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The map label for this gene is parE [H]

Identifier: 37678772

GI number: 37678772

Start: 570938

End: 572818

Strand: Direct

Name: parE [H]

Synonym: VV0588

Alternate gene names: 37678772

Gene position: 570938-572818 (Clockwise)

Preceding gene: 161486662

Following gene: 37678773

Centisome position: 17.02

GC content: 50.51

Gene sequence:

>1881_bases
ATGACTGAACAATATAATGCTGGTGCCATTGAAGTACTGAATGGTTTAGAGCCAGTACGTCGCCGACCAGGGATGTATAC
GGATACAGCGCGCCCGAACCATTTGGGCCAAGAAGTCATCGATAACAGTGTCGATGAAGCGCTGGCCGGACATGCCTCCA
AAGTACAAGTCATCCTACATGCAGACCAATCACTGGAAGTGATCGATGATGGTCGAGGCATGCCAGTCGATATTCACCCA
GAAGAGAAAGTCTCGGGCGTTGAGCTGATCCTATGTAAGCTGCACGCCGGTGGTAAATTCTCCAACAAAAACTATCAATT
TTCTGGTGGCTTGCACGGGGTAGGTATTTCGGTGGTGAACGCCCTGTCTAAAAGGGTTGAAGTGACAGTACGTCGAGATG
GTCAGGTTTACGAAATCGCTTTTGAACATGGTGACAAAGTGTCGGATCTCACCGTGACGGGGACGTGTGGTCGTCGCAAT
CGCGGTACCAGCGTGCACTTCTGGCCAGACACCAAATACTTTGATTCGCCAAATTTCTCGGTCACACGTTTAGTGAATAA
CTTGCGCGCGAAGGCGGTTCTTTGCCCAGGTTTGGAAATTACTTTCAGTGACCGTGTGAATGGTAAAGAGCATCAGTGGC
TCTACCAAGATGGTTTGAAAGATTATTTGATTGAAGGGGTGAAGGGTTACACCTTACTCCCTGAAGAGCCATTTACAGGC
CAATTCTCGGCAGAAACAGAAGCCGCGGATTGGGCGGTGATCTGGCAGCCTGAAGGCGGCGAGATGATCACCGAAAGCTA
CGTTAACCTGATCCCAACCGCACAAGGCGGTACGCATGTGAACGGTTTACGTCAAGGTTTGTTGGATGCGATGCGTGAGT
TCTGTGAATTCCGCAACTTACTGCCGCGTGGCGTGAAGTTAACGGGCGAAGACGTTTTCGACCGCTGTTCTTACGTGTTG
TCGGTGAAGATGCAAGATCCGCAGTTTGCTGGCCAGACCAAAGAGCGCCTTTCTTCTCGTCAAACCGCGGCGTTTGTCTC
TGGGGTAGTAAAAGACACTTTTAGCTTGTGGTTAAATGAAAAGCCACAACTTGCTGAGCAACTCGCGGAAGTGTGTATTG
CGAACGCCCATCGTCGTATGCGTGCGAGCAAGAAGGTCGTGCGTAAAAAGATTGCATCAGGCCCTGCTTTGCCAGGTAAG
TTGACCGATTGTTCCGTGCAAGACTTAGCTCGTACTGAAATCTTCTTCGTGGAAGGGGATTCGGCAGGCGGCAGTGCCAA
GCAAGCGCGTGATCGTGAATTCCAAGCCGTAATGCCGCTGCGGGGTAAAATCTTAAATACTTGGGAAGTCTCTGCCGATC
AAGTATTGGCGTCTCAAGAAGTGCACGATATTTCTGTGGCGCTAGGGATTGATCCAGATAGCGACAATCTTGAAGGACTG
CGTTACGGAAAAATCTGTATCCTCGCCGATGCGGACTCGGATGGTCTGCACATCGCGACACTCTTGTGTGCGCTATTCAC
ACGTCATTTCCGCGCGCTAGTTGAAGCCGGTCATATCTACGTAGCAATGCCACCACTGTATCGTATCGACTGTGGCAAAG
AGGTGTTCTATGCGCTGGATGATGCAGAAAAAGATGGCGTATTAGAGCGCCTAAGCCAGAAGCGCGCCAAAATCAACGTG
CAACGATTCAAAGGTCTGGGTGAGATGAACCCACTGCAGTTGCGTGAAACCACGATGGATCCCAATACGCGTCGTCTGGT
GCAACTGACCATTGATGACTCCGATGCGACCATGGAAATGATGGACATGCTGCTGGGTAAGAAACGCGCAGATGACCGTC
GTAGCTGGTTACAAAACAACGGCGATATGGCAGAGGTTTAA

Upstream 100 bases:

>100_bases
CTGTGAGTAACAGGGTAGCTTTTTCGTTGTCGTCAGTTGGTGCAAAAGTGTGACCAACTAGGCTCAGACAACAGGTAAAC
ATTGAGAACGATTCCGTATT

Downstream 100 bases:

>100_bases
TAGATGTCTACAGAAATTACTTATGATGGCGTCGAACAATTGCCAATGCGCAAGTTCACCGAAGATGCTTATCTAAACTA
TTCGATGTACGTCATTATGG

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 626; Mature: 625

Protein sequence:

>626_residues
MTEQYNAGAIEVLNGLEPVRRRPGMYTDTARPNHLGQEVIDNSVDEALAGHASKVQVILHADQSLEVIDDGRGMPVDIHP
EEKVSGVELILCKLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVTVRRDGQVYEIAFEHGDKVSDLTVTGTCGRRN
RGTSVHFWPDTKYFDSPNFSVTRLVNNLRAKAVLCPGLEITFSDRVNGKEHQWLYQDGLKDYLIEGVKGYTLLPEEPFTG
QFSAETEAADWAVIWQPEGGEMITESYVNLIPTAQGGTHVNGLRQGLLDAMREFCEFRNLLPRGVKLTGEDVFDRCSYVL
SVKMQDPQFAGQTKERLSSRQTAAFVSGVVKDTFSLWLNEKPQLAEQLAEVCIANAHRRMRASKKVVRKKIASGPALPGK
LTDCSVQDLARTEIFFVEGDSAGGSAKQARDREFQAVMPLRGKILNTWEVSADQVLASQEVHDISVALGIDPDSDNLEGL
RYGKICILADADSDGLHIATLLCALFTRHFRALVEAGHIYVAMPPLYRIDCGKEVFYALDDAEKDGVLERLSQKRAKINV
QRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDSDATMEMMDMLLGKKRADDRRSWLQNNGDMAEV

Sequences:

>Translated_626_residues
MTEQYNAGAIEVLNGLEPVRRRPGMYTDTARPNHLGQEVIDNSVDEALAGHASKVQVILHADQSLEVIDDGRGMPVDIHP
EEKVSGVELILCKLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVTVRRDGQVYEIAFEHGDKVSDLTVTGTCGRRN
RGTSVHFWPDTKYFDSPNFSVTRLVNNLRAKAVLCPGLEITFSDRVNGKEHQWLYQDGLKDYLIEGVKGYTLLPEEPFTG
QFSAETEAADWAVIWQPEGGEMITESYVNLIPTAQGGTHVNGLRQGLLDAMREFCEFRNLLPRGVKLTGEDVFDRCSYVL
SVKMQDPQFAGQTKERLSSRQTAAFVSGVVKDTFSLWLNEKPQLAEQLAEVCIANAHRRMRASKKVVRKKIASGPALPGK
LTDCSVQDLARTEIFFVEGDSAGGSAKQARDREFQAVMPLRGKILNTWEVSADQVLASQEVHDISVALGIDPDSDNLEGL
RYGKICILADADSDGLHIATLLCALFTRHFRALVEAGHIYVAMPPLYRIDCGKEVFYALDDAEKDGVLERLSQKRAKINV
QRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDSDATMEMMDMLLGKKRADDRRSWLQNNGDMAEV
>Mature_625_residues
TEQYNAGAIEVLNGLEPVRRRPGMYTDTARPNHLGQEVIDNSVDEALAGHASKVQVILHADQSLEVIDDGRGMPVDIHPE
EKVSGVELILCKLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVTVRRDGQVYEIAFEHGDKVSDLTVTGTCGRRNR
GTSVHFWPDTKYFDSPNFSVTRLVNNLRAKAVLCPGLEITFSDRVNGKEHQWLYQDGLKDYLIEGVKGYTLLPEEPFTGQ
FSAETEAADWAVIWQPEGGEMITESYVNLIPTAQGGTHVNGLRQGLLDAMREFCEFRNLLPRGVKLTGEDVFDRCSYVLS
VKMQDPQFAGQTKERLSSRQTAAFVSGVVKDTFSLWLNEKPQLAEQLAEVCIANAHRRMRASKKVVRKKIASGPALPGKL
TDCSVQDLARTEIFFVEGDSAGGSAKQARDREFQAVMPLRGKILNTWEVSADQVLASQEVHDISVALGIDPDSDNLEGLR
YGKICILADADSDGLHIATLLCALFTRHFRALVEAGHIYVAMPPLYRIDCGKEVFYALDDAEKDGVLERLSQKRAKINVQ
RFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDSDATMEMMDMLLGKKRADDRRSWLQNNGDMAEV

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=631, Percent_Identity=24.405705229794, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI19913408, Length=595, Percent_Identity=25.7142857142857, Blast_Score=130, Evalue=5e-30,
Organism=Escherichia coli, GI1789408, Length=628, Percent_Identity=79.2993630573248, Blast_Score=1058, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=558, Percent_Identity=40.8602150537634, Blast_Score=388, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI212645845, Length=606, Percent_Identity=23.2673267326733, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17535065, Length=624, Percent_Identity=22.4358974358974, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI212645657, Length=251, Percent_Identity=25.8964143426295, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=616, Percent_Identity=24.6753246753247, Blast_Score=141, Evalue=3e-34,
Organism=Drosophila melanogaster, GI17136538, Length=627, Percent_Identity=23.1259968102073, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 69529; Mature: 69398

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQYNAGAIEVLNGLEPVRRRPGMYTDTARPNHLGQEVIDNSVDEALAGHASKVQVILH
CCCCCCCCHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEE
ADQSLEVIDDGRGMPVDIHPEEKVSGVELILCKLHAGGKFSNKNYQFSGGLHGVGISVVN
CCCCCEEEECCCCCCEECCCCCCCCCEEEEEEEEECCCCCCCCCEEECCCCCHHHHHHHH
ALSKRVEVTVRRDGQVYEIAFEHGDKVSDLTVTGTCGRRNRGTSVHFWPDTKYFDSPNFS
HHHHHEEEEEECCCCEEEEEECCCCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCH
VTRLVNNLRAKAVLCPGLEITFSDRVNGKEHQWLYQDGLKDYLIEGVKGYTLLPEEPFTG
HHHHHHHHHHCEEECCCCEEEECCCCCCCCCHHHHHCCHHHHHHCCCCCCEECCCCCCCC
QFSAETEAADWAVIWQPEGGEMITESYVNLIPTAQGGTHVNGLRQGLLDAMREFCEFRNL
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
LPRGVKLTGEDVFDRCSYVLSVKMQDPQFAGQTKERLSSRQTAAFVSGVVKDTFSLWLNE
CCCCCEECCHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KPQLAEQLAEVCIANAHRRMRASKKVVRKKIASGPALPGKLTDCSVQDLARTEIFFVEGD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCEEEEEEECC
SAGGSAKQARDREFQAVMPLRGKILNTWEVSADQVLASQEVHDISVALGIDPDSDNLEGL
CCCCCHHHHHCCCHHEECCCCCCEEEEEECCHHHHHHHCCCEEEEEEEECCCCCCCCCCE
RYGKICILADADSDGLHIATLLCALFTRHFRALVEAGHIYVAMPPLYRIDCGKEVFYALD
EECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCCEEEEEEC
DAEKDGVLERLSQKRAKINVQRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDSDATMEM
CCCCCHHHHHHHHHHHHEEHHHHCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCHHHHH
MDMLLGKKRADDRRSWLQNNGDMAEV
HHHHHCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TEQYNAGAIEVLNGLEPVRRRPGMYTDTARPNHLGQEVIDNSVDEALAGHASKVQVILH
CCCCCCCHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEE
ADQSLEVIDDGRGMPVDIHPEEKVSGVELILCKLHAGGKFSNKNYQFSGGLHGVGISVVN
CCCCCEEEECCCCCCEECCCCCCCCCEEEEEEEEECCCCCCCCCEEECCCCCHHHHHHHH
ALSKRVEVTVRRDGQVYEIAFEHGDKVSDLTVTGTCGRRNRGTSVHFWPDTKYFDSPNFS
HHHHHEEEEEECCCCEEEEEECCCCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCH
VTRLVNNLRAKAVLCPGLEITFSDRVNGKEHQWLYQDGLKDYLIEGVKGYTLLPEEPFTG
HHHHHHHHHHCEEECCCCEEEECCCCCCCCCHHHHHCCHHHHHHCCCCCCEECCCCCCCC
QFSAETEAADWAVIWQPEGGEMITESYVNLIPTAQGGTHVNGLRQGLLDAMREFCEFRNL
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
LPRGVKLTGEDVFDRCSYVLSVKMQDPQFAGQTKERLSSRQTAAFVSGVVKDTFSLWLNE
CCCCCEECCHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KPQLAEQLAEVCIANAHRRMRASKKVVRKKIASGPALPGKLTDCSVQDLARTEIFFVEGD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCEEEEEEECC
SAGGSAKQARDREFQAVMPLRGKILNTWEVSADQVLASQEVHDISVALGIDPDSDNLEGL
CCCCCHHHHHCCCHHEECCCCCCEEEEEECCHHHHHHHCCCEEEEEEEECCCCCCCCCCE
RYGKICILADADSDGLHIATLLCALFTRHFRALVEAGHIYVAMPPLYRIDCGKEVFYALD
EECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCCEEEEEEC
DAEKDGVLERLSQKRAKINVQRFKGLGEMNPLQLRETTMDPNTRRLVQLTIDDSDATMEM
CCCCCHHHHHHHHHHHHEEHHHHCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCHHHHH
MDMLLGKKRADDRRSWLQNNGDMAEV
HHHHHCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2170028; 8388096; 9278503; 8227000; 8980775 [H]