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The map label for this gene is zraS [H]

Identifier: 37523667

GI number: 37523667

Start: 4295975

End: 4297324

Strand: Reverse

Name: zraS [H]

Synonym: gll4098

Alternate gene names: 37523667

Gene position: 4297324-4295975 (Counterclockwise)

Preceding gene: 37523680

Following gene: 37523666

Centisome position: 92.24

GC content: 63.33

Gene sequence:

>1350_bases
GTGGTATCCGCACAGAAATTAGGGAGCGAGCCGGGCCGGCGTTTATTCGACTTTGGTCGAAGATTTTGCGGCCCGCGCGG
ACATCCTCCGGCGGCGTTTTTCACCGGAACCGCTATACTCATGGCACCGGCGGCCCGGTGTCGGCCGGTTTTTTCCCTAG
CATCCCCTTGCCGCACTGTCCGCCACCGACACCCGATACCCGCCCCATCGGTAGCCGCCTCACCCATGAAGGTCTCACTC
TCCCCCGTGCTCGCCGCTTCCCAGGCAGCCGCCGGTTCCACCCCCCCCTCCTCCCAGTTGCACAGCCTCTGCCAGTTGCA
GGCGGAGCATCTGGCAATGGCCCACGCTCTGGTATGCGTCTTGATCGCTTACTACGATCCGCACACCGGCACCCAGCGGC
GCGTCACCCACACCGCCCAGGGTCCGCAGGGACTGCCGCGCGAGGCGCTCGCGGCCATCGCCGGGGAAGAATGGTCGACA
GGGTCATTGCCGGTCGCTACCGTCAGCGCCATCGAGATCGCCAATCTGCCGGGCTGTGTCTATATTTGTCCGCTGGTACA
GCGCGAACCACACCCCGAATTTCAGCTCATCGTCAGTGGACAGCCCCTGGACGCCGCCCGCAAACAGGCGCTCGAGCAGG
CCGCCGCGCTATTTACCCGCCACCTGGAGCTGTACCAGCGCTGCACCCGCCAGCAATCGGAAATTCAATTGTTGGAGCAG
GTCGTCCAGCGCACCGGCCACCAGTTGCGCAATCCCCTGGCCCTGATCGGTCTGTACGCGGAGAATCTCTGTTTGGGCCT
GGAGGAAGGCTCAACCCGCGAGCAGGCCCAGATTATCCGCGAGACGGTCAAAGAGCTGAACGCCAATCTGACTGAACTAG
TCTATTGCGGCCAGGGAGCGCGTCTGCGCATGGGCTTTCAAGATCTGCGCGCCTTGATGGCCCAGAGCGTCGAGGCCATC
GGCCCGTGGCTTGAGCGCAAGTGCCTGCGGGTGCGCTACCCCGACAGTTCACTGTTGTTTGCCTGCGACCGGCTGCAGAT
GAAGCAGGTTTTCGACAATCTGCTGAGCAACGCCGTGCACTTCAGCCCCGAGGGCGGCACGATCACCTGCCACTGGCGCT
CGTTTCAAAACGAGGTGCTCATCGAGATTGCCGATCAAGGCCCAGGACTTTCAGCGCAAGATCTCCAGCACGTGTTCACC
CCGTTCTATTCGCGCCGCCCCGGCGGCACCGGGTTGGGGCTCGCCATCGCCAAAAAGATCGTCCTGGATCACCAGGGCAG
CCTCTGGGTGCAAAATCTACCCACCGGCGGCGCCCAATTTTCCCTAGGTCTCCCTCGCGGCATCCATTGA

Upstream 100 bases:

>100_bases
GCGGGGCAAAGTCGATCTGCTCGGTACTGGTGAGGGACGTCCCCCCTGCCAGAATTTCGGCCAAGGTCTGACTCAGGGCA
GTGATCATGCGCTGTCGGCT

Downstream 100 bases:

>100_bases
ACTGCCGACGCCGAGGAGGTCCGCCTTGACCGTCCAGACCATCCTGCCCATCTTGCTCGTCGACGACGAATTGCGCTTTC
GTCAGGGTCTGCGCACGCTG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MVSAQKLGSEPGRRLFDFGRRFCGPRGHPPAAFFTGTAILMAPAARCRPVFSLASPCRTVRHRHPIPAPSVAASPMKVSL
SPVLAASQAAAGSTPPSSQLHSLCQLQAEHLAMAHALVCVLIAYYDPHTGTQRRVTHTAQGPQGLPREALAAIAGEEWST
GSLPVATVSAIEIANLPGCVYICPLVQREPHPEFQLIVSGQPLDAARKQALEQAAALFTRHLELYQRCTRQQSEIQLLEQ
VVQRTGHQLRNPLALIGLYAENLCLGLEEGSTREQAQIIRETVKELNANLTELVYCGQGARLRMGFQDLRALMAQSVEAI
GPWLERKCLRVRYPDSSLLFACDRLQMKQVFDNLLSNAVHFSPEGGTITCHWRSFQNEVLIEIADQGPGLSAQDLQHVFT
PFYSRRPGGTGLGLAIAKKIVLDHQGSLWVQNLPTGGAQFSLGLPRGIH

Sequences:

>Translated_449_residues
MVSAQKLGSEPGRRLFDFGRRFCGPRGHPPAAFFTGTAILMAPAARCRPVFSLASPCRTVRHRHPIPAPSVAASPMKVSL
SPVLAASQAAAGSTPPSSQLHSLCQLQAEHLAMAHALVCVLIAYYDPHTGTQRRVTHTAQGPQGLPREALAAIAGEEWST
GSLPVATVSAIEIANLPGCVYICPLVQREPHPEFQLIVSGQPLDAARKQALEQAAALFTRHLELYQRCTRQQSEIQLLEQ
VVQRTGHQLRNPLALIGLYAENLCLGLEEGSTREQAQIIRETVKELNANLTELVYCGQGARLRMGFQDLRALMAQSVEAI
GPWLERKCLRVRYPDSSLLFACDRLQMKQVFDNLLSNAVHFSPEGGTITCHWRSFQNEVLIEIADQGPGLSAQDLQHVFT
PFYSRRPGGTGLGLAIAKKIVLDHQGSLWVQNLPTGGAQFSLGLPRGIH
>Mature_449_residues
MVSAQKLGSEPGRRLFDFGRRFCGPRGHPPAAFFTGTAILMAPAARCRPVFSLASPCRTVRHRHPIPAPSVAASPMKVSL
SPVLAASQAAAGSTPPSSQLHSLCQLQAEHLAMAHALVCVLIAYYDPHTGTQRRVTHTAQGPQGLPREALAAIAGEEWST
GSLPVATVSAIEIANLPGCVYICPLVQREPHPEFQLIVSGQPLDAARKQALEQAAALFTRHLELYQRCTRQQSEIQLLEQ
VVQRTGHQLRNPLALIGLYAENLCLGLEEGSTREQAQIIRETVKELNANLTELVYCGQGARLRMGFQDLRALMAQSVEAI
GPWLERKCLRVRYPDSSLLFACDRLQMKQVFDNLLSNAVHFSPEGGTITCHWRSFQNEVLIEIADQGPGLSAQDLQHVFT
PFYSRRPGGTGLGLAIAKKIVLDHQGSLWVQNLPTGGAQFSLGLPRGIH

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: COG5002

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=27.8481012658228, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788393, Length=237, Percent_Identity=28.2700421940928, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788549, Length=223, Percent_Identity=27.3542600896861, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786600, Length=210, Percent_Identity=28.0952380952381, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789808, Length=204, Percent_Identity=29.4117647058824, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1790300, Length=233, Percent_Identity=29.6137339055794, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI145693157, Length=118, Percent_Identity=34.7457627118644, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787894, Length=217, Percent_Identity=26.2672811059908, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790346, Length=250, Percent_Identity=24.4, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790861, Length=220, Percent_Identity=30.4545454545455, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786783, Length=248, Percent_Identity=22.5806451612903, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786912, Length=293, Percent_Identity=28.6689419795222, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=273, Percent_Identity=25.6410256410256, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=102, Percent_Identity=38.2352941176471, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=26.5486725663717, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48948; Mature: 48948

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSAQKLGSEPGRRLFDFGRRFCGPRGHPPAAFFTGTAILMAPAARCRPVFSLASPCRTV
CCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHCHHHHHCCHHHHHHHHHHHHHHHHH
RHRHPIPAPSVAASPMKVSLSPVLAASQAAAGSTPPSSQLHSLCQLQAEHLAMAHALVCV
HHCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LIAYYDPHTGTQRRVTHTAQGPQGLPREALAAIAGEEWSTGSLPVATVSAIEIANLPGCV
HHHHCCCCCCCCCCEEECCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCE
YICPLVQREPHPEFQLIVSGQPLDAARKQALEQAAALFTRHLELYQRCTRQQSEIQLLEQ
EEEHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
VVQRTGHQLRNPLALIGLYAENLCLGLEEGSTREQAQIIRETVKELNANLTELVYCGQGA
HHHHHHHHHHCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCHHHEEEECCCC
RLRMGFQDLRALMAQSVEAIGPWLERKCLRVRYPDSSLLFACDRLQMKQVFDNLLSNAVH
EEECCHHHHHHHHHHHHHHHCHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHCEE
FSPEGGTITCHWRSFQNEVLIEIADQGPGLSAQDLQHVFTPFYSRRPGGTGLGLAIAKKI
ECCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
VLDHQGSLWVQNLPTGGAQFSLGLPRGIH
HHCCCCCEEEEECCCCCCEEECCCCCCCC
>Mature Secondary Structure
MVSAQKLGSEPGRRLFDFGRRFCGPRGHPPAAFFTGTAILMAPAARCRPVFSLASPCRTV
CCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHCHHHHHCCHHHHHHHHHHHHHHHHH
RHRHPIPAPSVAASPMKVSLSPVLAASQAAAGSTPPSSQLHSLCQLQAEHLAMAHALVCV
HHCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LIAYYDPHTGTQRRVTHTAQGPQGLPREALAAIAGEEWSTGSLPVATVSAIEIANLPGCV
HHHHCCCCCCCCCCEEECCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCE
YICPLVQREPHPEFQLIVSGQPLDAARKQALEQAAALFTRHLELYQRCTRQQSEIQLLEQ
EEEHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
VVQRTGHQLRNPLALIGLYAENLCLGLEEGSTREQAQIIRETVKELNANLTELVYCGQGA
HHHHHHHHHHCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCHHHEEEECCCC
RLRMGFQDLRALMAQSVEAIGPWLERKCLRVRYPDSSLLFACDRLQMKQVFDNLLSNAVH
EEECCHHHHHHHHHHHHHHHCHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHCEE
FSPEGGTITCHWRSFQNEVLIEIADQGPGLSAQDLQHVFTPFYSRRPGGTGLGLAIAKKI
ECCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
VLDHQGSLWVQNLPTGGAQFSLGLPRGIH
HHCCCCCEEEEECCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]