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The map label for this gene is fabG [H]

Identifier: 37523924

GI number: 37523924

Start: 4588235

End: 4588930

Strand: Direct

Name: fabG [H]

Synonym: glr4355

Alternate gene names: 37523924

Gene position: 4588235-4588930 (Clockwise)

Preceding gene: 37523918

Following gene: 37523926

Centisome position: 98.48

GC content: 65.37

Gene sequence:

>696_bases
ATGCAGGGAAGGCACGTATTGCTCACCGGCGGCACGGGCGGTTTGGGTCTGGGGGTGACCCCGGCGGTGCTGGCACGGGG
GGCGCATTTGACGATCCCGTTTATCGCGCAGCGGGAAGTCGAGCGCCTCAAAAGCCGCCTCTGCCCGGCGGATCTGAGCC
GCGTGCGCTTTGTGGAGGCGAACCTGGCCGAGGAGGCGAGTGTCGAGGGATTGTTGGCTGCGCTGGAGCGGGTCGACGTG
CTTATCCATCTAGTGGGAGGGTTCAACATGGGACCGACCCACCAGTACACCTACGCCGACTGGAAGCGCGACATCGAGTT
GAATCTGGATACGACGTTTTTATTGTGTAAGCACTGCCTGGGGCGGATGCTGGCCACGGGCTACGGACGGATCGTCACGG
TCGGTTCGCGCGGTGCGCTGGAGCCTGCCGGGCAACTGGCCGCCTATTCGGCGGCAAAAGCCGGGGTGGTGGCGCTCACC
AAGGCGATCGCCGCCGAGACCAAAGGCACCGGGATCACCGCCAATGTCGTGCTGCCGAGCGTCATCGACACCCCCGGCAA
CCGGGCGGCGATGGGTGCGGAAAATGCCGACAAGTGGGTTAAACCCGAGTCGCTCGCCGAGGTGATTTGTTTTCTCGCTT
CGGAGGCGGCCCGCGATGTGCGCGGGGCGGCGGTGCCGGTTTACGGCAGCGTCTAG

Upstream 100 bases:

>100_bases
TCCATTCTGTTTACCAATTTTGCGCCTGTCCAGTACAAATACTTACCAATTGTCGCCATTTCAGGAACAATCGATAAGCA
GCGACAAGCGAGGAGATCCG

Downstream 100 bases:

>100_bases
CCTGCCGCCTCCACCGCCCCCAAAGCCTGGAGCATCGACTTTTGGGCGTCGGTCAGACCCGTCACCCCGGTGATGTCCAT
GCCCTCGTAGAGCCGGTCGG

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MQGRHVLLTGGTGGLGLGVTPAVLARGAHLTIPFIAQREVERLKSRLCPADLSRVRFVEANLAEEASVEGLLAALERVDV
LIHLVGGFNMGPTHQYTYADWKRDIELNLDTTFLLCKHCLGRMLATGYGRIVTVGSRGALEPAGQLAAYSAAKAGVVALT
KAIAAETKGTGITANVVLPSVIDTPGNRAAMGAENADKWVKPESLAEVICFLASEAARDVRGAAVPVYGSV

Sequences:

>Translated_231_residues
MQGRHVLLTGGTGGLGLGVTPAVLARGAHLTIPFIAQREVERLKSRLCPADLSRVRFVEANLAEEASVEGLLAALERVDV
LIHLVGGFNMGPTHQYTYADWKRDIELNLDTTFLLCKHCLGRMLATGYGRIVTVGSRGALEPAGQLAAYSAAKAGVVALT
KAIAAETKGTGITANVVLPSVIDTPGNRAAMGAENADKWVKPESLAEVICFLASEAARDVRGAAVPVYGSV
>Mature_231_residues
MQGRHVLLTGGTGGLGLGVTPAVLARGAHLTIPFIAQREVERLKSRLCPADLSRVRFVEANLAEEASVEGLLAALERVDV
LIHLVGGFNMGPTHQYTYADWKRDIELNLDTTFLLCKHCLGRMLATGYGRIVTVGSRGALEPAGQLAAYSAAKAGVVALT
KAIAAETKGTGITANVVLPSVIDTPGNRAAMGAENADKWVKPESLAEVICFLASEAARDVRGAAVPVYGSV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=260, Percent_Identity=30, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI66933014, Length=244, Percent_Identity=25, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI5031737, Length=248, Percent_Identity=27.4193548387097, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI32483357, Length=239, Percent_Identity=25.5230125523013, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=28.9256198347107, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1786812, Length=240, Percent_Identity=27.5, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788459, Length=242, Percent_Identity=26.8595041322314, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI87082100, Length=218, Percent_Identity=28.4403669724771, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI87082160, Length=243, Percent_Identity=25.5144032921811, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1789208, Length=247, Percent_Identity=23.4817813765182, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=246, Percent_Identity=23.5772357723577, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=24, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=26.5873015873016, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24230; Mature: 24230

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGRHVLLTGGTGGLGLGVTPAVLARGAHLTIPFIAQREVERLKSRLCPADLSRVRFVEA
CCCCEEEEECCCCCCCCCCCHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHH
NLAEEASVEGLLAALERVDVLIHLVGGFNMGPTHQYTYADWKRDIELNLDTTFLLCKHCL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCEEECCCHHHHHHHHHH
GRMLATGYGRIVTVGSRGALEPAGQLAAYSAAKAGVVALTKAIAAETKGTGITANVVLPS
HHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECH
VIDTPGNRAAMGAENADKWVKPESLAEVICFLASEAARDVRGAAVPVYGSV
HHCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCC
>Mature Secondary Structure
MQGRHVLLTGGTGGLGLGVTPAVLARGAHLTIPFIAQREVERLKSRLCPADLSRVRFVEA
CCCCEEEEECCCCCCCCCCCHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHH
NLAEEASVEGLLAALERVDVLIHLVGGFNMGPTHQYTYADWKRDIELNLDTTFLLCKHCL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCEEECCCHHHHHHHHHH
GRMLATGYGRIVTVGSRGALEPAGQLAAYSAAKAGVVALTKAIAAETKGTGITANVVLPS
HHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECH
VIDTPGNRAAMGAENADKWVKPESLAEVICFLASEAARDVRGAAVPVYGSV
HHCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]