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The map label for this gene is wecB [H]

Identifier: 37678525

GI number: 37678525

Start: 348769

End: 349908

Strand: Direct

Name: wecB [H]

Synonym: VV0341

Alternate gene names: 37678525

Gene position: 348769-349908 (Clockwise)

Preceding gene: 37678524

Following gene: 37678526

Centisome position: 10.4

GC content: 45.7

Gene sequence:

>1140_bases
TTGTTGGTTAGTTGTATGTCAAAGAAGAAAGTTCTTACGGTTTTTGGAACACGCCCAGAAGCAATAAAAATGGCGCCATT
AGTGCATGCTTTAGCGGCGGATGAACGTTTCGAAGCAAAATGTTGTGTAACGGCTCAACACCGTGAAATGCTCGATCAAG
TTTTAGAGTTGTTTGAAATTACTCCGGACTATGATCTAAACCTGATGAAAGCAGGTCAAACGCTCAATGAAGTGACGGCG
CGAATTTTGTTAGAGTTAAAACCTGTTTTACAAGAGTTCAAACCTGATGTAGTCCTAGTTCACGGCGACACTGCTACAAC
GTTTGCCGCCAGCTTAGCAGCCTATTATGAGCAAATTGCTGTTGGGCATGTTGAAGCAGGCCTGCGCACAGGCAACATCT
ATTCACCATGGCCAGAGGAAGCTAACCGCAAGCTCACCGGTGCGTTAACCAAATACCATTTTGCTCCAACAGAAACCTCG
CAGCAAAATTTGCTGCAAGAGAATTACGCAGAAGAGAATATTTTCGTCACTGGCAATACGGTAATTGATGCGCTGCTAAT
GGTGAAAGAGAAAATTGAGCAAGATGCTGATCTAAAAGCAACCTTAGCCGCACAGTTCCCTTACTTAGATGAAAACAAAA
AGCTCATCTTGGTCACTGGTCATCGACGCGAAAGCTTTGGCGGTGGTTTTGAGCGTATTTGTGAAGCACTAGCACAAACC
GCAAAACAGCACCCTGAGGTGCAAATTCTCTACCCTATGCATTTAAACCCTAACGTGCGTGAACCGGTTAATCGTATTCT
AGGTAGCGTGGAAAATGTGCTGCTGATTGAGCCGCAACAGTACTTGCCCTTTATCTACTTAATGGACCGAGCGCACATTA
TTCTCACCGATTCCGGTGGTATTCAAGAAGAAGCGCCATCCCTTGGGAAACCCGTGTTATTGATGCGTGATACGACCGAG
CGCCCAGAAGCGGTGGCAGCAGGGACAGTTAAATTGGTGGGAACAGATGTAGAAAAAATCGTCTCCAACCTAAACACCTT
GCTTACCGATAGCGAAGCCTATCAAGCGATGAGCTTTGCCCATAACCCATACGGTGATGGTAAAGCGTGCCAGAGAATTC
TCGATTCTCTGTGCAAGTAA

Upstream 100 bases:

>100_bases
ACTATAGCTATGGTGAGAGTAATAAAGCTTAAATTAACCGGGGAGAACTGCTATTCGGCTGTTATCTCCTCGGTATCTCC
AGAATTTTGTATCTAAATTA

Downstream 100 bases:

>100_bases
CTTTTAAATATCTCCTAGAACCTAGAACCTAGAACCTAGAACCTAGAACAAAATTTATATATATTTTTAGGACTCAGAAA
AATGTCTTTTGAAACCATTT

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MLVSCMSKKKVLTVFGTRPEAIKMAPLVHALAADERFEAKCCVTAQHREMLDQVLELFEITPDYDLNLMKAGQTLNEVTA
RILLELKPVLQEFKPDVVLVHGDTATTFAASLAAYYEQIAVGHVEAGLRTGNIYSPWPEEANRKLTGALTKYHFAPTETS
QQNLLQENYAEENIFVTGNTVIDALLMVKEKIEQDADLKATLAAQFPYLDENKKLILVTGHRRESFGGGFERICEALAQT
AKQHPEVQILYPMHLNPNVREPVNRILGSVENVLLIEPQQYLPFIYLMDRAHIILTDSGGIQEEAPSLGKPVLLMRDTTE
RPEAVAAGTVKLVGTDVEKIVSNLNTLLTDSEAYQAMSFAHNPYGDGKACQRILDSLCK

Sequences:

>Translated_379_residues
MLVSCMSKKKVLTVFGTRPEAIKMAPLVHALAADERFEAKCCVTAQHREMLDQVLELFEITPDYDLNLMKAGQTLNEVTA
RILLELKPVLQEFKPDVVLVHGDTATTFAASLAAYYEQIAVGHVEAGLRTGNIYSPWPEEANRKLTGALTKYHFAPTETS
QQNLLQENYAEENIFVTGNTVIDALLMVKEKIEQDADLKATLAAQFPYLDENKKLILVTGHRRESFGGGFERICEALAQT
AKQHPEVQILYPMHLNPNVREPVNRILGSVENVLLIEPQQYLPFIYLMDRAHIILTDSGGIQEEAPSLGKPVLLMRDTTE
RPEAVAAGTVKLVGTDVEKIVSNLNTLLTDSEAYQAMSFAHNPYGDGKACQRILDSLCK
>Mature_379_residues
MLVSCMSKKKVLTVFGTRPEAIKMAPLVHALAADERFEAKCCVTAQHREMLDQVLELFEITPDYDLNLMKAGQTLNEVTA
RILLELKPVLQEFKPDVVLVHGDTATTFAASLAAYYEQIAVGHVEAGLRTGNIYSPWPEEANRKLTGALTKYHFAPTETS
QQNLLQENYAEENIFVTGNTVIDALLMVKEKIEQDADLKATLAAQFPYLDENKKLILVTGHRRESFGGGFERICEALAQT
AKQHPEVQILYPMHLNPNVREPVNRILGSVENVLLIEPQQYLPFIYLMDRAHIILTDSGGIQEEAPSLGKPVLLMRDTTE
RPEAVAAGTVKLVGTDVEKIVSNLNTLLTDSEAYQAMSFAHNPYGDGKACQRILDSLCK

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=368, Percent_Identity=72.2826086956522, Blast_Score=552, Evalue=1e-158,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 42123; Mature: 42123

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVSCMSKKKVLTVFGTRPEAIKMAPLVHALAADERFEAKCCVTAQHREMLDQVLELFEI
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHC
TPDYDLNLMKAGQTLNEVTARILLELKPVLQEFKPDVVLVHGDTATTFAASLAAYYEQIA
CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
VGHVEAGLRTGNIYSPWPEEANRKLTGALTKYHFAPTETSQQNLLQENYAEENIFVTGNT
HHHHHCCCEECCCCCCCCHHHCCHHHHHHHHEECCCCCCHHHHHHHHHCCCCCEEEECHH
VIDALLMVKEKIEQDADLKATLAAQFPYLDENKKLILVTGHRRESFGGGFERICEALAQT
HHHHHHHHHHHHCCCCCCEEEHHEECCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHH
AKQHPEVQILYPMHLNPNVREPVNRILGSVENVLLIEPQQYLPFIYLMDRAHIILTDSGG
HHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEECCHHHCCEEEEECCCEEEEECCCC
IQEEAPSLGKPVLLMRDTTERPEAVAAGTVKLVGTDVEKIVSNLNTLLTDSEAYQAMSFA
CCCCCCCCCCCEEEEECCCCCCCHHHCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHC
HNPYGDGKACQRILDSLCK
CCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLVSCMSKKKVLTVFGTRPEAIKMAPLVHALAADERFEAKCCVTAQHREMLDQVLELFEI
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHC
TPDYDLNLMKAGQTLNEVTARILLELKPVLQEFKPDVVLVHGDTATTFAASLAAYYEQIA
CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
VGHVEAGLRTGNIYSPWPEEANRKLTGALTKYHFAPTETSQQNLLQENYAEENIFVTGNT
HHHHHCCCEECCCCCCCCHHHCCHHHHHHHHEECCCCCCHHHHHHHHHCCCCCEEEECHH
VIDALLMVKEKIEQDADLKATLAAQFPYLDENKKLILVTGHRRESFGGGFERICEALAQT
HHHHHHHHHHHHCCCCCCEEEHHEECCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHH
AKQHPEVQILYPMHLNPNVREPVNRILGSVENVLLIEPQQYLPFIYLMDRAHIILTDSGG
HHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEECCHHHCCEEEEECCCEEEEECCCC
IQEEAPSLGKPVLLMRDTTERPEAVAAGTVKLVGTDVEKIVSNLNTLLTDSEAYQAMSFA
CCCCCCCCCCCEEEEECCCCCCCHHHCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHC
HNPYGDGKACQRILDSLCK
CCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]