SKQQKILFIDRDGTLIVEPPVDFQVDRLDKLKLEPFVIPSLLSLQDAGYRLVMVTNQDGLGTDSYPQEDFDAPHNMMMEI
FESQGVKFDDVLICPHFEKDNCSCRKPKLGLVKEYLQAGKVDFQNSFVIGDRQTDLQLAENMAIRGIQYNPETMGWKQIL
KDLTVKARVAEVVRTTKETDIKVFVNLDEQGGNAISTGLGFFDHMLDQIATHGGFQMVCKVEGDLHIDDHHTVEDTALAL
GQALKEALGDKRGIGRFGFSLPMDECLAQCALDLSGRPYLKFDAQFSREQVGDLSTEMVVHFFRSLTDTLACTLHLSSAG
NNDHHIIESLFKAFGRTLRQAIKVEGTELPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=353, Percent_Identity=69.6883852691218, Blast_Score=516, Evalue=1e-147,
Organism=Escherichia coli, GI1786399, Length=150, Percent_Identity=29.3333333333333, Blast_Score=71, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324776, Length=165, Percent_Identity=49.6969696969697, Blast_Score=164, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 39888; Mature: 39757

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQQKILFIDRDGTLIVEPPVDFQVDRLDKLKLEPFVIPSLLSLQDAGYRLVMVTNQDG
CCCCCEEEEEECCCCEEECCCCCCCCCCHHHCCCCCCHHHHHHHHCCCCEEEEEEECCCC
LGTDSYPQEDFDAPHNMMMEIFESQGVKFDDVLICPHFEKDNCSCRKPKLGLVKEYLQAG
CCCCCCCCHHCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHC
KVDFQNSFVIGDRQTDLQLAENMAIRGIQYNPETMGWKQILKDLTVKARVAEVVRTTKET
CCCCCCCEEECCCCHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DIKVFVNLDEQGGNAISTGLGFFDHMLDQIATHGGFQMVCKVEGDLHIDDHHTVEDTALA
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEECCCCCHHHHHHH
LGQALKEALGDKRGIGRFGFSLPMDECLAQCALDLSGRPYLKFDAQFSREQVGDLSTEMV
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCHHHHHH
VHFFRSLTDTLACTLHLSSAGNNDHHIIESLFKAFGRTLRQAIKVEGTELPSSKGVL
HHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SKQQKILFIDRDGTLIVEPPVDFQVDRLDKLKLEPFVIPSLLSLQDAGYRLVMVTNQDG
CCCCEEEEEECCCCEEECCCCCCCCCCHHHCCCCCCHHHHHHHHCCCCEEEEEEECCCC
LGTDSYPQEDFDAPHNMMMEIFESQGVKFDDVLICPHFEKDNCSCRKPKLGLVKEYLQAG
CCCCCCCCHHCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHC
KVDFQNSFVIGDRQTDLQLAENMAIRGIQYNPETMGWKQILKDLTVKARVAEVVRTTKET
CCCCCCCEEECCCCHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DIKVFVNLDEQGGNAISTGLGFFDHMLDQIATHGGFQMVCKVEGDLHIDDHHTVEDTALA
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEECCCCCHHHHHHH
LGQALKEALGDKRGIGRFGFSLPMDECLAQCALDLSGRPYLKFDAQFSREQVGDLSTEMV
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCHHHHHH
VHFFRSLTDTLACTLHLSSAGNNDHHIIESLFKAFGRTLRQAIKVEGTELPSSKGVL
HHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]