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The map label for this gene is wecC

Identifier: 37678526

GI number: 37678526

Start: 349990

End: 351252

Strand: Direct

Name: wecC

Synonym: VV0342

Alternate gene names: 37678526

Gene position: 349990-351252 (Clockwise)

Preceding gene: 37678525

Following gene: 37678527

Centisome position: 10.43

GC content: 44.89

Gene sequence:

>1263_bases
ATGTCTTTTGAAACCATTTCAGTAATTGGCTTAGGCTATATCGGTTTACCTACCGCGGCGATGTTTGCATCACGTAAAAA
GAAAGTCATTGGTGTGGATGTTAACCAACATGCGGTTGATACCATTAATCAAGGTAAGATTCATATTGTAGAGCCAGATC
TAGATATGATGGTGCATGCTGCAGTCAGCGGTGGCTATTTAAAAGCAACCACCACACCAGAAGCGGCCGATGCCTTTTTG
ATTGCCGTGCCAACGCCATTCTTACCTTGTGCAGAGGGTGATATTCCACCACCGGATCTCTCTTACATTGAAGCCGCCAG
CAAAGCGATTGCCCCTGTACTGAAAAAAGGCGACTTGGTGATTTTAGAATCGACCTCTCCTGTTGGCGCAACCGAGAAAA
TGGCCGCTTGGCTCGCAGAAGCTCGCTCTGATCTTACCTTCCCACAAACATACGGTGAAGAAGCGGATGTGAACATTGCT
CATTGTCCAGAGCGCGTTTTGCCTGGCCATGTGGTGCGTGAGCTTGTTGAAAACGACCGAGTGATCGGTGGTTTAACACC
TAAGTGCTCAGCGCGTGCGGTGGAACTCTATAAAACTTTTGTTCAAGGTGAATGTGTAATTACCAACGCACGTACCGCGG
AAATGGCTAAACTGACCGAGAACAGCTCCCGTGATGTACAAATTGCCTTTGCCAACGAGCTATCTATCATTTGTGACAAG
CTAGACATCAACGTATGGGAGCTAATTGCACTGGCAAACCGCCACCCTCGTGTTAACATTCTTCAGCCCGGCCCTGGTGT
GGGCGGCCACTGTATTGCCGTTGACCCTTGGTTTATTGTGTCTAAAACACCAGAAGAAGCACAGATTATCCATATGGCAC
GTAAAGTCAATGACAGCAAACCGCAGTGGGTGATAAATAAAGTGAAGTTGGCAATAGCAGACTTTTTGCAAGCCAATCCA
GAAAAAACAGCTAAAGACATGACCATTGCTTGCTACGGTTTGGCCTTTAAATCTGATATTGATGACTTGCGTGAGAGTCC
GTCCTTAGAAATAGCAAAGAAAGTTTCAGAATTTCATAGAGGGAAGGTTTTAGTGGTTGAACCTAACATTGCACAGCTTC
CATCTGAACTAGATGGAAATGTGGATCTTGTAGACATTTCTGATACCAATTATGCTGATTTACATGTTGTGCTTGTAGGT
CATAAAGAATTTGGGTCAAATCTATTCGACAAAAAAAATACGATTTTCGCAGTCAATGTCTAG

Upstream 100 bases:

>100_bases
CGATTCTCTGTGCAAGTAACTTTTAAATATCTCCTAGAACCTAGAACCTAGAACCTAGAACCTAGAACAAAATTTATATA
TATTTTTAGGACTCAGAAAA

Downstream 100 bases:

>100_bases
CTTAAAAAGTAACATAACGAAAGGGGCTTTATGGCAAAGTATTAGTATAGTATCTACGTTTATATTAATTCCAATATCCA
TTAGCTATTTGGGAAAAGAG

Product: UDP-N-acetyl-D-mannosamine dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSFETISVIGLGYIGLPTAAMFASRKKKVIGVDVNQHAVDTINQGKIHIVEPDLDMMVHAAVSGGYLKATTTPEAADAFL
IAVPTPFLPCAEGDIPPPDLSYIEAASKAIAPVLKKGDLVILESTSPVGATEKMAAWLAEARSDLTFPQTYGEEADVNIA
HCPERVLPGHVVRELVENDRVIGGLTPKCSARAVELYKTFVQGECVITNARTAEMAKLTENSSRDVQIAFANELSIICDK
LDINVWELIALANRHPRVNILQPGPGVGGHCIAVDPWFIVSKTPEEAQIIHMARKVNDSKPQWVINKVKLAIADFLQANP
EKTAKDMTIACYGLAFKSDIDDLRESPSLEIAKKVSEFHRGKVLVVEPNIAQLPSELDGNVDLVDISDTNYADLHVVLVG
HKEFGSNLFDKKNTIFAVNV

Sequences:

>Translated_420_residues
MSFETISVIGLGYIGLPTAAMFASRKKKVIGVDVNQHAVDTINQGKIHIVEPDLDMMVHAAVSGGYLKATTTPEAADAFL
IAVPTPFLPCAEGDIPPPDLSYIEAASKAIAPVLKKGDLVILESTSPVGATEKMAAWLAEARSDLTFPQTYGEEADVNIA
HCPERVLPGHVVRELVENDRVIGGLTPKCSARAVELYKTFVQGECVITNARTAEMAKLTENSSRDVQIAFANELSIICDK
LDINVWELIALANRHPRVNILQPGPGVGGHCIAVDPWFIVSKTPEEAQIIHMARKVNDSKPQWVINKVKLAIADFLQANP
EKTAKDMTIACYGLAFKSDIDDLRESPSLEIAKKVSEFHRGKVLVVEPNIAQLPSELDGNVDLVDISDTNYADLHVVLVG
HKEFGSNLFDKKNTIFAVNV
>Mature_419_residues
SFETISVIGLGYIGLPTAAMFASRKKKVIGVDVNQHAVDTINQGKIHIVEPDLDMMVHAAVSGGYLKATTTPEAADAFLI
AVPTPFLPCAEGDIPPPDLSYIEAASKAIAPVLKKGDLVILESTSPVGATEKMAAWLAEARSDLTFPQTYGEEADVNIAH
CPERVLPGHVVRELVENDRVIGGLTPKCSARAVELYKTFVQGECVITNARTAEMAKLTENSSRDVQIAFANELSIICDKL
DINVWELIALANRHPRVNILQPGPGVGGHCIAVDPWFIVSKTPEEAQIIHMARKVNDSKPQWVINKVKLAIADFLQANPE
KTAKDMTIACYGLAFKSDIDDLRESPSLEIAKKVSEFHRGKVLVVEPNIAQLPSELDGNVDLVDISDTNYADLHVVLVGH
KEFGSNLFDKKNTIFAVNV

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=371, Percent_Identity=27.2237196765499, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI296040438, Length=268, Percent_Identity=26.865671641791, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI48994968, Length=405, Percent_Identity=68.641975308642, Blast_Score=568, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17560350, Length=382, Percent_Identity=28.7958115183246, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17136908, Length=370, Percent_Identity=27.2972972972973, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 45590; Mature: 45459

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFETISVIGLGYIGLPTAAMFASRKKKVIGVDVNQHAVDTINQGKIHIVEPDLDMMVHA
CCCEEEEEEEECCHHHHHHHHHHHCCCEEEEECCCCHHHCCCCCCEEEEECCCHHHEEEE
AVSGGYLKATTTPEAADAFLIAVPTPFLPCAEGDIPPPDLSYIEAASKAIAPVLKKGDLV
ECCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEE
ILESTSPVGATEKMAAWLAEARSDLTFPQTYGEEADVNIAHCPERVLPGHVVRELVENDR
EEECCCCCCCHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHCCCHHCCCHHHHHHHHHCCC
VIGGLTPKCSARAVELYKTFVQGECVITNARTAEMAKLTENSSRDVQIAFANELSIICDK
EEECCCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCEEEEEEECCEEEEEEC
LDINVWELIALANRHPRVNILQPGPGVGGHCIAVDPWFIVSKTPEEAQIIHMARKVNDSK
CCCCHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHHCCCCC
PQWVINKVKLAIADFLQANPEKTAKDMTIACYGLAFKSDIDDLRESPSLEIAKKVSEFHR
CHHHHHHHHHHHHHHHHCCCCHHHCCEEEEEEEEEHHCCHHHHHCCCCHHHHHHHHHHHC
GKVLVVEPNIAQLPSELDGNVDLVDISDTNYADLHVVLVGHKEFGSNLFDKKNTIFAVNV
CEEEEECCCHHHCCHHCCCCEEEEEECCCCCCEEEEEEEECHHHCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SFETISVIGLGYIGLPTAAMFASRKKKVIGVDVNQHAVDTINQGKIHIVEPDLDMMVHA
CCEEEEEEEECCHHHHHHHHHHHCCCEEEEECCCCHHHCCCCCCEEEEECCCHHHEEEE
AVSGGYLKATTTPEAADAFLIAVPTPFLPCAEGDIPPPDLSYIEAASKAIAPVLKKGDLV
ECCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEE
ILESTSPVGATEKMAAWLAEARSDLTFPQTYGEEADVNIAHCPERVLPGHVVRELVENDR
EEECCCCCCCHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHCCCHHCCCHHHHHHHHHCCC
VIGGLTPKCSARAVELYKTFVQGECVITNARTAEMAKLTENSSRDVQIAFANELSIICDK
EEECCCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCEEEEEEECCEEEEEEC
LDINVWELIALANRHPRVNILQPGPGVGGHCIAVDPWFIVSKTPEEAQIIHMARKVNDSK
CCCCHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHHCCCCC
PQWVINKVKLAIADFLQANPEKTAKDMTIACYGLAFKSDIDDLRESPSLEIAKKVSEFHR
CHHHHHHHHHHHHHHHHCCCCHHHCCEEEEEEEEEHHCCHHHHHCCCCHHHHHHHHHHHC
GKVLVVEPNIAQLPSELDGNVDLVDISDTNYADLHVVLVGHKEFGSNLFDKKNTIFAVNV
CEEEEECCCHHHCCHHCCCCEEEEEECCCCCCEEEEEEEECHHHCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]