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The map label for this gene is dsbC [H]

Identifier: 37678850

GI number: 37678850

Start: 661927

End: 662721

Strand: Direct

Name: dsbC [H]

Synonym: VV0666

Alternate gene names: 37678850

Gene position: 661927-662721 (Clockwise)

Preceding gene: 161486657

Following gene: 37678851

Centisome position: 19.73

GC content: 49.94

Gene sequence:

>795_bases
GTGATTTTAATGAGCGTATTACGCCGATTAACTCTTTTAACTCTTCCTCTCTTTGTGACGGCCTGCGGTGCTGAAGAAAG
CCAAGCGGTCGAAACAGCTCAGCCAGCGGCACAAGTGGCGGCGAGCACGCATTTTGATAGCGAGGCTCTCAAAGCTCGTT
TTTCCAAGCTGGGCCTGAACATCATGGATATTCAACCTTCGGATGTGGCGGGTTTAGTCGAAATTCAAACCAGTGGCGGG
GTGTTATTTGCGTCTAAAGACGGTAGCCACTTTATCGCTGGAACCTTGTATTCCATCGACGAAAATGGTCAATACAAGGA
CGTGATCGCAGAACGCCAAGCGCCGCTCAACGCCAAGAAAATTGCCGAATTTGCTGACAGCGCGATCGAGTACAAAGCCA
AAGATGAAAAATACGTGGTGACGGTGTTTACCGACATTACTTGCGGTTACTGCGTTCGTCTACACAGCCAGATGCAGGGC
TACAATGACTTAGGTATCACCGTGCGTTACATGGCATACCCACGCCAAGGTGGCACGGGCCCTGTGGCAGAACAAATGGC
GGGCATCTGGTGTGCCGCTAATCCGCAAGAAGCGATGCATGATGCTAAAGTGAACCGCAAATTTGCCCCAGCGAAAAATG
ATTTACAGCAGTGCAAGCAGACCGTGGCTCAACATTACCAACTTGGTCAGCAACTCGGTATTACAGGCACGCCTGCGATT
TTCTTGCCAAATGGTGAGCTGGTTGCTGGTTACTTGCCACCAGAAAAACTGCTAGAACGTTTACAGCAACCATAA

Upstream 100 bases:

>100_bases
ACTTATCGACCACGCAAATTTATACTCACGTGGCAACAGAACGACTAAAACAGATTCATAGCCAACATCATCCGCGTGCT
TAAAGCGGAATAACGACAAG

Downstream 100 bases:

>100_bases
ACCTTCAAGGAGCAGAGCCTGCGCGTTTGACCCGCGGGCTCTATTCAATTAATGATAGAAATACAACGACGACCAGAACC
CGATCTTTCCCTCTTGCCCG

Product: protein-disulfide isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MILMSVLRRLTLLTLPLFVTACGAEESQAVETAQPAAQVAASTHFDSEALKARFSKLGLNIMDIQPSDVAGLVEIQTSGG
VLFASKDGSHFIAGTLYSIDENGQYKDVIAERQAPLNAKKIAEFADSAIEYKAKDEKYVVTVFTDITCGYCVRLHSQMQG
YNDLGITVRYMAYPRQGGTGPVAEQMAGIWCAANPQEAMHDAKVNRKFAPAKNDLQQCKQTVAQHYQLGQQLGITGTPAI
FLPNGELVAGYLPPEKLLERLQQP

Sequences:

>Translated_264_residues
MILMSVLRRLTLLTLPLFVTACGAEESQAVETAQPAAQVAASTHFDSEALKARFSKLGLNIMDIQPSDVAGLVEIQTSGG
VLFASKDGSHFIAGTLYSIDENGQYKDVIAERQAPLNAKKIAEFADSAIEYKAKDEKYVVTVFTDITCGYCVRLHSQMQG
YNDLGITVRYMAYPRQGGTGPVAEQMAGIWCAANPQEAMHDAKVNRKFAPAKNDLQQCKQTVAQHYQLGQQLGITGTPAI
FLPNGELVAGYLPPEKLLERLQQP
>Mature_264_residues
MILMSVLRRLTLLTLPLFVTACGAEESQAVETAQPAAQVAASTHFDSEALKARFSKLGLNIMDIQPSDVAGLVEIQTSGG
VLFASKDGSHFIAGTLYSIDENGQYKDVIAERQAPLNAKKIAEFADSAIEYKAKDEKYVVTVFTDITCGYCVRLHSQMQG
YNDLGITVRYMAYPRQGGTGPVAEQMAGIWCAANPQEAMHDAKVNRKFAPAKNDLQQCKQTVAQHYQLGQQLGITGTPAI
FLPNGELVAGYLPPEKLLERLQQP

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1789260, Length=224, Percent_Identity=42.4107142857143, Blast_Score=188, Evalue=3e-49,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: 5.3.4.1

Molecular weight: Translated: 28740; Mature: 28740

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILMSVLRRLTLLTLPLFVTACGAEESQAVETAQPAAQVAASTHFDSEALKARFSKLGLN
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCE
IMDIQPSDVAGLVEIQTSGGVLFASKDGSHFIAGTLYSIDENGQYKDVIAERQAPLNAKK
EEECCCCCCEEEEEEECCCCEEEEECCCCEEEEEEEEEECCCCCHHHHHHHHCCCCCHHH
IAEFADSAIEYKAKDEKYVVTVFTDITCGYCVRLHSQMQGYNDLGITVRYMAYPRQGGTG
HHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCC
PVAEQMAGIWCAANPQEAMHDAKVNRKFAPAKNDLQQCKQTVAQHYQLGQQLGITGTPAI
HHHHHHCCEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
FLPNGELVAGYLPPEKLLERLQQP
EECCCCEEEECCCHHHHHHHHCCC
>Mature Secondary Structure
MILMSVLRRLTLLTLPLFVTACGAEESQAVETAQPAAQVAASTHFDSEALKARFSKLGLN
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCE
IMDIQPSDVAGLVEIQTSGGVLFASKDGSHFIAGTLYSIDENGQYKDVIAERQAPLNAKK
EEECCCCCCEEEEEEECCCCEEEEECCCCEEEEEEEEEECCCCCHHHHHHHHCCCCCHHH
IAEFADSAIEYKAKDEKYVVTVFTDITCGYCVRLHSQMQGYNDLGITVRYMAYPRQGGTG
HHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCC
PVAEQMAGIWCAANPQEAMHDAKVNRKFAPAKNDLQQCKQTVAQHYQLGQQLGITGTPAI
HHHHHHCCEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
FLPNGELVAGYLPPEKLLERLQQP
EECCCCEEEECCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]