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The map label for this gene is thrB [H]

Identifier: 161486660

GI number: 161486660

Start: 647582

End: 648538

Strand: Direct

Name: thrB [H]

Synonym: VV0651

Alternate gene names: 161486660

Gene position: 647582-648538 (Clockwise)

Preceding gene: 229047217

Following gene: 37678836

Centisome position: 19.3

GC content: 49.32

Gene sequence:

>957_bases
ATGGCTGTGGTAGTGTACGCTCCCGCTTCTATTGGTAATGTCAGTGTTGGTTTTGATGTATTAGGGGCGGCAGTGTCGCC
CATCGATGGTACTTTGCTTGGCGATCGAGTCATGGTGAAAGCGGGGAATGAGCCGTTTTCGTTAAAGACGGCGGGTAGTT
TTGTCGCAAAGCTGCCAAGCGATCCGAAAGAAAACATTGTTTATGATTGCTGGCGAGTGTTTGCTCGCGAACTCGATAAA
AAAGGTCTTGAGCTCAAACCGCTTGAGATGACATTAGAAAAGAACATGCCGATTGGATCTGGGCTTGGCTCTAGTGCTTG
TTCTATTGTTGCCGCGTTAGATGCCCTCAATCAGTTCCATGCCAACCCACTGGATGAAATGGAATTGCTCGCACTGATGG
GTGAAATGGAAGGCCAAATCTCCGGTGGAGTGCACTATGACAACGTTGCACCATGCTATTTAGGTGGCTTGCAATTGATG
CTCGAAGAGCTCGGCATTATTAGCCAAGAAGTTCCGTGCTTCGATGATTGGTATTGGGTGATGGCCTACCCTGGCATTAA
GGTGTCGACGGCAGAAGCGCGTGCGATTTTACCTTCTCAATACCGACGTCAAGATGTGATCGCACATGGCCGCCATTTGG
CCGGCTTTATTCACGCTTGTCACTCAGGGCAGCCTGAGCTTGCCGCGAAGATGATCAAAGACGTGATCGCAGAGCCTTAT
CGTGAGAAACTGCTTCCCGGTTTTGCCGATGCGCGTAAATATGCCGCTTCTGCGGGGGCATTGGCAACGGGCATTTCTGG
CAGTGGGCCGACACTGTTTAGTATTTGCAAAGACCAAGATGTTGCACAGCGTGTGGCACGCTGGTTAGAACAAAATTACG
TACAAAATGAAGAAGGATTCGTCCACATTTGTCGTTTAGACAAAAAGGGCTCAATTGTGACAGGAAGTGAGCTATGA

Upstream 100 bases:

>100_bases
TTACGGTGCCGGTACTCAAGTGACTGCGGCAGGCGTGTTCTCAGATGTGATGCGTACTTTAGGCTGGAAATTAGGGGTTT
AATCGATGAGTTCAAGCGAT

Downstream 100 bases:

>100_bases
AGCTTTACAACATAAAAGAAAATGACGAACAAGTTTCCTTTGGCCAAGCCGTGCGCCAAGGGTTAGGCCGTAATCAGGGG
CTATTTTTCCCAGCAGAATT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MAVVVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVMVKAGNEPFSLKTAGSFVAKLPSDPKENIVYDCWRVFARELDK
KGLELKPLEMTLEKNMPIGSGLGSSACSIVAALDALNQFHANPLDEMELLALMGEMEGQISGGVHYDNVAPCYLGGLQLM
LEELGIISQEVPCFDDWYWVMAYPGIKVSTAEARAILPSQYRRQDVIAHGRHLAGFIHACHSGQPELAAKMIKDVIAEPY
REKLLPGFADARKYAASAGALATGISGSGPTLFSICKDQDVAQRVARWLEQNYVQNEEGFVHICRLDKKGSIVTGSEL

Sequences:

>Translated_318_residues
MAVVVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVMVKAGNEPFSLKTAGSFVAKLPSDPKENIVYDCWRVFARELDK
KGLELKPLEMTLEKNMPIGSGLGSSACSIVAALDALNQFHANPLDEMELLALMGEMEGQISGGVHYDNVAPCYLGGLQLM
LEELGIISQEVPCFDDWYWVMAYPGIKVSTAEARAILPSQYRRQDVIAHGRHLAGFIHACHSGQPELAAKMIKDVIAEPY
REKLLPGFADARKYAASAGALATGISGSGPTLFSICKDQDVAQRVARWLEQNYVQNEEGFVHICRLDKKGSIVTGSEL
>Mature_317_residues
AVVVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVMVKAGNEPFSLKTAGSFVAKLPSDPKENIVYDCWRVFARELDKK
GLELKPLEMTLEKNMPIGSGLGSSACSIVAALDALNQFHANPLDEMELLALMGEMEGQISGGVHYDNVAPCYLGGLQLML
EELGIISQEVPCFDDWYWVMAYPGIKVSTAEARAILPSQYRRQDVIAHGRHLAGFIHACHSGQPELAAKMIKDVIAEPYR
EKLLPGFADARKYAASAGALATGISGSGPTLFSICKDQDVAQRVARWLEQNYVQNEEGFVHICRLDKKGSIVTGSEL

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=311, Percent_Identity=70.096463022508, Blast_Score=451, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 34316; Mature: 34185

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVVVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVMVKAGNEPFSLKTAGSFVAKLPS
CEEEEEECCCCCCCEECHHHHHHHCCCCCCCEECCEEEEEECCCCCEEEHHHHHHHHCCC
DPKENIVYDCWRVFARELDKKGLELKPLEMTLEKNMPIGSGLGSSACSIVAALDALNQFH
CCHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHC
ANPLDEMELLALMGEMEGQISGGVHYDNVAPCYLGGLQLMLEELGIISQEVPCFDDWYWV
CCCHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
MAYPGIKVSTAEARAILPSQYRRQDVIAHGRHLAGFIHACHSGQPELAAKMIKDVIAEPY
EECCCEEEECHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHH
REKLLPGFADARKYAASAGALATGISGSGPTLFSICKDQDVAQRVARWLEQNYVQNEEGF
HHHHCCCHHHHHHHHHHCCHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCE
VHICRLDKKGSIVTGSEL
EEEEEECCCCCEECCCCC
>Mature Secondary Structure 
AVVVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVMVKAGNEPFSLKTAGSFVAKLPS
EEEEEECCCCCCCEECHHHHHHHCCCCCCCEECCEEEEEECCCCCEEEHHHHHHHHCCC
DPKENIVYDCWRVFARELDKKGLELKPLEMTLEKNMPIGSGLGSSACSIVAALDALNQFH
CCHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHC
ANPLDEMELLALMGEMEGQISGGVHYDNVAPCYLGGLQLMLEELGIISQEVPCFDDWYWV
CCCHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
MAYPGIKVSTAEARAILPSQYRRQDVIAHGRHLAGFIHACHSGQPELAAKMIKDVIAEPY
EECCCEEEECHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHH
REKLLPGFADARKYAASAGALATGISGSGPTLFSICKDQDVAQRVARWLEQNYVQNEEGF
HHHHCCCHHHHHHHHHHCCHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCE
VHICRLDKKGSIVTGSEL
EEEEEECCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]