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The map label for this gene is parC [H]

Identifier: 37678773

GI number: 37678773

Start: 572822

End: 575107

Strand: Direct

Name: parC [H]

Synonym: VV0589

Alternate gene names: 37678773

Gene position: 572822-575107 (Clockwise)

Preceding gene: 37678772

Following gene: 37678777

Centisome position: 17.08

GC content: 49.61

Gene sequence:

>2286_bases
ATGTCTACAGAAATTACTTATGATGGCGTCGAACAATTGCCAATGCGCAAGTTCACCGAAGATGCTTATCTAAACTATTC
GATGTACGTCATTATGGATCGTGCGTTGCCTTATATTGGTGACGGTCTGAAACCGGTTCAACGACGTATTATCTACGCGA
TGTCGGAGCTTGGGCTTTCGGCGGCGGCAAAATATAAAAAATCAGCGCGTACCGTGGGTGACGTGTTGGGTAAGTACCAT
CCGCATGGCGACTCTGCGTGTTATGAAGCGATGGTTCTGATGGCACAGCCATTCTCATACCGTTATCCGTTGGTGGACGG
TCAAGGTAACTGGGGTGCACCGGATGATCCGAAATCCTTCGCTGCGATGCGTTATACCGAAGCCAAATTGTCGAAATTTG
CCGATGTGCTTCTGGGAGAGCTTGGTCAAGGCACGGTCGAGTGGCAGCCTAACTTTGATGGCACGATGAAAGAGCCAAAA
ATGCTGCCCGCACGTTTGCCTCACATTCTTCTCAATGGTGTGACAGGGATTGCGGTGGGTATGGCGACCGATATTCCCCC
TCATAACGTACGTGAAGTTGCGGATGCCACCATTCATTTGATTGATAATCCAGCTGCGCCGCTGATGGATTTAATGCAGT
ACGTCAAAGGGCCTGATTTCCCAACAGAAGCAGAGATCATTACCCCAAGCAGCGATCTGGAAAAAATGTATCGCAGTGGC
CGTGGCAGCGTGAAAATGCGCGCGGTTTGGTGCAAAGAGGGCAGTGACATCGTTATCACGGCGCTCCCGCATCAAGTCTC
AGGGGCCAAGCTGCTTGAGCAAATTGCCGCGCAAATGCGCGCGAAAAAATTGCCGATGGTGGAAGACTTGCGTGATGAGT
CTGACCACGAAAACCCAACTCGTATTGTGATTGTACCGCGCTCAAATCGCGTTGATTGCGACCAGTTGATGAACCATTTG
TTTGCGTCCACCGATTTGGAGAAGAGCTATCGTGTTAACTTAAACATGATTGGTCTCGACAACCGCCCACAAGTGAAAGG
CTTGGTGCAGATTTTGACGGAATGGATCACTTTCCGTCGCGAAACGGTACGTTCACGCTTGCAATACCGTCTTGATAAAG
TGCTGGCTCGCTTGCACATCTTGGAAGGTTTGTTGATCGCGTATCTCAACATCGATGAGGTGATTGAGATCATTCGTACT
GAAGACGATCCTAAAGCGGTATTGATGGCCAGATTTGGCATTACCGATATTCAAGCCGATGCGATTCTGGATACCAAACT
TCGTCACTTAGCCAAATTGGAAGAGATGAAGATCCGCGGTGAACAAGATGAGCTGGAAAAAGAACGTAAGAAACTGGAAG
AGTTACTGGGTTCTGAGCGTCGTCTGAATACCTTGCTGAAAAAAGAGATCCGTGCCGATGCCGAGAAATTTGGTGATGAT
CGCCGTTCTCCGCTAGTGGTTCGTGAAGAAGCGAAAGCACTGACTGAACGTGACCTGATGCCGAATGAAGCTATTACGGT
TGTCTTGTCAGAGAAAGGTTGGATTCGTCACGCCAAAGGTCATGAAGTGGATTGTCAGGGGCTGAGCTACAAAGCGGGTG
ACAGCTATCTGGCGCATGCGTGTGGTAAGAGTAACCAGCAAGCGGTACTGCTTGGTTCAGATGGCCGCAGTTACTCATTA
GAATCGCACACACTGCCTTCGGCTCGCGGTCAAGGTGAGCCGATTACTGGCCGCCTCAACATCACGCCAGGAAGCAGTAT
TCGCCAAGTGATCATGGGTGAAGAAGAACAGCTATGGCTGATTGGCTCTGATGCGGGTTACGGCTTCGTGTGTAAAGGCA
GTGATTTGTTGTCGAAAAACCGCAGTGGTAAAGCACTGGTATCGTTGCCTGAAAACGCAGAAGTGATGACCCCATCGGCG
GTATTGGATTTGGACAATGACGATATTCTTGCCATTACCAACCAAGGCCGTATGTTGATGTTCCCAATTAAAGACTTGCC
GCAACTGGGTAAGGGTAAAGGGAATAAGATCATCAATATTCCAGCCGCGAAAGCTAAAGCGAAAGAAGAGATCCTGTCGC
ATTTGATTGCTTTGCCAAAAGGCGCTTCACTGACACTGTACGCAGGCAAACGTAAGTTGGGCTTGAAGCCTGCCGATTTG
GATAACTTCCGTGGAGAGCGAGGCCGTCGAGGTGGTTTGCTGCCACGCGGCTTGCAGCGTGTTACTCGTATTGAGCTTGA
GCAAAGTGACTCATCGGATAGCTCAGAAACGGCTACTGACGCGTAA

Upstream 100 bases:

>100_bases
TGCGACCATGGAAATGATGGACATGCTGCTGGGTAAGAAACGCGCAGATGACCGTCGTAGCTGGTTACAAAACAACGGCG
ATATGGCAGAGGTTTAATAG

Downstream 100 bases:

>100_bases
TAGAAGCAGAAAAAGAACCCCAAGCCTAGGCTTGGGGTTCTTTTTATCACTCGGATTGCATCGTTTGGATTGAGATTAGA
TTTCTCGGTTATCTTCCGCA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 761; Mature: 760

Protein sequence:

>761_residues
MSTEITYDGVEQLPMRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLSAAAKYKKSARTVGDVLGKYH
PHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEAKLSKFADVLLGELGQGTVEWQPNFDGTMKEPK
MLPARLPHILLNGVTGIAVGMATDIPPHNVREVADATIHLIDNPAAPLMDLMQYVKGPDFPTEAEIITPSSDLEKMYRSG
RGSVKMRAVWCKEGSDIVITALPHQVSGAKLLEQIAAQMRAKKLPMVEDLRDESDHENPTRIVIVPRSNRVDCDQLMNHL
FASTDLEKSYRVNLNMIGLDNRPQVKGLVQILTEWITFRRETVRSRLQYRLDKVLARLHILEGLLIAYLNIDEVIEIIRT
EDDPKAVLMARFGITDIQADAILDTKLRHLAKLEEMKIRGEQDELEKERKKLEELLGSERRLNTLLKKEIRADAEKFGDD
RRSPLVVREEAKALTERDLMPNEAITVVLSEKGWIRHAKGHEVDCQGLSYKAGDSYLAHACGKSNQQAVLLGSDGRSYSL
ESHTLPSARGQGEPITGRLNITPGSSIRQVIMGEEEQLWLIGSDAGYGFVCKGSDLLSKNRSGKALVSLPENAEVMTPSA
VLDLDNDDILAITNQGRMLMFPIKDLPQLGKGKGNKIINIPAAKAKAKEEILSHLIALPKGASLTLYAGKRKLGLKPADL
DNFRGERGRRGGLLPRGLQRVTRIELEQSDSSDSSETATDA

Sequences:

>Translated_761_residues
MSTEITYDGVEQLPMRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLSAAAKYKKSARTVGDVLGKYH
PHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEAKLSKFADVLLGELGQGTVEWQPNFDGTMKEPK
MLPARLPHILLNGVTGIAVGMATDIPPHNVREVADATIHLIDNPAAPLMDLMQYVKGPDFPTEAEIITPSSDLEKMYRSG
RGSVKMRAVWCKEGSDIVITALPHQVSGAKLLEQIAAQMRAKKLPMVEDLRDESDHENPTRIVIVPRSNRVDCDQLMNHL
FASTDLEKSYRVNLNMIGLDNRPQVKGLVQILTEWITFRRETVRSRLQYRLDKVLARLHILEGLLIAYLNIDEVIEIIRT
EDDPKAVLMARFGITDIQADAILDTKLRHLAKLEEMKIRGEQDELEKERKKLEELLGSERRLNTLLKKEIRADAEKFGDD
RRSPLVVREEAKALTERDLMPNEAITVVLSEKGWIRHAKGHEVDCQGLSYKAGDSYLAHACGKSNQQAVLLGSDGRSYSL
ESHTLPSARGQGEPITGRLNITPGSSIRQVIMGEEEQLWLIGSDAGYGFVCKGSDLLSKNRSGKALVSLPENAEVMTPSA
VLDLDNDDILAITNQGRMLMFPIKDLPQLGKGKGNKIINIPAAKAKAKEEILSHLIALPKGASLTLYAGKRKLGLKPADL
DNFRGERGRRGGLLPRGLQRVTRIELEQSDSSDSSETATDA
>Mature_760_residues
STEITYDGVEQLPMRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLSAAAKYKKSARTVGDVLGKYHP
HGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEAKLSKFADVLLGELGQGTVEWQPNFDGTMKEPKM
LPARLPHILLNGVTGIAVGMATDIPPHNVREVADATIHLIDNPAAPLMDLMQYVKGPDFPTEAEIITPSSDLEKMYRSGR
GSVKMRAVWCKEGSDIVITALPHQVSGAKLLEQIAAQMRAKKLPMVEDLRDESDHENPTRIVIVPRSNRVDCDQLMNHLF
ASTDLEKSYRVNLNMIGLDNRPQVKGLVQILTEWITFRRETVRSRLQYRLDKVLARLHILEGLLIAYLNIDEVIEIIRTE
DDPKAVLMARFGITDIQADAILDTKLRHLAKLEEMKIRGEQDELEKERKKLEELLGSERRLNTLLKKEIRADAEKFGDDR
RSPLVVREEAKALTERDLMPNEAITVVLSEKGWIRHAKGHEVDCQGLSYKAGDSYLAHACGKSNQQAVLLGSDGRSYSLE
SHTLPSARGQGEPITGRLNITPGSSIRQVIMGEEEQLWLIGSDAGYGFVCKGSDLLSKNRSGKALVSLPENAEVMTPSAV
LDLDNDDILAITNQGRMLMFPIKDLPQLGKGKGNKIINIPAAKAKAKEEILSHLIALPKGASLTLYAGKRKLGLKPADLD
NFRGERGRRGGLLPRGLQRVTRIELEQSDSSDSSETATDA

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=752, Percent_Identity=69.1489361702128, Blast_Score=1101, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=726, Percent_Identity=35.6749311294766, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI212645845, Length=502, Percent_Identity=23.9043824701195, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=197, Percent_Identity=27.4111675126904, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84573; Mature: 84442

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEITYDGVEQLPMRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLS
CCCCCCCCCHHHCCHHHHCHHHHCCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHCHH
AAAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSF
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHH
AAMRYTEAKLSKFADVLLGELGQGTVEWQPNFDGTMKEPKMLPARLPHILLNGVTGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCHHHHEEE
MATDIPPHNVREVADATIHLIDNPAAPLMDLMQYVKGPDFPTEAEIITPSSDLEKMYRSG
EECCCCCCHHHHHHHHEEEEECCCCHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHCC
RGSVKMRAVWCKEGSDIVITALPHQVSGAKLLEQIAAQMRAKKLPMVEDLRDESDHENPT
CCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCC
RIVIVPRSNRVDCDQLMNHLFASTDLEKSYRVNLNMIGLDNRPQVKGLVQILTEWITFRR
EEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
ETVRSRLQYRLDKVLARLHILEGLLIAYLNIDEVIEIIRTEDDPKAVLMARFGITDIQAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCHH
AILDTKLRHLAKLEEMKIRGEQDELEKERKKLEELLGSERRLNTLLKKEIRADAEKFGDD
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
RRSPLVVREEAKALTERDLMPNEAITVVLSEKGWIRHAKGHEVDCQGLSYKAGDSYLAHA
CCCCEEEEHHHHHHHHHCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCCCHHHHHH
CGKSNQQAVLLGSDGRSYSLESHTLPSARGQGEPITGRLNITPGSSIRQVIMGEEEQLWL
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCEEEE
IGSDAGYGFVCKGSDLLSKNRSGKALVSLPENAEVMTPSAVLDLDNDDILAITNQGRMLM
EECCCCCEEEECCCHHHHCCCCCCEEEECCCCCCEECCCEEEECCCCCEEEEECCCCEEE
FPIKDLPQLGKGKGNKIINIPAAKAKAKEEILSHLIALPKGASLTLYAGKRKLGLKPADL
EECHHCHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCC
DNFRGERGRRGGLLPRGLQRVTRIELEQSDSSDSSETATDA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
STEITYDGVEQLPMRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLS
CCCCCCCCHHHCCHHHHCHHHHCCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHCHH
AAAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSF
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHH
AAMRYTEAKLSKFADVLLGELGQGTVEWQPNFDGTMKEPKMLPARLPHILLNGVTGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCHHHHEEE
MATDIPPHNVREVADATIHLIDNPAAPLMDLMQYVKGPDFPTEAEIITPSSDLEKMYRSG
EECCCCCCHHHHHHHHEEEEECCCCHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHCC
RGSVKMRAVWCKEGSDIVITALPHQVSGAKLLEQIAAQMRAKKLPMVEDLRDESDHENPT
CCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCC
RIVIVPRSNRVDCDQLMNHLFASTDLEKSYRVNLNMIGLDNRPQVKGLVQILTEWITFRR
EEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
ETVRSRLQYRLDKVLARLHILEGLLIAYLNIDEVIEIIRTEDDPKAVLMARFGITDIQAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCHH
AILDTKLRHLAKLEEMKIRGEQDELEKERKKLEELLGSERRLNTLLKKEIRADAEKFGDD
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
RRSPLVVREEAKALTERDLMPNEAITVVLSEKGWIRHAKGHEVDCQGLSYKAGDSYLAHA
CCCCEEEEHHHHHHHHHCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCCCHHHHHH
CGKSNQQAVLLGSDGRSYSLESHTLPSARGQGEPITGRLNITPGSSIRQVIMGEEEQLWL
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCEEEE
IGSDAGYGFVCKGSDLLSKNRSGKALVSLPENAEVMTPSAVLDLDNDDILAITNQGRMLM
EECCCCCEEEECCCHHHHCCCCCCEEEECCCCCCEECCCEEEECCCCCEEEEECCCCEEE
FPIKDLPQLGKGKGNKIINIPAAKAKAKEEILSHLIALPKGASLTLYAGKRKLGLKPADL
EECHHCHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCC
DNFRGERGRRGGLLPRGLQRVTRIELEQSDSSDSSETATDA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]