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The map label for this gene is wzc [H]

Identifier: 37678524

GI number: 37678524

Start: 346520

End: 348700

Strand: Direct

Name: wzc [H]

Synonym: VV0340

Alternate gene names: 37678524

Gene position: 346520-348700 (Clockwise)

Preceding gene: 37678523

Following gene: 37678525

Centisome position: 10.33

GC content: 45.07

Gene sequence:

>2181_bases
ATGAACGAGACAATGACAACACCACAAAACCGATCTTCCGTTGATAACTCGTCTGACGAAATCGATTTAGGCAAGCTGCT
TGGCATTCTTTTGGATGCAAAATGGATCATCCTAGTAACAACCTTTTTATTTGCGGTTGGTGGAGTCGCGGTTGCGCTAC
TTTCAACGCCTATCTACAAAGCCGATGCGCTGATTCAAATTGAGCAAAAAAGCTCGGGCGGCATTAGCTCGCTGGTTGGG
GATATGGGGGAGTTATTCTCACAAGAATCTTCTGCTACAACGGAAATCGAAATCATCAAGTCACGAATGATTTTGGGCGA
TACGGTGGATAAGTTCAATTTGACCACAGTAGCAGAGCCAAAATACTTGCCTGTGATTGGTAAGGGATTGGCTCGCATCG
CTGGAAAGGTGAATCAAATCGAAATCAGCCGTTATACAGTGCCAGAATACGCTCAAGAGATGAAGCATACCTTAGTGGTG
CTGGATGCGGAGAAGAAAACGTATCAATTGGTACGTGGTGATGAGCAAGTGGTGCTGCAAGGTGCTGCAGGAGAGCTAGC
AAAAAAAGATGGCTACGAGCTGTTTGTTACGGAATTACGTTCCCACAATGAACAAGAGTTTTCTCTATCGCAACAGAGCC
GCCTAGAGGCGATTGAGTGGCTGAAAAAGAACTTAGCGATCAGTGAGCGTGGTAAGCAAACGGGCATTTTAATGCTGAGC
TTCGAAGGTGAAAACCGTAAGCAAATCAGTGAAATTCTCAACCATATTAGCCAAACTTACTTTTTGCAAAATGTAGAGCG
CAATTCGGCAGAAGCGGAAAAAAGCTTGACCTTCTTAAAAGGCCATTTACCAGACATCAAAAACAGCCTTACAACGGCAG
AAGATACACTGAATCGATTCCGTCAAGACAACGAATCGATCGACTTAGGCTTAGAAGCCAAATCAACTCTGGATGTGATG
GTAAAACTGGAAGCACAACTCAACGAGCTGACCTTCAAAGAAAGCGAAATCAGCCAACGTTTTACCAAAGATCACCCGGC
ATACCGTTCTCTACTCGATAAGCGAGAAACGCTGCTTAAAGAGCGTGAGCGTTTAAATCAGCAAGTGCAAAAACTGCCAA
AGACGCAACGTGAAGTGCTGCGCATGACGCGTGATGTAGAAGTTAACCAACAGATCTACATTCAATTACTGAACAAAGTA
CAAGAACTCAGCATTATCAAAGCAGGTACCGTAGGTAACGTGCGTATCCTCGATGAAGCGCAAAGTTACGCAAAACCTGT
TAAACCTAAGAAGCCATTGATTGTAGTGCTCGCGACTCTGTTAGGTGGCATGCTCAGTGTGGCCTTGGTATTGGTTAAAG
CGGCGTTTCATCGGGGTGTAGAAAATCCAGATGAGATTGAACAGATTGGCCTTTCTGTGTATGCAAGTGTGCCAAAATCC
AATCTACAGTTAGAGCTGGCCAATAAGCTTGCTCGCAAGAAGCGCAATACAGATTTGACGCTACTGGCGGAGAGTAACCC
TGCCGACCTATCTATTGAAGCATTGCGTGGCCTGCGTACCAGCTTACACTTTGCGATGATGGAAGCAAAAAACAACGTAT
TGATGATCTCAGGCCCTGCACCTGGCATTGGTAAATCGTTTGTTTCTACCAACTTTGCAGCGGTAGCAGCAAAAACAGGA
CAAAAAGTATTGCTGATTGATGCAGATATGCGCAAAGGCTATTTGCAACAGTGTTTTGGTTTAAATTGGGAAAATGGCCT
ATCGGATTTGCTCAGTGGGAAAGTAACAAGAGACGTCGCAGTGCAATCTGCCAAAGTAGAGAACTTAGACATCATCACCC
GTGGTCAAGTGCCACCAAACCCTTCAGAGCTGCTCATGCATCCGCGCTTTAAAGAGCTTGTAGATTGGGCAAGTGAAAAC
TACGACTTAGTCATTGTAGATACTCCACCTGTGCTCGCGGTAACCGACCCAAGCATAGTAGGTGCAATAGCGGGCACCAC
ATTAATGGTGGCTCGCTTTGGCCAAAACACAGTGAAAGAGATTGATGTGGCACGTAGCCGCTTTGAGCAAGCAGGCATCG
AAGTAAAAGGTGTGATTCTAAACGCGATAGAGAAAAAAGCCTCTTCATCTTATGGCTACGGTTATTACAACTATAGCTAT
GGTGAGAGTAATAAAGCTTAA

Upstream 100 bases:

>100_bases
GTACCCTTCTCTTCCCTAGCAACCTGCTCTTCCCTAGAATCCTAGCAATCTTCTCTTCCCTAGAACCTTATTTTAAAATC
ATAAATCCACCAACCCGGAA

Downstream 100 bases:

>100_bases
ATTAACCGGGGAGAACTGCTATTCGGCTGTTATCTCCTCGGTATCTCCAGAATTTTGTATCTAAATTATTGTTGGTTAGT
TGTATGTCAAAGAAGAAAGT

Product: putative tyrosine-protein kinase Wzc

Products: ADP; protein tyrosine phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 726; Mature: 726

Protein sequence:

>726_residues
MNETMTTPQNRSSVDNSSDEIDLGKLLGILLDAKWIILVTTFLFAVGGVAVALLSTPIYKADALIQIEQKSSGGISSLVG
DMGELFSQESSATTEIEIIKSRMILGDTVDKFNLTTVAEPKYLPVIGKGLARIAGKVNQIEISRYTVPEYAQEMKHTLVV
LDAEKKTYQLVRGDEQVVLQGAAGELAKKDGYELFVTELRSHNEQEFSLSQQSRLEAIEWLKKNLAISERGKQTGILMLS
FEGENRKQISEILNHISQTYFLQNVERNSAEAEKSLTFLKGHLPDIKNSLTTAEDTLNRFRQDNESIDLGLEAKSTLDVM
VKLEAQLNELTFKESEISQRFTKDHPAYRSLLDKRETLLKERERLNQQVQKLPKTQREVLRMTRDVEVNQQIYIQLLNKV
QELSIIKAGTVGNVRILDEAQSYAKPVKPKKPLIVVLATLLGGMLSVALVLVKAAFHRGVENPDEIEQIGLSVYASVPKS
NLQLELANKLARKKRNTDLTLLAESNPADLSIEALRGLRTSLHFAMMEAKNNVLMISGPAPGIGKSFVSTNFAAVAAKTG
QKVLLIDADMRKGYLQQCFGLNWENGLSDLLSGKVTRDVAVQSAKVENLDIITRGQVPPNPSELLMHPRFKELVDWASEN
YDLVIVDTPPVLAVTDPSIVGAIAGTTLMVARFGQNTVKEIDVARSRFEQAGIEVKGVILNAIEKKASSSYGYGYYNYSY
GESNKA

Sequences:

>Translated_726_residues
MNETMTTPQNRSSVDNSSDEIDLGKLLGILLDAKWIILVTTFLFAVGGVAVALLSTPIYKADALIQIEQKSSGGISSLVG
DMGELFSQESSATTEIEIIKSRMILGDTVDKFNLTTVAEPKYLPVIGKGLARIAGKVNQIEISRYTVPEYAQEMKHTLVV
LDAEKKTYQLVRGDEQVVLQGAAGELAKKDGYELFVTELRSHNEQEFSLSQQSRLEAIEWLKKNLAISERGKQTGILMLS
FEGENRKQISEILNHISQTYFLQNVERNSAEAEKSLTFLKGHLPDIKNSLTTAEDTLNRFRQDNESIDLGLEAKSTLDVM
VKLEAQLNELTFKESEISQRFTKDHPAYRSLLDKRETLLKERERLNQQVQKLPKTQREVLRMTRDVEVNQQIYIQLLNKV
QELSIIKAGTVGNVRILDEAQSYAKPVKPKKPLIVVLATLLGGMLSVALVLVKAAFHRGVENPDEIEQIGLSVYASVPKS
NLQLELANKLARKKRNTDLTLLAESNPADLSIEALRGLRTSLHFAMMEAKNNVLMISGPAPGIGKSFVSTNFAAVAAKTG
QKVLLIDADMRKGYLQQCFGLNWENGLSDLLSGKVTRDVAVQSAKVENLDIITRGQVPPNPSELLMHPRFKELVDWASEN
YDLVIVDTPPVLAVTDPSIVGAIAGTTLMVARFGQNTVKEIDVARSRFEQAGIEVKGVILNAIEKKASSSYGYGYYNYSY
GESNKA
>Mature_726_residues
MNETMTTPQNRSSVDNSSDEIDLGKLLGILLDAKWIILVTTFLFAVGGVAVALLSTPIYKADALIQIEQKSSGGISSLVG
DMGELFSQESSATTEIEIIKSRMILGDTVDKFNLTTVAEPKYLPVIGKGLARIAGKVNQIEISRYTVPEYAQEMKHTLVV
LDAEKKTYQLVRGDEQVVLQGAAGELAKKDGYELFVTELRSHNEQEFSLSQQSRLEAIEWLKKNLAISERGKQTGILMLS
FEGENRKQISEILNHISQTYFLQNVERNSAEAEKSLTFLKGHLPDIKNSLTTAEDTLNRFRQDNESIDLGLEAKSTLDVM
VKLEAQLNELTFKESEISQRFTKDHPAYRSLLDKRETLLKERERLNQQVQKLPKTQREVLRMTRDVEVNQQIYIQLLNKV
QELSIIKAGTVGNVRILDEAQSYAKPVKPKKPLIVVLATLLGGMLSVALVLVKAAFHRGVENPDEIEQIGLSVYASVPKS
NLQLELANKLARKKRNTDLTLLAESNPADLSIEALRGLRTSLHFAMMEAKNNVLMISGPAPGIGKSFVSTNFAAVAAKTG
QKVLLIDADMRKGYLQQCFGLNWENGLSDLLSGKVTRDVAVQSAKVENLDIITRGQVPPNPSELLMHPRFKELVDWASEN
YDLVIVDTPPVLAVTDPSIVGAIAGTTLMVARFGQNTVKEIDVARSRFEQAGIEVKGVILNAIEKKASSSYGYGYYNYSY
GESNKA

Specific function: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg [H]

COG id: COG3206

COG function: function code M; Uncharacterized protein involved in exopolysaccharide biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the etk/wzc family [H]

Homologues:

Organism=Escherichia coli, GI87082032, Length=712, Percent_Identity=49.5786516853933, Blast_Score=688, Evalue=0.0,
Organism=Escherichia coli, GI1787216, Length=718, Percent_Identity=46.5181058495822, Blast_Score=640, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR005702
- InterPro:   IPR003856 [H]

Pfam domain/function: PF01656 CbiA; PF02706 Wzz [H]

EC number: 2.7.1.112 [C]

Molecular weight: Translated: 80402; Mature: 80402

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNETMTTPQNRSSVDNSSDEIDLGKLLGILLDAKWIILVTTFLFAVGGVAVALLSTPIYK
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
ADALIQIEQKSSGGISSLVGDMGELFSQESSATTEIEIIKSRMILGDTVDKFNLTTVAEP
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCC
KYLPVIGKGLARIAGKVNQIEISRYTVPEYAQEMKHTLVVLDAEKKTYQLVRGDEQVVLQ
CCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCEEEEEECCHHHHHHHCCCCEEEEE
GAAGELAKKDGYELFVTELRSHNEQEFSLSQQSRLEAIEWLKKNLAISERGKQTGILMLS
CCCCHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEEE
FEGENRKQISEILNHISQTYFLQNVERNSAEAEKSLTFLKGHLPDIKNSLTTAEDTLNRF
ECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RQDNESIDLGLEAKSTLDVMVKLEAQLNELTFKESEISQRFTKDHPAYRSLLDKRETLLK
HCCCCCEEECCCCCCCEEEEEEHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
ERERLNQQVQKLPKTQREVLRMTRDVEVNQQIYIQLLNKVQELSIIKAGTVGNVRILDEA
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCCCEEEHHHH
QSYAKPVKPKKPLIVVLATLLGGMLSVALVLVKAAFHRGVENPDEIEQIGLSVYASVPKS
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCC
NLQLELANKLARKKRNTDLTLLAESNPADLSIEALRGLRTSLHFAMMEAKNNVLMISGPA
CCCHHHHHHHHHHHCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEEECCC
PGIGKSFVSTNFAAVAAKTGQKVLLIDADMRKGYLQQCFGLNWENGLSDLLSGKVTRDVA
CCCCHHHHHCCHHHEEECCCCEEEEEECHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHH
VQSAKVENLDIITRGQVPPNPSELLMHPRFKELVDWASENYDLVIVDTPPVLAVTDPSIV
HHHCCCCCCEEEECCCCCCCHHHHHCCCCHHHHHHHHCCCCCEEEECCCCEEEECCCHHH
GAIAGTTLMVARFGQNTVKEIDVARSRFEQAGIEVKGVILNAIEKKASSSYGYGYYNYSY
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCEEEECC
GESNKA
CCCCCC
>Mature Secondary Structure
MNETMTTPQNRSSVDNSSDEIDLGKLLGILLDAKWIILVTTFLFAVGGVAVALLSTPIYK
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
ADALIQIEQKSSGGISSLVGDMGELFSQESSATTEIEIIKSRMILGDTVDKFNLTTVAEP
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCC
KYLPVIGKGLARIAGKVNQIEISRYTVPEYAQEMKHTLVVLDAEKKTYQLVRGDEQVVLQ
CCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCEEEEEECCHHHHHHHCCCCEEEEE
GAAGELAKKDGYELFVTELRSHNEQEFSLSQQSRLEAIEWLKKNLAISERGKQTGILMLS
CCCCHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEEE
FEGENRKQISEILNHISQTYFLQNVERNSAEAEKSLTFLKGHLPDIKNSLTTAEDTLNRF
ECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RQDNESIDLGLEAKSTLDVMVKLEAQLNELTFKESEISQRFTKDHPAYRSLLDKRETLLK
HCCCCCEEECCCCCCCEEEEEEHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
ERERLNQQVQKLPKTQREVLRMTRDVEVNQQIYIQLLNKVQELSIIKAGTVGNVRILDEA
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCCCEEEHHHH
QSYAKPVKPKKPLIVVLATLLGGMLSVALVLVKAAFHRGVENPDEIEQIGLSVYASVPKS
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCC
NLQLELANKLARKKRNTDLTLLAESNPADLSIEALRGLRTSLHFAMMEAKNNVLMISGPA
CCCHHHHHHHHHHHCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEEECCC
PGIGKSFVSTNFAAVAAKTGQKVLLIDADMRKGYLQQCFGLNWENGLSDLLSGKVTRDVA
CCCCHHHHHCCHHHEEECCCCEEEEEECHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHH
VQSAKVENLDIITRGQVPPNPSELLMHPRFKELVDWASENYDLVIVDTPPVLAVTDPSIV
HHHCCCCCCEEEECCCCCCCHHHHHCCCCHHHHHHHHCCCCCEEEECCCCEEEECCCHHH
GAIAGTTLMVARFGQNTVKEIDVARSRFEQAGIEVKGVILNAIEKKASSSYGYGYYNYSY
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCEEEECC
GESNKA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; a protein tyrosine [C]

Specific reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]