Click here to switch to the map view.

The map label for this gene is hisG

Identifier: 37679534

GI number: 37679534

Start: 1375839

End: 1376735

Strand: Direct

Name: hisG

Synonym: VV1350

Alternate gene names: 37679534

Gene position: 1375839-1376735 (Clockwise)

Preceding gene: 37679533

Following gene: 37679535

Centisome position: 41.01

GC content: 45.15

Gene sequence:

>897_bases
ATGCAAACACAACGCTTAAGAATTGCAATTCAGAAAAAAGGCCGACTGAGTGAAGAGTGCCAAGGGCTCTTAAAAAAGTG
TGGCGTTAAATTCAATATTATGGGTGAGCGTTTAGTCGTGCACTCAGAAAATATGCCAATTGATCTGTTATTAGTTCGTG
ATGATGACATCCCAGGGCTGATCATGGATGGCGTTGTTGACCTTGGTTTTATCGGTGAAAACGTGTTGGAAGAAGTGCGT
CTAGAGCGCAAAGCCACTGGTGATGCTTGTCAATTTGAAACCTTGAGTCGTCTAGATTTTGGTGGATGTCGTTTGTCCAT
CGCGATTGATAAAGATGAAAAATACAATGGCCCACAAGATCTTGCTGGGAAACGTATTGCGACGACTTACCCACAACTGC
TCAAAGCGTATATGGATCGACAAGGTGTGCCTTTCTCAACCTGTATGCTGACAGGCTCAGTTGAAGTGGCGCCTCGTGCT
GGTTTGGCGGATGCAATCGCTGATTTGGTTTCAACAGGCGCAACACTTGAAGCCAATGGCCTAAAAGAGGCTGAGGTTAT
TTTCCAATCGAAAGCAACACTTATTCAACGTTCAGGTGAGTTTGCCCAAGACAAGCAAGCGCTTATCGAGAAGCTGTTAA
CGCGTATGCAAGGCGTTCAGCAAGCCAAAGAATCCAAATACATCATGCTACATGCTCCAGTTGATAAGCTAGAACAGATC
AAAGCACTGTTGCCAGGGGCGGAAGATCCAACCGTGTTACCACTGTCTGCAGAGAAACAACGAGTGGCCGTCCACTTGGT
GAGTACAGAAAACCTATTCTGGGAAACGATGGAACAGCTCAAAGAACTTGGCGCGAGCTCTATTCTTGTTTTACCAATTG
AAAAAATGATGGAGTAA

Upstream 100 bases:

>100_bases
CATCAAATTCAGATTTTAAACCCTCGGGAGACCAACATCTCTCGAGGGTTTTTTAGTTTTCACTTTCATCATTTTCAAAT
TGAAGCACAGGGACAATGTC

Downstream 100 bases:

>100_bases
GGCTCATGAGAACGGTTGTTTGGCAATCTCTTAGTGAGACGCAACAAGACGCTATTTTGGAACGTCCAGCGATAACAGAA
GGTGCGAATATTACCGCTGC

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MQTQRLRIAIQKKGRLSEECQGLLKKCGVKFNIMGERLVVHSENMPIDLLLVRDDDIPGLIMDGVVDLGFIGENVLEEVR
LERKATGDACQFETLSRLDFGGCRLSIAIDKDEKYNGPQDLAGKRIATTYPQLLKAYMDRQGVPFSTCMLTGSVEVAPRA
GLADAIADLVSTGATLEANGLKEAEVIFQSKATLIQRSGEFAQDKQALIEKLLTRMQGVQQAKESKYIMLHAPVDKLEQI
KALLPGAEDPTVLPLSAEKQRVAVHLVSTENLFWETMEQLKELGASSILVLPIEKMME

Sequences:

>Translated_298_residues
MQTQRLRIAIQKKGRLSEECQGLLKKCGVKFNIMGERLVVHSENMPIDLLLVRDDDIPGLIMDGVVDLGFIGENVLEEVR
LERKATGDACQFETLSRLDFGGCRLSIAIDKDEKYNGPQDLAGKRIATTYPQLLKAYMDRQGVPFSTCMLTGSVEVAPRA
GLADAIADLVSTGATLEANGLKEAEVIFQSKATLIQRSGEFAQDKQALIEKLLTRMQGVQQAKESKYIMLHAPVDKLEQI
KALLPGAEDPTVLPLSAEKQRVAVHLVSTENLFWETMEQLKELGASSILVLPIEKMME
>Mature_298_residues
MQTQRLRIAIQKKGRLSEECQGLLKKCGVKFNIMGERLVVHSENMPIDLLLVRDDDIPGLIMDGVVDLGFIGENVLEEVR
LERKATGDACQFETLSRLDFGGCRLSIAIDKDEKYNGPQDLAGKRIATTYPQLLKAYMDRQGVPFSTCMLTGSVEVAPRA
GLADAIADLVSTGATLEANGLKEAEVIFQSKATLIQRSGEFAQDKQALIEKLLTRMQGVQQAKESKYIMLHAPVDKLEQI
KALLPGAEDPTVLPLSAEKQRVAVHLVSTENLFWETMEQLKELGASSILVLPIEKMME

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=294, Percent_Identity=68.3673469387755, Blast_Score=424, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6320896, Length=300, Percent_Identity=30, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 32912; Mature: 32912

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTQRLRIAIQKKGRLSEECQGLLKKCGVKFNIMGERLVVHSENMPIDLLLVRDDDIPGL
CCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCEEEEECCCCCEEEEEEECCCCCCH
IMDGVVDLGFIGENVLEEVRLERKATGDACQFETLSRLDFGGCRLSIAIDKDEKYNGPQD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCCCHH
LAGKRIATTYPQLLKAYMDRQGVPFSTCMLTGSVEVAPRAGLADAIADLVSTGATLEANG
HCCCCHHHHHHHHHHHHHCCCCCCHHHEEEECCEEECCCCCHHHHHHHHHHCCCEEECCC
LKEAEVIFQSKATLIQRSGEFAQDKQALIEKLLTRMQGVQQAKESKYIMLHAPVDKLEQI
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHH
KALLPGAEDPTVLPLSAEKQRVAVHLVSTENLFWETMEQLKELGASSILVLPIEKMME
HHHCCCCCCCEEEECCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure
MQTQRLRIAIQKKGRLSEECQGLLKKCGVKFNIMGERLVVHSENMPIDLLLVRDDDIPGL
CCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCEEEEECCCCCEEEEEEECCCCCCH
IMDGVVDLGFIGENVLEEVRLERKATGDACQFETLSRLDFGGCRLSIAIDKDEKYNGPQD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCCCHH
LAGKRIATTYPQLLKAYMDRQGVPFSTCMLTGSVEVAPRAGLADAIADLVSTGATLEANG
HCCCCHHHHHHHHHHHHHCCCCCCHHHEEEECCEEECCCCCHHHHHHHHHHCCCEEECCC
LKEAEVIFQSKATLIQRSGEFAQDKQALIEKLLTRMQGVQQAKESKYIMLHAPVDKLEQI
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHH
KALLPGAEDPTVLPLSAEKQRVAVHLVSTENLFWETMEQLKELGASSILVLPIEKMME
HHHCCCCCCCEEEECCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA