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The map label for this gene is thrC [H]

Identifier: 37678836

GI number: 37678836

Start: 648535

End: 649815

Strand: Direct

Name: thrC [H]

Synonym: VV0652

Alternate gene names: 37678836

Gene position: 648535-649815 (Clockwise)

Preceding gene: 161486660

Following gene: 37678838

Centisome position: 19.33

GC content: 48.09

Gene sequence:

>1281_bases
ATGAAGCTTTACAACATAAAAGAAAATGACGAACAAGTTTCCTTTGGCCAAGCCGTGCGCCAAGGGTTAGGCCGTAATCA
GGGGCTATTTTTCCCAGCAGAATTGCCGAAATTTGACGATATCGATGCATTGCTTGCGCAAGATTTTATCTCGCGCAGCA
CTGCGATTCTTTCCGCGTTAATTGGTGATGAGCTAGCAGAAGACAAAGTTAACTCAATGGTGGATGCGGCATTCCAGTTC
CCAGCACCGATTAAACAAGTGAAAGAGGGTGTCTACGCGCTTGAACTGTTCCATGGACCGACACTTGCCTTCAAAGACTT
CGGTGGCCGCTTTATGGCTCAGTCGTTGGCTGCGGTTTCTGATGGTGGAAAAATCACTATTCTAACAGCGACATCGGGTG
ATACAGGAGCCGCGGTTGCACACGCTTTTTACGGTATGGAAGACATCAATGTGGTCATTCTTTATCCGAAAGGCAAAATC
AGCCCATTGCAAGAAAAGCTGTTCTGCACATTAGGCAAAAACATTCACACGGTAGCGATCAATGGTGACTTTGACGCGTG
TCAGGCGCTGGTGAAACAAGCGTTTGATGATGCAGAACTGCGTGAAGAGATTGGTCTAAACTCTGCAAACTCAATCAACA
TTAGCCGTTTGATGGCGCAAATCTGCTACTACTTTGAAGCAGCGGCGCAAATGAGTAAGCAAGAGCGCGAGAATCTGGTG
GTTTCGGTACCAAGCGGCAACTTTGGTAACCTTACTGCGGGTTTGCTTGCTAAAGCTCTGGGGTTACCGATTAAGCGCTT
TATCGCTGCAACGAATGCCAATGATACCGTGCCTCGTTACCTAGAAACCGGTAAATGGGATCCAAAACCGACTGTCGCGA
CGACCTCAAATGCCATGGACGTGAGTCAGCCTAATAACTGGCCACGAATTGAAGAGTTGTGCCGTGTGAAAGAGTGGGGT
TTGGAAACTTTGGGCAAAGGTGCTGTGTCTGATGAGCAAAGTGCGCAATCGGTGAAAGATCTCTATTCACTTGGTTACCT
GTGTGAACCACATGGTGCGATTGCCTATCGTGTGCTGGATCAGCAGCTACAAGAAGGTGAAACTGGCTTGTTCCTCTGTA
CCGCACATCCGGCGAAGTTTAAGGAAGTGGTCGATGACATTCTTGGCAGTGACATCGATTTGCCAGCACCTCTAGCAAAA
CATGCCGTGATGGAGCTGCTCTCTGAAGAGTTGGATGCGGATTTTACGGCTCTGAAAGAAGTATTGCGTCGCGTGCAATA
A

Upstream 100 bases:

>100_bases
TGGCACGCTGGTTAGAACAAAATTACGTACAAAATGAAGAAGGATTCGTCCACATTTGTCGTTTAGACAAAAAGGGCTCA
ATTGTGACAGGAAGTGAGCT

Downstream 100 bases:

>100_bases
GCAGGCATCAATCTCAAAGGTGGAGCTTGGCCTCCACCCTATCGTTTTCTATGGAAAACAAATGCAAGAATAGAAAAACG
GCGCTCGATGAGCGCCGTTT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKLYNIKENDEQVSFGQAVRQGLGRNQGLFFPAELPKFDDIDALLAQDFISRSTAILSALIGDELAEDKVNSMVDAAFQF
PAPIKQVKEGVYALELFHGPTLAFKDFGGRFMAQSLAAVSDGGKITILTATSGDTGAAVAHAFYGMEDINVVILYPKGKI
SPLQEKLFCTLGKNIHTVAINGDFDACQALVKQAFDDAELREEIGLNSANSINISRLMAQICYYFEAAAQMSKQERENLV
VSVPSGNFGNLTAGLLAKALGLPIKRFIAATNANDTVPRYLETGKWDPKPTVATTSNAMDVSQPNNWPRIEELCRVKEWG
LETLGKGAVSDEQSAQSVKDLYSLGYLCEPHGAIAYRVLDQQLQEGETGLFLCTAHPAKFKEVVDDILGSDIDLPAPLAK
HAVMELLSEELDADFTALKEVLRRVQ

Sequences:

>Translated_426_residues
MKLYNIKENDEQVSFGQAVRQGLGRNQGLFFPAELPKFDDIDALLAQDFISRSTAILSALIGDELAEDKVNSMVDAAFQF
PAPIKQVKEGVYALELFHGPTLAFKDFGGRFMAQSLAAVSDGGKITILTATSGDTGAAVAHAFYGMEDINVVILYPKGKI
SPLQEKLFCTLGKNIHTVAINGDFDACQALVKQAFDDAELREEIGLNSANSINISRLMAQICYYFEAAAQMSKQERENLV
VSVPSGNFGNLTAGLLAKALGLPIKRFIAATNANDTVPRYLETGKWDPKPTVATTSNAMDVSQPNNWPRIEELCRVKEWG
LETLGKGAVSDEQSAQSVKDLYSLGYLCEPHGAIAYRVLDQQLQEGETGLFLCTAHPAKFKEVVDDILGSDIDLPAPLAK
HAVMELLSEELDADFTALKEVLRRVQ
>Mature_426_residues
MKLYNIKENDEQVSFGQAVRQGLGRNQGLFFPAELPKFDDIDALLAQDFISRSTAILSALIGDELAEDKVNSMVDAAFQF
PAPIKQVKEGVYALELFHGPTLAFKDFGGRFMAQSLAAVSDGGKITILTATSGDTGAAVAHAFYGMEDINVVILYPKGKI
SPLQEKLFCTLGKNIHTVAINGDFDACQALVKQAFDDAELREEIGLNSANSINISRLMAQICYYFEAAAQMSKQERENLV
VSVPSGNFGNLTAGLLAKALGLPIKRFIAATNANDTVPRYLETGKWDPKPTVATTSNAMDVSQPNNWPRIEELCRVKEWG
LETLGKGAVSDEQSAQSVKDLYSLGYLCEPHGAIAYRVLDQQLQEGETGLFLCTAHPAKFKEVVDDILGSDIDLPAPLAK
HAVMELLSEELDADFTALKEVLRRVQ

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=421, Percent_Identity=30.166270783848, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI149193323, Length=419, Percent_Identity=30.0715990453461, Blast_Score=162, Evalue=5e-40,
Organism=Escherichia coli, GI1786185, Length=428, Percent_Identity=67.0560747663551, Blast_Score=571, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6319901, Length=449, Percent_Identity=33.630289532294, Blast_Score=215, Evalue=9e-57,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46414; Mature: 46414

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYNIKENDEQVSFGQAVRQGLGRNQGLFFPAELPKFDDIDALLAQDFISRSTAILSAL
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IGDELAEDKVNSMVDAAFQFPAPIKQVKEGVYALELFHGPTLAFKDFGGRFMAQSLAAVS
HHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEECCCCCEEHHHCCCHHHHHHHHHHC
DGGKITILTATSGDTGAAVAHAFYGMEDINVVILYPKGKISPLQEKLFCTLGKNIHTVAI
CCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEE
NGDFDACQALVKQAFDDAELREEIGLNSANSINISRLMAQICYYFEAAAQMSKQERENLV
CCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEE
VSVPSGNFGNLTAGLLAKALGLPIKRFIAATNANDTVPRYLETGKWDPKPTVATTSNAMD
EECCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEECCCCCC
VSQPNNWPRIEELCRVKEWGLETLGKGAVSDEQSAQSVKDLYSLGYLCEPHGAIAYRVLD
CCCCCCCHHHHHHHHHHHHCHHHHCCCCCCCHHHHHHHHHHHHHCCEECCCCHHHHHHHH
QQLQEGETGLFLCTAHPAKFKEVVDDILGSDIDLPAPLAKHAVMELLSEELDADFTALKE
HHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
VLRRVQ
HHHHCC
>Mature Secondary Structure
MKLYNIKENDEQVSFGQAVRQGLGRNQGLFFPAELPKFDDIDALLAQDFISRSTAILSAL
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IGDELAEDKVNSMVDAAFQFPAPIKQVKEGVYALELFHGPTLAFKDFGGRFMAQSLAAVS
HHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEECCCCCEEHHHCCCHHHHHHHHHHC
DGGKITILTATSGDTGAAVAHAFYGMEDINVVILYPKGKISPLQEKLFCTLGKNIHTVAI
CCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEE
NGDFDACQALVKQAFDDAELREEIGLNSANSINISRLMAQICYYFEAAAQMSKQERENLV
CCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEE
VSVPSGNFGNLTAGLLAKALGLPIKRFIAATNANDTVPRYLETGKWDPKPTVATTSNAMD
EECCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEECCCCCC
VSQPNNWPRIEELCRVKEWGLETLGKGAVSDEQSAQSVKDLYSLGYLCEPHGAIAYRVLD
CCCCCCCHHHHHHHHHHHHCHHHHCCCCCCCHHHHHHHHHHHHHCCEECCCCHHHHHHHH
QQLQEGETGLFLCTAHPAKFKEVVDDILGSDIDLPAPLAKHAVMELLSEELDADFTALKE
HHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
VLRRVQ
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]